C. Erik Hack

9.4k citations

99 papers · 8.2k · 3 hit papers · h-index 45

Impact in

Immunology top 1%
- Immune Response and Inflammation
- Complement system in diseases
- Immune Cell Function and Interaction
Hematology top 0.5%
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments

Papers in

Immunology 35
- Complement system in diseases 8
- Immune Response and Inflammation 7
Hematology 20
- Blood Coagulation and Thrombosis Mechanisms 13

Co-authors: Augueste Sturk (6 shared papers)Rienk Nieuwland (4 shared papers)Fred P.H.T.M. Romijn (3 shared papers)Anita N. Böing (3 shared papers)René J. Berckmans (3 shared papers)JW ten Cate (1 shared paper)L Aarden (1 shared paper)August Sturk (1 shared paper)
Journals: Blood (17 papers)Journal of Immunological Methods (5 papers)Thrombosis and Haemostasis (5 papers)Arteriosclerosis Thrombosis and Vascular Biology (4 papers)The Journal of Infectious Diseases (3 papers)
Partner nations: Netherlands United States United Kingdom

In The Last Decade

C. Erik Hack

94 papers receiving 7.8k citations

C. Erik Hack's Hit Papers

align trajectories log scale

Cell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation 2001 · 569 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2001 Thrombosis and Haemostasis
1990 Blood
1989 Blood

Peers

Countries citing papers authored by C. Erik Hack

Since Specialization

Citations

This map shows the geographic impact of C. Erik Hack's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by C. Erik Hack with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites C. Erik Hack more than expected).

Fields of papers citing papers by C. Erik Hack

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by C. Erik Hack. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by C. Erik Hack. The network helps show where C. Erik Hack may publish in the future.

Co-authors

The 25 scholars most cited alongside C. Erik Hack, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with C. Erik Hack Line = papers co-authored together C. Erik Hack links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Showing the 20 most-cited of 99 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Increased plasma levels of interleukin-6 in sepsis [see comments] Blood ·C. Erik Hack, ER de Groot, RJ Felt-Bersma, Nuijens Jh, RJ Strack van Schijndel, AJ Eerenberg-Belmer, L. G. Thijs, LA Aarden Hit paper breakdown →	1989	727
2	Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways Blood ·SJ van Deventer, HR Büller, JW ten Cate, L Aarden, C. Erik Hack, August Sturk Hit paper breakdown →	1990	682
3	Cell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation Thrombosis and Haemostasis ·Rienk Nieuwland, Anita N. Böing, Fred P.H.T.M. Romijn, C. Erik Hack, Augueste Sturk, René J. Berckmans Hit paper breakdown →	2001	569
4	Cellular origin and procoagulant properties of microparticles in meningococcal sepsis Blood ·Rienk Nieuwland, René J. Berckmans, Sarah McGregor, Anita N. Böing, Fred P.H.T.M. Romijn, Rudi G. J. Westendorp, C. Erik Hack, Augueste Sturk	2000	512
5	C-Reactive Protein Colocalizes With Complement in Human Hearts During Acute Myocardial Infarction Circulation ·Wim K. Lagrand, Hans W.M. Niessen, Gerrit Jan Wolbink, Lies H. Jaspars, Cees A. Visser, Freek W.A. Verheugt, Chris J.L.M. Meijer, C. Erik Hack	1997	350
6	Proinflammatory Effects of IL-10 During Human Endotoxemia The Journal of Immunology ·Fanny N. Lauw, Dasja Pajkrt, C. Erik Hack, Masashi Kurimoto, Sander J. H. van Deventer, Tom van der Poll	2000	276
7	Role of Cytokines in Sepsis Advances in immunology ·C. Erik Hack, Lucien A. Aarden, LAMBERTUS G. THUS	1997	253
8	Aprotinin inhibits the contact, neutrophil, and platelet activation systems during simulated extracorporeal perfusion Journal of Thoracic and Cardiovascular Surgery ·Yanina T. Wachtfogel, Umberto Kucich, C. Erik Hack, Piotr Głuszko, Stefan Niewiarowski, Robert W. Colman, L. Henry Edmunds	1993	200
9	P-Selectin- and CD63-Exposing Platelet Microparticles Reflect Platelet Activation in Peripheral Arterial Disease and Myocardial Infarction Clinical Chemistry ·Petrus M. van der Zee, Éva Bíró, Yung Ko, Robbert J. de Winter, C. Erik Hack, Augueste Sturk, Rienk Nieuwland	2006	184
10	Cell‐derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII–dependent mechanism Arthritis & Rheumatism ·René J. Berckmans, Rienk Nieuwland, Paul Peter Tak, Anita N. Böing, Fred P.H.T.M. Romijn, Maarten C. Kraan, Ferdinand C. Breedveld, C. Erik Hack	2002	177
11	IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Arteriosclerosis Thrombosis and Vascular Biology ·S. Matthijs Boekholdt, Ron J.G. Peters, C. Erik Hack, Nicholas Day, Robert Luben, Sheila Anne Bingham, Nicholas J. Wareham, Pieter H. Reitsma	2004	174
12	Plasminogen Activator and Plasminogen Activator Inhibitor I Release during Experimental Endotoxaemia in Chimpanzees: Effect of Interventions in the Cytokine and Coagulation Cascades Clinical Science ·Bart J. Biemond, Marcel M Levi, Hugo Ten Cate, Tom van der Poll, Harry Roger Buller, C. Erik Hack, Jan W. ten Cate	1995	168
13	A role for secretory phospholipase A2 and C-reactive protein in the removal of injured cells Immunology Today ·C. Erik Hack, Gerrit Jan Wolbink, Caspar Schalkwijk, Han Speijer, W.Th. Hermens, Henk van den Bosch	1997	164
14	C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: The EPIC-Norfolk prospective population study 1993–2003 Atherosclerosis ·S. Matthijs Boekholdt, C. Erik Hack, Manjinder S. Sandhu, Robert Luben, Sheila Anne Bingham, Nicholas J. Wareham, Ron J.G. Peters, J. Wouter Jukema	2005	152
15	Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma Blood ·Cornelia M. Tschopp, Nicole Spiegl, Svetlana A. Didichenko, Werner Lutmann, Peter Julius, Johann Christian Virchow Jr., C. Erik Hack, Clemens A. Dahinden	2006	147
16	Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system? Blood ·Bellinda A. Bladergroen, Chris J.L.M. Meijer, Rosita L. ten Berge, C. Erik Hack, Jettie J.F. Muris, Danny F. Dukers, Andreas Chott, Yoshiaki Kazama	2002	137
17	Complement-Mediated Ischemia-Reperfusion Injury Annals of Surgery ·Gwendolyn M.P. Diepenhorst, Thomas M. van Gulik, C. Erik Hack	2009	132
18	Inactivation of factor XIa in human plasma assessed by measuring factor XIa-protease inhibitor complexes: major role for C1-inhibitor Blood ·WA Wuillemin, Monique C. Minnema, JC Meijers, Dorina Roem, AJ Eerenberg, JH Nuijens, Hugo Ten Cate, C. Erik Hack	1995	130
19	Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor Experimental Neurology ·Robert Veerhuis, Ingrid Janssen, Corline J.A. De Groot, Freek L. Van Muiswinkel, C. Erik Hack, Piet Eikelenboom	1999	126
20	Granzyme‐positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue Arthritis & Rheumatism ·Paul Peter Tak, Jean Alain Kummer, C. Erik Hack, Mohamed R. Daha, Tom J. M. Smeets, G. Wilhelmina Erkelens, A. Edo Meinders, Philip M. Kluin	1994	118

