Dirk E. Smith

9.9k citations

47 papers · 7.6k · 4 hit papers · h-index 33

Impact in

Immunology top 0.2%
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Immune Response and Inflammation
Immunology and Allergy top 2%

Papers in

Immunology 31
- IL-33, ST2, and ILC Pathways 21
- Immune Response and Inflammation 9
- Immune Cell Function and Interaction 8
Molecular Biology 12
- Inflammasome and immune disorders 5

Co-authors: John E. Sims (12 shared papers)Michael R. Comeau (5 shared papers)Marilyn M. Cornwell (4 shared papers)Zoulfia Allakhverdi (3 shared papers)Guy Delespesse (2 shared papers)Dale T. Umetsu (3 shared papers)Molly D. Smithgall (2 shared papers)Rosemarie H. DeKruyff (2 shared papers)
Journals: Journal of Biological Chemistry (6 papers)Journal of Allergy and Clinical Immunology (4 papers)Immunity (2 papers)Proceedings of the National Academy of Sciences (2 papers)Clinical & Experimental Allergy (2 papers)
Partner nations: United States Canada United Kingdom

In The Last Decade

Dirk E. Smith

46 papers receiving 7.4k citations

Dirk E. Smith's Hit Papers

align trajectories log scale

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity 2011 · 662 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2011 Nature Immunology
2010 Nature reviews. Immunology
2008 International Immunology
2001 Nature

Peers

Countries citing papers authored by Dirk E. Smith

Since Specialization

Citations

This map shows the geographic impact of Dirk E. Smith's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dirk E. Smith with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dirk E. Smith more than expected).

Fields of papers citing papers by Dirk E. Smith

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dirk E. Smith. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dirk E. Smith. The network helps show where Dirk E. Smith may publish in the future.

