Lefkos Middleton

17.8k citations

139 papers · 7.2k · 3 hit papers · h-index 41

Impact in

Neurology top 0.5%
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Neurological disorders and treatments
Biological Psychiatry top 1%

Papers in

Molecular Biology 38
Cellular and Molecular Neuroscience 25
- Hereditary Neurological Disorders 11
- Genetic Neurodegenerative Diseases 10

Co-authors: Stanley B. Prusiner (6 shared papers)Steve Gentleman (7 shared papers)Kurt Giles (4 shared papers)Abby Oehler (5 shared papers)Joel C. Watts (4 shared papers)Josip Car (6 shared papers)Kyproula Christodoulou (16 shared papers)Chinedu Udeh‐Momoh (22 shared papers)
Journals: Alzheimer s & Dementia (14 papers)The Journal of Prevention of Alzheimer s Disease (10 papers)Neurology (4 papers)Proceedings of the National Academy of Sciences (3 papers)Neuromuscular Disorders (3 papers)
Partner nations: United Kingdom United States Cyprus

In The Last Decade

Lefkos Middleton

135 papers receiving 7.1k citations

Lefkos Middleton's Hit Papers

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Associations of Social Isolation with Anxiety and Depression During the Early COVID-19 Pandemic: A Survey of Older Adults in London, UK 2020 · 304 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2020 Frontiers in Psychiatry
2015 Proceedings of the National Academy of Sciences
2013 The Lancet

Peers

Countries citing papers authored by Lefkos Middleton

Since Specialization

Citations

This map shows the geographic impact of Lefkos Middleton's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lefkos Middleton with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lefkos Middleton more than expected).

Fields of papers citing papers by Lefkos Middleton

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lefkos Middleton. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lefkos Middleton. The network helps show where Lefkos Middleton may publish in the future.

