Casper Shyr

4.1k citations

21 papers · 2.7k · 3 hit papers · h-index 14

Impact in

Molecular Biology top 5%
- Genomics and Chromatin Dynamics
- Genomics, phytochemicals, and oxidative stress
- RNA Research and Splicing
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Glutathione Transferases and Polymorphisms
Cancer Research top 5%
- Cancer-related molecular mechanisms research

Papers in

Molecular Biology 13
- Ion channel regulation and function 3
- Genomics and Chromatin Dynamics 2
- RNA Research and Splicing 2
- RNA and protein synthesis mechanisms 2
Genetics 8
- Genomics and Rare Diseases 5
- Genetics and Neurodevelopmental Disorders 4

Co-authors: Wyeth W. Wasserman (18 shared papers)David J. Arenillas (3 shared papers)Albin Sandelin (2 shared papers)Allen W. Zhang (2 shared papers)François Parcy (2 shared papers)Chih‐Yu Chen (2 shared papers)Ge Tan (2 shared papers)Boris Lenhard (2 shared papers)
Journals: Orphanet Journal of Rare Diseases (4 papers)Nucleic Acids Research (3 papers)Molecular Genetics and Metabolism (2 papers)Neurogenetics (2 papers)Journal of the American Medical Informatics Association (1 paper)
Partner nations: Canada United Kingdom United States

In The Last Decade

Casper Shyr

21 papers receiving 2.6k citations

Casper Shyr's Hit Papers

align trajectories log scale

JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles 2015 · 725 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Nucleic Acids Research
2013 Nucleic Acids Research
2010 Nucleic Acids Research

Peers

Countries citing papers authored by Casper Shyr

Since Specialization

Citations

This map shows the geographic impact of Casper Shyr's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Casper Shyr with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Casper Shyr more than expected).

Fields of papers citing papers by Casper Shyr

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Casper Shyr. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Casper Shyr. The network helps show where Casper Shyr may publish in the future.

