Taebo Sim

9.0k citations

124 papers · 5.5k · 1 hit paper · h-index 31

Impact in

Molecular Biology top 2%
- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Melanoma and MAPK Pathways
Hematology top 2%
- Chronic Myeloid Leukemia Treatments

Papers in

Molecular Biology 86
- Melanoma and MAPK Pathways 20
- Protein Kinase Regulation and GTPase Signaling 15
- PI3K/AKT/mTOR signaling in cancer 14
- Protein Degradation and Inhibitors 11
Organic Chemistry 44
- Synthesis and biological activity 18
- Quinazolinone synthesis and applications 11
- Synthetic Organic Chemistry Methods 10

Co-authors: Nathanael S. Gray (42 shared papers)Jianming Zhang (11 shared papers)Qingsong Liu (6 shared papers)David M. Sabatini (5 shared papers)Carson C. Thoreen (5 shared papers)Seong A. Kang (5 shared papers)Jae Won Chang (4 shared papers)Laurie J. Reichling (1 shared paper)
Journals: Journal of Medicinal Chemistry (15 papers)Bioorganic & Medicinal Chemistry Letters (15 papers)European Journal of Medicinal Chemistry (12 papers)ACS Medicinal Chemistry Letters (6 papers)Tetrahedron Letters (5 papers)
Partner nations: South Korea United States United Kingdom

In The Last Decade

Taebo Sim

121 papers receiving 5.3k citations

Taebo Sim's Hit Papers

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An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1 2009 · 1.5k citations

Peers

Countries citing papers authored by Taebo Sim

Since Specialization

Citations

This map shows the geographic impact of Taebo Sim's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Taebo Sim with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Taebo Sim more than expected).

Fields of papers citing papers by Taebo Sim

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Taebo Sim. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Taebo Sim. The network helps show where Taebo Sim may publish in the future.