Co-authors

The 25 scholars most cited alongside Lefkos Middleton, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Lefkos Middleton Line = papers co-authored together Lefkos Middleton links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 139 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism Proceedings of the National Academy of Sciences ·Stanley B. Prusiner, Amanda L. Woerman, Daniel A. Mordes, Joel C. Watts, Ryan Rampersaud, David B. Berry, Smita S. Patel, Abby Oehler, Jennifer K. Lowe, Stephanie N. Kravitz, Daniel H. Geschwind, David V. Glidden, Glenda M. Halliday, Lefkos Middleton, Steve Gentleman, Lea T. Grinberg, Kurt Giles Hit paper breakdown →	2015	550
2	Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990–2010: a systematic review and analysis The Lancet ·Kit Yee Chan, Wei Wang, Jing Wu, Li Liu, Evropi Τheodoratou, Josip Car, Lefkos Middleton, Tom C. Russ, Ian J. Deary, Harry Campbell, Igor Rudan Hit paper breakdown →	2013	549
3	Glycyl tRNA Synthetase Mutations in Charcot-Marie-Tooth Disease Type 2D and Distal Spinal Muscular Atrophy Type V The American Journal of Human Genetics ·Anthony Antonellis, Rachel E. Ellsworth, Nyamkhishig Sambuughin, Imke Puls, Annette Abel, Shih-Queen Lee-Lin, Albena Jordanova, Ivo Kremensky, Kyproula Christodoulou, Lefkos Middleton, Kumaraswamy Sivakumar, Victor Ionâşescu, Benoît Funalot, Jeffery M. Vance, Lev G. Goldfarb, Kenneth H. Fischbeck, Eric D. Green	2003	421
4	Mutations in the Dystrophin-Associated Protein γ-Sarcoglycan in Chromosome 13 Muscular Dystrophy Science ·S. Noguchi, Elizabeth M. McNally, Kamel Ben Othmane, Yasuko Hagiwara, Yuji Mizuno, Mikiharu Yoshida, Hideko Yamamoto, Carsten G. Bönnemann, Emanuela Gussoni, Peter H. Denton, Theodoros Kyriakides, Lefkos Middleton, Fayçal Hentati, Mongi Ben Hamida, Ikuya Nonaka, Jeffery M. Vance, Louis M. Kunkel, Eijiro Ozawa	1995	415
5	Transmission of multiple system atrophy prions to transgenic mice Proceedings of the National Academy of Sciences ·Joel C. Watts, Kurt Giles, Abby Oehler, Lefkos Middleton, David T. Dexter, Steve Gentleman, Stephen J. DeArmond, Stanley B. Prusiner	2013	342
6	Associations of Social Isolation with Anxiety and Depression During the Early COVID-19 Pandemic: A Survey of Older Adults in London, UK Frontiers in Psychiatry ·Catherine Robb, Celeste A. de Jager, Sara Ahmadi‐Abhari, Parthenia Giannakopoulou, Chinedu Udeh‐Momoh, James McKeand, Geraint Price, Josip Car, Azeem Majeed, Helen Ward, Lefkos Middleton Hit paper breakdown →	2020	304
7	Plasma Protein Biomarkers for Depression and Schizophrenia by Multi Analyte Profiling of Case-Control Collections PLoS ONE ·Enrico Domenici, David Willé, Federica Tozzi, Inga Prokopenko, Sam Miller, Astrid McKeown, Claire Brittain, Dan Rujescu, Ina Giegling, Christoph W. Turck, (unknown), Edward T. Bullmore, Lefkos Middleton, Emilio Merlo‐Pich, Robert Alexander, Pierandrea Muglia	2010	286
8	Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta‐analyses Alzheimer s & Dementia ·Vanesa Bellou, Lazaros Belbasis, Ioanna Tzoulaki, Lefkos Middleton, John P. A. Ioannidis, Εvangelos Εvangelou	2016	208
9	Propagation of prions causing synucleinopathies in cultured cells Proceedings of the National Academy of Sciences ·Amanda L. Woerman, Jan Stöhr, Atsushi Aoyagi, Ryan Rampersaud, Zuzana Krejciova, Joel C. Watts, Takao Ohyama, Smita S. Patel, Kartika Widjaja, Abby Oehler, David W. Sanders, Marc I. Diamond, William W. Seeley, Lefkos Middleton, Steve Gentleman, Daniel A. Mordes, Thomas C. Südhof, Kurt Giles, Stanley B. Prusiner	2015	195
10	The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors BMC Psychiatry ·Martin Preisig, Gérard Waeber, Péter Vollenweider, Pascal Bovet, Stéphane Rothen, Caroline L. Vandeleur, Patrice Guex, Lefkos Middleton, Dawn Waterworth, Vincent Mooser, Federica Tozzi, Pierandrea Muglia	2009	189
11	Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts Molecular Psychiatry ·Pierandrea Muglia, Federica Tozzi, N. W. Galwey, Clyde Francks, Ruchi Upmanyu, Xiangyang Kong, Άθως Αντωνιάδης, Enrico Domenici, J Perry, Stéphane Rothen, Caroline L. Vandeleur, Vincent Mooser, Gérard Waeber, Péter Vollenweider, Martin Preisig, Susanne Lucae, Bertram Müller‐Myhsok, (unknown), Lefkos Middleton, Allen D. Roses	2008	185
12	Why has therapy development for dementia failed in the last two decades? Alzheimer s & Dementia ·Serge Gauthier, Marilyn Albert, Nick C. Fox, Michel Goedert, Miia Kivipelto, Jorge Mestre‐Ferrandiz, Lefkos Middleton	2015	168
13	Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid Alzheimer s & Dementia ·Petros Takousis, Angélique Sadlon, Jessica Schulz, Inken Wohlers, Valerija Dobričić, Lefkos Middleton, Christina M. Lill, Robert Perneczky, Lars Bertram	2019	135
14	Factor structure and external validity of the PANSS revisited Schizophrenia Research ·Edwin J. C. G. van den Oord, Dan Rujescu, Jaime R. Robles, Ina Giegling, Claire Birrell, József Bukszár, Lenn Murrelle, Hans‐Jürgen Möller, Lefkos Middleton, Pierandrea Muglia	2005	121
15	LRRK2 Gly2019Ser penetrance in Arab–Berber patients from Tunisia: a case-control genetic study The Lancet Neurology ·Mary Hulihan, L. Ishihara-Paul, Jennifer M. Kachergus, Liling Warren, Rim Amouri, Ramu Elango, Rab K. Prinjha, Ruchi Upmanyu, Mounir Kefi, M. Zouari, Samia Ben Sassi, Samia Ben Yahmed, Ghada El Euch‐Fayeche, Paul M. Matthews, Lefkos Middleton, Rachel A. Gibson, Fayçal Hentati, Matthew J. Farrer	2008	121
16	Localization of a Gene (CMT2A) for Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 to Chromosome 1p and Evidence of Genetic Heterogeneity Genomics ·Kamel Ben Othmane, Lefkos Middleton, Lorraine Loprest, Kenneth M. Wilkinson, Felicia Lennon, Marvin P. Rozear, Jeffrey U. Stajich, P. C. Gaskell, Allen D. Roses, Margaret A. Pericak‐Vance, Jeffery M. Vance	1993	120
17	Neural network models in EMG diagnosis IEEE Transactions on Biomedical Engineering ·Constantinos S. Pattichis, Christos N. Schizas, Lefkos Middleton	1995	103
18	Whole genome linkage scan of recurrent depressive disorder from the depression network study Human Molecular Genetics ·Peter McGuffin, Jo Knight, Gerome Breen, Shyama Brewster, Peter R. Boyd, Nick Craddock, (unknown), Ania Korszun, Wolfgang Maier, Lefkos Middleton, Ole Mors, Michael J. Owen, Julia Perry, Martin Preisig, Theodore Reich, John P. Rice, Marcella Rietschel, Lisa Jones, Pak C. Sham, Anne Farmer	2005	102
19	Friedreich's ataxia phenotype not linked to chromosome 9 and associated with selective autosomal recessive vitamin E deficiency in two inbred Tunisian families Neurology ·M. Ben Hamida, Samir Belal, Giorgio Sirugo, Christiane Ben Hamida, Kyproula Panayides, P. Ionannou, J. Beckmann, Jean‐Louis Mandel, F. Hentati, M. Koenig, Lefkos Middleton	1993	96
20	Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score—the CoLaus Study Diabetologia ·Xu Lin, Kijoung Song, Noha Lim, Xin Yuan, Toby Johnson, Amar Abderrahmani, Péter Vollenweider, Heide A. Stirnadel, Scott S. Sundseth, Eric Lai, Daniel K. Burns, Lefkos Middleton, Allen D. Roses, Paul M. Matthews, Gérard Waeber, Lon R. Cardon, Dawn Waterworth, Vincent Mooser	2009	92

