Vivian Hook

9.0k citations

193 papers · 6.2k · h-index 45

Impact in

Cellular and Molecular Neuroscience top 0.5%
- Neuropeptides and Animal Physiology
- Genetic Neurodegenerative Diseases
Cell Biology top 0.5%
- Cellular transport and secretion

Papers in

Molecular Biology 120
- Protein Hydrolysis and Bioactive Peptides 21
- Receptor Mechanisms and Signaling 19
- Biochemical and Structural Characterization 18
Cellular and Molecular Neuroscience 85
- Neuropeptides and Animal Physiology 66

Co-authors: Gregory Hook (19 shared papers)Thomas Toneff (41 shared papers)Mark S. Kindy (14 shared papers)Shin‐Rong Hwang (26 shared papers)Lydiane Funkelstein (17 shared papers)Steven J. Bark (12 shared papers)Sukkid Yasothornsrikul (16 shared papers)Terry Reisine (6 shared papers)
Journals: Journal of Neurochemistry (16 papers)Journal of Biological Chemistry (15 papers)Biochemical and Biophysical Research Communications (13 papers)Biochemistry (13 papers)Biological Chemistry (10 papers)
Partner nations: United States France Germany

In The Last Decade

Vivian Hook

191 papers receiving 6.1k citations

Peers

Countries citing papers authored by Vivian Hook

Since Specialization

Citations

This map shows the geographic impact of Vivian Hook's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Vivian Hook with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Vivian Hook more than expected).

Fields of papers citing papers by Vivian Hook

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Vivian Hook. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Vivian Hook. The network helps show where Vivian Hook may publish in the future.

