Z. Dave Sharp

9.7k citations

71 papers · 7.8k · 3 hit papers · h-index 28

Impact in

Aging top 0.05%
- Genetics, Aging, and Longevity in Model Organisms
Geriatrics and Gerontology top 0.5%

Papers in

Molecular Biology 53
- Genomics and Chromatin Dynamics 13
- RNA Research and Splicing 10
- CRISPR and Genetic Engineering 10
- PI3K/AKT/mTOR signaling in cancer 8
Genetics 17
- Estrogen and related hormone effects 7

Co-authors: Randy Strong (12 shared papers)Martin A. Javors (10 shared papers)James F. Nelson (5 shared papers)Richard A. Miller (4 shared papers)Nancy L. Nadon (4 shared papers)Clinton M. Astle (3 shared papers)Kevin Flurkey (3 shared papers)Elizabeth Fernández (3 shared papers)
Journals: Molecular and Cellular Biology (6 papers)The Journals of Gerontology Series A (5 papers)Journal of Biological Chemistry (4 papers)Aging Cell (3 papers)Journal of Cellular Biochemistry (3 papers)
Partner nations: United States Czechia Canada

In The Last Decade

Z. Dave Sharp

70 papers receiving 7.6k citations

Z. Dave Sharp's Hit Papers

align trajectories log scale

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice 2010 · 743 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2010 The Journals of Gerontology Series A
2009 Nature
1999 Science

Peers

Countries citing papers authored by Z. Dave Sharp

Since Specialization

Citations

This map shows the geographic impact of Z. Dave Sharp's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Z. Dave Sharp with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Z. Dave Sharp more than expected).

Fields of papers citing papers by Z. Dave Sharp

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Z. Dave Sharp. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Z. Dave Sharp. The network helps show where Z. Dave Sharp may publish in the future.

