James B. Doherty

1.4k citations

37 papers · 1.2k · h-index 19

Impact in

Organic Chemistry top 5%
- Synthesis of β-Lactam Compounds
- Synthesis and biological activity
- Carbohydrate Chemistry and Synthesis
- Sulfur-Based Synthesis Techniques
Cancer Research top 10%
- Protease and Inhibitor Mechanisms

Papers in

Organic Chemistry 22
- Synthesis of β-Lactam Compounds 9
- Synthesis and biological activity 8
- Quinazolinone synthesis and applications 4
- Carbohydrate Chemistry and Synthesis 3
Molecular Biology 18
- Melanoma and MAPK Pathways 10

Co-authors: Paul E. Finke (20 shared papers)Bonnie M. Ashe (16 shared papers)S. Natarajan (6 shared papers)Ronald Breslow (1 shared paper)Geneviève Guillot (1 shared paper)Alan L. Maycock (16 shared papers)Stephen J. O’Keefe (9 shared papers)Gilbert O. Chandler (8 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (15 papers)Journal of Medicinal Chemistry (2 papers)Biochemistry (2 papers)Nature (2 papers)Annals of the New York Academy of Sciences (2 papers)
Partner nations: United States Germany Brazil

In The Last Decade

James B. Doherty

37 papers receiving 1.1k citations

Peers

Countries citing papers authored by James B. Doherty

Since Specialization

Citations

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Fields of papers citing papers by James B. Doherty

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James B. Doherty. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James B. Doherty. The network helps show where James B. Doherty may publish in the future.