Co-authors

The 25 scholars most cited alongside Casper Shyr, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Casper Shyr Line = papers co-authored together Casper Shyr links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 21 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles Nucleic Acids Research ·Anthony Mathelier, Xiaobei Zhao, Allen W. Zhang, François Parcy, Rebecca Worsley-Hunt, David J. Arenillas, Sorana Buchman, Chih‐Yu Chen, Alice Chou, Hans Ienasescu, Jonathan Lim, Casper Shyr, Ge Tan, Michelle Zhou, Boris Lenhard, Albin Sandelin, Wyeth W. Wasserman Hit paper breakdown →	2013	801
2	JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles Nucleic Acids Research ·Anthony Mathelier, Oriol Fornés, David J. Arenillas, Chih‐Yu Chen, Grégoire Denay, Jessica Lee, Wenqiang Shi, Casper Shyr, Ge Tan, Rebecca Worsley-Hunt, Allen W. Zhang, François Parcy, Boris Lenhard, Albin Sandelin, Wyeth W. Wasserman Hit paper breakdown →	2015	725
3	Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis Nucleic Acids Research ·Deepti Malhotra, Élodie Portales-Casamar, Anju Singh, Siddhartha Srivastava, David J. Arenillas, Christine Happel, Casper Shyr, Nobunao Wakabayashi, Thomas W. Kensler, Wyeth W. Wasserman, Shyam Biswal Hit paper breakdown →	2010	632
4	A novel recurrent mutation in ATP1A3 causes CAPOS syndrome Orphanet Journal of Rare Diseases ·Michelle Demos, Clara DM van Karnebeek, Colin J.D. Ross, Shelin Adam, Yaoqing Shen, Shing H. Zhan, Casper Shyr, Gabriella Horváth, Mohnish Suri, Alan Fryer, Steven J.M. Jones, Jan M. Friedman	2014	135
5	FLAGS, frequently mutated genes in public exomes BMC Medical Genomics ·Casper Shyr, Maja Tarailo‐Graovac, Michael Gottlieb, Jessica J. Y. Lee, Clara van Karnebeek, Wyeth W. Wasserman	2014	100
6	The genotypic and phenotypic spectrum of PIGA deficiency Orphanet Journal of Rare Diseases ·Maja Tarailo‐Graovac, Graham Sinclair, Sylvia Stöckler‐Ipsiroglu, Margot Van Allen, Jacob Rozmus, Casper Shyr, Roberta Biancheri, Tracey Oh, Bryan Sayson, Mirafe Lafek, Colin J.D. Ross, Wendy P. Robinson, Wyeth W. Wasserman, Andrea Rossi, Clara DM van Karnebeek	2015	58
7	Secondary neurotransmitter deficiencies in epilepsy caused by voltage-gated sodium channelopathies: A potential treatment target? Molecular Genetics and Metabolism ·Gabriella Horváth, Michelle Demos, Casper Shyr, Allison Matthews, Linhua Zhang, Simone Race, Sylvia Stöckler‐Ipsiroglu, Margot I. Van Allen, B. Ogan Mancarci, Lilah Toker, Paul Pavlidis, Colin J.D. Ross, Wyeth W. Wasserman, Natalie Trump, Simon Heales, Simon Pope, J. Helen Cross, Clara van Karnebeek	2015	33
8	RMND1 deficiency associated with neonatal lactic acidosis, infantile onset renal failure, deafness, and multiorgan involvement European Journal of Human Genetics ·Alexandre Janer, Clara DM van Karnebeek, Florin Sasarman, Hana Antonická, Malak Al Ghamdi, Casper Shyr, Mary Dunbar, Sylvia Stockler-Ispiroglu, Colin J.D. Ross, Hilary Vallance, Janis M. Dionne, Wyeth W. Wasserman, Eric A. Shoubridge	2015	23
9	Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis Molecular Genetics and Metabolism ·Saikat Santra, Jessie M. Cameron, Casper Shyr, Linhua Zhang, Britt I. Drögemöller, Colin J.D. Ross, Wyeth W. Wasserman, Ron A. Wevers, Richard J. Rodenburg, Girish Gupte, Mary Anne Preece, Clara D. van Karnebeek	2016	22
10	Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking Orphanet Journal of Rare Diseases ·Sylvia Stöckler, Silvia Corvera, David G. Lambright, Kevin E. Fogarty, Ekaterina Nosova, Deborah M. Leonard, Robert Steinfeld, Cameron Ackerley, Casper Shyr, Nicholas Au, Kathrin Selby, Margot Van Allen, Hilary Vallance, Ron A. Wevers, David Watkins, David S. Rosenblatt, Colin J.D. Ross, Elizabeth Conibear, Wyeth W. Wasserman, Clara van Karnebeek	2014	21
11	Gain-of-function KCNJ6 Mutation in a Severe Hyperkinetic Movement Disorder Phenotype Neuroscience ·Gabriella Horváth, Yulin Zhao, Maja Tarailo‐Graovac, Cyrus Boelman, Harinder Gill, Casper Shyr, James Lee, Ingrid Blydt-Hansen, Britt I. Drögemöller, Jacqueline Moreland, Colin J.D. Ross, Wyeth W. Wasserman, Andrea Masotti, Paul A. Slesinger, Clara van Karnebeek	2018	20
12	Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms Orphanet Journal of Rare Diseases ·Sandra Sirrs, Clara DM van Karnebeek, Xiaoxue Peng, Casper Shyr, Maja Tarailo‐Graovac, Rupasri Mandal, Daniel Testa, Devin Dubin, Gregory Carbonetti, Steven E. Glynn, Bryan Sayson, Wendy P. Robinson, Beom-Soo Han, David S. Wishart, Colin J.D. Ross, Wyeth W. Wasserman, Trevor A. Hurwitz, Graham Sinclair, Martin Kaczocha	2015	19
13	AIMP1 deficiency presents as a cortical neurodegenerative disease with infantile onset Neurogenetics ·Linlea Armstrong, Roberta Biancheri, Casper Shyr, Andrea Rossi, Graham Sinclair, Colin J.D. Ross, Maja Tarailo‐Graovac, Wyeth W. Wasserman, Clara van Karnebeek	2014	15
14	Further Validation of the SIGMAR1 c.151+1G>T Mutation as Cause of Distal Hereditary Motor Neuropathy SHILAP Revista de lepidopterología ·Jessica J. Y. Lee, Clara van Karnebeek, Britt I. Drögemöller, Casper Shyr, Maja Tarailo‐Graovac, Patrice Eydoux, Colin J.D. Ross, Wyeth W. Wasserman, Bruce Björnson, John K. Wu	2016	13
15	Usability study of clinical exome analysis software: Top lessons learned and recommendations Journal of Biomedical Informatics ·Casper Shyr, André Kushniruk, Wyeth W. Wasserman	2014	11
16	Optic atrophy, cataracts, lipodystrophy/lipoatrophy, and peripheral neuropathy caused by a de novo OPA3 mutation Molecular Case Studies ·Stephanie C. Bourne, Katelin N. Townsend, Casper Shyr, Allison Matthews, Scott A. Lear, Raj Attariwala, Anna Lehman, Wyeth W. Wasserman, Clara van Karnebeek, Graham Sinclair, Hilary Vallance, William T. Gibson	2016	10
17	Dynamic software design for clinical exome and genome analyses: insights from bioinformaticians, clinical geneticists, and genetic counselors Journal of the American Medical Informatics Association ·Casper Shyr, André Kushniruk, Clara van Karnebeek, Wyeth W. Wasserman	2015	8
18	Team-based care: A clinical pharmacist and family physicians Canadian Pharmacists Journal / Revue des Pharmaciens du Canada ·Lori Blain, Priti S. Flanagan, Casper Shyr	2021	4
19	Linkage analysis identifies an isolated strabismus locus at 14q12 overlapping with FOXG1 syndrome region Journal of Medical Genetics ·Xin Ye, Nicole M. Roslin, Andrew D. Paterson, Christopher J. Lyons, Victor Pegado, Phillip A. Richmond, Casper Shyr, Oriol Fornés, Xiaohua Han, Michelle Higginson, Colin J.D. Ross, Deborah Giaschi, Cheryl Y. Gregory‐Evans, Millan S. Patel, Wyeth W. Wasserman	2020	2
20	Secondary biogenic amine deficiencies: genetic etiology, therapeutic interventions, and clinical effects Neurogenetics ·Clara D. van Karnebeek, Ingrid Blydt-Hansen, Allison Matthews, Vladimir Avramović, Magda Price, Britt I. Drögemöller, Casper Shyr, Jessica Lee, Jill Mwenifumbo, Aisha Ghani, Sylvia Stöckler, Jan M. Friedman, Anna Lehman, (unknown), Colin J.D. Ross, Wyeth W. Wasserman, Maja Tarailo‐Graovac, Gabriella Horváth	2021	2