Co-authors

The 25 scholars most cited alongside Dirk E. Smith, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Dirk E. Smith Line = papers co-authored together Dirk E. Smith links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 47 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	The IL-1 family: regulators of immunity Nature reviews. Immunology ·John E. Sims, Dirk E. Smith Hit paper breakdown →	2010	1141
2	Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction Nature ·Katherine A. Fitzgerald, Eva M. Pålsson‐McDermott, Andrew Bowie, Caroline A. Jefferies, Ashley Mansell, Gareth Brady, Elizabeth Brint, Aisling Dunne, Pearl Gray, Mary T. Harte, Diane McMurray, Dirk E. Smith, John E. Sims, Timothy A. Bird, Luke O'neill Hit paper breakdown →	2001	1039
3	Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity Nature Immunology ·Ya‐Jen Chang, Hye Young Kim, Lee A. Albacker, Nicole Baumgarth, Andrew N. J. McKenzie, Dirk E. Smith, Rosemarie H. DeKruyff, Dale T. Umetsu Hit paper breakdown →	2011	662
4	IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK Cells International Immunology ·Molly D. Smithgall, Michael R. Comeau, Bo Ruem Yoon, David R. Kaufman, Richard Armitage, Dirk E. Smith Hit paper breakdown →	2008	531
5	Cutting Edge: The ST2 Ligand IL-33 Potently Activates and Drives Maturation of Human Mast Cells The Journal of Immunology ·Zoulfia Allakhverdi, Dirk E. Smith, Michael R. Comeau, Guy Delespesse	2007	427
6	Four New Members Expand the Interleukin-1 Superfamily Journal of Biological Chemistry ·Dirk E. Smith, Blair R. Renshaw, Randal R. Ketchem, Marek Kubin, Kirsten E. Garka, John E. Sims	2000	289
7	Inhibition of interleukin‐33 signaling attenuates the severity of experimental arthritis Arthritis & Rheumatism ·Gaby Palmer, Dominique Talabot‐Ayer, Céline Lamacchia, Dean Toy, Christian A. Seemayer, Sébastien Viatte, Axel Finckh, Dirk E. Smith, Cem Gabay	2009	275
8	Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity Journal of Allergy and Clinical Immunology ·Hye Young Kim, Ya‐Jen Chang, Srividya Subramanian, Hyun-Hee Lee, Lee A. Albacker, Ponpan Matangkasombut, Paul B. Savage, Andrew N. J. McKenzie, Dirk E. Smith, James B. Rottman, Rosemarie H. DeKruyff, Dale T. Umetsu	2011	271
9	CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation Journal of Allergy and Clinical Immunology ·Zoulfia Allakhverdi, Michael R. Comeau, Dirk E. Smith, Dean Toy, Léandra Mfuna Endam, Martin Desrosiers, Yongjun Liu, Karen Howie, Judah A. Denburg, Gail M. Gauvreau, Guy Delespesse	2008	200
10	IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms Proceedings of the National Academy of Sciences ·Li‐Yin Hung, Ian Lewkowich, Lucas Dawson, Jordan Downey, Yanfen Yang, Dirk E. Smith, De’Broski R. Herbert	2012	177
11	IL‐33: a tissue derived cytokine pathway involved in allergic inflammation and asthma Clinical & Experimental Allergy ·Dirk E. Smith	2009	169
12	Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection The Journal of Experimental Medicine ·Marsha Wills‐Karp, Reena Rani, Krista Dienger, Ian Lewkowich, James G. Fox, Charles Perkins, Lauren Lewis, Fred D. Finkelman, Dirk E. Smith, Paul Bryce, Evelyn A. Kurt‐Jones, Timothy C. Wang, Umasundari Sivaprasad, Gurjit K. Khurana Hershey, De’Broski R. Herbert	2012	167
13	Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis Science Translational Medicine ·Kevin M. Vannella, Thirumalai R. Ramalingam, Lee A. Borthwick, Luke Barron, Kevin M. Hart, Robert W. Thompson, Kristen N. Kindrachuk, Allen W. Cheever, Sandra White, Alison Budelsky, Michael R. Comeau, Dirk E. Smith, Thomas A. Wynn	2016	156
14	The Soluble Form of IL-1 Receptor Accessory Protein Enhances the Ability of Soluble Type II IL-1 Receptor to Inhibit IL-1 Action Immunity ·Dirk E. Smith, Roberta Hanna, Della Friend, Heather M. Moore, Hongbo Chen, Ann M. Farese, Thomas J. MacVittie, G. Duke Virca, John E. Sims	2003	154
15	The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33 Cytokine ·Gaby Palmer, Brian P. Lipsky, Molly D. Smithgall, David Meininger, Sophia Siu, Dominique Talabot‐Ayer, Cem Gabay, Dirk E. Smith	2008	152
16	A new nomenclature for IL-1-family genes Trends in Immunology ·John E. Sims, Yang Pan, Dirk E. Smith, Martin J.H. Nicklin, Jenny L. Barton, J. Fernando Bazán, Robert A. Kastelein, Samantha J. Busfield, J. E. Ford, Haishan Lin, Julio J. Mulero, Sanjay Kumar, James Pan, Peter R. Young	2001	144
17	Neuron-Specific Effects of Interleukin-1β Are Mediated by a Novel Isoform of the IL-1 Receptor Accessory Protein Journal of Neuroscience ·Yangyang Huang, Dirk E. Smith, Osvaldo Ibáñez-Sandoval, John E. Sims, Wilma Friedman	2011	143
18	Genomic Organization of the Interleukin-1 Locus Genomics ·Scott L. Taylor, Blair R. Renshaw, Kirsten E. Garka, Dirk E. Smith, John E. Sims	2002	128
19	SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity. Journal of Biological Chemistry ·Marilyn M. Cornwell, Dirk E. Smith	1993	127
20	A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1 Immunity ·Dirk E. Smith, Brian P. Lipsky, Chris B. Russell, Randal R. Ketchem, Jacqueline Kirchner, Kelly Hensley, Yangyang Huang, Wilma Friedman, Vincent Boissonneault, Marie-Michèle Plante, Serge Rivest, John E. Sims	2009	111

About Dirk E. Smith

Dirk E. Smith is a scholar working on Immunology, Molecular Biology, Surgery, Physiology and Pulmonary and Respiratory Medicine, having authored 47 papers that have together received 7.6k indexed citations. Recurring topics across this work include IL-33, ST2, and ILC Pathways (21 papers), Eosinophilic Esophagitis (9 papers), Immune Response and Inflammation (9 papers), Immune Cell Function and Interaction (8 papers), Asthma and respiratory diseases (8 papers), Inflammasome and immune disorders (5 papers), Neuroinflammation and Neurodegeneration Mechanisms (3 papers) and NF-κB Signaling Pathways (3 papers). The work is most often cited by research in Immunology (5.2k citations), Immunology and Allergy (293 citations), Dermatology (408 citations), Surgery (1.8k citations) and Physiology (1.0k citations). Dirk E. Smith has collaborated with scholars based in United States, Canada and United Kingdom. Frequent co-authors include John E. Sims, Michael R. Comeau, Marilyn M. Cornwell, Zoulfia Allakhverdi, Guy Delespesse, Dale T. Umetsu, Molly D. Smithgall, Rosemarie H. DeKruyff, Andrew N. J. McKenzie and Lee A. Albacker. Their work appears in journals such as Journal of Biological Chemistry, Journal of Allergy and Clinical Immunology, Immunity, Proceedings of the National Academy of Sciences and Clinical & Experimental Allergy.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Dirk E. Smith

Dirk E. Smith's Hit Papers

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All Works

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