Jonathan C. O’Connell

1.4k citations

24 papers · 1.2k · 1 hit paper · h-index 16

Impact in

Molecular Biology top 10%
- Protein Kinase Regulation and GTPase Signaling
- Receptor Mechanisms and Signaling
- Phosphodiesterase function and regulation
- Cancer-related gene regulation
Cellular and Molecular Neuroscience top 10%
- Neuropeptides and Animal Physiology

Papers in

Molecular Biology 19
- Receptor Mechanisms and Signaling 7
- Phosphodiesterase function and regulation 3
- Chemical Synthesis and Analysis 3
- Protein Tyrosine Phosphatases 2
- Protein Kinase Regulation and GTPase Signaling 2
Biophysics 2
- Cell Image Analysis Techniques 2

Co-authors: Martyn N. Banks (10 shared papers)Neil T. Burford (5 shared papers)Andrew J. Alt (6 shared papers)Miles D. Houslay (3 shared papers)Tom S. Wehrman (3 shared papers)Graeme B. Bolger (2 shared papers)Samuel W. Gerritz (4 shared papers)John R. Traynor (2 shared papers)
Journals: SLAS DISCOVERY (7 papers)Journal of Medicinal Chemistry (3 papers)Bioorganic & Medicinal Chemistry Letters (2 papers)ACS Medicinal Chemistry Letters (1 paper)Biochemical Society Transactions (1 paper)
Partner nations: United States United Kingdom Austria

In The Last Decade

Jonathan C. O’Connell

24 papers receiving 1.1k citations

Jonathan C. O’Connell's Hit Papers

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BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition 2020 · 346 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2020 Cancer Discovery

Peers

Countries citing papers authored by Jonathan C. O’Connell

Since Specialization

Citations

This map shows the geographic impact of Jonathan C. O’Connell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jonathan C. O’Connell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jonathan C. O’Connell more than expected).

Fields of papers citing papers by Jonathan C. O’Connell

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jonathan C. O’Connell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jonathan C. O’Connell. The network helps show where Jonathan C. O’Connell may publish in the future.

