Punit P. Seth

8.7k citations

125 papers · 7.3k · 1 hit paper · h-index 49

Impact in

Molecular Biology top 1%
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- RNA modifications and cancer
Cancer Research top 5%
- MicroRNA in disease regulation

Papers in

Molecular Biology 110
- DNA and Nucleic Acid Chemistry 64
- RNA Interference and Gene Delivery 62
- Advanced biosensing and bioanalysis techniques 59
- RNA and protein synthesis mechanisms 25
- RNA Research and Splicing 14
- CRISPR and Genetic Engineering 10
Organic Chemistry 20

Co-authors: Eric E. Swayze (70 shared papers)Thazha P. Prakash (37 shared papers)Hans J. Gaus (26 shared papers)Michael E. Østergaard (29 shared papers)Michael T. Migawa (23 shared papers)Stanley T. Crooke (14 shared papers)Alfred E. Chappell (12 shared papers)Garth A. Kinberger (14 shared papers)
Journals: Nucleic Acids Research (23 papers)Bioorganic & Medicinal Chemistry Letters (14 papers)Nucleic Acid Therapeutics (10 papers)The Journal of Organic Chemistry (9 papers)Journal of the American Chemical Society (8 papers)
Partner nations: United States Canada Japan

In The Last Decade

Punit P. Seth

124 papers receiving 7.0k citations

Punit P. Seth's Hit Papers

align trajectories log scale

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice 2014 · 534 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2014 Nucleic Acids Research

Peers

Countries citing papers authored by Punit P. Seth

Since Specialization

Citations

This map shows the geographic impact of Punit P. Seth's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Punit P. Seth with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Punit P. Seth more than expected).

Fields of papers citing papers by Punit P. Seth

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Punit P. Seth. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Punit P. Seth. The network helps show where Punit P. Seth may publish in the future.

