Ronan O’Brien

5.6k citations

45 papers · 4.8k · 2 hit papers · h-index 28

Impact in

Molecular Biology top 2%
- Heat shock proteins research
- Protein Structure and Dynamics
- ATP Synthase and ATPases Research
Cell Biology top 2%
- Cellular transport and secretion

Papers in

Molecular Biology 31
- Protein Structure and Dynamics 12
- RNA and protein synthesis mechanisms 8
- DNA and Nucleic Acid Chemistry 6
- Viral Infectious Diseases and Gene Expression in Insects 3
Physical and Theoretical Chemistry 5
- thermodynamics and calorimetric analyses 5

Co-authors: John Edward Ladbury (24 shared papers)Laurence H. Pearl (2 shared papers)Stephen Mark Roe (2 shared papers)Chrisostomos Prodromou (2 shared papers)Peter W. Piper (2 shared papers)Gerta Vrbovà (6 shared papers)Anna Östberg (4 shared papers)Paul B. Sigler (2 shared papers)
Journals: Biochemistry (6 papers)Protein Science (5 papers)Neuroscience (4 papers)Journal of Molecular Biology (4 papers)The Journal of Physiology (3 papers)
Partner nations: United Kingdom United States Ireland

In The Last Decade

Ronan O’Brien

45 papers receiving 4.6k citations

Ronan O’Brien's Hit Papers

align trajectories log scale

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin 1999 · 880 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

1999 Journal of Medicinal Chemistry
1997 Cell

Peers

Countries citing papers authored by Ronan O’Brien

Since Specialization

Citations

This map shows the geographic impact of Ronan O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ronan O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ronan O’Brien more than expected).

Fields of papers citing papers by Ronan O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ronan O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ronan O’Brien. The network helps show where Ronan O’Brien may publish in the future.