Co-authors

The 25 scholars most cited alongside Jonathan C. O’Connell, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Jonathan C. O’Connell Line = papers co-authored together Jonathan C. O’Connell links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 24 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition Cancer Discovery ·Marco H. Hofmann, Michael Gmachl, Jürgen Ramharter, Fabio Savarese, Daniel Gerlach, Joseph R. Marszalek, Michael P. Sanderson, Dirk Kessler Hit paper breakdown →	2020	346
2	Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor Proceedings of the National Academy of Sciences ·Neil T. Burford, Mary Jo Clark, Tom S. Wehrman, Samuel W. Gerritz, Martyn N. Banks, Jonathan C. O’Connell, John R. Traynor, Andrew J. Alt	2013	138
3	The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5) Biochemical Journal ·Jonathan C. O’Connell, J. Fraser McCALLUM, Jill M. WAKEFIELD, Emma S. Houslay, William L. Wishart, Graeme B. Bolger, Margaret C. Frame, Miles D. Houslay +1 other	1996	92
4	Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1) Bioorganic & Medicinal Chemistry Letters ·Ashok V. Purandare, Zhong Chen, Tram Huynh, Suhong Pang, Jieping Geng, Wayne D. Vaccaro, Michael A. Poss, Jonathan C. O’Connell	2008	80
5	Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor Journal of Medicinal Chemistry ·Neil T. Burford, Kathryn E. Livingston, Meritxell Canals, Molly R. Ryan, Lauren Budenholzer, Ying Mei Han, Jonathan C. O’Connell, Martyn N. Banks	2015	67
6	The unique N‐terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains FEBS Letters ·Matthew Beard, Jonathan C. O’Connell, Graeme B. Bolger, Miles D. Houslay	1999	60
7	One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS Journal of Medicinal Chemistry ·Jürgen Ramharter, Dirk Kessler, Marco H. Hofmann, Thomas Gerstberger, Michael Gmachl, Tobias Wunberg, Christiane C. Kofink, Michael P. Sanderson	2021	52
8	Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors Journal of Pharmacology and Experimental Therapeutics ·Andrew J. Alt, Annapurna Pendri, Robert L. Bertekap, Guoping Li, Yulia Benitex, Michelle J. Nophsker, Kristin L. Rockwell, Neil T. Burford	2015	40
9	Synthesis of Multifunctional 2-Aminobenzimidazoles on DNA via Iodine-Promoted Cyclization Organic Letters ·Liqiang Su, Jing Feng, Ting Peng, Jinqiao Wan, Jing Fan, Jin Li, Jonathan C. O’Connell, David R. Lancia	2020	36
10	The deubiquitylase USP9X controls ribosomal stalling The Journal of Cell Biology ·Anne Clancy, Claire Heride, Adán Pinto-Fernández, Hannah Elcocks, Andreas Kallinos, Katherine J. Kayser-Bricker, Victoria Smith, Simon A. Davis	2020	34
11	2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: Optimization via array synthesis Bioorganic & Medicinal Chemistry Letters ·Lalgudi S. Harikrishnan, Muthoni G. Kamau, Timothy F. Herpin, George C. Morton, Yalei Liu, Christopher B. Cooper, Mark Salvati, Jennifer Xiaoxin Qiao	2008	31
12	Identification of Selective Agonists and Positive Allosteric Modulators for µ- and δ-Opioid Receptors from a Single High-Throughput Screen SLAS DISCOVERY ·Neil T. Burford, Tom S. Wehrman, Daniel L. Bassoni, Jonathan C. O’Connell, Martyn N. Banks, Litao Zhang, Andrew J. Alt	2014	28
13	Use of Cryopreserved Transiently Transfected Cells in High-Throughput Pregnane X Receptor Transactivation Assay SLAS DISCOVERY ·Zhengrong Zhu, Jaime Puglisi, David Connors, Jeremy Stewart, Michael Sinz, Jonathan C. O’Connell, Martyn N. Banks, Kenneth E.J. Dickinson	2007	21
14	Small Molecule Receptor Protein Tyrosine Phosphatase γ (RPTPγ) Ligands That Inhibit Phosphatase Activity via Perturbation of the Tryptophan–Proline–Aspartate (WPD) Loop Journal of Medicinal Chemistry ·S. Sheriff, Brett R. Beno, Weixu Zhai, Walter A. Kostich, Patricia A. McDonnell, Kevin Kish, Valentina Goldfarb, Mian Gao	2011	19
15	Identification of Small Molecules That Selectively Inhibit Diacylglycerol Lipase–α Activity SLAS DISCOVERY ·Kingsley K. Appiah, Yuval Blat, Barbara Robertson, Bradley C. Pearce, Donna L. Pedicord, Robert G. Gentles, Xuan‐Chuan Yu, Faika Mseeh	2013	16
16	Design and Synthesis of 4-Heteroaryl 1,2,3,4-Tetrahydroisoquinolines as Triple Reuptake Inhibitors ACS Medicinal Chemistry Letters ·Shuang Liu, Congxiang Zha, Kassoum Nacro, Min Shan Hu, Wenge Cui, Yuh‐Lin Yang, Ulhas Bhatt, Aruna Sambandam	2014	16
17	Development of Novel, 384-Well High-Throughput Assay Panels for Human Drug Transporters: Drug Interaction and Safety Assessment in Support of Discovery Research SLAS DISCOVERY ·Huaping Tang, Ding Ren Shen, Yong–Hae Han, Praveen V. Balimane, Mian Gao, Sophie Wu, Dianlin Xie, Matthew G. Soars	2013	15
18	The Impact of Variable Selection Coverage on Detection of Ligands from a DNA-Encoded Library Screen SLAS DISCOVERY ·Kelly A. McCarthy, G. Joseph Franklin, David R. Lancia, Martin Olbrot, Eneida Pardo, Jonathan C. O’Connell, Christopher S. Kollmann	2020	15
19	Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in Vmax, stability and membrane association Biochemical Society Transactions ·Miles D. Houslay, Grant Scotland, Linda Pooley, Sandra Spence, Ian Wilkinson, Fraser McCallum, Pascale Julien, Graham Rena	1995	13
20	Development of a High-Throughput Calcium Flux Assay for Identification of All Ligand Types Including Positive, Negative, and Silent Allosteric Modulators for G Protein-Coupled Receptors Assay and Drug Development Technologies ·Devin J. Noblin, Robert L. Bertekap, Neil T. Burford, Adam W. Hendricson, Litao Zhang, Ronald J. Knox, Martyn N. Banks, Jonathan C. O’Connell	2012	11

About Jonathan C. O’Connell

Jonathan C. O’Connell is a scholar working on Molecular Biology, Biophysics, Pharmacology, Oncology and Pharmacology, having authored 24 papers that have together received 1.2k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (7 papers), Phosphodiesterase function and regulation (3 papers), Chemical Synthesis and Analysis (3 papers), Protein Tyrosine Phosphatases (2 papers), Cell Image Analysis Techniques (2 papers), Synthesis and biological activity (2 papers), Protein Kinase Regulation and GTPase Signaling (2 papers) and Drug Transport and Resistance Mechanisms (2 papers). The work is most often cited by research in Molecular Biology (769 citations), Cellular and Molecular Neuroscience (112 citations), Oncology (122 citations), Anesthesiology and Pain Medicine (26 citations) and Computational Theory and Mathematics (58 citations). Jonathan C. O’Connell has collaborated with scholars based in United States, United Kingdom and Austria. Frequent co-authors include Martyn N. Banks, Neil T. Burford, Andrew J. Alt, Miles D. Houslay, Tom S. Wehrman, Graeme B. Bolger, Samuel W. Gerritz, John R. Traynor, Mary Jo Clark and Matthew Beard. Their work appears in journals such as SLAS DISCOVERY, Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, ACS Medicinal Chemistry Letters and Biochemical Society Transactions.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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In The Last Decade

Jonathan C. O’Connell

Jonathan C. O’Connell's Hit Papers

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Countries citing papers authored by Jonathan C. O’Connell

Fields of papers citing papers by Jonathan C. O’Connell

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About Jonathan C. O’Connell

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