Gregory Hook

1.6k citations

21 papers · 1.3k · h-index 17

Impact in

Physiology top 5%
- Alzheimer's disease research and treatments
Neurology top 5%
- Neuroinflammation and Neurodegeneration Mechanisms

Papers in

Physiology 14
- Alzheimer's disease research and treatments 14
Cancer Research 5
- Protease and Inhibitor Mechanisms 5

Co-authors: VIVIAN Y. H. HOOK (19 shared papers)Mark S. Kindy (11 shared papers)Thomas Toneff (2 shared papers)Christoph Peters (2 shared papers)Thomas Reinheckel (2 shared papers)Michael C. Yoon (3 shared papers)Anthony John O’Donoghue (3 shared papers)J. Steven Jacobsen (2 shared papers)
Journals: Biological Chemistry (6 papers)Journal of Alzheimer s Disease (3 papers)Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2 papers)Journal of Histochemistry & Cytochemistry (1 paper)Journal of Neurochemistry (1 paper)
Partner nations: United States Germany Israel

In The Last Decade

Gregory Hook

21 papers receiving 1.2k citations

Peers

Countries citing papers authored by Gregory Hook

Since Specialization

Citations

This map shows the geographic impact of Gregory Hook's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gregory Hook with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gregory Hook more than expected).

Fields of papers citing papers by Gregory Hook

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gregory Hook. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gregory Hook. The network helps show where Gregory Hook may publish in the future.

Co-authors

The 25 scholars most cited alongside Gregory Hook, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Gregory Hook Line = papers co-authored together Gregory Hook links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 21 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein Journal of Biological Chemistry ·VIVIAN Y. H. HOOK, Mark S. Kindy, Gregory Hook	2008	181
2	Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease Biological Chemistry ·VIVIAN Y. H. HOOK, Thomas Toneff, Matthew S. Bogyo, Doron C. Greenbaum, Katalin F. Medzihradszky, John M. Neveu, William S. Lane, Gregory Hook	2005	143
3	Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ·VIVIAN Y. H. HOOK, Michael C. Yoon, Charles Mosier, Gen Ito, Sonia Podvin, Brian Patrick Head, Robert A. Rissman, Anthony John O’Donoghue	2020	134
4	The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid-β and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but not BACE1, β-Secretase Activity Journal of Alzheimer s Disease ·Gregory Hook, VIVIAN Y. H. HOOK, Mark S. Kindy	2011	100
5	Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate Frontiers in Neurology ·Gregory Hook, J. Steven Jacobsen, Kenneth H. Grabstein, Mark S. Kindy, VIVIAN Y. H. HOOK	2015	91
6	Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein Biochemical and Biophysical Research Communications ·VIVIAN Y. H. HOOK, Mark S. Kindy, Thomas Reinheckel, Christoph Peters, Gregory Hook	2009	90
7	Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders Pharmacological Reviews ·Gregory Hook, Thomas Reinheckel, Junjun Ni, Zhou Wu, Mark S. Kindy, Christoph Peters, VIVIAN Y. H. HOOK	2022	72
8	Alternative pathways for production of β-amyloid peptides of Alzheimer's disease Biological Chemistry ·VIVIAN Y. H. HOOK, Israël Schechter, Hans‐Ulrich Demuth, Gregory Hook	2008	71
9	Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic Journal of Alzheimer s Disease ·Gregory Hook, Jin Yu, Thomas Toneff, Mark S. Kindy, VIVIAN Y. H. HOOK	2014	68
10	Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ·VIVIAN Y. H. HOOK, Lydiane Funkelstein, Jill Wegrzyn, Steven J. Bark, Mark S. Kindy, Gregory Hook	2011	58
11	Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions ACS Chemical Biology ·Michael C. Yoon, Angelo Solania, Zhenze Jiang, Mitchell P. Christy, Sonia Podvin, Charles Mosier, Christopher B. Lietz, Gen Ito	2021	48
12	Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce β-amyloid related to Alzheimer's disease Biological Chemistry ·VIVIAN Y. H. HOOK, Gregory Hook, Mark S. Kindy	2010	42
13	Cysteine protease inhibitors effectively reduce in vivo levels of brain β-amyloid related to Alzheimer's disease Biological Chemistry ·VIVIAN Y. H. HOOK, Mark S. Kindy, Gregory Hook	2007	41
14	Cysteine protease inhibitors reduce brain β-amyloid and β-secretase activity in vivo and are potential Alzheimer's disease therapeutics Biological Chemistry ·Gregory Hook, VIVIAN Y. H. HOOK, Mark S. Kindy	2007	34
15	Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B Biochemistry ·Michael C. Yoon, Mitchell P. Christy, Von V. Phan, William H. Gerwick, Gregory Hook, Anthony John O’Donoghue, VIVIAN Y. H. HOOK	2022	28
16	Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling Journal of Neurochemistry ·Muzhou Jiang, Jie Meng, Fan Zeng, Hong Qing, Gregory Hook, VIVIAN Y. H. HOOK, Zhou Wu, Junjun Ni	2020	25
17	Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid Journal of Neurotrauma ·Angela M. Boutté, VIVIAN Y. H. HOOK, Bharani Thangavelu, George Anis Sarkis, Brittany N. Abbatiello, Gregory Hook, J. Steven Jacobsen, Claudia Sue Robertson	2020	19
18	Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer’s Disease Condition Journal of Alzheimer s Disease ·Gregory Hook, Mark S. Kindy, VIVIAN Y. H. HOOK	2023	14
19	Topographic localization of a 116,000-dalton protein in cartilage. Journal of Histochemistry & Cytochemistry ·R S Fife, Gregory Hook, Kenneth D. Brandt	1985	12
20	Frozen-Hydrated Lung Preparation for Low Temperature Scanning Electron Microscopy Proceedings annual meeting Electron Microscopy Society of America ·Gregory Hook, Jacob Bastacky, Thomas Hayes, Robert L. Conhaim, Norman C. Staub	1982	6

About Gregory Hook

Gregory Hook is a scholar working on Physiology, Cancer Research, Nutrition and Dietetics, Molecular Biology and Pharmacology, having authored 21 papers that have together received 1.3k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (14 papers), S100 Proteins and Annexins (7 papers), Trace Elements in Health (5 papers), Protease and Inhibitor Mechanisms (5 papers), Cholinesterase and Neurodegenerative Diseases (3 papers), Cellular transport and secretion (3 papers), Traumatic Brain Injury and Neurovascular Disturbances (2 papers) and Computational Drug Discovery Methods (2 papers). The work is most often cited by research in Physiology (604 citations), Neurology (153 citations), Biological Psychiatry (38 citations), Cancer Research (213 citations) and Cell Biology (220 citations). Gregory Hook has collaborated with scholars based in United States, Germany and Israel. Frequent co-authors include VIVIAN Y. H. HOOK, Mark S. Kindy, Thomas Toneff, Christoph Peters, Thomas Reinheckel, Michael C. Yoon, Anthony John O’Donoghue, J. Steven Jacobsen, Sonia Podvin and Charles Mosier. Their work appears in journals such as Biological Chemistry, Journal of Alzheimer s Disease, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Journal of Histochemistry & Cytochemistry and Journal of Neurochemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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