Sichen Chang

841 citations
34 papers · 488 · h-index 13

Impact in

Papers in

  • Molecular Biology 31
    • Receptor Mechanisms and Signaling 24
    • Pharmacological Receptor Mechanisms and Effects 12
    • Nicotinic Acetylcholine Receptors Study 8
    • Chemical Synthesis and Analysis 5
    • Ion channel regulation and function 3
  • Cellular and Molecular Neuroscience 17
    • Neuroscience and Neuropharmacology Research 16
Co-authors
Colleen M. Niswender (31 shared papers)Craig W. Lindsley (33 shared papers)P. Jeffrey Conn (29 shared papers)Alice L. Rodriguez (25 shared papers)Carrie K. Jones (16 shared papers)Anna L. Blobaum (12 shared papers)Julie L. Engers (15 shared papers)Hyekyung P. Cho (15 shared papers)
Journals
Bioorganic & Medicinal Chemistry Letters (18 papers)ACS Medicinal Chemistry Letters (6 papers)ACS Chemical Neuroscience (4 papers)Journal of Medicinal Chemistry (3 papers)Journal of Natural Products (1 paper)
Partner nations
United StatesAustraliaDenmark

In The Last Decade

Sichen Chang

32 papers receiving 486 citations

Peers

Sichen Chang
Comparison fields: 5 of 46
  • Cellular and Molecular Neuroscience 284
  • Biological Psychiatry 26
  • Molecular Biology 355
  • Organic Chemistry 101
  • Computational Theory and Mathematics 55
Replace Frank W. Byers with:
Frank W. Byers United States
François Bischoff Belgium
Nicholas D. Smith United States
Sándor Kolok Hungary
William D. Shipe United States
Isabelle Berque‐Bestel France
Gentaroh Suzuki Japan
Thomas J. Bleisch United States
Laura Iturrino Belgium
Ara M. Abramyan United States
Sichen Chang relative to Frank W. Byers United States Frank W. Byers's profile →
Citations per field
00.5×2×2.8×
Frank W. Byers · 1×
Citations per year

Countries citing papers authored by Sichen Chang

Since Specialization
Citations

This map shows the geographic impact of Sichen Chang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sichen Chang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sichen Chang more than expected).

Fields of papers citing papers by Sichen Chang

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sichen Chang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sichen Chang. The network helps show where Sichen Chang may publish in the future.

Co-authors

The 25 scholars most cited alongside Sichen Chang, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Sichen Chang Line = papers co-authored together Sichen Chang links everyone, so they are left out of the graph.

All Works

20 of 20 papers shown

Showing the 20 most-cited of 34 papers — load more, or switch the sort, to bring in the rest.

