William E. O’Brien

7k citations

152 papers · 8.7k · 1 hit paper · h-index 50

Impact in

Clinical Biochemistry top 0.05%
- Metabolism and Genetic Disorders
Biochemistry top 0.2%
- Amino Acid Enzymes and Metabolism

Papers in

Clinical Biochemistry 55
- Metabolism and Genetic Disorders 55
Biochemistry 30
- Amino Acid Enzymes and Metabolism 29

Co-authors: Arthur L. Beaudet (59 shared papers)Anthony R. Gregg (10 shared papers)Lars G. Ljungdahl (5 shared papers)Sidney M. Morris (8 shared papers)J. Edward Spence (8 shared papers)Marian J. Jackson (5 shared papers)Tsung‐Sheng Su (6 shared papers)Brendan Lee (10 shared papers)
Journals: Journal of Biological Chemistry (11 papers)Proceedings of the National Academy of Sciences (7 papers)Nucleic Acids Research (7 papers)Genomics (6 papers)Molecular Genetics and Metabolism (6 papers)
Partner nations: United States Canada Austria

In The Last Decade

William E. O’Brien

151 papers receiving 8.2k citations

William E. O’Brien's Hit Papers

align trajectories log scale

Evolutionary and Biomedical Insights from the Rhesus Macaque Genome 2007 · 1.1k citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2007 Science

Peers

Countries citing papers authored by William E. O’Brien

Since Specialization

Citations

This map shows the geographic impact of William E. O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William E. O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William E. O’Brien more than expected).

Fields of papers citing papers by William E. O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William E. O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William E. O’Brien. The network helps show where William E. O’Brien may publish in the future.