Co-authors

The 25 scholars most cited alongside Taebo Sim, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Taebo Sim Line = papers co-authored together Taebo Sim links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 124 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1 Journal of Biological Chemistry ·Carson C. Thoreen, Seong A. Kang, Jae Won Chang, Qingsong Liu, Jianming Zhang, Yi Gao, Laurie J. Reichling, Taebo Sim, David M. Sabatini, Nathanael S. Gray Hit paper breakdown →	2009	1482
2	Allosteric inhibitors of Bcr-abl–dependent cell proliferation Nature Chemical Biology ·Francisco Adrián, Qiang Ding, Taebo Sim, Anastasia Velentza, Christine Sloan, Yi Liu, Guobao Zhang, Wooyoung Hur, Sheng Ding, Paul W. Manley, Jürgen Mestan, Doriano Fabbro, Nathanael S. Gray	2006	305
3	Discovery of Potent and Selective Covalent Inhibitors of JNK Chemistry & Biology ·Tinghu Zhang, Francisco Iñesta-Vaquera, Mario Niepel, Jianming Zhang, Scott B. Ficarro, Thomas Machleidt, Ting Xie, Jarrod A. Marto, NamDoo Kim, Taebo Sim, John D. Laughlin, HaJeung Park, Philip V. LoGrasso, Matt Patricelli, Tyzoon Nomanbhoy, Peter K. Sorger, Dario R. Alessi, Nathanael S. Gray	2012	294
4	Therapeutic Targeting of Oncogenic K‐Ras by a Covalent Catalytic Site Inhibitor Angewandte Chemie International Edition ·Sang Min Lim, Kenneth D. Westover, Scott B. Ficarro, Rane A. Harrison, Hwan Geun Choi, Michael E. Pacold, Martin A. Carrasco, John C. Hunter, Nam Doo Kim, Ting Xie, Taebo Sim, Pasi A. Jänne, Matthew Meyerson, Jarrod A. Marto, John R. Engen, Nathanael S. Gray	2013	257
5	Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer Journal of Medicinal Chemistry ·Qingsong Liu, Jae Won Chang, Jinhua Wang, Seong A. Kang, Carson C. Thoreen, Andrew L. Markhard, Wooyoung Hur, Jianming Zhang, Taebo Sim, David M. Sabatini, Nathanael S. Gray	2010	208
6	Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function Nature Chemical Biology ·Nicholas Kwiatkowski, Nannette Jelluma, P. Filippakopoulos, M. Soundararajan, Michael S. Manak, Mijung Kwon, Hwan Geun Choi, Taebo Sim, Quinn L. Deveraux, Sabine Rottmann, David Pellman, Jagesh V. Shah, Geert J.P.L. Kops, Stefan Knapp, Nathanael S. Gray	2010	185
7	Pharmacological targeting of the pseudokinase Her3 Nature Chemical Biology ·Ting Xie, Sang Min Lim, Kenneth D. Westover, Michael Dodge, Dalia Ercan, Scott B. Ficarro, Durga Udayakumar, Deepak Gurbani, Hyun Seop Tae, Steven M. Riddle, Taebo Sim, Jarrod A. Marto, Pasi A. Jänne, Craig M. Crews, Nathanael S. Gray	2014	170
8	A General Strategy for Creating “Inactive-Conformation” Abl Inhibitors Chemistry & Biology ·Okram Barun, A. S. Nagle, Francisco Adrián, Christian Lee, Pingda Ren, Xia Wang, Taebo Sim, Yongping Xie, Xing Wang, Gang Xia, Glen Spraggon, Markus Warmuth, Yi Liu, Nathanael S. Gray	2006	125
9	Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype Cell chemical biology ·(unknown), Yanke Liang, Alan L. Leggett, Woojun D. Park, Lianbo Li, Caitlin E. Mills, Selma Z. Elsarrag, Scott B. Ficarro, Tinghu Zhang, Robert Düster, Matthias Geyer, Taebo Sim, Jarrod A. Marto, Peter K. Sorger, Kenneth D. Westover, Charles Y. Lin, Nicholas Kwiatkowski, Nathanael S. Gray	2019	121
10	Acquired MET D1228V Mutation and Resistance to MET Inhibition in Lung Cancer Cancer Discovery ·Magda Bahcall, Taebo Sim, Cloud P. Paweletz, Jyoti D. Patel, Ryan S. Alden, Yanan Kuang, Adrian G. Sacher, Nam Doo Kim, Christine Lydon, Mark M. Awad, Michael T. Jaklitsch, Lynette M. Sholl, Pasi A. Jänne, Geoffrey R. Oxnard	2016	119
11	Identification of Existing Drugs That Effectively Target NTRK1 and ROS1 Rearrangements in Lung Cancer Clinical Cancer Research ·Curtis R. Chong, Magda Bahcall, Marzia Capelletti, Takayuki Kosaka, Dalia Ercan, Taebo Sim, Lynette M. Sholl, Mizuki Nishino, Bruce E. Johnson, Nathanael S. Gray, Pasi A. Jänne	2016	72
12	Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 ACS Medicinal Chemistry Letters ·John M. Hatcher, Eric S. Wang, Liv Johannessen, Nicholas Kwiatkowski, Taebo Sim, Nathanael S. Gray	2018	68
13	Inverse Agonist of Nuclear Receptor ERRγ Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis Diabetes ·Don‐Kyu Kim, Gil-Tae Gang, Dongryeol Ryu, Minseob Koh, Yo-Na Kim, Su Sung Kim, Jinyoung Park, Yong‐Hoon Kim, Taebo Sim, In‐Kyu Lee, Cheol Soo Choi, Seung Bum Park, Chul‐Ho Lee, Seung‐Hoi Koo, Hueng-Sik Choi	2013	64
14	A Type-II Kinase Inhibitor Capable of Inhibiting the T315I “Gatekeeper” Mutant of Bcr-Abl Journal of Medicinal Chemistry ·Hwan Geun Choi, Pingda Ren, Francisco Adrián, Fangxian Sun, Hyun Soo Lee, Xia Wang, Qiang Ding, Guobao Zhang, Yongping Xie, Jianming Zhang, Yi Liu, Tove Tuntland, Markus Warmuth, Paul W. Manley, Jürgen Mestan, Nathanael S. Gray, Taebo Sim	2010	61
15	Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) Journal of Medicinal Chemistry ·Li Tan, Tyzoon Nomanbhoy, Deepak Gurbani, Matthew P. Patricelli, John C. Hunter, Jiefei Geng, Lina Herhaus, Jianming Zhang, Eduardo Pauls, Youngjin Ham, Hwan Geun Choi, Ting Xie, Xianming Deng, Sara J. Buhrlage, Taebo Sim, Philip Cohen, Gopal P. Sapkota, Kenneth D. Westover, Nathanael S. Gray	2014	59
16	Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo ACS Chemical Biology ·Thomas B. Sundberg, Yanke Liang, Huixian Wu, Hwan Geun Choi, Nam Doo Kim, Taebo Sim, Liv Johannessen, Adam Petrone, Bernard Khor, Daniel B. Graham, Isabel Latorre, Andrew J. Phillips, Stuart L. Schreiber, José R. Perez, Alykhan F. Shamji, Nathanael S. Gray, Ramnik J. Xavier	2016	59
17	Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1 Bioorganic & Medicinal Chemistry Letters ·Ha-Soon Choi, Zhicheng Wang, Wendy Richmond, Xiaohui He, Kunyong Yang, Tao Jiang, Taebo Sim, Donald S. Karanewsky, Xiang-ju Gu, Vicki Zhou, Yi Liu, Osamu Ohmori, Jeremy S. Caldwell, Nathanael S. Gray, Yun He	2006	56
18	Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1 ACS Medicinal Chemistry Letters ·Xianming Deng, Qingkai Yang, Nicholas Kwiatkowski, Taebo Sim, Ultan McDermott, Jeffrey Settleman, Jiing-Dwan Lee, Nathanael S. Gray	2011	54
19	Covalent Guanosine Mimetic Inhibitors of G12C KRAS ACS Medicinal Chemistry Letters ·Yuan Xiong, Jia Lu, John C. Hunter, Lianbo Li, David A. Scott, Hwan Geun Choi, Sang Min Lim, Anuj Manandhar, Sudershan Reddy Gondi, Taebo Sim, Kenneth D. Westover, Nathanael S. Gray	2016	53
20	Development of small molecules targeting the pseudokinase Her3 Bioorganic & Medicinal Chemistry Letters ·Sang Min Lim, Ting Xie, Kenneth D. Westover, Scott B. Ficarro, Hyun Seop Tae, Deepak Gurbani, Taebo Sim, Jarrod A. Marto, Pasi A. Jänne, Craig M. Crews, Nathanael S. Gray	2015	53

