Xin Chen

12.6k citations

244 papers · 9.6k · 3 hit papers · h-index 49

Impact in

Immunology top 0.5%
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
Toxicology top 0.2%
- Bioactive Compounds and Antitumor Agents

Papers in

Immunology 114
- Immune Cell Function and Interaction 54
- Immunotherapy and Immune Responses 44
- T-cell and B-cell Immunology 39
- Immune Response and Inflammation 25
- Immune cells in cancer 13
- Psoriasis: Treatment and Pathogenesis 13
Molecular Biology 66

Co-authors: Joost J. Oppenheim (47 shared papers)O. M. Zack Howard (32 shared papers)Malcolm Whitman (2 shared papers)Mengmeng Jiang (9 shared papers)Lu Yang (5 shared papers)Luis J. Montaner (2 shared papers)Daniela N. Männel (2 shared papers)Jin Wang (1 shared paper)
Journals: The Journal of Immunology (12 papers)Scientific Reports (7 papers)Frontiers in Immunology (7 papers)International Immunopharmacology (6 papers)Blood (5 papers)
Partner nations: China United States Macao

In The Last Decade

Xin Chen

224 papers receiving 9.4k citations

Xin Chen's Hit Papers

align trajectories log scale

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts 2020 · 517 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2020 Journal of Leukocyte Biology
2002 Nature Biotechnology
1996 Nature

Peers

Countries citing papers authored by Xin Chen

Since Specialization

Citations

This map shows the geographic impact of Xin Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Xin Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Xin Chen more than expected).

Fields of papers citing papers by Xin Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Xin Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Xin Chen. The network helps show where Xin Chen may publish in the future.

