John Brognard

5.6k citations

55 papers · 4.8k · 1 hit paper · h-index 28

Impact in

Molecular Biology top 2%
- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- Protein Tyrosine Phosphatases
- Melanoma and MAPK Pathways
- DNA Repair Mechanisms
- Nicotinic Acetylcholine Receptors Study
Cancer Research top 5%

Papers in

Molecular Biology 39
- Protein Kinase Regulation and GTPase Signaling 12
- PI3K/AKT/mTOR signaling in cancer 11
- Melanoma and MAPK Pathways 9
- Protein Tyrosine Phosphatases 7
- Protein Degradation and Inhibitors 5
Cancer Research 10
- Cancer Genomics and Diagnostics 9

Co-authors: Phillip A. Dennis (7 shared papers)Alexandra C. Newton (10 shared papers)Amy Sanders Clark (2 shared papers)Tianyan Gao (3 shared papers)Tony Hunter (6 shared papers)Emma Sierecki (2 shared papers)Kip A. West (3 shared papers)Ilona R. Linnoila (2 shared papers)
Journals: Journal of Biological Chemistry (6 papers)Cancer Research (5 papers)Proceedings of the National Academy of Sciences (4 papers)Molecular Cell (3 papers)Molecular Cancer Therapeutics (2 papers)
Partner nations: United States United Kingdom Poland

In The Last Decade

John Brognard

54 papers receiving 4.7k citations

John Brognard's Hit Papers

align trajectories log scale

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. 2001 · 806 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2001 PubMed

Peers

Countries citing papers authored by John Brognard

Since Specialization

Citations

This map shows the geographic impact of John Brognard's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Brognard with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Brognard more than expected).

Fields of papers citing papers by John Brognard

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Brognard. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Brognard. The network helps show where John Brognard may publish in the future.

