Clint Mitchell

2.9k citations

41 papers · 2.6k · h-index 29

Impact in

Oncology top 5%
- Drug Transport and Resistance Mechanisms
- Cytokine Signaling Pathways and Interactions
Molecular Biology top 5%
- Cell death mechanisms and regulation
- Sphingolipid Metabolism and Signaling
- PI3K/AKT/mTOR signaling in cancer
- Histone Deacetylase Inhibitors Research

Papers in

Molecular Biology 32
- Cell death mechanisms and regulation 20
- Protein Kinase Regulation and GTPase Signaling 6
- Melanoma and MAPK Pathways 5
- Heat shock proteins research 3
- Histone Deacetylase Inhibitors Research 3
Oncology 8
- Drug Transport and Resistance Mechanisms 3

Co-authors: Paul Dent (40 shared papers)Adly Yacoub (27 shared papers)Steven Grant (25 shared papers)Margaret A. Park (15 shared papers)Paul B. Fisher (17 shared papers)Mohamed Rahmani (11 shared papers)Sarah Spiegel (6 shared papers)Aditi Pandya Martin (7 shared papers)
Journals: Cancer Biology & Therapy (8 papers)Molecular Pharmacology (8 papers)Molecular Cancer Therapeutics (7 papers)Cancer Research (4 papers)Hepatology (2 papers)
Partner nations: United States Germany Argentina

In The Last Decade

Clint Mitchell

41 papers receiving 2.5k citations

Peers

Countries citing papers authored by Clint Mitchell

Since Specialization

Citations

This map shows the geographic impact of Clint Mitchell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Clint Mitchell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Clint Mitchell more than expected).

Fields of papers citing papers by Clint Mitchell

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Clint Mitchell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Clint Mitchell. The network helps show where Clint Mitchell may publish in the future.

