David D. Christ

3.0k citations

49 papers · 1.9k · h-index 25

Impact in

Pharmacology top 0.5%
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
Behavioral Neuroscience top 5%
- Stress Responses and Cortisol

Papers in

Molecular Biology 18
- Receptor Mechanisms and Signaling 7
- Chemical Synthesis and Analysis 6
Pharmacology 16
- Pharmacogenetics and Drug Metabolism 15

Co-authors: J G Kenna (7 shared papers)L R Pohl (5 shared papers)Hiroaki Satoh (4 shared papers)Robert Newton (14 shared papers)Maryanne Covington (14 shared papers)Mingxin Qian (14 shared papers)Rui‐Qin Liu (13 shared papers)Hiroshi Satoh (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry Letters (10 papers)Drug Metabolism and Disposition (9 papers)Journal of Medicinal Chemistry (5 papers)Journal of Pharmacology and Experimental Therapeutics (3 papers)Xenobiotica (2 papers)
Partner nations: United States Germany Japan

In The Last Decade

David D. Christ

49 papers receiving 1.9k citations

Peers

Countries citing papers authored by David D. Christ

Since Specialization

Citations

This map shows the geographic impact of David D. Christ's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David D. Christ with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David D. Christ more than expected).

Fields of papers citing papers by David D. Christ

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David D. Christ. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David D. Christ. The network helps show where David D. Christ may publish in the future.