Co-authors

The 25 scholars most cited alongside Ronan O’Brien, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Ronan O’Brien Line = papers co-authored together Ronan O’Brien links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 45 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone Cell ·Chrisostomos Prodromou, Stephen Mark Roe, Ronan O’Brien, John Edward Ladbury, Peter W. Piper, Laurence H. Pearl Hit paper breakdown →	1997	1108
2	Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin Journal of Medicinal Chemistry ·Stephen Mark Roe, Chrisostomos Prodromou, Ronan O’Brien, John Edward Ladbury, Peter W. Piper, Laurence H. Pearl Hit paper breakdown →	1999	880
3	Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proceedings of the National Academy of Sciences ·Mark A. Lemmon, K M Ferguson, Ronan O’Brien, Paul B. Sigler, Joseph Schlessinger	1995	490
4	Observations on the elimination of polyneuronal innervation in developing mammalian skeletal muscle. The Journal of Physiology ·Ronan O’Brien, Anna Östberg, Gerta Vrbovà	1978	331
5	Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate Structure ·Elena Baraldi, Kristina Djinović‐Carugo, Marko Hyvönen, Paola Lo Surdo, Andrew M. Riley, Barry V. L. Potter, Ronan O’Brien, John Edward Ladbury	1999	170
6	What makes a protein a protein? Hydrophobic core designs that specify stability and structural properties Protein Science ·Mary Munson, Suganthi Balasubramanian, Karen G. Fleming, Athena D. Nagi, Ronan O’Brien, Julian M. Sturtevant, Lynne Regan	1996	161
7	The Crystal Structure of a Hyperthermophilic Archaeal TATA-box Binding Protein Journal of Molecular Biology ·Brian S. DeDecker, Ronan O’Brien, Patrick J. Fleming, James H. Geiger, Stephen Philip Jackson, Paul B. Sigler	1996	146
8	The high-resolution crystal structure of a 24-kDa gyrase B fragment fromE. coli complexed with one of the most potent coumarin inhibitors, clorobiocin Proteins Structure Function and Bioinformatics ·Francis Tsai, Onkar M. P. Singh, Tadeusz J. Skarzynski, Alan J. Wonacott, Simon A. Weston, Alec D. Tucker, Richard A. Pauptit, Alexander L. Breeze	1997	135
9	Redesigning the hydrophobic core of a four‐helix‐bundle protein Protein Science ·Mary Munson, Lynne Regan, Ronan O’Brien, Julian M. Sturtevant	1994	113
10	Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat Biochemical Journal ·Ruth H. Flatman, Russell W. McLAUCHLAN, Nathalie Juge, Caroline S.M. Furniss, Jean‐Guy Berrin, Richard K. Hughes, Paloma Manzanares, John Edward Ladbury	2002	113
11	Heat Capacity Effects of Water Molecules and Ions at a Protein–DNA Interface Journal of Molecular Biology ·Simon Bergqvist, Mark Anthony Williams, Ronan O’Brien, John Edward Ladbury	2004	108
12	RT Loop Flexibility Enhances the Specificity of Src Family SH3 Domains for HIV-1 Nef, Biochemistry ·Stefan T. Arold, Ronan O’Brien, Peet A. Franken, Marie‐Paule Strub, François Hoh, Christian Dumas, John Edward Ladbury	1998	104
13	The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon Journal of Molecular Biology ·Ronan O’Brien, Brian S. DeDecker, Karen G. Fleming, Paul B. Sigler, John Edward Ladbury	1998	94
14	Localization and characterization of the hyaluronan-binding site on the Link module from human TSG-6 Structure ·Jan D. Kahmann, Ronan O’Brien, Jörn M. Werner, Dick K. Heinegård, John Edward Ladbury, Iain Donald Campbell, Anthony J. Day	2000	88
15	Protease inhibitors reduce the loss of nerve terminals induced by activity and calcium in developing rat soleus muscles in vitro Neuroscience ·Ronan O’Brien, Anna Östberg, Gerta Vrbovà	1984	75
16	Thermodynamic Optimisation in Drug Discovery: A Case Study using Carbonic Anhydrase Inhibitors ChemMedChem ·Andrew D. Scott, Chris Phillips, Alexander Alex, Maria M. Flocco, Andrew F. Bent, Amy Randall, Ronan O’Brien, Luminita Damian	2009	61
17	Scanning Microcalorimetric Investigations of Phase Transitions in Dilute Aqueous Solutions of Poly(oxypropylene) The Journal of Physical Chemistry ·Jonathan K. Armstrong, Babur Z. Chowdhry, Ronan O’Brien, Anthony E. Beezer, John C. Mitchell, Stephen A. Leharne	1995	46
18	Site-Specific Cation Binding Mediates TATA Binding Protein−DNA Interaction from a Hyperthermophilic Archaeon Biochemistry ·Simon Bergqvist, Ronan O’Brien, John Edward Ladbury	2001	38
19	A Structural Characterization of the Interactions between Titin Z-Repeats and the α-Actinin C-Terminal Domain Biochemistry ·Catherine Joseph, Günter Stier, Ronan O’Brien, Anastasia S. Politou, Roger Atkinson, Alberto Bianco, John Edward Ladbury, Steven R. Martin	2001	38
20	Metal-dependent Folding and Stability of Nuclear Hormone Receptor DNA-binding Domains Journal of Molecular Biology ·Lieh Yoon Low, Helena Hernández, Carol V. Robinson, Ronan O’Brien, J. Günter Grossmann, John Edward Ladbury, Ben F. Luisi	2002	35

About Ronan O’Brien

Ronan O’Brien is a scholar working on Molecular Biology, Physical and Theoretical Chemistry, Genetics, Cell Biology and Materials Chemistry, having authored 45 papers that have together received 4.8k indexed citations. Recurring topics across this work include Protein Structure and Dynamics (12 papers), Enzyme Structure and Function (9 papers), RNA and protein synthesis mechanisms (8 papers), Bacterial Genetics and Biotechnology (6 papers), DNA and Nucleic Acid Chemistry (6 papers), thermodynamics and calorimetric analyses (5 papers), Nerve injury and regeneration (4 papers) and Viral Infectious Diseases and Gene Expression in Insects (3 papers). The work is most often cited by research in Molecular Biology (3.8k citations), Cell Biology (780 citations), Physical and Theoretical Chemistry (432 citations), Aging (52 citations) and Toxicology (91 citations). Ronan O’Brien has collaborated with scholars based in United Kingdom, United States and Ireland. Frequent co-authors include John Edward Ladbury, Laurence H. Pearl, Stephen Mark Roe, Chrisostomos Prodromou, Peter W. Piper, Gerta Vrbovà, Anna Östberg, Paul B. Sigler, Joseph Schlessinger and Mark A. Lemmon. Their work appears in journals such as Biochemistry, Protein Science, Neuroscience, Journal of Molecular Biology and The Journal of Physiology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Ronan O’Brien

Ronan O’Brien's Hit Papers

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