Co-authors

The 25 scholars most cited alongside Clint Mitchell, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Clint Mitchell Line = papers co-authored together Clint Mitchell links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 41 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance Cancer Research ·Nathan T. Ihle, Robert Lemos, Peter Wipf, Adly Yacoub, Clint Mitchell, Doris R. Siwak, Gordon Brent Mills, Paul Dent	2008	248
2	Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts Cancer Research ·Dmitri Kapitonov, Jeremy C. Allegood, Clint Mitchell, Nitai C. Hait, Jorge A. Almenara, Jeffrey K. Adams, Robert E. Zipkin, Paul Dent	2009	161
3	Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation Cancer Biology & Therapy ·Margaret A. Park, Guo Zhang, Aditi Pandya Martin, Hossein A. Hamed, Clint Mitchell, Philip B. Hylemon, Martin R. Graf, Mohamed Rahmani	2008	156
4	Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction Proceedings of the National Academy of Sciences ·Anindita Das, David Durrant, Clint Mitchell, Eric K. Mayton, Nicholas N Hoke, Fadi N. Salloum, Margaret A. Park, Ian Z. Qureshi	2010	141
5	Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes Hepatology ·Youwen Fang, Song Iy Han, Clint Mitchell, Seema Gupta, Elaine J. Studer, Steven Grant, Phillip B. Hylemon, Paul Dent	2004	120
6	Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin–sensitive mechanism in murine and human hepatocytes† Hepatology ·Paul Dent, Youwen Fang, Seema Gupta, Elaine J. Studer, Clint Mitchell, Sarah Spiegel, Philip B. Hylemon	2005	107
7	Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation Clinical Cancer Research ·Guo Zhang, Margaret A. Park, Clint Mitchell, Hossein A. Hamed, Mohamed Rahmani, Aditi Pandya Martin, David T. Curiel, Adly Yacoub	2008	104
8	Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+- De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway Cancer Research ·Margaret A. Park, Clint Mitchell, Guo Zhang, Adly Yacoub, Jeremy C. Allegood, Dieter Häussinger, Roland Reinehr, Andrew C. Larner	2010	94
9	PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda -7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells Cancer Research ·Adly Yacoub, Hossein A. Hamed, Jeremy C. Allegood, Clint Mitchell, Sarah Spiegel, Maciej S. Lesniak, Besim Öğretmen, Rupesh Dash	2010	94
10	Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms Molecular Pharmacology ·Teneille D. Walker, Clint Mitchell, Margaret A. Park, Adly Yacoub, Martin R. Graf, Mohamed Rahmani, Peter J. Houghton, Christina Voelkel‐Johnson	2009	86
11	mda-7(IL-24) Inhibits Growth and Enhances Radiosensitivity of Glioma Cells In Vitro via JNK Signaling Cancer Biology & Therapy ·Adly Yacoub, Clint Mitchell, Irina V. Lebedeva, Devanand Sarkar, Zao-zhong Su, Robert P. McKinstry, Rahul V. Gopalkrishnan, Steven Grant	2003	85
12	Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy Cancer Biology & Therapy ·Aditi Pandya Martin, Clint Mitchell, Mohamed Rahmani, Kenneth P. Nephew, Steven Grant, Paul Dent	2009	85
13	BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing Molecular Pharmacology ·Aditi Pandya Martin, Margaret A. Park, Clint Mitchell, Teneille D. Walker, Mohamed Rahmani, Andrew M. Thorburn, Dieter Häussinger, Roland Reinehr	2009	76
14	MDA-7 regulates cell growth and radiosensitivity in vitro of primary (Non-Established) human glioma cells Cancer Biology & Therapy ·Adly Yacoub, Clint Mitchell, Young Ki Hong, Rahul V. Gopalkrishnan, Zhao-zhong Su, Pankaj Gupta, Moira Sauane, Irina V. Lebedeva	2004	73
15	OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells Molecular Pharmacology ·Adly Yacoub, Margaret A. Park, David E. Hanna, Young Ki Hong, Clint Mitchell, Aditi P. Pandya, Hisashi Harada, Garth Powis	2006	71
16	Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival Molecular Cancer Therapeutics ·Rubén W. Carón, Adly Yacoub, Min Li, Xiaoyu Zhu, Clint Mitchell, Young Ki Hong, William Hawkins, Takehiko Sasazuki	2005	70
17	Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo Cancer Biology & Therapy ·Clint Mitchell, Adly Yacoub, Hossein A. Hamed, Aditi Pandya Martin, Mary Danielle Bareford, Patrick J. Eulitt, Yang Chen, Kenneth P. Nephew	2010	70
18	Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation Molecular Pharmacology ·Aditi Pandya Martin, Anna V. Miller, Luni Emad, Mohamed Rahmani, Teneille D. Walker, Clint Mitchell, Michael Philip Hagan, Margaret A. Park	2008	54
19	MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity. PubMed ·Adly Yacoub, Clint Mitchell, Jessica Brannon, Elizabeth Rosenberg, Robert P. McKinstry, William Marston Linehan, Zao-shong Su, Devanand Sarkar	2003	53
20	Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo. PubMed ·Adly Yacoub, Clint Mitchell, Irina V. Lebedeva, Devanand Sarkar, Zao-zhong Su, Carter Sigmon, Robert P. McKinstry, Viswanathan Ramakrishnan	2003	52

About Clint Mitchell

Clint Mitchell is a scholar working on Molecular Biology, Oncology, Genetics, Hepatology and Cell Biology, having authored 41 papers that have together received 2.6k indexed citations. Recurring topics across this work include Cell death mechanisms and regulation (20 papers), Protein Kinase Regulation and GTPase Signaling (6 papers), Melanoma and MAPK Pathways (5 papers), Glioma Diagnosis and Treatment (4 papers), Heat shock proteins research (3 papers), Histone Deacetylase Inhibitors Research (3 papers), Drug Transport and Resistance Mechanisms (3 papers) and Liver physiology and pathology (3 papers). The work is most often cited by research in Oncology (537 citations), Molecular Biology (1.3k citations), Biotechnology (92 citations), Genetics (112 citations) and Hepatology (112 citations). Clint Mitchell has collaborated with scholars based in United States, Germany and Argentina. Frequent co-authors include Paul Dent, Adly Yacoub, Steven Grant, Margaret A. Park, Paul B. Fisher, Mohamed Rahmani, Sarah Spiegel, Aditi Pandya Martin, Hossein A. Hamed and Elaine J. Studer. Their work appears in journals such as Cancer Biology & Therapy, Molecular Pharmacology, Molecular Cancer Therapeutics, Cancer Research and Hepatology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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