John Hynes

1.5k citations

28 papers · 733 · h-index 14

Impact in

Organic Chemistry top 5%
- Carbohydrate Chemistry and Synthesis
- Catalytic C–H Functionalization Methods
- Click Chemistry and Applications
- Synthesis and Catalytic Reactions
Toxicology top 10%

Papers in

Organic Chemistry 16
- Asymmetric Synthesis and Catalysis 5
- Synthesis and Catalytic Reactions 3
- Chemical Reaction Mechanisms 3
- Synthesis of Indole Derivatives 2
- Synthesis and biological activity 2
Molecular Biology 15
- Chemical Synthesis and Analysis 6
- Melanoma and MAPK Pathways 4

Co-authors: Katerina Leftheris (9 shared papers)Hong Wu (2 shared papers)Amos B. Smith (6 shared papers)Ralph Hirschmann (5 shared papers)Paul A. Sprengeler (2 shared papers)Wenqing Yao (2 shared papers)Susanne Kiau (2 shared papers)Alaric J. Dyckman (2 shared papers)
Journals: Organic Letters (6 papers)Bioorganic & Medicinal Chemistry Letters (5 papers)Journal of Medicinal Chemistry (4 papers)The Journal of Organic Chemistry (2 papers)Organic Process Research & Development (1 paper)
Partner nations: United States Germany Sweden

In The Last Decade

John Hynes

28 papers receiving 697 citations

Peers

Countries citing papers authored by John Hynes

Since Specialization

Citations

This map shows the geographic impact of John Hynes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Hynes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Hynes more than expected).

Fields of papers citing papers by John Hynes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Hynes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Hynes. The network helps show where John Hynes may publish in the future.