Co-authors

The 25 scholars most cited alongside Z. Dave Sharp, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Z. Dave Sharp Line = papers co-authored together Z. Dave Sharp links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 71 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Nature ·(unknown), Randy Strong, Z. Dave Sharp, James F. Nelson, Clinton M. Astle, Kevin Flurkey, Nancy L. Nadon, John E. Wilkinson, Krystyna Frenkel, Christy S. Carter, Marco Pahor, Martin A. Javors, Elizabeth Fernández, Richard A. Miller Hit paper breakdown →	2009	2969
2	Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice The Journals of Gerontology Series A ·Richard A. Miller, (unknown), Clinton M. Astle, Joseph A. Baur, Angela R. Boyd, Rafael de Cabo, Elizabeth Fernández, Kevin Flurkey, Martin A. Javors, James F. Nelson, Carlos J. Orihuela, Scott D. Pletcher, Z. Dave Sharp, David Sinclair, Joseph W. Starnes, John E. Wilkinson, Nancy L. Nadon, Randy Strong Hit paper breakdown →	2010	743
3	Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response Science ·Qing Zhong, Chi‐Fen Chen, Shang Li, Yumay Chen, Chuan-Cheng Wang, Jun Xiao, Phang‐Lang Chen, Z. Dave Sharp, Wen‐Hwa Lee Hit paper breakdown →	1999	537
4	Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction Aging Cell ·Richard A. Miller, David E. Harrison, Clinton M. Astle, Elizabeth Fernández, Kevin Flurkey, Melissa Han, Martin A. Javors, Xinna Li, Nancy L. Nadon, James F. Nelson, Scott D. Pletcher, Adam B. Salmon, Z. Dave Sharp, Sabrina Van Roekel, Lynn Winkleman, Randy Strong	2013	461
5	A general method for polyethylene-glycol-induced genetic transformation of bacteria and yeast Gene ·Robert J. Klebe, June V. Harriss, Z. Dave Sharp, Michael G. Douglas	1983	431
6	The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment Proceedings of the National Academy of Sciences ·Phang‐Lang Chen, Chi‐Fen Chen, Yumay Chen, Jun Xiao, Z. Dave Sharp, Wen‐Hwa Lee	1998	334
7	The Nuclear Localization Sequences of the BRCA1 Protein Interact with the Importin-α Subunit of the Nuclear Transport Signal Receptor Journal of Biological Chemistry ·Chi‐Fen Chen, Shang Li, Yumay Chen, Phang‐Lang Chen, Z. Dave Sharp, Wen‐Hwa Lee	1996	175
8	Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage Journal of Biological Chemistry ·Shang Li, Phang‐Lang Chen, Thirugnana Subramanian, G. Chinnadurai, Gail E. Tomlinson, C. Kent Osborne, Z. Dave Sharp, Wen‐Hwa Lee	1999	171
9	Expression of BRC Repeats in Breast Cancer Cells Disrupts the BRCA2-Rad51 Complex and Leads to Radiation Hypersensitivity and Loss of G2/M Checkpoint Control Journal of Biological Chemistry ·Chi‐Fen Chen, Phang‐Lang Chen, Qing Zhong, Z. Dave Sharp, Wen‐Hwa Lee	1999	171
10	Evidence for Down-Regulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice The Journals of Gerontology Series A ·Z. Dave Sharp, A. Bartke	2005	130
11	Design of aging intervention studies: the NIA interventions testing program AGE ·Nancy L. Nadon, Randy Strong, Richard A. Miller, James F. Nelson, Martin A. Javors, Z. Dave Sharp, Josep Maria Peralba, (unknown)	2008	120
12	Chronic mTOR inhibition in mice with rapamycin alters T , B , myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice Aging Cell ·Vincent Hurez, Vinh Dao, Aijie Liu, Srilakshmi Pandeswara, Jonathan Gelfond, Lishi Sun, Molly A. Bergman, Carlos J. Orihuela, Verónica Galván, Álvaro Padrón, Justin Drerup, Yang Liu, Paul Hasty, Z. Dave Sharp, Tyler J. Curiel	2015	104
13	Estrogen-receptor-α exchange and chromatin dynamics are ligand- and domain-dependent Journal of Cell Science ·Z. Dave Sharp, Maureen G. Mancini, Cruz A. Hinojos, Fangyan Dai, Valeria Berno, Adam T. Szafran, Kelly P. Smith, Tanmay T. Lele, Donald E. Ingber, Michael A. Mancini	2006	93
14	mTORC1 and p53 Cell Cycle ·Paul Hasty, Z. Dave Sharp, Tyler J. Curiel, Judith Campisi	2012	77
15	Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice Frontiers in Molecular Neuroscience ·Karl A. Rodriguez, Sherry G. Dodds, Randy Strong, Verónica Galván, Z. Dave Sharp, Rochelle Buffenstein	2014	75
16	Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors Aging ·Carolina B. Livi, Rulon L. Hardman, Barbara A. Christy, Sherry G. Dodds, D.R. Jones, Charnae Williams, Randy Strong, Alex Bokov, Martin A. Javors, Yuji Ikeno, Gene B. Hubbard, Paul Hasty, Z. Dave Sharp	2013	73
17	Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs The Journals of Gerontology Series A ·Cheresa Calhoun, Pooja Shivshankar, Mirna Saker, Lauren Sloane, Carolina B. Livi, Z. Dave Sharp, Carlos J. Orihuela, Serge Adnot, Eric S. White, Arlan Richardson, Claude Jourdan Le Saux	2015	70
18	eRapa Restores a Normal Life Span in a FAP Mouse Model Cancer Prevention Research ·Paul Hasty, Carolina B. Livi, Sherry G. Dodds, D.R. Jones, Randy Strong, Martin A. Javors, Kathleen E. Fischer, Lauren Sloane, Kruthi Murthy, Gene B. Hubbard, Lishi Sun, Vincent Hurez, Tyler J. Curiel, Z. Dave Sharp	2013	60
19	Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus Proceedings of the National Academy of Sciences ·Yumay Chen, Phang‐Lang Chen, Chi‐Fen Chen, Z. Dave Sharp, Wen‐Hwa Lee	1999	59
20	Vasoactive Intestinal Peptide Increases Prolactin Messenger Ribonucleic Acid Content in GH3 Cells* Endocrinology ·Alberto J. Carrillo, Thomas B. Pool, Z. Dave Sharp	1985	58

About Z. Dave Sharp

Z. Dave Sharp is a scholar working on Molecular Biology, Genetics, Aging, Endocrinology, Diabetes and Metabolism and Physiology, having authored 71 papers that have together received 7.8k indexed citations. Recurring topics across this work include Genetics, Aging, and Longevity in Model Organisms (16 papers), Genomics and Chromatin Dynamics (13 papers), Growth Hormone and Insulin-like Growth Factors (12 papers), RNA Research and Splicing (10 papers), CRISPR and Genetic Engineering (10 papers), PI3K/AKT/mTOR signaling in cancer (8 papers), Estrogen and related hormone effects (7 papers) and Circadian rhythm and melatonin (7 papers). The work is most often cited by research in Aging (2.3k citations), Geriatrics and Gerontology (460 citations), Endocrine and Autonomic Systems (734 citations), Physiology (1.9k citations) and Molecular Biology (4.5k citations). Z. Dave Sharp has collaborated with scholars based in United States, Czechia and Canada. Frequent co-authors include Randy Strong, Martin A. Javors, James F. Nelson, Richard A. Miller, Nancy L. Nadon, Clinton M. Astle, Kevin Flurkey, Elizabeth Fernández, John E. Wilkinson and Krystyna Frenkel. Their work appears in journals such as Molecular and Cellular Biology, The Journals of Gerontology Series A, Journal of Biological Chemistry, Aging Cell and Journal of Cellular Biochemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Z. Dave Sharp

Z. Dave Sharp's Hit Papers

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