Co-authors

The 25 scholars most cited alongside William E. O’Brien, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William E. O’Brien Line = papers co-authored together William E. O’Brien links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 152 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Evolutionary and Biomedical Insights from the Rhesus Macaque Genome Science ·Richard A. Gibbs, Jeffrey Rogers, Michael G. Katze, Roger E. Bumgarner, George M. Weinstock, Elaine R. Mardis, Karin Remington, Robert L. Strausberg Hit paper breakdown →	2007	1096
2	Uniparental disomy as a mechanism for human genetic disease. PubMed ·J. Edward Spence, R G Perciaccante, Gillian M. Greig, Huntington F. Willard, David H. Ledbetter, James Fielding Hejtmancik, M S Pollack, William E. O’Brien	1988	399
3	Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice Science ·Annie E. Hill, Lindsay Catherine Burrage, Keith R. Olszens, Junghan Song, Monica J. Justice, William E. O’Brien, David V. Conti, John S. Witte	2004	283
4	Gene sharing by delta-crystallin and argininosuccinate lyase. Proceedings of the National Academy of Sciences ·Joram Piatigorsky, William E. O’Brien, B. Norman, K. E. Kalumuck, Graeme J. Wistow, Teresa Borrás, J M Nickerson, Eric F. Wawrousek	1988	227
5	Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis Proceedings of the National Academy of Sciences ·Lindsay Catherine Burrage, David S. Sinasac, Annie E. Hill, Sheila R. Ernest, William E. O’Brien, Hayden‐William Courtland, Karl J. Jepsen, Andrew Kirby	2008	210
6	Gene targeting yields a CD18-mutant mouse for study of inflammation. The Journal of Immunology ·Raymond W. Wilson, Christie Mitchell Ballantyne, C. Wayne Smith, Chuck Montgomery, Allan Bradley, William E. O’Brien, Arthur L. Beaudet	1993	206
7	Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation Proceedings of the National Academy of Sciences ·Piero Rinaldo, William J. Rhead, Liqun Tian, David S. Millington, Jerry E. Vockley, Doug A. Hamm, Amy E. Brix, J. Russell Lindsey	1998	205
8	Requirement of argininosuccinate lyase for systemic nitric oxide production Nature Medicine ·Ayelet Erez, Sandesh C.S. Nagamani, Oleg A. Shchelochkov, Muralidhar H. Premkumar, Philippe M. Campeau, Yuqing Chen, Harsha K. Garg, Li Li	2011	195
9	Mutation Analysis for Heterozygote Detection and the Prenatal Diagnosis of Cystic Fibrosis New England Journal of Medicine ·Wanda K. Lemna, Gerald L. Feldman, Batsheva Kerem, Susan D. Fernbach, Elaine P. Zevkovich, William E. O’Brien, John R. Riordan, Francis S. Collins	1990	190
10	Mouse Model for Human Arginase Deficiency Molecular and Cellular Biology ·Ramaswamy K. Iyer, Paul K. Yoo, Rita M. Kern, Nora Rozengurt, Rosemarie W. Tsoa, William E. O’Brien, Hong Yu, Wayne W. Grody	2002	157
11	Arginase I Expression and Activity in Human Mononuclear Cells After Injury Annals of Surgery ·Juan B. Ochoa, Andrew C. Bernard, William E. O’Brien, Margaret Mary Griffen, Mary E. Maley, Anna K. Rockich, Betty J. Tsuei, Bernard R. Boulanger	2001	137
12	Generation of a Mouse Model for Arginase II Deficiency by Targeted Disruption of the Arginase II Gene Molecular and Cellular Biology ·Ou Shi, Sidney M. Morris, Huda Yahya Zoghbi, Carl W. Porter, William E. O’Brien	2001	130
13	Regulation of mRNA levels for five urea cycle enzymes in rat liver by diet, cyclic AMP, and glucocorticoids Archives of Biochemistry and Biophysics ·Sidney M. Morris, Carole L. Moncman, Katherine Deml Rand, George J. Dizikes, Stephen D. Cederbaum, William E. O’Brien	1987	117
14	Isolation and characterization of a pyrophosphate-dependent phosphofructokinase from Propionibacterium shermanii. Journal of Biological Chemistry ·William E. O’Brien, Susanne Bowien, H.G. Wood	1975	116
15	MAMMALIAN UREA CYCLE ENZYMES Annual Review of Genetics ·Marian J. Jackson, Arthur L. Beaudet, William E. O’Brien	1986	116
16	Cloning of cDNA for argininosuccinate synthetase mRNA and study of enzyme overproduction in a human cell line. Journal of Biological Chemistry ·T S Su, H G Bock, William E. O’Brien, Arthur L. Beaudet	1981	111
17	Immunohistochemical localization of argininosuccinate synthetase in the rat brain in relation to nitric oxide synthase-containing neurons Neuroscience ·L.R. Arnt-Ramos, William E. O’Brien, Steve R. Vincent	1992	111
18	Arginase I Suppresses IL-12/IL-23p40–Driven Intestinal Inflammation during Acute Schistosomiasis The Journal of Immunology ·De’Broski R. Herbert, Tatyana Orekov, Amanda Roloson, Monica Ilies, Charles L. Perkins, William E. O’Brien, Stephen D. Cederbaum, David W. Christianson	2010	110
19	Molecular definition of bovine argininosuccinate synthetase deficiency. Proceedings of the National Academy of Sciences ·J. A. Dennis, P.J. Healy, Arthur L. Beaudet, William E. O’Brien	1989	97
20	Effect of alternative pathway therapy on branched chain amino acid metabolism in urea cycle disorder patients Molecular Genetics and Metabolism ·Fernando Scaglia, William E. O’Brien, Brendan Lee +1 other	2004	88

About William E. O’Brien

William E. O’Brien is a scholar working on Clinical Biochemistry, Biochemistry, Genetics, Molecular Biology and Physiology, having authored 152 papers that have together received 8.7k indexed citations. Recurring topics across this work include Metabolism and Genetic Disorders (55 papers), Amino Acid Enzymes and Metabolism (29 papers), Biochemical and Molecular Research (28 papers), Nitric Oxide and Endothelin Effects (13 papers), Virus-based gene therapy research (9 papers), Cystic Fibrosis Research Advances (9 papers), Genetic Mapping and Diversity in Plants and Animals (8 papers) and Genetic Associations and Epidemiology (8 papers). The work is most often cited by research in Clinical Biochemistry (1.6k citations), Biochemistry (797 citations), Genetics (1.8k citations), Molecular Biology (2.1k citations) and Physiology (715 citations). William E. O’Brien has collaborated with scholars based in United States, Canada and Austria. Frequent co-authors include Arthur L. Beaudet, Anthony R. Gregg, Lars G. Ljungdahl, Sidney M. Morris, J. Edward Spence, Marian J. Jackson, Tsung‐Sheng Su, Brendan Lee, Joseph H. Nadeau and David H. Ledbetter. Their work appears in journals such as Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, Nucleic Acids Research, Genomics and Molecular Genetics and Metabolism.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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William E. O’Brien

William E. O’Brien's Hit Papers

Peers

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Fields of papers citing papers by William E. O’Brien

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About William E. O’Brien

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