Zhenning He

1.4k citations

24 papers · 1.2k · 2 hit papers · h-index 14

Impact in

Business and International Management top 2%
- Innovation and Socioeconomic Development
Genetics top 5%
- Virus-based gene therapy research

Papers in

Genetics 9
- Virus-based gene therapy research 10
- Hemoglobinopathies and Related Disorders 9
Hematology 4
- Iron Metabolism and Disorders 4

Co-authors: Lili Wang (12 shared papers)James M. Wilson (12 shared papers)Peter L. Bell (11 shared papers)John White (7 shared papers)Hongwei Yu (6 shared papers)Deirdre McMenamin (4 shared papers)Janice Russell (9 shared papers)Yang Yang (3 shared papers)
Journals: Blood (4 papers)Nature Biotechnology (3 papers)Molecular Therapy (2 papers)Molecular Therapy — Methods & Clinical Development (2 papers)Journal of Hematology & Oncology (1 paper)
Partner nations: United States China Taiwan

In The Last Decade

Zhenning He

23 papers receiving 1.1k citations

Zhenning He's Hit Papers

align trajectories log scale

Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration 2023 · 109 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2023 Nature Biotechnology
2016 Nature Biotechnology

Peers

Countries citing papers authored by Zhenning He

Since Specialization

Citations

This map shows the geographic impact of Zhenning He's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Zhenning He with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Zhenning He more than expected).

Fields of papers citing papers by Zhenning He

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Zhenning He. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Zhenning He. The network helps show where Zhenning He may publish in the future.