About Lefkos Middleton

Lefkos Middleton is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Psychiatry and Mental health and Neurology, having authored 139 papers that have together received 7.2k indexed citations. Recurring topics across this work include Dementia and Cognitive Impairment Research (19 papers), Parkinson's Disease Mechanisms and Treatments (16 papers), Neurological diseases and metabolism (13 papers), Muscle activation and electromyography studies (11 papers), Hereditary Neurological Disorders (11 papers), Neural Networks and Applications (10 papers), Genetic Neurodegenerative Diseases (10 papers) and Alzheimer's disease research and treatments (8 papers). The work is most often cited by research in Neurology (1.0k citations), Neurology (1.8k citations), Biological Psychiatry (261 citations), Cellular and Molecular Neuroscience (1.5k citations) and Physiology (1.2k citations). Lefkos Middleton has collaborated with scholars based in United Kingdom, United States and Cyprus. Frequent co-authors include Stanley B. Prusiner, Steve Gentleman, Kurt Giles, Abby Oehler, Joel C. Watts, Josip Car, Kyproula Christodoulou, Chinedu Udeh‐Momoh, Amanda L. Woerman and Jeffery M. Vance. Their work appears in journals such as Alzheimer s & Dementia, The Journal of Prevention of Alzheimer s Disease, Neurology, Proceedings of the National Academy of Sciences and Neuromuscular Disorders.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Lefkos Middleton

Lefkos Middleton's Hit Papers

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About Lefkos Middleton

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