Co-authors

The 25 scholars most cited alongside David D. Christ, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David D. Christ Line = papers co-authored together David D. Christ links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 49 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane. Journal of Pharmacology and Experimental Therapeutics ·J G Kenna, Hiroaki Satoh, David D. Christ, L R Pohl	1988	170
2	The Immunologic and Metabolic Basis of Drug Hypersensitivities The Annual Review of Pharmacology and Toxicology ·L R Pohl, Hiroshi Satoh, David D. Christ, J G Kenna	1988	143
3	Identification and Characterization of Efavirenz Metabolites by Liquid Chromatography/Mass Spectrometry and High Field NMR: Species Differences in the Metabolism of Efavirenz Drug Metabolism and Disposition ·Abdul Mutlib, Hua Chen, Gregory A. Nemeth, Jay A. Markwalder, Steven P. Seitz, L.‐S. Gan, David D. Christ	1999	113
4	Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase. Proceedings of the National Academy of Sciences ·Hiroaki Satoh, Brian M. Martin, A H Schulick, David D. Christ, J G Kenna, L R Pohl	1989	102
5	Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme: Design, Synthesis, and Structure−Activity Relationships Journal of Medicinal Chemistry ·James J.‐W. Duan, Lihua Chen, Zelda R. Wasserman, Zhonghui Lu, Rui‐Qin Liu, Maryanne Covington, Mingxin Qian, Karl D. Hardman, Ronald L. Magolda, Robert Newton, David D. Christ, Ruth R. Wexler, Carl P. Decicco	2002	99
6	4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: A Potent, Orally Bioavailable CRF₁ Receptor Antagonist Journal of Medicinal Chemistry ·Liqi He, Paul J. Gilligan, Robert Zaczek, Lawrence W. Fitzgerald, John Mcelroy, H-S. L. Shen, J Saye, Ned H. Kalin, Steven E. Shelton, David D. Christ, George L. Trainor, Paul Hartig	2000	94
7	Enflurane Metabolism Produces Covalently Bound Liver Adducts Recognized by Antibodies from Patients with Halothane Hepatitis Anesthesiology ·David D. Christ, J G Kenna, William Hammerer, Hiroko Satoh, Lance R. Pohl	1988	92
8	Sultam Hydroxamates as Novel Matrix Metalloproteinase Inhibitors Journal of Medicinal Chemistry ·Robert J. Cherney, Ruowei Mo, Dayton T. Meyer, Karl D. Hardman, Rui‐Qin Liu, Maryanne Covington, Mingxin Qian, Zelda R. Wasserman, David D. Christ, James M. Trzăskos, Robert Newton, Carl P. Decicco	2004	83
9	Neoantigens Associated with Halothane Hepatitis Drug Metabolism Reviews ·Lance R. Pohl, J G Kenna, Hiroko Satoh, David D. Christ, Jackie L. Martin	1989	79
10	The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine: A corticotropin-releasing factor (hCRF1) antagonist Bioorganic & Medicinal Chemistry ·Paul J. Gilligan, Caryn Baldauf, Anthony J. Cocuzza, Dennis R. Chidester, Robert Zaczek, Lawrence W. Fitzgerald, John Mcelroy, Mark A. Smith, H.-S.L. Shen, J Saye, David D. Christ, George L. Trainor, David W. Robertson, Paul Hartig	2000	78
11	The Species-Dependent Metabolism of Efavirenz Produces a Nephrotoxic Glutathione Conjugate in Rats Toxicology and Applied Pharmacology ·Abdul Mutlib, Ronald J. Gerson, Paul C. Meunier, Patrick J. Haley, Hao Chen, Lawrence S. Gan, Marc H. Davies, Brian Gemzik, David D. Christ, David F. Krahn, Jay A. Markwalder, Steven P. Seitz, Richard T. Robertson, Gerald T. Miwa	2000	63
12	Potential metabolic basis for enflurane hepatitis and the apparent cross-sensitization between enflurane and halothane. Drug Metabolism and Disposition ·David D. Christ, Hiroaki Satoh, J G Kenna, L R Pohl	1988	63
13	Design and Synthesis of a Series of (2R)-N⁴-Hydroxy-2-(3-hydroxybenzyl)-N- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden- 1-yl]butanediamide Derivatives as Potent, Selective, and Orally Bioavailable Aggrecanase Inhibitors Journal of Medicinal Chemistry ·Wenqing Yao, Zelda R. Wasserman, Michael C. Chao, Gade S. Reddy, Eric Shi, Rui‐Qin Liu, Maryanne Covington, Elizabeth C. Arner, Michael A. Pratta, Micky D. Tortorella, Ronald L. Magolda, Robert Newton, Mingxin Qian, Maria Ribadeneira, David D. Christ, Ruth R. Wexler, Carl P. Decicco	2001	54
14	Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-α converting enzyme (TACE): Discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1′ substituents Bioorganic & Medicinal Chemistry Letters ·Zhonghui Lu, Gregory R. Ott, Rajan Anand, Rui‐Qin Liu, Maryanne Covington, Krishna Vaddi, Mingxin Qian, Robert Newton, David D. Christ, James M. Trzăskos, James J.‐W. Duan	2008	53
15	Design, Synthesis, and Evaluation of Benzothiadiazepine Hydroxamates as Selective Tumor Necrosis Factor-α Converting Enzyme Inhibitors Journal of Medicinal Chemistry ·Robert J. Cherney, James J.‐W. Duan, Matthew E. Voss, Lihua Chen, Li Wang, Dayton T. Meyer, Zelda R. Wasserman, Karl D. Hardman, Rui‐Qin Liu, Maryanne Covington, Mingxin Qian, Sandhya Mandlekar, David D. Christ, James M. Trzăskos, Robert Newton, Ronald L. Magolda, Ruth R. Wexler, Carl P. Decicco	2003	50
16	Human Plasma Protein Binding of the Angiotensin II Receptor Antagonist Losartan Potassium (DuP 753/MK 954) and Its Pharmacologically Active Metabolite EXP3174 The Journal of Clinical Pharmacology ·David D. Christ	1995	47
17	Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans Drug Metabolism and Disposition ·Mingxin Qian, Stephen A. Bai, Bernice L. Brogdon, Jing‐Tao Wu, Rui‐Qin Liu, Maryanne Covington, Kris Vaddi, Robert Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James M. Trzăskos, James J.‐W. Duan, Carl P. Decicco, David D. Christ	2007	44
18	The pharmacokinetics and pharmacodynamics of the angiotensin II receptor antagonist losartan potassium (DuP 753/MK 954) in the dog. Journal of Pharmacology and Experimental Therapeutics ·David D. Christ, P C Wong, Y. Nancy Wong, S D Hart, Check Y. Quon, Gilbert N. Lam	1994	44
19	Losartan (DuP 753), An Orally Active Nonpeptide Angiotensin II Receptor Antagonist Cardiovascular Drug Reviews ·Pancras C. Wong, Tyler Barnes, Andrew T. Chiu, David D. Christ, John V. Duncia, William F. Herblin, Pieter B.M.W.M. Timmermans	1991	44
20	Potent, exceptionally selective, orally bioavailable inhibitors of TNF-α Converting Enzyme (TACE): Novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1′ substituents Bioorganic & Medicinal Chemistry Letters ·Gregory R. Ott, Naoyuki Asakawa, Zhonghui Lu, Rajan Anand, Rui‐Qin Liu, Maryanne Covington, Krishna Vaddi, Mingxin Qian, Robert Newton, David D. Christ, James M. Trzăskos, James J.‐W. Duan	2008	41

About David D. Christ

David D. Christ is a scholar working on Molecular Biology, Pharmacology, Oncology, Infectious Diseases and Organic Chemistry, having authored 49 papers that have together received 1.9k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (15 papers), Drug Transport and Resistance Mechanisms (9 papers), Receptor Mechanisms and Signaling (7 papers), HIV/AIDS drug development and treatment (6 papers), Chemical Synthesis and Analysis (6 papers), Computational Drug Discovery Methods (5 papers), Cytokine Signaling Pathways and Interactions (4 papers) and Monoclonal and Polyclonal Antibodies Research (3 papers). The work is most often cited by research in Pharmacology (450 citations), Behavioral Neuroscience (107 citations), Biological Psychiatry (71 citations), Anesthesiology and Pain Medicine (101 citations) and Developmental Neuroscience (68 citations). David D. Christ has collaborated with scholars based in United States, Germany and Japan. Frequent co-authors include J G Kenna, L R Pohl, Hiroaki Satoh, Robert Newton, Maryanne Covington, Mingxin Qian, Rui‐Qin Liu, Hiroshi Satoh, Carl P. Decicco and Hiroko Satoh. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Drug Metabolism and Disposition, Journal of Medicinal Chemistry, Journal of Pharmacology and Experimental Therapeutics and Xenobiotica.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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