About Taebo Sim

Taebo Sim is a scholar working on Molecular Biology, Organic Chemistry, Oncology, Hematology and Pharmacology, having authored 124 papers that have together received 5.5k indexed citations. Recurring topics across this work include Melanoma and MAPK Pathways (20 papers), Synthesis and biological activity (18 papers), Protein Kinase Regulation and GTPase Signaling (15 papers), PI3K/AKT/mTOR signaling in cancer (14 papers), Chronic Myeloid Leukemia Treatments (11 papers), Protein Degradation and Inhibitors (11 papers), Quinazolinone synthesis and applications (11 papers) and Synthetic Organic Chemistry Methods (10 papers). The work is most often cited by research in Molecular Biology (3.6k citations), Hematology (438 citations), Oncology (1.0k citations), Cell Biology (614 citations) and Organic Chemistry (967 citations). Taebo Sim has collaborated with scholars based in South Korea, United States and United Kingdom. Frequent co-authors include Nathanael S. Gray, Jianming Zhang, Qingsong Liu, David M. Sabatini, Carson C. Thoreen, Seong A. Kang, Jae Won Chang, Laurie J. Reichling, Yi Gao and Nam Doo Kim. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, European Journal of Medicinal Chemistry, ACS Medicinal Chemistry Letters and Tetrahedron Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Taebo Sim

Taebo Sim's Hit Papers

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All Works

About Taebo Sim

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