Andrew P. Combs

6.5k citations

65 papers · 4.0k · 2 hit papers · h-index 25

Impact in

Biological Psychiatry top 1%
- Tryptophan and brain disorders
Organic Chemistry top 0.5%
- Multicomponent Synthesis of Heterocycles
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Synthesis and biological activity
- Sulfur-Based Synthesis Techniques

Papers in

Molecular Biology 41
- Chemical Synthesis and Analysis 11
- Protein Tyrosine Phosphatases 10
- Protein Degradation and Inhibitors 6
Organic Chemistry 22
- Catalytic Cross-Coupling Reactions 7
- Carbohydrate Chemistry and Synthesis 5
- Microwave-Assisted Synthesis and Applications 5

Co-authors: Thomas A. Keating (2 shared papers)Paul Tempest (2 shared papers)Robert W. Armstrong (2 shared papers)S. David Brown (2 shared papers)Patrick Y. S. Lam (6 shared papers)Simon Saubern (4 shared papers)Charles G. Clark (3 shared papers)Dominic M. T. Chan (3 shared papers)
Journals: Cancer Research (11 papers)Journal of Medicinal Chemistry (5 papers)Journal of Biological Chemistry (5 papers)Tetrahedron Letters (4 papers)Bioorganic & Medicinal Chemistry Letters (4 papers)
Partner nations: United States Germany Hungary

In The Last Decade

Andrew P. Combs

64 papers receiving 3.8k citations

Andrew P. Combs's Hit Papers

align trajectories log scale

New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation 1998 · 904 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1998 Tetrahedron Letters
1996 Accounts of Chemical Research

Peers

Countries citing papers authored by Andrew P. Combs

Since Specialization

Citations

This map shows the geographic impact of Andrew P. Combs's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Andrew P. Combs with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Andrew P. Combs more than expected).

Fields of papers citing papers by Andrew P. Combs

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Andrew P. Combs. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Andrew P. Combs. The network helps show where Andrew P. Combs may publish in the future.

