Derek C. Cole

2.8k citations

39 papers · 1.9k · h-index 21

Impact in

Organic Chemistry top 2%
- Asymmetric Synthesis and Catalysis
- Synthesis and biological activity
- Synthesis and Catalytic Reactions
Molecular Biology top 10%
- Chemical Synthesis and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Receptor Mechanisms and Signaling

Papers in

Molecular Biology 25
- Protein Kinase Regulation and GTPase Signaling 6
- Receptor Mechanisms and Signaling 5
- Chemical Synthesis and Analysis 5
Organic Chemistry 18
- Synthesis and biological activity 7
- Synthesis and Reactivity of Heterocycles 3
- Chemical synthesis and alkaloids 3

Co-authors: John W. Ellingboe (12 shared papers)Deborah L. Smith (6 shared papers)Lee E. Schechter (6 shared papers)Paul Jackson (2 shared papers)Diane A. Trainor (1 shared paper)Barbara S. Slusher (2 shared papers)Bruce A. Donzanti (2 shared papers)Paweł Nowak (5 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (12 papers)Journal of Medicinal Chemistry (10 papers)The Journal of Organic Chemistry (3 papers)Journal of Clinical Oncology (1 paper)Assay and Drug Development Technologies (1 paper)
Partner nations: United States Japan Canada

In The Last Decade

Derek C. Cole

38 papers receiving 1.9k citations

Peers

Countries citing papers authored by Derek C. Cole

Since Specialization

Citations

This map shows the geographic impact of Derek C. Cole's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Derek C. Cole with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Derek C. Cole more than expected).

Fields of papers citing papers by Derek C. Cole

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Derek C. Cole. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Derek C. Cole. The network helps show where Derek C. Cole may publish in the future.