Co-authors

The 25 scholars most cited alongside Xin Chen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Xin Chen Line = papers co-authored together Xin Chen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 244 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	BMP4 initiates human embryonic stem cell differentiation to trophoblast Nature Biotechnology ·Ren‐He Xu, Xin Chen, Dong S. Li, Rui Li, Gregory C. Addicks, Clay Glennon, Thomas P. Zwaka, James A. Thomson Hit paper breakdown →	2002	847
2	A transcriptional partner for MAD proteins in TGF-β signalling Nature ·Xin Chen, Melissa J. Rubock, Malcolm Whitman Hit paper breakdown →	1996	614
3	Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts Journal of Leukocyte Biology ·Jin Wang, Mengmeng Jiang, Xin Chen, Luis J. Montaner Hit paper breakdown →	2020	517
4	Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells The Journal of Immunology ·Xin Chen, Monika Bäumel, Daniela N. Männel, O. M. Zack Howard, Joost J. Oppenheim	2007	443
5	Cellular pharmacology studies of shikonin derivatives Phytotherapy Research ·Xin Chen, Lu Yang, Joost J. Oppenheim, O. M. Zack Howard	2002	355
6	Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells The Journal of Immunology ·Xin Chen, Jeffrey Subleski, Heather Kopf, O. M. Zack Howard, Daniela N. Männel, Joost J. Oppenheim	2008	263
7	Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics Frontiers in Pharmacology ·Ping Li, Ying Zheng, Xin Chen	2017	261
8	TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment The Journal of Immunology ·Xin Chen, Xueqiang Wu, Qiong Zhou, O. M. Zack Howard, Mihai G. Netea, Joost J. Oppenheim	2012	232
9	Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells International Immunopharmacology ·Heather Kopf, Gonzalo M. de la Rosa, O. M. Zack Howard, Xin Chen	2007	218
10	Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1 Antimicrobial Agents and Chemotherapy ·Xin Chen, Lu Yang, Ning Zhang, Jim A. Turpin, Robert W. Buckheit, Clay Osterling, Joost J. Oppenheim, O. M. Zack Howard	2003	197
11	Glucocorticoid amplifies IL‐2‐dependent expansion of functional FoxP3⁺CD4⁺CD25⁺ T regulatory cells in vivo and enhances their capacity to suppress EAE European Journal of Immunology ·Xin Chen, Joost J. Oppenheim, Robin Winkler-Pickett, John R. Ortaldo, O. M. Zack Howard	2006	188
12	Co‐expression of TNFR2 and CD25 identifies more of the functional CD4⁺FOXP3⁺ regulatory T cells in human peripheral blood European Journal of Immunology ·Xin Chen, Jeffrey Subleski, Ryoko Hamano, O. M. Zack Howard, Robert H. Wiltrout, Joost J. Oppenheim	2010	174
13	Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel Journal of Controlled Release ·Lin Sun, Zeyu Liu, Lun Wang, Dongmei Cun, Henry H. Y. Tong, Ru Yan, Xin Chen, Ruibing Wang, Ying Zheng	2017	168
14	Differential response of murine CD4⁺CD25⁺ and CD4⁺CD25^– T cells to dexamethasone‐induced cell death European Journal of Immunology ·Xin Chen, Takaya Murakami, Joost J. Oppenheim, O. M. Zack Howard	2004	159
15	The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells Mucosal Immunology ·Françoise Meylan, Eric Hawley, L Barron, Jillian L. Barlow, Pallavi Penumetcha, Martin Pelletier, Giuseppe Sciumè, Arianne C. Richard, Erika Hayes, Julio Gómez‐Rodríguez, Xin Chen, W E Paul, Thomas A. Wynn, Andrew N. J. McKenzie, Richard M. Siegel	2013	117
16	Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3− Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells The Journal of Immunology ·Xin Chen, Ryoko Hamano, Jeffrey Subleski, Arthur A. Hurwitz, O. M. Zack Howard, Joost J. Oppenheim	2010	107
17	BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25− responder T cells than C57BL/6 mice Journal of Leukocyte Biology ·Xin Chen, Joost J. Oppenheim, O. M. Zack Howard	2005	103
18	Development of regulatory T cells requires IL-7Rα stimulation by IL-7 or TSLP Blood ·Renata Mazzucchelli, Julie A. Hixon, Rosanne Spolski, Xin Chen, Wenqing Li, Veronica L. Hall, Jami Willette‐Brown, Arthur A. Hurwitz, Warren J. Leonard, Scott K. Durum	2008	102
19	TNF-α: An Activator of CD4+FoxP3+TNFR2+ Regulatory T Cells PubMed ·Xin Chen, Joost J. Oppenheim	2010	93
20	Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells International Immunopharmacology ·Xin Chen, Joost J. Oppenheim	2011	89

About Xin Chen

Xin Chen is a scholar working on Immunology, Molecular Biology, Oncology, Cancer Research and Pharmacology, having authored 244 papers that have together received 9.6k indexed citations. Recurring topics across this work include Immune Cell Function and Interaction (54 papers), Immunotherapy and Immune Responses (44 papers), T-cell and B-cell Immunology (39 papers), Immune Response and Inflammation (25 papers), Immune cells in cancer (13 papers), Psoriasis: Treatment and Pathogenesis (13 papers), Cancer Immunotherapy and Biomarkers (10 papers) and Cytokine Signaling Pathways and Interactions (9 papers). The work is most often cited by research in Immunology (3.9k citations), Toxicology (487 citations), Oncology (1.4k citations), Molecular Biology (3.4k citations) and Complementary and alternative medicine (371 citations). Xin Chen has collaborated with scholars based in China, United States and Macao. Frequent co-authors include Joost J. Oppenheim, O. M. Zack Howard, Malcolm Whitman, Mengmeng Jiang, Lu Yang, Luis J. Montaner, Daniela N. Männel, Jin Wang, Ying Zheng and Rui Li. Their work appears in journals such as The Journal of Immunology, Scientific Reports, Frontiers in Immunology, International Immunopharmacology and Blood.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Xin Chen's Hit Papers

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About Xin Chen

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