Co-authors

The 25 scholars most cited alongside Vivian Hook, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Vivian Hook Line = papers co-authored together Vivian Hook links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 193 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Proteases for Processing Proneuropeptides into Peptide Neurotransmitters and Hormones The Annual Review of Pharmacology and Toxicology ·Vivian Hook, Lydiane Funkelstein, Douglas Lu, Steven J. Bark, Jill Wegrzyn, Shin‐Rong Hwang	2008	206
2	Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter Proceedings of the National Academy of Sciences ·Sukkid Yasothornsrikul, Doron C. Greenbaum, Katalin F. Medzihradszky, Thomas Toneff, Richard A. Bundey, Ruthellen Miller, Birgit Schilling, Ivonne Petermann, Jessica Dehnert, Anna Logvinova, Paul Goldsmith, John M. Neveu, William S. Lane, Bradford W. Gibson, Thomas Reinheckel, Christoph Peters, Matthew Bogyo, Vivian Hook	2003	183
3	Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein Journal of Biological Chemistry ·Vivian Hook, Mark S. Kindy, Gregory Hook	2008	177
4	Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease Cell Death and Differentiation ·Evan Hermel, Juliette Gafni, Stephanie Propp, Blair R. Leavitt, Cheryl L. Wellington, Jessica E. Young, Abigail S. Hackam, Anna Logvinova, Alyson Peel, S F Chen, Vivian Hook, Roshni R. Singaraja, Stanisław Krajewski, Paul C. Goldsmith, H. Michael Ellerby, Michael R. Hayden, Dale E. Bredesen, Lisa Ellerby	2004	170
5	Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease Biological Chemistry ·Vivian Hook, Thomas Toneff, Matthew Bogyo, Doron C. Greenbaum, Katalin F. Medzihradszky, John M. Neveu, William S. Lane, Gregory Hook, Terry Reisine	2005	138
6	Tissue-Specific Proteolysis of Huntingtin (htt) in Human Brain: Evidence of Enhanced Levels of N- and C-Terminal htt Fragments in Huntington's Disease Striatum Journal of Neuroscience ·Liane Mende‐Mueller, Thomas Toneff, Shin‐Rong Hwang, Marie-Françoise Chesselet, Vivian Hook	2001	129
7	A carboxypeptidase processing enzyme for enkephalin precursors Nature ·Vivian Hook, Lee E. Eiden, Michael Brownstein	1982	125
8	Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ·Vivian Hook, Michael C. Yoon, Charles Mosier, Gen Ito, Sonia Podvin, Brian P. Head, Robert A. Rissman, Anthony J. O’Donoghue, Gregory Hook	2020	119
9	Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary. Proceedings of the National Academy of Sciences ·Vivian Hook, Y. Peng Loh	1984	112
10	Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells. Proceedings of the National Academy of Sciences ·S. Heisler, Terry Reisine, Vivian Hook, J Axelrod	1982	108
11	The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid-β and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but not BACE1, β-Secretase Activity Journal of Alzheimer s Disease ·Gregory Hook, Vivian Hook, Mark S. Kindy	2011	96
12	Corticotropin releasing factor stimulates adrenocorticotropin and β-endorphin release from AtT-20 mouse pituitary tumor cells Biochemical and Biophysical Research Communications ·Vivian Hook, Seymour Heisler, Steven L. Sabol, Julius Axelrod	1982	88
13	Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate Frontiers in Neurology ·Gregory Hook, J. Steven Jacobsen, Kenneth H. Grabstein, Mark S. Kindy, Vivian Hook	2015	84
14	Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein Biochemical and Biophysical Research Communications ·Vivian Hook, Mark S. Kindy, Thomas Reinheckel, Christoph Peters, Gregory Hook	2009	83
15	Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons Stem Cell Reports ·Vivian Hook, Kristen Brennand, Yong Sung Kim, Thomas Toneff, Lydiane Funkelstein, Kelly C. Lee, Michael G. Ziegler, Fred H. Gage	2014	83
16	Deletion of the Cathepsin B Gene Improves Memory Deficits in a Transgenic Alzheimer's Disease Mouse Model Expressing AβPP Containing the Wild-Type β-Secretase Site Sequence Journal of Alzheimer s Disease ·Mark S. Kindy, Jin Yu, Hong Zhu, Salim S. El‐Amouri, Vivian Hook, G. R. Hook	2012	78
17	Expansion of the mycobacterial “PUPylome” Molecular BioSystems ·Jeramie D. Watrous, Kristin E. Burns, Wei-Ting Liu, Anand Patel, Vivian Hook, Vineet Bafna, Clifton E. Barry, Steve Bark, Pieter C. Dorrestein	2009	73
18	Formation of the Catecholamine Release-inhibitory Peptide Catestatin from Chromogranin A Journal of Biological Chemistry ·Carolyn V. Taylor, Laurent Taupenot, Sushil K. Mahata, Manjula Mahata, Haibo Wu, Sukkid Yasothornsrikul, Thomas Toneff, Carlo Caporale, Qijiao Jiang, Robert J. Parmer, Vivian Hook, Daniel T. O’Connor	2000	69
19	Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders Pharmacological Reviews ·Gregory Hook, Thomas Reinheckel, Junjun Ni, Zhou Wu, Mark S. Kindy, Christoph Peters, Vivian Hook	2022	66
20	Alternative pathways for production of β-amyloid peptides of Alzheimer's disease Biological Chemistry ·Vivian Hook, Israël Schechter, Hans‐Ulrich Demuth, Gregory Hook	2008	65

About Vivian Hook

Vivian Hook is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience, Physiology, Cell Biology and Cancer Research, having authored 193 papers that have together received 6.2k indexed citations. Recurring topics across this work include Neuropeptides and Animal Physiology (66 papers), Alzheimer's disease research and treatments (38 papers), Cellular transport and secretion (36 papers), Protease and Inhibitor Mechanisms (33 papers), Peptidase Inhibition and Analysis (30 papers), Protein Hydrolysis and Bioactive Peptides (21 papers), Receptor Mechanisms and Signaling (19 papers) and Biochemical and Structural Characterization (18 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (1.9k citations), Cell Biology (1.2k citations), Physiology (1.5k citations), Cancer Research (806 citations) and Behavioral Neuroscience (191 citations). Vivian Hook has collaborated with scholars based in United States, France and Germany. Frequent co-authors include Gregory Hook, Thomas Toneff, Mark S. Kindy, Shin‐Rong Hwang, Lydiane Funkelstein, Steven J. Bark, Sukkid Yasothornsrikul, Terry Reisine, Lee E. Eiden and Sonia Podvin. Their work appears in journals such as Journal of Neurochemistry, Journal of Biological Chemistry, Biochemical and Biophysical Research Communications, Biochemistry and Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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