Co-authors

The 25 scholars most cited alongside Punit P. Seth, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Punit P. Seth Line = papers co-authored together Punit P. Seth links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 125 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice Nucleic Acids Research ·Thazha P. Prakash, Mark J. Graham, Jinghua Yu, Rick Carty, Audrey Low, Alfred E. Chappell, Karsten Schmidt, Chenguang Zhao Hit paper breakdown →	2014	534
2	The Medicinal Chemistry of Therapeutic Oligonucleotides Journal of Medicinal Chemistry ·Punit P. Seth +1 other	2016	362
3	Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index Nature Biotechnology ·Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa, Timothy A. Vickers, Hong Wei Sun, Audrey Low, Thomas A. Bell, Meghdad Rahdar	2019	281
4	Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals Journal of Medicinal Chemistry ·Punit P. Seth, Andrew M. Siwkowski, Charles R. Allerson, Guillermo Vasquez, Sam S. Lee, Thazha P. Prakash, Edward V. Wancewicz, Donna R. Witchell	2008	236
5	Single-Stranded siRNAs Activate RNAi in Animals Cell ·Walt F. Lima, Thazha P. Prakash, Heather M. Murray, Garth A. Kinberger, Wenyu Li, Alfred E. Chappell, Cheryl Li, Susan Murray	2012	227
6	Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′ O -Methoxyethyl and 2′,4′-Constrained 2′ O -Ethyl Nucleic Acid Analogues The Journal of Organic Chemistry ·Punit P. Seth, Guillermo Vasquez, Charles A. Allerson, Andrés Berdeja, Hans J. Gaus, Garth A. Kinberger, Thazha P. Prakash, Michael T. Migawa	2010	188
7	Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts Nucleic Acids Research ·Sebastien A. Burel, Christopher E. Hart, Patrick Cauntay, Jill Hsiao, Todd Machemer, Melanie Katz, Andy Watt, Huynh‐Hoa Bui	2015	173
8	Targeted delivery of antisense oligonucleotides to pancreatic β-cells Science Advances ·Carina Ämmälä, William J. Drury, Laurent Knerr, Ingela Ahlstedt, Pia Stillemark-Billton, Charlotte Wennberg-Huldt, Eva-Marie Andersson, Eric Valeur	2018	155
9	SAR by MS: Discovery of a New Class of RNA-Binding Small Molecules for the Hepatitis C Virus: Internal Ribosome Entry Site IIA Subdomain Journal of Medicinal Chemistry ·Punit P. Seth, Alycia Miyaji, Elizabeth Anne Jefferson, Kristin A. Sannes‐Lowery, Stephen A. Osgood, Stephanie S. Propp, Ray Ranken, Christian Massire	2005	145
10	Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver Nucleic Acids Research ·Colton M. Miller, Aaron Joseph Donner, Emma E Blank, Andrew W. Egger, Brianna M. Kellar, Michael E. Østergaard, Punit P. Seth, Edward N. Harris	2016	145
11	Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS Nucleic Acids Research ·Michael E. Østergaard, Amber L. Southwell, Holly B. Kordasiewicz, Andrew T. Watt, Niels Henning Skotte, Crystal N. Doty, Kuljeet Vaid, Erika B. Villanueva	2013	138
12	Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes Nucleic Acids Research ·Michael Tanowitz, Lisa A. Hettrick, Alexey S. Revenko, Garth A. Kinberger, Thazha P. Prakash, Punit P. Seth	2017	135
13	Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle Nucleic Acids Research ·Thazha P. Prakash, Adam E. Mullick, Richard G. Lee, Jinghua Yu, Steve T. Yeh, Audrey Low, Alfred E. Chappell, Michael E. Østergaard	2019	127
14	Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay Nucleic Acids Research ·Hans J. Gaus, Ruchi Gupta, Alfred E. Chappell, Michael E. Østergaard, Eric E. Swayze, Punit P. Seth	2018	127
15	In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides Molecular Therapy ·Amber L. Southwell, Niels Henning Skotte, Holly B. Kordasiewicz, Michael E. Østergaard, Andrew T. Watt, Jeffrey B. Carroll, Crystal N. Doty, Erika B. Villanueva	2014	120
16	Comprehensive Structure–Activity Relationship of TriantennaryN-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes Journal of Medicinal Chemistry ·Thazha P. Prakash, Jinghua Yu, Michael T. Migawa, Garth A. Kinberger, Michael E. Østergaard, Recaldo L. Carty, Guillermo Vasquez, Audrey Low	2016	117
17	DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing Nature Communications ·Kazutaka Nishina, Wenying Piao, Kie Yoshida‐Tanaka, Yumiko Sujino, Tomoko Nishina, Tsuyoshi Yamamoto, Keiko Nitta, Kotaro Yoshioka	2015	114
18	Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS Nature Biotechnology ·Tetsuya Nagata, Chrissa A. Dwyer, Kie Yoshida‐Tanaka, Kensuke Ihara, Masaki Ohyagi, Hidetoshi Kaburagi, Haruka Miyata, Satoe Ebihara	2021	112
19	Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages Nucleic Acids Research ·Michael T. Migawa, Guillermo Vasquez, Heather M. Murray, Josh G. Nichols, Hans J. Gaus, Andrés Berdeja, Sam S. Lee, Christopher E. Hart	2014	111
20	The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents Journal of the American Chemical Society ·Stanley T. Crooke, Punit P. Seth, Timothy A. Vickers, Xue‐hai Liang	2020	108

About Punit P. Seth

Punit P. Seth is a scholar working on Molecular Biology, Organic Chemistry, Cellular and Molecular Neuroscience, Hepatology and Cardiology and Cardiovascular Medicine, having authored 125 papers that have together received 7.3k indexed citations. Recurring topics across this work include DNA and Nucleic Acid Chemistry (64 papers), RNA Interference and Gene Delivery (62 papers), Advanced biosensing and bioanalysis techniques (59 papers), RNA and protein synthesis mechanisms (25 papers), RNA Research and Splicing (14 papers), CRISPR and Genetic Engineering (10 papers), Genetic Neurodegenerative Diseases (7 papers) and Viral Infections and Immunology Research (6 papers). The work is most often cited by research in Molecular Biology (6.0k citations), Cancer Research (574 citations), Genetics (348 citations), Organic Chemistry (737 citations) and Cellular and Molecular Neuroscience (471 citations). Punit P. Seth has collaborated with scholars based in United States, Canada and Japan. Frequent co-authors include Eric E. Swayze, Thazha P. Prakash, Hans J. Gaus, Michael E. Østergaard, Michael T. Migawa, Stanley T. Crooke, Alfred E. Chappell, Garth A. Kinberger, Audrey Low and Michael Tanowitz. Their work appears in journals such as Nucleic Acids Research, Bioorganic & Medicinal Chemistry Letters, Nucleic Acid Therapeutics, The Journal of Organic Chemistry and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Punit P. Seth

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In The Last Decade

Punit P. Seth

Punit P. Seth's Hit Papers

Peers

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Fields of papers citing papers by Punit P. Seth

All Works

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