About Casper Shyr

Casper Shyr is a scholar working on Molecular Biology, Genetics, Physiology, Cellular and Molecular Neuroscience and Epidemiology, having authored 21 papers that have together received 2.7k indexed citations. Recurring topics across this work include Genomics and Rare Diseases (5 papers), Genetics and Neurodevelopmental Disorders (4 papers), Ion channel regulation and function (3 papers), Metabolism and Genetic Disorders (2 papers), Genomics and Chromatin Dynamics (2 papers), RNA Research and Splicing (2 papers), Lysosomal Storage Disorders Research (2 papers) and RNA and protein synthesis mechanisms (2 papers). The work is most often cited by research in Molecular Biology (2.1k citations), Cancer Research (363 citations), Aging (35 citations), Genetics (383 citations) and Clinical Biochemistry (83 citations). Casper Shyr has collaborated with scholars based in Canada, United Kingdom and United States. Frequent co-authors include Wyeth W. Wasserman, David J. Arenillas, Albin Sandelin, Allen W. Zhang, François Parcy, Chih‐Yu Chen, Ge Tan, Boris Lenhard, Anthony Mathelier and Rebecca Worsley-Hunt. Their work appears in journals such as Orphanet Journal of Rare Diseases, Nucleic Acids Research, Molecular Genetics and Metabolism, Neurogenetics and Journal of the American Medical Informatics Association.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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In The Last Decade

Casper Shyr

Casper Shyr's Hit Papers

Peers

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All Works

About Casper Shyr

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