Co-authors

The 25 scholars most cited alongside John Brognard, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John Brognard Line = papers co-authored together John Brognard links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 55 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. PubMed ·John Brognard, Amy Sanders Clark, Phillip A. Dennis +1 other Hit paper breakdown →	2001	806
2	PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms Molecular Cell ·John Brognard, Emma Sierecki, Tianyan Gao, Alexandra C. Newton	2007	495
3	Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells Journal of Clinical Investigation ·Kip A. West, John Brognard, Amy Sanders Clark, Ilona R. Linnoila, Xiaowei Yang, Sandra M. Swain, Curtis C. Harris, Steven A. Belinsky	2003	494
4	Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor Cell ·Corina E. Antal, Andrew Hudson, Ciro Zanca, Christopher Wirth, Natalie L. Stephenson, Eleanor W. Trotter, Lisa L. Gallegos, Crispin J. Miller	2015	289
5	Tobacco components stimulate Akt-dependent proliferation and NFκB-dependent survival in lung cancer cells Carcinogenesis ·Junji Tsurutani, S. Sianna Castillo, John Brognard, Courtney A. Granville, Chunyu Zhang, Joell J. Gills, Jacqueline Sayyah, Phillip A. Dennis	2005	250
6	Protein kinase signaling networks in cancer Current Opinion in Genetics & Development ·John Brognard, Tony Hunter	2010	196
7	Novel PI Analogues Selectively Block Activation of the Pro-survival Serine/Threonine Kinase Akt Journal of the American Chemical Society ·Alan P. Kozikowski, Haiying Sun, John Brognard, Phillip A. Dennis	2003	182
8	Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma Cancer Cell ·María Romina Girotti, Natasha Preece, Dan Niculescu‐Duvaz, Alfonso Zambon, Lawrence C. Davies, Steven R. Whittaker, Grazia Saturno, Amaya Virós	2014	181
9	The mRNA Surveillance Protein hSMG-1 Functions in Genotoxic Stress Response Pathways in Mammalian Cells Molecular Cell ·Kathryn M. Brumbaugh, Diane M. Otterness, Christoph Geisen, Vasco A. Oliveira, John Brognard, Xiaojie Li, Fabrice Lejeune, Randal S. Tibbetts	2004	179
10	The Phosphatase PHLPP Controls the Cellular Levels of Protein Kinase C Journal of Biological Chemistry ·Tianyan Gao, John Brognard, Alexandra C. Newton	2007	172
11	Protein Kinase Cδ Deficiency Causes Mendelian Systemic Lupus Erythematosus With B Cell‐Defective Apoptosis and Hyperproliferation Arthritis & Rheumatism ·Alexandre Bélot, Paul R. Kasher, Eleanor W. Trotter, Anne‐Perrine Foray, Anne‐Laure Mathieu, Gillian Rice, Marcin Szynkiewicz, M. T. Zabot	2013	159
12	PHLiPPing the switch on Akt and protein kinase C signaling Trends in Endocrinology and Metabolism ·John Brognard, Alexandra C. Newton	2008	154
13	The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress Molecular Cell ·You-Wei Zhang, John Brognard, Zhongsheng You, Marisa P Dolled-Filhart, Aaron Aslanian, Gerard Manning, Robert T. Abraham, Tony Hunter +1 other	2009	150
14	Preferential Inhibition of Akt and Killing of Akt-Dependent Cancer Cells by Rationally Designed Phosphatidylinositol Ether Lipid Analogues Cancer Research ·S. Sianna Castillo, John Brognard, Pavel A. Petukhov, Chunyu Zhang, Junji Tsurutani, Courtney A. Granville, Kip A. West, Joell G. Gills	2004	106
15	Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor Trends in Pharmacological Sciences ·Alexandra C. Newton, John Brognard	2017	89
16	Serine-linked PARP1 auto-modification controls PARP inhibitor response Nature Communications ·Evgeniia A. Prokhorova, Florian Zobel, Rebecca Smith, Siham Zentout, Ian Gibbs‐Seymour, Kira Schützenhofer, Alessandra Peters, Joséphine Groslambert	2021	83
17	Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants Cell Death and Differentiation ·John Brognard +1 other	2002	81
18	Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors Nature Communications ·Anna A. Marusiak, Zoe C. Edwards, Willy Hugo, Eleanor W. Trotter, María Romina Girotti, Natalie L. Stephenson, Xiangju Kong, Michael G. Gartside	2014	73
19	Cancer-Associated Loss-of-Function Mutations Implicate DAPK3 as a Tumor-Suppressing Kinase Cancer Research ·John Brognard, You-Wei Zhang, Lorena A. Puto, Tony Hunter	2011	68
20	Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer Proceedings of the National Academy of Sciences ·Shameem Fawdar, Eleanor W. Trotter, Yaoyong Li, Natalie L. Stephenson, Franziska Hanke, Anna A. Marusiak, Zoe C. Edwards, Sara Ientile	2013	52

About John Brognard

John Brognard is a scholar working on Molecular Biology, Cancer Research, Oncology, Otorhinolaryngology and Pulmonary and Respiratory Medicine, having authored 55 papers that have together received 4.8k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (12 papers), PI3K/AKT/mTOR signaling in cancer (11 papers), Cancer Genomics and Diagnostics (9 papers), Melanoma and MAPK Pathways (9 papers), Lung Cancer Treatments and Mutations (7 papers), Protein Tyrosine Phosphatases (7 papers), Cancer-related Molecular Pathways (5 papers) and Protein Degradation and Inhibitors (5 papers). The work is most often cited by research in Molecular Biology (2.7k citations), Cancer Research (473 citations), Oncology (631 citations), Pulmonary and Respiratory Medicine (464 citations) and Otorhinolaryngology (83 citations). John Brognard has collaborated with scholars based in United States, United Kingdom and Poland. Frequent co-authors include Phillip A. Dennis, Alexandra C. Newton, Amy Sanders Clark, Tianyan Gao, Tony Hunter, Emma Sierecki, Kip A. West, Ilona R. Linnoila, Curtis C. Harris and Steven A. Belinsky. Their work appears in journals such as Journal of Biological Chemistry, Cancer Research, Proceedings of the National Academy of Sciences, Molecular Cell and Molecular Cancer Therapeutics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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John Brognard

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John Brognard

John Brognard's Hit Papers

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