Co-authors

The 25 scholars most cited alongside Zhenning He, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Zhenning He Line = papers co-authored together Zhenning He links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 24 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice Nature Biotechnology ·Yang Yang, Lili Wang, Peter L. Bell, Deirdre McMenamin, Zhenning He, John White, Hongwei Yu, Chenyu Xu Hit paper breakdown →	2016	465
2	Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration Nature Biotechnology ·Jenny A. Greig, Kelly M. Martins, Camilo Ayala Breton, Jason Lamontagne, Yanqing Zhu, Zhenning He, John Wesley White, Jingxu Zhu Hit paper breakdown →	2023	109
3	Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol Nature Biotechnology ·Lili Wang, Jeff Smith, Camilo Ayala Breton, Peter Clark, Jia Zhang, Ying Lei, Yan Che, Janel Lape	2018	102
4	Comparative Study of Liver Gene Transfer With AAV Vectors Based on Natural and Engineered AAV Capsids Molecular Therapy ·Lili Wang, Peter L. Bell, Suryanarayan Somanathan, Qiang Wang, Zhenning He, Hongwei Yu, Deirdre McMenamin, Tamara L. Goode	2015	92
5	CRISPR/Cas9-mediated in vivo gene targeting corrects hemostasis in newborn and adult factor IX–knockout mice Blood ·Lili Wang, Yang Yang, Camilo Ayala Breton, John White, Jia Zhang, Yan Che, A. Saveliev, Deirdre McMenamin	2019	70
6	A mutation-independent CRISPR-Cas9–mediated gene targeting approach to treat a murine model of ornithine transcarbamylase deficiency Science Advances ·Lili Wang, Yang Yang, Camilo Ayala Breton, Peter L. Bell, Mingyao Li, Jia Zhang, Yan Che, A. Saveliev	2020	58
7	Long-term stable reduction of low-density lipoprotein in nonhuman primates following in vivo genome editing of PCSK9 Molecular Therapy ·Lili Wang, Camilo Ayala Breton, Claude C. Warzecha, Peter L. Bell, Hanying Yan, Zhenning He, John White, Yanqing Zhu	2021	55
8	AAV gene therapy corrects OTC deficiency and prevents liver fibrosis in aged OTC-knock out heterozygous mice Molecular Genetics and Metabolism ·Lili Wang, Peter L. Bell, Hiroki Morizono, Zhenning He, Elena Pumbo, Hongwei Yu, John White, Mark L. Batshaw	2017	42
9	Expression, purification, and characterization of human hemoglobins Gower-1 (ζ2ε2), Gower-2 (α2ε2), and Portland-2 (ζ2β2) assembled in complex transgenic–knockout mice Blood ·Zhenning He, Janice Russell	2001	37
10	Effects of Self-Complementarity, Codon Optimization, Transgene, and Dose on Liver Transduction with AAV8 Human Gene Therapy Methods ·Peter L. Bell, Lili Wang, Shu‐Jen Chen, Hongwei Yu, Yanqing Zhu, Mohamad Nayal, Zhenning He, John White	2016	23
11	Prednisolone reduces the interferon response to AAV in cynomolgus macaques and may increase liver gene expression Molecular Therapy — Methods & Clinical Development ·Lili Wang, Claude C. Warzecha, Alexander Kistner, Jessica A. Chichester, Peter L. Bell, Elizabeth L. Buza, Zhenning He, María Betina Pampena	2022	21
12	Developing a second-generation clinical candidate AAV vector for gene therapy of familial hypercholesterolemia Molecular Therapy — Methods & Clinical Development ·Lili Wang, Ilayaraja Muthuramu, Suryanarayan Somanathan, Hong Zhang, Peter L. Bell, Zhenning He, Hongwei Yu, Yanqing Zhu	2021	19
13	A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease Proceedings of the National Academy of Sciences ·Zhenning He, Janice Russell	2002	17
14	Antisickling effects of an endogenous human α-like globin Nature Medicine ·Zhenning He, Janice Russell	2004	16
15	Functional effects of replacing human α‐ and β‐globins with their embryonic globin homologues in defined haemoglobin heterotetramers British Journal of Haematology ·Zhenning He, Lurong Lian, Toshio Asakura, Janice Russell	2000	10
16	Effect of ζ-globin substitution on the O2-transport properties of Hb S in vitro and in vivo Biochemical and Biophysical Research Communications ·Zhenning He, Janice Russell	2004	10
17	Structure of fully liganded Hb ζ2β2strapped in a tense conformation Acta Crystallographica Section D Biological Crystallography ·Martin K. Safo, Tzu‐Ping Ko, Osheiza Y. Abdulmalik, Zhenning He, Andrew H.-J. Wang, Eric R. Schreiter, Janice Russell	2013	5
18	Dynamic posttranscriptional regulation of ϵ-globin gene expression in vivo Blood ·Zhenning He, Janice Russell	2006	5
19	A High-Throughput Microplate Method for Assessing Aggregation of Deoxygenated Hemoglobin S Heterotetramers in Vitro Analytical Biochemistry ·Zhenning He, Janice Russell	2002	5
20	IDO1-mediated AhR activation up-regulates pentose phosphate pathway via NRF2 to inhibit ferroptosis in lung cancer Biochemical Pharmacology ·Yijia Chen, Yuying Liu, Yunqiu Chen, Zhiyao Li, Xuewen Li, Zhenning He, Lili Yang +4 others	2025	4

About Zhenning He

Zhenning He is a scholar working on Genetics, Genetics, Hematology, Pediatrics, Perinatology and Child Health and Molecular Biology, having authored 24 papers that have together received 1.2k indexed citations. Recurring topics across this work include Virus-based gene therapy research (10 papers), Hemoglobinopathies and Related Disorders (9 papers), CRISPR and Genetic Engineering (7 papers), Iron Metabolism and Disorders (4 papers), Viral gastroenteritis research and epidemiology (3 papers), Hemoglobin structure and function (3 papers), Viral Infections and Immunology Research (3 papers) and RNA Interference and Gene Delivery (3 papers). The work is most often cited by research in Business and International Management (77 citations), Genetics (521 citations), Aging (28 citations), Molecular Biology (872 citations) and Clinical Biochemistry (76 citations). Zhenning He has collaborated with scholars based in United States, China and Taiwan. Frequent co-authors include Lili Wang, James M. Wilson, Peter L. Bell, John White, Hongwei Yu, Deirdre McMenamin, Janice Russell, Yang Yang, Mark L. Batshaw and Hiroki Morizono. Their work appears in journals such as Blood, Nature Biotechnology, Molecular Therapy, Molecular Therapy — Methods & Clinical Development and Journal of Hematology & Oncology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Zhenning He's Hit Papers

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Fields of papers citing papers by Zhenning He

All Works

About Zhenning He

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