Co-authors

The 25 scholars most cited alongside Derek C. Cole, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Derek C. Cole Line = papers co-authored together Derek C. Cole links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 39 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Recent stereoselective synthetic approaches to β-amino acids Tetrahedron ·Derek C. Cole	1994	415
2	Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin Cancer Research ·Ker Yu, Lourdes Toral‐Barza, Celine Shi, Weiguo Zhang, Judy Lucas, Boris Shor, Jamie Kim, Jeroen C. Verheijen, Kevin J. Curran, David J. Malwitz, Derek C. Cole, John W. Ellingboe, Semiramis Ayral‐Kaloustian, Tarek S. Mansour, James J. Gibbons, Robert T. Abraham, Paweł Nowak, Arie Zask	2009	278
3	Design, Synthesis, and Biological Activity of a Potent Inhibitor of the Neuropeptidase N-Acetylated α-Linked Acidic Dipeptidase Journal of Medicinal Chemistry ·Paul Jackson, Derek C. Cole, Barbara S. Slusher, S.L. Stetz, Laurie E. Ross, Bruce A. Donzanti, Diane A. Trainor	1996	226
4	Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466 Neuropsychopharmacology ·Lee E. Schechter, Qian Lin, Deborah L. Smith, Guoming Zhang, (unknown), Brian J. Platt, Michael R. Brandt, Lee A. Dawson, Derek C. Cole, Ron Bernotas, Albert J. Robichaud, Sharon Rosenzweig‐Lipson, Chad E. Beyer	2007	178
5	Discovery of 5-Arylsulfonamido-3- (pyrrolidin-2-ylmethyl)-1H-indole Derivatives as Potent, Selective 5-HT₆Receptor Agonists and Antagonists Journal of Medicinal Chemistry ·Derek C. Cole, William J. Lennox, Sabrina Lombardi, John W. Ellingboe, Ronald C. Bernotas, Gregory J. Tawa, Hossein Mazandarani, Deborah L. Smith, Guoming Zhang, Joseph Coupet, Lee E. Schechter	2004	93
6	Formation of Angularly-Fused Triquinanes by Successive Use of the Pauson-Khand Reaction and Radical Closure The Journal of Organic Chemistry ·Derrick L. J. Clive, Derek C. Cole, Yong Tao	1994	54
7	Discovery of N₁-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT₆Receptor Agonist Journal of Medicinal Chemistry ·Derek C. Cole, Joseph R. Stock, William J. Lennox, Ronald C. Bernotas, John W. Ellingboe, Steve Boikess, Joseph Coupet, Deborah L. Smith, Louis Leung, Guoming Zhang, Xidong Feng, Michael F. Kelly, Rocco J. Galante, Pingzhong Huang, Lee A. Dawson, Karen L. Marquis, Sharon Rosenzweig‐Lipson, Chad E. Beyer, Lee E. Schechter	2007	47
8	Discovery of Potent and Selective Inhibitors of the Mammalian Target of Rapamycin (mTOR) Kinase Journal of Medicinal Chemistry ·Paweł Nowak, Derek C. Cole, Natasja Brooijmans, Matthew G. Bursavich, Kevin J. Curran, John W. Ellingboe, James J. Gibbons, Irwin Hollander, Yongbo Hu, Joshua A. Kaplan, David J. Malwitz, Lourdes Toral‐Barza, Jeroen C. Verheijen, Arie Zask, Weiguo Zhang, Ker Yu	2009	46
9	Identification, Characterization and Initial Hit-to-Lead Optimization of a Series of 4-Arylamino-3-Pyridinecarbonitrile as Protein Kinase C theta (PKCθ) Inhibitors Journal of Medicinal Chemistry ·Derek C. Cole, Magda Asselin, Agnes Brennan, Robert Czerwiński, John W. Ellingboe, Lori Fitz, Rita Greco, Xinyi Huang, Diane Joseph‐McCarthy, Michael F. Kelly, Matthew Kirisits, Julie Lee, Yuanhong Li, Paul Morgan, Joseph R. Stock, Désirée H.H. Tsao, Allan Wissner, Xiaoke Yang, Divya Chaudhary	2008	41
10	A fluorescent assay suitable for inhibitor screening and vanin tissue quantification Analytical Biochemistry ·Benfang Helen Ruan, Derek C. Cole, Paul W. Wu, Amira Quazi, Karen Page, Jill F. Wright, Nelson Huang, Joseph R. Stock, Karl Nocka, Ann Aulabaugh, Rustem Krykbaev, Lori Fitz, Neil M. Wolfman, Margaret L. Fleming	2009	41
11	N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists Bioorganic & Medicinal Chemistry Letters ·Derek C. Cole, John W. Ellingboe, William J. Lennox, Hossein Mazandarani, Deborah L. Smith, Joseph R. Stock, Guoming Zhang, Ping Zhou, Lee E. Schechter	2004	37
12	Inhibition of the Signal Transducer and Activator of Transcription-3 (STAT3) Signaling Pathway by 4-Oxo-1-Phenyl-1,4-Dihydroquinoline-3-Carboxylic Acid Esters Journal of Medicinal Chemistry ·Jun Xu, Derek C. Cole, Chao-Pei Betty Chang, Ramzi Ayyad, Magda Asselin, Wenshan Hao, James J. Gibbons, Scott A. Jelinsky, Kathryn A. Saraf, Kaapjoo Park	2008	36
13	Silicon-Containing Amino Acids and Peptides. Asymmetric Synthesis of (Trialkylsilyl)alanines The Journal of Organic Chemistry ·Robert D. Walkup, Derek C. Cole, Bruce R. Whittlesey	1995	35
14	Synthesis of Pyrazolo[1,5-α]pyrimidinone Regioisomers The Journal of Organic Chemistry ·Lori K. Gavrin, Arthur Lee, Brian A. Provencher, Walter Massefski, Stephen D. Huhn, Gregory Ciszewski, Derek C. Cole, John C. McKew	2006	35
15	Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure ACS Medicinal Chemistry Letters ·Marion Lanier, Jason Pickens, Simone V. Bigi, Erica L. Bradshaw‐Pierce, Alison Chambers, Zacharia S. Cheruvallath, Derek C. Cole, Douglas R. Dougan, Jacques Ermolieff, Tony Gibson, Petro Halkowycz, Aki Hirokawa, Anthony Ivetac, Joanne Miura, Evan Nunez, M. Sabat, John Tyhonas, Haixia Wang, Xiaolun Wang, Steve Swann	2017	33
16	Identification and Characterization of Acidic Mammalian Chitinase Inhibitors Journal of Medicinal Chemistry ·Derek C. Cole, Andrea Olland, Jaison Jacob, J.C. Brooks, Matthew G. Bursavich, Robert Czerwiński, Charlene DeClercq, M. Catherine Johnson, Diane Joseph‐McCarthy, John W. Ellingboe, Laura Lin, Paweł Nowak, Ella Presman, James C. Strand, Amy Tam, Cara Williams, Shihua Yao, Désirée H.H. Tsao, Lori Fitz	2010	31
17	Synthesis and PKCθ inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles Bioorganic & Medicinal Chemistry Letters ·Diane H. Boschelli, Biqi Wu, Ana Carolina Barrios Sosa, Joan Chen, Magda Asselin, Derek C. Cole, Julie Lee, Xiaoke Yang, Divya Chaudhary	2008	31
18	Analytical Techniques for Combinatorial Chemistry: Quantitative Infrared Spectroscopic Measurements of Deuterium-Labeled Protecting Groups Journal of the American Chemical Society ·Keith C. Russell, Derek C. Cole, Frances M. McLaren, Don E. Pivonka	1996	29
19	Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists Bioorganic & Medicinal Chemistry Letters ·Derek C. Cole, William J. Lennox, Joseph R. Stock, John W. Ellingboe, Hossein Mazandarani, Deborah L. Smith, Guoming Zhang, Gregory J. Tawa, Lee E. Schechter	2005	28
20	Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Yike Ni, Ariamala Gopalsamy, Derek C. Cole, Yonghan Hu, R. Aldrin Denny, Manus Ipek, Julie Liu, Julie Lee, J. Perry Hall, Michael Luong, Jean‐Baptiste Telliez, Lih‐Ling Lin	2011	27

About Derek C. Cole

Derek C. Cole is a scholar working on Molecular Biology, Organic Chemistry, Oncology, Cellular and Molecular Neuroscience and Pharmacology, having authored 39 papers that have together received 1.9k indexed citations. Recurring topics across this work include Synthesis and biological activity (7 papers), Protein Kinase Regulation and GTPase Signaling (6 papers), Receptor Mechanisms and Signaling (5 papers), Chemical Synthesis and Analysis (5 papers), Peptidase Inhibition and Analysis (4 papers), Computational Drug Discovery Methods (4 papers), Synthesis and Reactivity of Heterocycles (3 papers) and Chemical synthesis and alkaloids (3 papers). The work is most often cited by research in Organic Chemistry (903 citations), Molecular Biology (1.1k citations), Cellular and Molecular Neuroscience (263 citations), Pharmacology (138 citations) and Inorganic Chemistry (110 citations). Derek C. Cole has collaborated with scholars based in United States, Japan and Canada. Frequent co-authors include John W. Ellingboe, Deborah L. Smith, Lee E. Schechter, Paul Jackson, Diane A. Trainor, Barbara S. Slusher, Bruce A. Donzanti, Paweł Nowak, James J. Gibbons and Guoming Zhang. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, The Journal of Organic Chemistry, Journal of Clinical Oncology and Assay and Drug Development Technologies.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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