#Work
1
Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents
Journal of Medicinal Chemistry ·Julie L. Engers, Alice L. Rodriguez, Leah C. Konkol, Ryan D. Morrison, Analisa D. Thompson, Frank W. Byers, Anna L. Blobaum, Sichen Chang, Daryl F. Venable, Matthew T. Loch, Colleen M. Niswender, J. Scott Daniels, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte
201555
2
A Novel M 1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity
ACS Chemical Neuroscience ·Jerri M. Rook, Jeanette L. Bertron, Hyekyung P. Cho, Pedro M. García-Barrantes, Sean P. Moran, James Maksymetz, Kellie D. Nance, Jonathan W. Dickerson, Daniel H. Remke, Sichen Chang, Joel M. Harp, Anna L. Blobaum, Colleen M. Niswender, Carrie K. Jones, Shaun R. Stauffer, P. Jeffrey Conn, Craig W. Lindsley
201849
3
Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs
ACS Chemical Neuroscience ·Jerri M. Rook, Masahito Abe, Hyekyung P. Cho, Kellie D. Nance, Vincent B. Luscombe, Jeffrey J. Adams, Jonathan W. Dickerson, Daniel H. Remke, Pedro M. García-Barrantes, Darren W. Engers, Julie L. Engers, Sichen Chang, Jarrett J. Foster, Anna L. Blobaum, Colleen M. Niswender, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley
201641
4
Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs
ACS Medicinal Chemistry Letters ·Julie L. Engers, Katrina A. Bollinger, Rebecca L. Weiner, Alice L. Rodriguez, Madeline F. Long, Megan M. Breiner, Sichen Chang, Sean R. Bollinger, Michael Bubser, Carrie K. Jones, Ryan D. Morrison, Thomas M. Bridges, Anna L. Blobaum, Colleen M. Niswender, P. Jeffrey Conn, Kyle A. Emmitte, Craig W. Lindsley
201736
5
Design and Synthesis of mGlu2NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core
ACS Medicinal Chemistry Letters ·Katrina A. Bollinger, Andrew S. Felts, Christopher J. Brassard, Julie L. Engers, Alice L. Rodriguez, Rebecca L. Weiner, Hyekyung P. Cho, Sichen Chang, Michael Bubser, Carrie K. Jones, Anna L. Blobaum, Colleen M. Niswender, P. Jeffrey Conn, Kyle A. Emmitte, Craig W. Lindsley
201731
6
Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2
Journal of Medicinal Chemistry ·Andrew S. Felts, Alice L. Rodriguez, Katrina A. Smith, Julie L. Engers, Ryan D. Morrison, Frank W. Byers, Anna L. Blobaum, Charles W. Locuson, Sichen Chang, Daryl F. Venable, Colleen M. Niswender, J. Scott Daniels, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte
201529
7
Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines
ACS Medicinal Chemistry Letters ·Masahito Abe, Mabel Seto, Rocco G. Gogliotti, Matthew T. Loch, Katrina A. Bollinger, Sichen Chang, Eileen M. Engelberg, Vincent B. Luscombe, Joel M. Harp, Michael Bubser, Darren W. Engers, Carrie K. Jones, Alice L. Rodriguez, Anna L. Blobaum, P. Jeffrey Conn, Colleen M. Niswender, Craig W. Lindsley
201729
8
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs
Bioorganic & Medicinal Chemistry Letters ·Michael R. Wood, Meredith J. Noetzel, Michael S. Poslusney, Bruce J. Melancon, James C. Tarr, Atin Lamsal, Sichen Chang, Vincent B. Luscombe, Rebecca L. Weiner, Hyekyung P. Cho, Michael Bubser, Carrie K. Jones, Colleen M. Niswender, Michael W. Wood, Darren W. Engers, Nicholas J. Brandon, Mark E. Duggan, P. Jeffrey Conn, Thomas M. Bridges, Craig W. Lindsley
201627
9
Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation
Journal of Medicinal Chemistry ·Andrew S. Felts, Alice L. Rodriguez, Anna L. Blobaum, Ryan D. Morrison, Brittney S. Bates, Analisa Thompson Gray, Jerri M. Rook, Mohammed Noor Tantawy, Frank W. Byers, Sichen Chang, Daryl F. Venable, Vincent B. Luscombe, Gilles Tamagnan, Colleen M. Niswender, J. Scott Daniels, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte
201724
10
Evaluation of 1,2,3‐Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX‐770 and VX‐809
Chemistry - A European Journal ·Jake E. Doiron, Christina A. Le, Britton K. Ody, Jonathon B. Brace, Savannah J. Post, Nathan L. Thacker, Harrison M. Hill, Gary W. Breton, Matthew J. Mulder, Sichen Chang, Thomas M. Bridges, Liping Tang, Wei Wang, Steven M. Rowe, Stephen G. Aller, Mark Turlington
201921
11
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides
Bioorganic & Medicinal Chemistry Letters ·James C. Tarr, Michael R. Wood, Meredith J. Noetzel, Jeanette L. Bertron, Rebecca L. Weiner, Alice L. Rodriguez, Atin Lamsal, Frank W. Byers, Sichen Chang, Hyekyung P. Cho, Carrie K. Jones, Colleen M. Niswender, Michael W. Wood, Nicholas J. Brandon, Mark E. Duggan, P. Jeffrey Conn, Thomas M. Bridges, Craig W. Lindsley
201718
12
Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping
Bioorganic & Medicinal Chemistry Letters ·Madeline F. Long, Julie L. Engers, Sichen Chang, Xiaoyan Zhan, Rebecca L. Weiner, Vincent B. Luscombe, Alice L. Rodriguez, Hyekyung P. Cho, Colleen M. Niswender, Thomas M. Bridges, P. Jeffrey Conn, Darren W. Engers, Craig W. Lindsley