Co-authors

The 25 scholars most cited alongside James B. Doherty, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with James B. Doherty Line = papers co-authored together James B. Doherty links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase Nature ·James B. Doherty, Bonnie M. Ashe, Lawrence W. Argenbright, Peter L. Barker, Robert J. Bonney, Gilbert O. Chandler, Mary Ellen Dahlgren, Conrad P. Dorn, Paul E. Finke, Raymond A. Firestone, Daniel S. Fletcher, William K. Hagmann, Richard A. Mumford, Laura O’Grady, Alan L. Maycock, Judith M. Pisano, Shrenik K. Shah, Kevan R. Thompson, Morris Zimmerman	1986	134
2	.beta.-Cyclodextrinylbisimidazole, a model for ribonuclease Journal of the American Chemical Society ·Ronald Breslow, James B. Doherty, Geneviève Guillot, Carol Lipsey	1978	121
3	SAR of 3,4-Dihydropyrido[3,2-d]pyrimidone p38 inhibitors Bioorganic & Medicinal Chemistry Letters ·Luping Liu, John E. Stelmach, S. Natarajan, Meng‐Hsin Chen, Suresh B. Singh, Cheryl D. Schwartz, Catherine E. Fitzgerald, Stephen J. O’Keefe, Dennis M. Zaller, Dennis M. Schmatz, James B. Doherty	2003	104
4	Crystallographie study of a β-lactam inhibitor complex with elastase at 1.84 Å resolution Nature ·Manuel A. Navia, James P. Springer, Tsau-Yen Lin, Hollis R. Williams, Raymond A. Firestone, Judith M. Pisano, James B. Doherty, Paul E. Finke, Karst Hoogsteen	1987	86
5	Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase Bioorganic & Medicinal Chemistry Letters ·John E. Stelmach, Luping Liu, Sangita B. Patel, James V. Pivnichny, Giovanna Scapin, Suresh B. Singh, Cornelis E. C. A. Hop, Zhen Wang, John R. Strauss, Patricia M. Cameron, E.A. Nichols, Stephen J. O’Keefe, Edward A. O’Neill, Dennis M. Schmatz, Cheryl D. Schwartz, Chris M. Thompson, Dennis M. Zaller, James B. Doherty	2003	68
6	Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters Journal of Medicinal Chemistry ·James B. Doherty, Bonnie M. Ashe, Peter L. Barker, Thomas J. Blacklock, John W. Butcher, Gilbert O. Chandler, Mary Ellen Dahlgren, Philip R. Davies, Conrad P. Dorn	1990	63
7	Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins Journal of Medicinal Chemistry ·S. K. Shah, Karen A. Brause, Gilbert O. Chandler, Paul E. Finke, Bonnie M. Ashe, Hazel Weston, Wilson B. Knight, Alan L. Maycock, James B. Doherty	1990	43
8	A Comparison of α1-Proteinase Inhibitor Methoxysuccinyl-Ala-Ala-Pro-Val-Chloromethylketone and Specific β-Lactam Inhibitors in an Acute Model of Human Polymorphonuclear Leukocyte Elastase-induced Lung Hemorrhage in the Hamster American Review of Respiratory Disease ·Daniel S. Fletcher, Donald G. Osinga, Karen M. Hand, Pam S. Dellea, Bonnie M. Ashe, Richard A. Mumford, Philip R. Davies, William K. Hagmann, Paul E. Finke, James B. Doherty, Robert J. Bonney	1990	40
9	Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Meng‐Hsin Chen, Patricia Fitzgerald, Suresh B. Singh, Edward A. O’Neill, Cheryl D. Schwartz, Chris M. Thompson, Stephen J. O’Keefe, Dennis M. Zaller, James B. Doherty	2006	38
10	Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives Biochemistry ·Wilson B. Knight, Alan L. Maycock, B. G. Green, Bonnie M. Ashe, Philip A. Gale, Hazel Weston, Paul E. Finke, W. K. HAGMANN, Shrenik K. Shah, James B. Doherty	1992	34
11	p38MAP kinase inhibitors. part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold Bioorganic & Medicinal Chemistry Letters ·S. Natarajan, David D. Wisnoski, Suresh B. Singh, John E. Stelmach, Edward A. O’Neill, Cheryl D. Schwartz, Chris M. Thompson, Catherine E. Fitzgerald, Stephen J. O’Keefe, Sanjeev Kumar, Cornelis E. C. A. Hop, Dennis M. Zaller, Dennis M. Schmatz, James B. Doherty	2003	33
12	PMN elastases: A comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors Archives of Biochemistry and Biophysics ·B.G. Green, Hazel Weston, Bonnie M. Ashe, James B. Doherty, Paul E. Finke, W. K. HAGMANN, Michael W. Lark, JENNIFER MAO, Alan L. Maycock, Vernon L. Moore, Richard A. Mumford, Samir K. Shah, Lori A. Walakovits, Wilson B. Knight	1991	31
13	p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones Bioorganic & Medicinal Chemistry Letters ·Julianne A. Hunt, Florida Kallashi, Rowena D. Ruzek, (unknown), Ida E. Ita, Sherrie X McCormick, James V. Pivnichny, Cornelis E. C. A. Hop, Sanjeev Kumar, Zhen Wang, Stephen J. O’Keefe, Edward A. O’Neill, Gene Porter, James E. Thompson, Andrea Woods, Dennis M. Zaller, James B. Doherty	2003	30
