Daniel P. Walker

1.8k citations

35 papers · 1.5k · 1 hit paper · h-index 15

Impact in

Pharmacology top 1%
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Inflammatory mediators and NSAID effects
Computational Theory and Mathematics top 2%
- Computational Drug Discovery Methods

Papers in

Organic Chemistry 18
- Synthesis and biological activity 6
- Organic Chemistry Synthesis Methods 5
- Synthesis of heterocyclic compounds 4
Pharmacology 5
- Pharmacogenetics and Drug Metabolism 5
- Inflammatory mediators and NSAID effects 3

Co-authors: Amit S.S. Kalgutkar (3 shared papers)Jonathan N. Bauman (3 shared papers)Thomas A. Baillie (1 shared paper)Antonia F. Stepan (1 shared paper)Michael D. Aleo (1 shared paper)David A. Price (1 shared paper)Anil Mistry (2 shared papers)Peter C. Bonnette (2 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (8 papers)Tetrahedron Letters (5 papers)Journal of Medicinal Chemistry (3 papers)Synlett (2 papers)Chemical Research in Toxicology (2 papers)
Partner nations: United States Serbia Australia

In The Last Decade

Daniel P. Walker

35 papers receiving 1.4k citations

Daniel P. Walker's Hit Papers

align trajectories log scale

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States 2011 · 581 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2011 Chemical Research in Toxicology

Peers

Countries citing papers authored by Daniel P. Walker

Since Specialization

Citations

This map shows the geographic impact of Daniel P. Walker's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Daniel P. Walker with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Daniel P. Walker more than expected).

Fields of papers citing papers by Daniel P. Walker

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Daniel P. Walker. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Daniel P. Walker. The network helps show where Daniel P. Walker may publish in the future.