201715
13
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides
Bioorganic & Medicinal Chemistry Letters ·James C. Tarr, Michael R. Wood, Meredith J. Noetzel, Bruce J. Melancon, Atin Lamsal, Vincent B. Luscombe, Alice L. Rodriguez, Frank W. Byers, Sichen Chang, Hyekyung P. Cho, Darren W. Engers, Carrie K. Jones, Colleen M. Niswender, Michael W. Wood, Nicholas J. Brandon, Mark E. Duggan, P. Jeffrey Conn, Thomas M. Bridges, Craig W. Lindsley
201713
14
Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold
ACS Chemical Neuroscience ·Aaron M. Bender, Hyekyung P. Cho, Kellie D. Nance, Kaelyn S. Lingenfelter, Vincent B. Luscombe, Patrick R. Gentry, Karl R. Voigtritter, Alice E. Berizzi, Patrick M. Sexton, Christopher J. Langmead, Arthur Christopoulos, Charles W. Locuson, Thomas M. Bridges, Sichen Chang, Jordan C. O’Neill, Xiaoyan Zhan, Colleen M. Niswender, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley
201812
15
Discovery of a novel 3,4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping
Bioorganic & Medicinal Chemistry Letters ·Kayla J. Temple, Julie L. Engers, Madeline F. Long, Alison R. Gregro, Katherine J. Watson, Sichen Chang, Matthew T. Jenkins, Vincent B. Luscombe, Alice L. Rodriguez, Colleen M. Niswender, Thomas M. Bridges, P. Jeffrey Conn, Darren W. Engers, Craig W. Lindsley
201911
16
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists
Bioorganic & Medicinal Chemistry Letters ·Aaron M. Bender, Rebecca L. Weiner, Vincent B. Luscombe, Sonia Ajmera, Hyekyung P. Cho, Sichen Chang, Xiaoyan Zhan, Alice L. Rodriguez, Colleen M. Niswender, Darren W. Engers, Thomas M. Bridges, P. Jeffrey Conn, Craig W. Lindsley
20179
17
Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration
Bioorganic & Medicinal Chemistry Letters ·Joseph D. Panarese, Hykeyung P. Cho, Jeffrey J. Adams, Kellie D. Nance, Pedro M. García-Barrantes, Sichen Chang, Ryan D. Morrison, Anna L. Blobaum, Colleen M. Niswender, Shaun R. Stauffer, P. Jeffrey Conn, Craig W. Lindsley
20169
18
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist
ACS Medicinal Chemistry Letters ·Matthew Spock, Trever R. Carter, Katrina A. Bollinger, Changho Han, Logan A. Baker, Alice L. Rodriguez, Peng Li, Jonathan W. Dickerson, Aidong Qi, Jerri M. Rook, Jordan C. O’Neill, Katherine J. Watson, Sichen Chang, Thomas M. Bridges, Julie L. Engers, Darren W. Engers, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Aaron M. Bender
20218
19
Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core
Bioorganic & Medicinal Chemistry Letters ·Blake R. Bewley, Paul K. Spearing, Rebecca L. Weiner, Vincent B. Luscombe, Xiaoyan Zhan, Sichen Chang, Hyekyung P. Cho, Alice L. Rodriguez, Colleen M. Niswender, P. Jeffrey Conn, Thomas M. Bridges, Darren W. Engers, Craig W. Lindsley
20177
20
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition
Bioorganic & Medicinal Chemistry Letters ·Michael R. Wood, Meredith J. Noetzel, James C. Tarr, Alice L. Rodriguez, Atin Lamsal, Sichen Chang, Jarrett J. Foster, Emery Smith, Peter Chase, Peter Hodder, Darren W. Engers, Colleen M. Niswender, Nicholas J. Brandon, Michael W. Wood, Mark E. Duggan, P. Jeffrey Conn, Thomas M. Bridges, Craig W. Lindsley
20167

About Sichen Chang

Sichen Chang is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience, Computational Theory and Mathematics, Organic Chemistry and Pharmacology, having authored 34 papers that have together received 488 indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (24 papers), Neuroscience and Neuropharmacology Research (16 papers), Pharmacological Receptor Mechanisms and Effects (12 papers), Nicotinic Acetylcholine Receptors Study (8 papers), Computational Drug Discovery Methods (6 papers), Chemical Synthesis and Analysis (5 papers), Ion channel regulation and function (3 papers) and Genetics and Neurodevelopmental Disorders (2 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (284 citations), Biological Psychiatry (26 citations), Molecular Biology (355 citations), Organic Chemistry (101 citations) and Computational Theory and Mathematics (55 citations). Sichen Chang has collaborated with scholars based in United States, Australia and Denmark. Frequent co-authors include Colleen M. Niswender, Craig W. Lindsley, P. Jeffrey Conn, Alice L. Rodriguez, Carrie K. Jones, Anna L. Blobaum, Julie L. Engers, Hyekyung P. Cho, Thomas M. Bridges and Vincent B. Luscombe. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, ACS Medicinal Chemistry Letters, ACS Chemical Neuroscience, Journal of Medicinal Chemistry and Journal of Natural Products.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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