14	P38 MAP Kinase Inhibitors: Evolution of Imidazole-Based and Pyrido- Pyrimidin-2-One Lead Classes Current Topics in Medicinal Chemistry ·S. Natarajan, James B. Doherty	2005	30
15	Chemical, biochemical, pharmacokinetic, and biological properties of L-680,833: a potent, orally active monocyclic beta-lactam inhibitor of human polymorphonuclear leukocyte elastase. Proceedings of the National Academy of Sciences ·James B. Doherty, S. K. Shah, Paul E. Finke, Conrad P. Dorn, W. K. HAGMANN, Jeffrey J. Hale, A L Kissinger, Kevan R. Thompson, Karen A. Brause, Gilbert O. Chandler	1993	29
16	Pharmacological profile of the substituted beta‐lactam L‐659,286: A member of a new class of human PMN elastase inhibitors Journal of Cellular Biochemistry ·Robert J. Bonney, Bonnie M. Ashe, Alan L. Maycock, Pam S. Dellea, K. M. HAND, Donald G. Osinga, D. Fletcher, Richard A. Mumford, Philip R. Davies, D. Frankenfield, T. Nolan, Laura Schaeffer, W. K. HAGMANN, Paul E. Finke, Samir K. Shah, C. Richard Dorn, James B. Doherty	1989	27
17	Prevention of human leukocyte elastase-mediated lung damage by 3-alkyl-4-azetidinones Bioorganic & Medicinal Chemistry Letters ·William K. Hagmann, Shrenik K. Shah, Conrad P. Dorn, Laura O’Grady, Jeffrey J. Hale, Pau.E. Finke, Kevan R. Thompson, Karen A. Brause, Bonnie M. Ash, Hazel Weston, Mary Ellen Dahlgren, Alan L. Maycock, Pam S. Dellea, Karen M. Hand, Donald G. Osinga, Robert J. Bonney, Philip R. Davies, Daniel S. Fletcher, James B. Doherty	1991	25
18	The Discovery and Biologic Properties of Cephalosporin‐Based Inhibitors of PMN Elastase Annals of the New York Academy of Sciences ·Philip R. Davies, Bonnie M. Ashe, Robert J. Bonney, Conrad P. Dorn, Paul E. Finke, D. Fletcher, William A. Hanlon, John L. Humes, Alan L. Maycock, Richard A. Mumford, Manuel A. Navia, Evan E. Opas, Stephen G Pacholok, S Shah, M.D. Zimmerman, James B. Doherty	1991	24
19	Mechanism of Inhibition of Human Leukocyte Elastase by .beta.-Lactams. 3. Use of Electrospray Ionization Mass Spectrometry and Two-Dimensional NMR Techniques To Identify .beta.-Lactam-Derived E-I Complexes Biochemistry ·Dennis Underwood, B. G. Green, Renee M. Chabin, Stephen Mills, James B. Doherty, Paul E. Finke, Malcolm MacCoss, Shrenik K. Shah, Christopher S. Burgey	1995	19
20	Selective, Direct Activation of High-Conductance, Calcium-Activated Potassium Channels Causes Smooth Muscle Relaxation Molecular Pharmacology ·Cristiano G. Ponte, Owen B. McManus, William A. Schmalhofer, Dong‐Ming Shen, Ge Dai, Andrá S. Stevenson, Sylvie Sur, Tarak Shah, László Kiss, Min Shu, James B. Doherty, Ravi P. Nargund, Gregory J. Kaczorowski, Guilherme Suarez‐Kurtz, María L. García	2012	18

About James B. Doherty

James B. Doherty is a scholar working on Organic Chemistry, Molecular Biology, Oncology, Cancer Research and Immunology, having authored 37 papers that have together received 1.2k indexed citations. Recurring topics across this work include Melanoma and MAPK Pathways (10 papers), Synthesis of β-Lactam Compounds (9 papers), Synthesis and biological activity (8 papers), Protease and Inhibitor Mechanisms (5 papers), Quinazolinone synthesis and applications (4 papers), Peptidase Inhibition and Analysis (4 papers), Cytokine Signaling Pathways and Interactions (4 papers) and Carbohydrate Chemistry and Synthesis (3 papers). The work is most often cited by research in Organic Chemistry (651 citations), Cancer Research (185 citations), Immunology and Allergy (70 citations), Oncology (229 citations) and Molecular Biology (460 citations). James B. Doherty has collaborated with scholars based in United States, Germany and Brazil. Frequent co-authors include Paul E. Finke, Bonnie M. Ashe, S. Natarajan, Ronald Breslow, Geneviève Guillot, Alan L. Maycock, Stephen J. O’Keefe, Gilbert O. Chandler, Dennis M. Zaller and Mary Ellen Dahlgren. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Biochemistry, Nature and Annals of the New York Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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