Dirk E. Smith

10.0k citations

53 papers · 8.5k · 3 hit papers · h-index 38

Impact in

Immunology top 0.2%
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Psoriasis: Treatment and Pathogenesis
Immunology and Allergy top 2%

Papers in

Immunology 36
- IL-33, ST2, and ILC Pathways 24
- Immune Response and Inflammation 9
- Immune Cell Function and Interaction 9
Physiology 13
- Asthma and respiratory diseases 12

Co-authors: John E. Sims (12 shared papers)Michael R. Comeau (5 shared papers)Marilyn M. Cornwell (4 shared papers)Zoulfia Allakhverdi (3 shared papers)Guy J. Delespesse (2 shared papers)Dale T. Umetsu (3 shared papers)Molly D. Smithgall (2 shared papers)Lee A. Albacker (2 shared papers)
Journals: Journal of Biological Chemistry (6 papers)Journal of Allergy and Clinical Immunology (5 papers)Nature Immunology (4 papers)Proceedings of the National Academy of Sciences (2 papers)Immunity (2 papers)
Partner nations: United States United Kingdom Germany

In The Last Decade

Dirk E. Smith

52 papers receiving 8.3k citations

Dirk E. Smith's Hit Papers

align trajectories log scale

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity 2011 · 689 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2011 Nature Immunology
2010 Nature reviews. Immunology
2001 Nature

Peers

Countries citing papers authored by Dirk E. Smith

Since Specialization

Citations

This map shows the geographic impact of Dirk E. Smith's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dirk E. Smith with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dirk E. Smith more than expected).

Fields of papers citing papers by Dirk E. Smith

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dirk E. Smith. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dirk E. Smith. The network helps show where Dirk E. Smith may publish in the future.