Co-authors

The 25 scholars most cited alongside Daniel P. Walker, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Daniel P. Walker Line = papers co-authored together Daniel P. Walker links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 35 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States Chemical Research in Toxicology ·Antonia F. Stepan, Daniel P. Walker, Jonathan N. Bauman, David A. Price, Thomas A. Baillie, Amit S.S. Kalgutkar, Michael D. Aleo Hit paper breakdown →	2011	581
2	Discovery ofN-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship Journal of Medicinal Chemistry ·Donn G. Wishka, Daniel P. Walker, Karen M. Yates, Steven C. Reitz, Shaojuan Jia, Jason K. Myers, Kirk L. Olson, E. Jon Jacobsen	2006	171
3	Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design Journal of Biological Chemistry ·Seungil Han, Anil Mistry, Jeanne S. Chang, Matt Griffor, Peter C. Bonnette, Boris A. Chrunyk, Gary E. Aspnes, Daniel P. Walker	2009	89
4	Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists Bioorganic & Medicinal Chemistry ·Daniel P. Walker, Donn G. Wishka, David W. Piotrowski, Shaojuan Jia, Steven C. Reitz, Karen M. Yates, Jason K. Myers, Tatiana N. Vetman	2006	83
5	Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity Bioorganic & Medicinal Chemistry Letters ·Daniel P. Walker, Michael P. Zawistoski, Molly A. McGlynn, Jiancheng Li, Daniel W. Kung, Peter C. Bonnette, Amy P. Baumann, Leonard Buckbinder	2009	80
6	Novel Riboswitch-Binding Flavin Analog That Protects Mice against Clostridium difficile Infection without Inhibiting Cecal Flora Antimicrobial Agents and Chemotherapy ·Ken Blount, Cynthia M. Megyola, Mark S. Plummer, David G. Osterman, Paul A. Aristoff, Cheryl L. Quinn, R. Alan Chrusciel, Toni Jo Poel	2015	79
7	Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity Bioorganic & Medicinal Chemistry Letters ·Brad A. Acker, E. Jon Jacobsen, Bruce N. Rogers, Donn G. Wishka, Steven C. Reitz, David W. Piotrowski, Jason K. Myers, Mark L. Wolfe	2008	54
8	Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1 H -pyrazolo-[3,4- b ]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator Journal of Medicinal Chemistry ·L. Lena Zhang, Gayatri Balan, Gabriela Barreiro, Brian P. Boscoe, Lois K. Chenard, Julie A. Cianfrogna, Michelle M. Claffey, Laigao M. Chen	2014	45
9	Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation Bioorganic & Medicinal Chemistry Letters ·Daniel P. Walker, F. Christopher Bi, Amit S.S. Kalgutkar, Jonathan N. Bauman, Sabrina X. Zhao, John R. Soglia, Gary E. Aspnes, Daniel W. Kung	2008	44
10	Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation Bioorganic & Medicinal Chemistry Letters ·Graciela B. Arhancet, Daniel P. Walker, Sue Metz, Yvette M. Fobian, Steven E. Heasley, Jeffrey S. Carter, John R. Springer, Darin E. Jones	2012	44
11	Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design Bioorganic & Medicinal Chemistry Letters ·Daniel P. Walker, Graciela B. Arhancet, Hwang‐Fun Lu, Steven E. Heasley, Sue Metz, Natasha M. Kablaoui, Francisco M. Franco, Cathleen E. Hanau	2012	25
12	Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning ACS Medicinal Chemistry Letters ·Mark E. Schnute, Stephen Benoit, Ingrid P. Buchler, Nicole L. Caspers, Margaret L. Grapperhaus, Seungil Han, Rajeev Hotchandani, Nelson Huang	2018	24
13	Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists Bioorganic & Medicinal Chemistry Letters ·Mary T. Didiuk, David A. Griffith, John W. Benbow, Kevin K.‐C. Liu, Daniel P. Walker, F. Christopher Bi, Joel Morris, Angel Guzmán-Pérez	2009	21
14	Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis Chemical Research in Toxicology ·Amit S.S. Kalgutkar, David A. Griffith, Tim F. Ryder, Hao Sun, Zhuang Miao, Jonathan N. Bauman, Mary T. Didiuk, Kosea S. Frederick	2010	18
15	Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide Drug Metabolism and Disposition ·David D. Boyer, Jonathan N. Bauman, Daniel P. Walker, Brendon Kapinos, Amit S.S. Kalgutkar +1 other	2009	16
16	Single-Cellular Biological Effects of Cholesterol-Catabolic Bile Acid-Based Nano/Micro Capsules as Anti-Inflammatory Cell Protective Systems Biomolecules ·Armin Mooranian, Corina Mihaela Ionescu, Daniel P. Walker, Melissa Jones, Susbin Raj Wagle, Božica Kovačević, Jacqueline Chester, Edan Johnston	2022	14
17	Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors Bioorganic & Medicinal Chemistry Letters ·Samit K. Bhattacharya, Gary E. Aspnes, Scott W. Bagley, Markus Boehm, Arthur D. Brosius, Leonard Buckbinder, Jeanne S. Chang, Joseph DiBrino	2012	13
18	Three step, one-pot process to prepare thiophene-2-carbonyl chloride (TCC), a key raw material in the manufacture of tioxazafen (Nemastrike®) Tetrahedron Letters ·Daniel P. Walker, Kevin J. Koeller +2 others	2019	12
19	Total Synthesis of 5(R)- and 5(S)-Polyandrane Journal of the American Chemical Society ·Daniel P. Walker, Paul A. Grieco	1999	9
20	Novel syntheses of 3-anilino-pyrazin-2(1H)-ones and 3-anilino-quinoxalin-2-(1H)-ones via microwave-mediated Smiles rearrangement Tetrahedron Letters ·F. Christopher Bi, Gary E. Aspnes, Angel Guzmán-Pérez, Daniel P. Walker	2008	8

About Daniel P. Walker

Daniel P. Walker is a scholar working on Organic Chemistry, Pharmacology, Molecular Biology, Pharmaceutical Science and Pharmacology, having authored 35 papers that have together received 1.5k indexed citations. Recurring topics across this work include Synthesis and biological activity (6 papers), Nicotinic Acetylcholine Receptors Study (5 papers), Organic Chemistry Synthesis Methods (5 papers), Pharmacogenetics and Drug Metabolism (5 papers), Synthesis of heterocyclic compounds (4 papers), Inflammatory mediators and NSAID effects (3 papers), Protein Kinase Regulation and GTPase Signaling (3 papers) and Computational Drug Discovery Methods (3 papers). The work is most often cited by research in Pharmacology (333 citations), Computational Theory and Mathematics (236 citations), Organic Chemistry (292 citations), Pharmacology (122 citations) and Molecular Biology (476 citations). Daniel P. Walker has collaborated with scholars based in United States, Serbia and Australia. Frequent co-authors include Amit S.S. Kalgutkar, Jonathan N. Bauman, Thomas A. Baillie, Antonia F. Stepan, Michael D. Aleo, David A. Price, Anil Mistry, Peter C. Bonnette, Leonard Buckbinder and Seungil Han. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, Journal of Medicinal Chemistry, Synlett and Chemical Research in Toxicology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Daniel P. Walker

Daniel P. Walker's Hit Papers

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About Daniel P. Walker

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