About C. Erik Hack

C. Erik Hack is a scholar working on Immunology, Hematology, Genetics, Nutrition and Dietetics and Epidemiology, having authored 99 papers that have together received 8.2k indexed citations. Recurring topics across this work include Coagulation, Bradykinin, Polyphosphates, and Angioedema (17 papers), Blood Coagulation and Thrombosis Mechanisms (13 papers), Sepsis Diagnosis and Treatment (10 papers), Vitamin K Research Studies (10 papers), Complement system in diseases (8 papers), Immune Response and Inflammation (7 papers), Monoclonal and Polyclonal Antibodies Research (6 papers) and Autoimmune Bullous Skin Diseases (5 papers). The work is most often cited by research in Immunology (2.6k citations), Hematology (1.4k citations), Internal Medicine (294 citations), Critical Care and Intensive Care Medicine (263 citations) and Genetics (575 citations). C. Erik Hack has collaborated with scholars based in Netherlands, United States and United Kingdom. Frequent co-authors include Augueste Sturk, Rienk Nieuwland, Fred P.H.T.M. Romijn, Anita N. Böing, René J. Berckmans, JW ten Cate, L Aarden, August Sturk, SJ van Deventer and Lucien A. Aarden. Their work appears in journals such as Blood, Journal of Immunological Methods, Thrombosis and Haemostasis, Arteriosclerosis Thrombosis and Vascular Biology and The Journal of Infectious Diseases.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

C. Erik Hack

Impact in

Papers in i

In The Last Decade

C. Erik Hack

C. Erik Hack's Hit Papers

Peers

Countries citing papers authored by C. Erik Hack

Fields of papers citing papers by C. Erik Hack

All Works

About C. Erik Hack

Explore authors with similar magnitude of impact

Papers in