Co-authors

The 25 scholars most cited alongside Dirk E. Smith, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Dirk E. Smith Line = papers co-authored together Dirk E. Smith links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Showing the 20 most-cited of 53 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	The IL-1 family: regulators of immunity Nature reviews. Immunology ·John E. Sims, Dirk E. Smith Hit paper breakdown →	2010	1164
2	Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction Nature ·Katherine A. Fitzgerald, Eva M. Pålsson‐McDermott, Andrew G. Bowie, Caroline Anne Jefferies, Ashley S. Mansell, Gareth Brady, Elizabeth K. Brint, Aisling Dunne Hit paper breakdown →	2001	1059
3	Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity Nature Immunology ·Ya‐Jen Chang, Hye Young Kim, Lee A. Albacker, Nicole Baumgarth, Andrew N. J. McKenzie, Dirk E. Smith, Rosemarie H. DeKruyff, Dale T. Umetsu Hit paper breakdown →	2011	689
4	IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK Cells International Immunology ·Molly D. Smithgall, Michael R. Comeau, Bo Ruem Yoon, David Ross Kaufman, Richard C. Armitage, Dirk E. Smith	2008	539
5	Cutting Edge: The ST2 Ligand IL-33 Potently Activates and Drives Maturation of Human Mast Cells The Journal of Immunology ·Zoulfia Allakhverdi, Dirk E. Smith, Michael R. Comeau, Guy J. Delespesse	2007	437
6	Four New Members Expand the Interleukin-1 Superfamily Journal of Biological Chemistry ·Dirk E. Smith, Blair R. Renshaw, Randal R. Ketchem, Marek Z. Kubin, Kirsten E. Garka, John E. Sims	2000	300
7	IL-1 family nomenclature Nature Immunology ·Charles Anthony Dinarello, William P. Arend, John E. Sims, Dirk E. Smith, Hal Blumberg, Luke A.J. O'Neill, Raphaela T. Goldbach‐Mansky, Theresa Torres Pizarro	2010	298
8	Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity Journal of Allergy and Clinical Immunology ·Hye Young Kim, Ya‐Jen Chang, Srividya Subramanian, Hyun-Hee Lee, Lee A. Albacker, Ponpan Matangkasombut, Paul B. Savage, Andrew N. J. McKenzie	2011	276
9	Inhibition of interleukin‐33 signaling attenuates the severity of experimental arthritis Arthritis & Rheumatism ·Gaby Palmer, Dominique Talabot‐Ayer, Céline Lamacchia, Dean Y. Toy, Christian Alexander Seemayer, Sébastien Viatte, Axel Finckh, Dirk E. Smith	2009	275
10	CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation Journal of Allergy and Clinical Immunology ·Zoulfia Allakhverdi, Michael R. Comeau, Dirk E. Smith, Dean Y. Toy, Léandra Mfuna Endam, Martin Desrosiers, Yongjun Liu, Karen J. Howie	2008	210
11	IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms Proceedings of the National Academy of Sciences ·Li‐Yin Hung, Ian Paul Lewkowich, Lucas A. Dawson, Jordan Downey, Yanfen Yang, Dirk E. Smith, De’Broski R. Herbert	2012	180
12	IL‐33: a tissue derived cytokine pathway involved in allergic inflammation and asthma Clinical & Experimental Allergy ·Dirk E. Smith	2009	170
13	Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection The Journal of Experimental Medicine ·Marsha A. Wills-Karp, Reena Rani, Krista M. Dienger, Ian Paul Lewkowich, James G. Fox, Charles L. Perkins, Lauren Lewis, Fred D. Finkelman	2012	168
14	Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis Science Translational Medicine ·Kevin M. Vannella, Thirumalai R. Ramalingam, Lee Anthony Borthwick, Luke Barron, Kevin M. Hart, Robert William Thompson, Kristen N. Kindrachuk, Allen W. Cheever	2016	167
15	The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33 Cytokine ·Gaby Palmer, Brian P. Lipsky, Molly D. Smithgall, David P. Meininger, Sophia Siu, Dominique Talabot‐Ayer, Cem Gabay, Dirk E. Smith	2008	157
16	The Soluble Form of IL-1 Receptor Accessory Protein Enhances the Ability of Soluble Type II IL-1 Receptor to Inhibit IL-1 Action Immunity ·Dirk E. Smith, Roberta K Hanna, Della J. Friend, Heather M. Moore, Hongbo Chen, Ann M. Farese, Thomas J. MacVittie, G. Duke Virca	2003	154
17	A new nomenclature for IL-1-family genes Trends in Immunology ·John E. Sims, Yang Pan, Dirk E. Smith, Martin J.H. Nicklin, Jenny L. Barton, J. Fernando Bazán, Robert A. Kastelein, Samantha J. Busfield	2001	145
18	Neuron-Specific Effects of Interleukin-1β Are Mediated by a Novel Isoform of the IL-1 Receptor Accessory Protein Journal of Neuroscience ·Yangyang Huang, Dirk E. Smith, Osvaldo Ibáñez-Sandoval, John E. Sims, Wilma Friedman	2011	145
19	Genomic Organization of the Interleukin-1 Locus Genomics ·Scott L. Taylor, Blair R. Renshaw, Kirsten E. Garka, Dirk E. Smith, John E. Sims	2002	133
20	SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity. Journal of Biological Chemistry ·Marilyn M. Cornwell, Dirk E. Smith	1993	126

About Dirk E. Smith

Dirk E. Smith is a scholar working on Immunology, Physiology, Immunology and Allergy, Surgery and Neurology, having authored 53 papers that have together received 8.5k indexed citations. Recurring topics across this work include IL-33, ST2, and ILC Pathways (24 papers), Asthma and respiratory diseases (12 papers), Eosinophilic Esophagitis (11 papers), Immune Response and Inflammation (9 papers), Immune Cell Function and Interaction (9 papers), Inflammasome and immune disorders (5 papers), NF-κB Signaling Pathways (3 papers) and Neuroinflammation and Neurodegeneration Mechanisms (3 papers). The work is most often cited by research in Immunology (5.7k citations), Immunology and Allergy (342 citations), Dermatology (509 citations), Physiology (1.3k citations) and Surgery (1.9k citations). Dirk E. Smith has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include John E. Sims, Michael R. Comeau, Marilyn M. Cornwell, Zoulfia Allakhverdi, Guy J. Delespesse, Dale T. Umetsu, Molly D. Smithgall, Lee A. Albacker, Ya‐Jen Chang and Rosemarie H. DeKruyff. Their work appears in journals such as Journal of Biological Chemistry, Journal of Allergy and Clinical Immunology, Nature Immunology, Proceedings of the National Academy of Sciences and Immunity.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Dirk E. Smith

Impact in

Papers in i

In The Last Decade

Dirk E. Smith

Dirk E. Smith's Hit Papers

Peers

Countries citing papers authored by Dirk E. Smith

Fields of papers citing papers by Dirk E. Smith

All Works

About Dirk E. Smith

Explore authors with similar magnitude of impact

Papers in