Co-authors

The 25 scholars most cited alongside John Hynes, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John Hynes Line = papers co-authored together John Hynes links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 28 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Modulation of Receptor and Receptor Subtype Affinities Using Diastereomeric and Enantiomeric Monosaccharide Scaffolds as a Means to Structural and Biological Diversity. A New Route to Ether Synthesis Journal of Medicinal Chemistry ·Ralph Hirschmann, John Hynes, Maria A. Cichy-Knight, Rachel D. van Rijn, Paul A. Sprengeler, P. Grant Spoors, William C. Shakespeare, Sherrie Pietranico-Cole, Joseph Barbosa, Josephine Liu, Wenqing Yao, Susan P. Rohrer, Amos B. Smith	1998	101
2	Copper-Catalyzed Chlorination of Functionalized Arylboronic Acids Organic Letters ·Hong Wu, John Hynes	2010	78
3	N-Amination of Pyrrole and Indole Heterocycles with Monochloramine (NH₂Cl) The Journal of Organic Chemistry ·John Hynes, Wendel W. Doubleday, Alaric J. Dyckman, Jollie D. Godfrey, John A. Grosso, Susanne Kiau, Katerina Leftheris	2004	61
4	DBS Sampling Can be Used to Stabilize Prodrugs in Drug Discovery Rodent Studies without the Addition of Esterase Inhibitors Bioanalysis ·Celia D’Arienzo, Qin Ji, Lorell Discenza, Georgia Cornelius, John Hynes, Lyndon A. M. Cornelius, Joseph B. Santella, Timothy Olah	2010	61
5	Small Molecule p38 Inhibitors: Novel Structural Features and Advances from 2002-2005 Current Topics in Medicinal Chemistry ·John Hynes, Katerina Leftheris	2005	55
6	Rational Design and Synthesis of an Orally Active Indolopyridone as a Novel Conformationally Constrained Cannabinoid Ligand Possessing Antiinflammatory Properties Journal of Medicinal Chemistry ·Stephen T. Wrobleski, Ping Chen, John Hynes, Shuqun Lin, Derek Norris, Chennagiri R. Pandit, Steven H. Spergel, Wu Hong, John S. Tokarski, Xiaorong Chen, Kathleen M. Gillooly, Peter A. Kiener, Kim W. McIntyre, Vina Patil-koota, David J. Shuster, Lori A. Turk, Guchen Yang, Katerina Leftheris	2003	53
7	Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic Journal of Medicinal Chemistry ·Ralph Hirschmann, Wenqing Yao, Margaret A. Cascieri, Catherine D. Strader, Laurie Maechler, Maria A. Cichy-Knight, John Hynes, Rachel D. van Rijn, Paul A. Sprengeler, Amos B. Smith	1996	52
8	Design and Synthesis of Novel Scaffolds for Drug Discovery: Hybrids of β-d-Glucose with 1,2,3,4-Tetrahydrobenzo[e][1,4]diazepin-5-one, the Corresponding 1-Oxazepine, and 2- and 4-Pyridyldiazepines Organic Letters ·Leïla Abrous, John Hynes, Sarah R. Friedrich, Amos B. Smith, Ralph Hirschmann	2001	49
9	C-3 Amido-Indole cannabinoid receptor modulators Bioorganic & Medicinal Chemistry Letters ·John Hynes, Katerina Leftheris, Wu Hong, Chennagiri R. Pandit, Ping Chen, Derek Norris, Bang‐Chi Chen, (unknown), Peter A. Kiener, Xiaorong Chen, Lori A. Turk, Vina Patil-koota, Kathleen M. Gillooly, David J. Shuster, Kim W. McIntyre	2002	29
10	Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Shuqun Lin, Stephen T. Wrobleski, John Hynes, Sidney Pitt, Rosemary Zhang, Yi Fan, Arthur M. Doweyko, Kevin Kish, John S. Sack, Mary F. Malley, Susan E. Kiefer, John A. Newitt, Murray McKinnon, James M. Trzăskos, Joel C. Barrish, John H. Dodd, Gary L. Schieven, Katerina Leftheris	2010	28
11	Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38α MAP kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Stephen T. Wrobleski, Shuqun Lin, John Hynes, Hong Wu, Sidney Pitt, Ding Ren Shen, Rosemary Zhang, Kathleen M. Gillooly, David J. Shuster, Kim W. McIntyre, Arthur M. Doweyko, Kevin Kish, Jeffrey Tredup, Gerald J. Duke, John S. Sack, Murray McKinnon, John H. Dodd, Joel C. Barrish, Gary L. Schieven, Katerina Leftheris	2008	27
12	Novel Chimeric Scaffolds to Extend the Exploration of Receptor Space: Hybrid β-d-Glucose−Benzoheterodiazepine Structures for Broad Screening. Effect of Amide Alkylation on the Course of Cyclization Reactions The Journal of Organic Chemistry ·Leïla Abrous, Patrick A. Jokiel, Sarah R. Friedrich, John Hynes, Amos B. Smith, Ralph Hirschmann	2003	26
13	Advances in the Discovery of Small-Molecule IRAK4 Inhibitors Annual reports in medicinal chemistry ·John Hynes, Satheesh K. Nair	2014	17
14	One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent Organic Letters ·Qing Shi, Nathaniel S. Greenwood, Mariah C. Meehan, Hyunsoo Park, Michael A. Galella, Bhupinder Sandhu, Purnima Khandelwal, John R. Coombs, William P. Gallagher, Carlos A. Guerrero, John Hynes, T. G. Murali Dhar, Francisco González‐Bobes, David Marcoux	2019	15
15	Amination of Heterocyclic Compounds with O-Benzoylhydroxylamine Derivatives Organic Letters ·Luca Parlanti, Robert P. Discordia, John Hynes, Michael M. Miller, Harold R. O'Grady, Zhongping Shi	2007	13
16	Development of a Practical Synthesis of a p38 Kinase Inhibitor via a Safe and Robust Amination Organic Process Research & Development ·Zhongping Shi, Susanne Kiau, Paul C. Lobben, John Hynes, Hong Wu, Luca Parlanti, Robert P. Discordia, Wendel W. Doubleday, Katerina Leftheris, Alaric J. Dyckman, Stephen T. Wrobleski, Konstantinos Dambalas, Srinivas Tummala, Simon Leung, Ehrlic Lo	2012	12
17	A General Large Scale Synthesis of 2-Alkyl-7-methoxyindoles Heterocycles ·Bang‐Chi Chen, John Hynes, Chennagiri R. Pandit, (unknown), Amanda P. Skoumbourdis, Hong Wu, Joseph E. Sundeen, Katerina Leftheris	2001	12
18	Protected Chloroethyl and Chloropropyl Amines as Conformationally Unrestricted Annulating Reagents Organic Letters ·Qing Shi, Mariah C. Meehan, Michael A. Galella, Hyunsoo Park, Purnima Khandelwal, John Hynes, T. G. Murali Dhar, David Marcoux	2017	9
19	Identification of highly potent and selective PI3Kδ inhibitors Bioorganic & Medicinal Chemistry Letters ·David Marcoux, Lan-Ying Qin, Zheming Ruan, Qing Shi, Qian Ruan, Carolyn A. Weigelt, Hongchen Qiu, Gary L. Schieven, John Hynes, Rajeev S. Bhide, Michael A. Poss, Joseph A. Tino	2017	8
20	Discovery and Lead Optimization of a Novel Series of CC Chemokine Receptor 1 (CCR1)-Selective Piperidine Antagonists via Parallel Synthesis Journal of Medicinal Chemistry ·Cullen L. Cavallaro, Stephanie W. Briceno, Jing Chen, Mary Ellen Cvijic, Paul Davies, John Hynes, Rui‐Qin Liu, Sandhya Mandlekar, Anne Rose, Andrew J. Tebben, Katy Van Kirk, Andrew J. Watson, Hong Wu, Guchen Yang, Percy H. Carter	2012	6

About John Hynes

John Hynes is a scholar working on Organic Chemistry, Molecular Biology, Pharmacology, Oncology and Immunology, having authored 28 papers that have together received 733 indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (6 papers), Asymmetric Synthesis and Catalysis (5 papers), Melanoma and MAPK Pathways (4 papers), Synthesis and Catalytic Reactions (3 papers), Chemical Reaction Mechanisms (3 papers), Cannabis and Cannabinoid Research (2 papers), Synthesis of Indole Derivatives (2 papers) and Synthesis and biological activity (2 papers). The work is most often cited by research in Organic Chemistry (460 citations), Toxicology (22 citations), Pharmacology (86 citations), Pharmaceutical Science (32 citations) and Molecular Biology (337 citations). John Hynes has collaborated with scholars based in United States, Germany and Sweden. Frequent co-authors include Katerina Leftheris, Hong Wu, Amos B. Smith, Ralph Hirschmann, Paul A. Sprengeler, Wenqing Yao, Susanne Kiau, Alaric J. Dyckman, Wendel W. Doubleday and Jollie D. Godfrey. Their work appears in journals such as Organic Letters, Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, The Journal of Organic Chemistry and Organic Process Research & Development.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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