Co-authors

The 25 scholars most cited alongside Andrew P. Combs, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Andrew P. Combs Line = papers co-authored together Andrew P. Combs links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 65 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Multiple-Component Condensation Strategies for Combinatorial Library Synthesis Accounts of Chemical Research ·Robert W. Armstrong, Andrew P. Combs, Paul Tempest, S. David Brown, Thomas A. Keating Hit paper breakdown →	1996	1015
2	New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation Tetrahedron Letters ·Patrick Y. S. Lam, Charles G. Clark, Simon Saubern, Jessica Adams, Michael P. Winters, Dominic M. T. Chan, Andrew P. Combs Hit paper breakdown →	1998	904
3	Recent Advances in the Discovery of Competitive Protein Tyrosine Phosphatase 1B Inhibitors for the Treatment of Diabetes, Obesity, and Cancer Journal of Medicinal Chemistry ·Andrew P. Combs	2009	295
4	Hydroxyamidine Inhibitors of Indoleamine-2,3-dioxygenase Potently Suppress Systemic Tryptophan Catabolism and the Growth of IDO-Expressing Tumors Molecular Cancer Therapeutics ·Holly K. Koblish, Michael Hansbury, Kevin Bowman, Gengjie Yang, (unknown), Patrick J. Haley, Timothy C. Burn, Paul Waeltz, Richard Sparks, Eddy W. Yue, Andrew P. Combs, Peggy Scherle, Kris Vaddi, Jordan S. Fridman	2010	206
5	Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model Journal of Medicinal Chemistry ·Eddy W. Yue, Brent Douty, Brian Wayland, Michael J. Bower, Xiangdong Liu, Lynn Leffet, Qian Wang, Kevin Bowman, Michael Hansbury, Changnian Liu, Min Wei, Yanlong Li, Richard Wynn, Timothy C. Burn, Holly K. Koblish, Jordan S. Fridman, Brian Metcalf, Peggy Scherle, Andrew P. Combs	2009	187
6	Solid supported CN cross-coupling reactions Tetrahedron Letters ·Andrew P. Combs, Simon Saubern, Maria Rafalski, Patrick Y. S. Lam	1999	102
7	N-Arylation of α-aminoesters with p-tolylboronic acid promoted by copper(II) acetate Tetrahedron Letters ·Patrick Y. S. Lam, Damien Bonne, Guillaume Vincent, Charles G. Clark, Andrew P. Combs	2003	94
8	Microwave-Assisted Synthesis of 2,4,5-Triaryl-imidazole; A Novel Thermally Induced N-Hydroxyimidazole N−O Bond Cleavage Organic Letters ·Richard Sparks, Andrew P. Combs	2004	78
9	Protein Structure-Based Combinatorial Chemistry: Discovery of Non-Peptide Binding Elements to Src SH3 Domain Journal of the American Chemical Society ·Andrew P. Combs, Tarun M. Kapoor, Sibo Feng, James Chen, Lygia F. Daudé-Snow, Stuart L. Schreiber	1996	66
10	INCB16562, a JAK1/2 Selective Inhibitor, Is Efficacious against Multiple Myeloma Cells and Reverses the Protective Effects of Cytokine and Stromal Cell Support Neoplasia ·Jun Li, Margaret Favata, Jennifer Kelley, Eian Caulder, Beth Ann Thomas, Xiaoming Wen, Richard Sparks, Ari Arvanitis, James D. Rogers, Andrew P. Combs, Kris Vaddi, Kimberly A. Solomon, Peggy Scherle, Robert Newton, Jordan S. Fridman	2010	62
11	Structural Basis for Inhibition of Protein-tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics Journal of Biological Chemistry ·(unknown), Lucie Gonneville, Milton C. Hillman, Mary Becker-Pasha, Min Wei, Brian G. Reid, Ronald M. Klabe, Eddy W. Yue, Brian Wayland, Brent Douty, Padmaja Polam, Zelda R. Wasserman, Michael J. Bower, Andrew P. Combs, Timothy C. Burn, Gregory Hollis, Richard Wynn	2006	61
12	Assay Miniaturization for Ultra-High Throughput Screening of Combinatorial and Discrete Compound Libraries: A 9600-Well (0.2 Microliter) Assay System SLAS DISCOVERY ·Kevin R. Oldenburg, Ji-Hu Zhang, Tongming Chen, Anthony M. Maffia, Karl F. Blom, Andrew P. Combs, Thomas D.Y. Chung	1998	58
13	Structural Insights into the Design of Nonpeptidic Isothiazolidinone-containing Inhibitors of Protein-tyrosine Phosphatase 1B Journal of Biological Chemistry ·(unknown), Lucie Gonneville, Milton C. Hillman, Mary Becker-Pasha, Eddy W. Yue, Brent Douty, Brian Wayland, Padmaja Polam, Matthew L. Crawley, Erin McLaughlin, Richard Sparks, Brian Glass, Amy Takvorian, Andrew P. Combs, Timothy C. Burn, Gregory Hollis, Richard Wynn	2006	56
14	Helicobacter pylori-selective Antibacterials Based on Inhibition of Pyrimidine Biosynthesis Journal of Biological Chemistry ·Robert A. Copeland, Jovita Marcinkeviciene, Tasir S. Haque, Lisa M. Kopcho, Wenjun Jiang, Kathy Wang, Lisa D. Ecret, Christine Sizemore, Karen A. Amsler, Lori Foster, Seifu Tadesse, Andrew P. Combs, Andrew M. Stern, George L. Trainor, Andrew Slee, Michael J. Rogers, Frank W. Hobbs	2000	56
15	Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis Blood ·Priya Koppikar, Omar Abdel‐Wahab, Cyrus V. Hedvat, Sachie Marubayashi, Jay Patel, Aviva Goel, Nicole Kucine, Jeffrey R. Gardner, Andrew P. Combs, Kris Vaddi, Patrick J. Haley, Timothy C. Burn, Mark Rupar, Jacqueline Bromberg, Mark Heaney, Elisa de Stanchina, Jordan S. Fridman, Ross L. Levine	2010	55
16	Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines Bioorganic & Medicinal Chemistry Letters ·Brent Douty, Brian Wayland, (unknown), Michael J. Bower, James R. Pruitt, Lori L. Bostrom, Min Wei, Ronald M. Klabe, Lucie Gonneville, Richard Wynn, Timothy C. Burn, Phillip C.C. Liu, Andrew P. Combs, Eddy W. Yue	2007	55
17	Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors Bioorganic & Medicinal Chemistry Letters ·Richard Sparks, Padmaja Polam, Wenyu Zhu, Matthew L. Crawley, Amy Takvorian, Erin McLaughlin, Min Wei, (unknown), Lucie Gonneville, Nancy J. Taylor, Yanlong Li, Richard Wynn, Timothy C. Burn, Phillip C.C. Liu, Andrew P. Combs	2006	49
18	Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter pylori Dihydroorotate Dehydrogenase Journal of Medicinal Chemistry ·Tasir S. Haque, Seifu Tadesse, Jovita Marcinkeviciene, Michael J. Rogers, Christine Sizemore, Lisa M. Kopcho, Karen Amsler, Lisa D. Ecret, Dong Zhan, Frank W. Hobbs, Andrew Slee, George L. Trainor, Andrew M. Stern, Robert A. Copeland, Andrew P. Combs	2002	49
19	Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis Chemistry & Biology ·Sibo Feng, Tarun M. Kapoor, Fumiyuki Shirai, Andrew P. Combs, Stuart L. Schreiber	1996	46
20	Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure–activity relationships of a peptide scaffold Bioorganic & Medicinal Chemistry ·Eddy W. Yue, Brian Wayland, Brent Douty, Matthew L. Crawley, Erin McLaughlin, Amy Takvorian, Zelda R. Wasserman, Michael J. Bower, Min Wei, Yanlong Li, (unknown), Lucie Gonneville, Richard Wynn, Timothy C. Burn, Phillip C.C. Liu, Andrew P. Combs	2006	43

About Andrew P. Combs

Andrew P. Combs is a scholar working on Molecular Biology, Organic Chemistry, Oncology, Genetics and Hematology, having authored 65 papers that have together received 4.0k indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (11 papers), Protein Tyrosine Phosphatases (10 papers), Catalytic Cross-Coupling Reactions (7 papers), Cytokine Signaling Pathways and Interactions (6 papers), Protein Degradation and Inhibitors (6 papers), Carbohydrate Chemistry and Synthesis (5 papers), Microwave-Assisted Synthesis and Applications (5 papers) and Myeloproliferative Neoplasms: Diagnosis and Treatment (4 papers). The work is most often cited by research in Biological Psychiatry (318 citations), Organic Chemistry (2.4k citations), Toxicology (154 citations), Behavioral Neuroscience (93 citations) and Molecular Biology (1.6k citations). Andrew P. Combs has collaborated with scholars based in United States, Germany and Hungary. Frequent co-authors include Thomas A. Keating, Paul Tempest, Robert W. Armstrong, S. David Brown, Patrick Y. S. Lam, Simon Saubern, Charles G. Clark, Dominic M. T. Chan, Michael P. Winters and Richard Sparks. Their work appears in journals such as Cancer Research, Journal of Medicinal Chemistry, Journal of Biological Chemistry, Tetrahedron Letters and Bioorganic & Medicinal Chemistry Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Andrew P. Combs

Andrew P. Combs's Hit Papers

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