William A. O’Brien

8.0k citations

65 papers · 6.5k · 3 hit papers · h-index 34

Impact in

Virology top 0.05%
- HIV Research and Treatment
Infectious Diseases top 0.2%
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions

Papers in

Virology 39
- HIV Research and Treatment 39
Infectious Diseases 30
- HIV/AIDS drug development and treatment 24
- HIV/AIDS Research and Interventions 16

Co-authors: Georges Herbein (6 shared papers)Jerome A. Zack (5 shared papers)Yoshio Koyanagi (3 shared papers)Irvin S. Y. Chen (3 shared papers)George M. Shaw (3 shared papers)Julie M. Decker (3 shared papers)Lee Ratner (3 shared papers)Cynthia A. Derdeyn (2 shared papers)
Journals: Journal of Virology (12 papers)JAIDS Journal of Acquired Immune Deficiency Syndromes (4 papers)Clinical Infectious Diseases (3 papers)Virology (2 papers)Nature (2 papers)
Partner nations: United States Spain Brazil

In The Last Decade

William A. O’Brien

62 papers receiving 6.3k citations

William A. O’Brien's Hit Papers

align trajectories log scale

Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120 2000 · 647 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2000 Journal of Virology
1996 New England Journal of Medicine
1990 Nature

Peers

Countries citing papers authored by William A. O’Brien

Since Specialization

Citations

This map shows the geographic impact of William A. O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William A. O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William A. O’Brien more than expected).

Fields of papers citing papers by William A. O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William A. O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William A. O’Brien. The network helps show where William A. O’Brien may publish in the future.

Co-authors

The 25 scholars most cited alongside William A. O’Brien, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William A. O’Brien Line = papers co-authored together William A. O’Brien links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120 Journal of Virology ·Cynthia A. Derdeyn, Julie M. Decker, Jeffrey N. Sfakianos, Xiaoyun Wu, William A. O’Brien, Lee Ratner, John C. Kappes, George M. Shaw, Eric Hunter Hit paper breakdown →	2000	647
2	Changes in Plasma HIV-1 RNA and CD4+ Lymphocyte Counts and the Risk of Progression to AIDS New England Journal of Medicine ·William A. O’Brien, Pamela Hartigan, David E. Martin, James D. Esinhart, Andrew Hill, Sharon L. Benoit, Marc Rubin, Michael S. Simberkoff, John D. Hamilton Hit paper breakdown →	1996	594
3	HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain Nature ·William A. O’Brien, Yoshio Koyanagi, Ali Namazie, Jiaqi Zhao, Amadou Diagne, Ken ldler, Jerome A. Zack, Irvin S. Y. Chen Hit paper breakdown →	1990	503
4	Cytokines Alter Production of HIV-1 from Primary Mononuclear Phagocytes Science ·Yoshio Koyanagi, William A. O’Brien, Zhao Jia, David W. Golde, Judith C. Gasson, Irvin S. Y. Chen	1988	413
5	HIV viral load markers in clinical practice Nature Medicine ·Michael S. Saag, Mark Holodniy, Daniel R. Kuritzkes, William A. O’Brien, Robert W. Coombs, Margaret E. Poscher, Donna M. Jacobsen, George M. Shaw, Douglas D. Richman, Paul A. Volberding	1996	394
6	Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4 Nature ·Georges Herbein, Ulrich Mahlknecht, Franak Batliwalla, Peter K. Gregersen, Todd C. Pappas, John Butler, William A. O’Brien, Eric Verdin	1998	353
7	The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival Development ·Kathleen Molyneaux, Hélène Zinszner, Prabhat S. Kunwar, Kyle Schaible, Jürg Stebler, Mary Jean Sunshine, William A. O’Brien, Erez Raz, Dan R. Littman, Chris Wylie, Ruth Lehmann	2003	351
8	A Small-molecule Inhibitor Directed against the Chemokine Receptor CXCR4 Prevents its Use as an HIV-1 Coreceptor The Journal of Experimental Medicine ·Benjamin J. Doranz, Kathie Grovit‐Ferbas, Matthew Sharron, Si‐Hua Mao, Matthew Bidwell Goetz, Eric S. Daar, Robert W. Doms, William A. O’Brien	1997	283
9	A Controlled Trial of Early versus Late Treatment with Zidovudine in Symptomatic Human Immunodeficiency Virus Infection New England Journal of Medicine ·John D. Hamilton, Pamela Hartigan, Michael S. Simberkoff, Philip L. Day, Gigi R. Diamond, Gordon M. Dickinson, George L. Drusano, Merrill J. Egorin, W. Lance George, Fred M. Gordin, Clifton A. Hawkes, Peter Jensen, Nancy G. Klimas, Ann M. Labriola, Christopher J. Lahart, William A. O’Brien, Charles N. Oster, Kent J. Weinhold, (unknown), Susan Zolla‐Pazner	1992	242
10	Changes in Plasma HIV RNA Levels and CD4+ Lymphocyte Counts Predict Both Response to Antiretroviral Therapy and Therapeutic Failure Annals of Internal Medicine ·William A. O’Brien, (unknown), (unknown), (unknown), (unknown)	1997	207
11	Increased susceptibility of differentiated mononuclear phagocytes to productive infection with human immunodeficiency virus-1 (HIV-1). Journal of Clinical Investigation ·Elizabeth A. Rich, I S Chen, Jerome A. Zack, Michelle L. Leonard, William A. O’Brien	1992	194
12	Tumor Necrosis Factor (TNF)-alpha and TNF Receptors in Viral Pathogenesis Proceedings of The Society for Experimental Biology and Medicine ·Georges Herbein, William A. O’Brien	2000	174
13	Sensitivity of Human Immunodeficiency Virus Type 1 to Fusion Inhibitors Targeted to the gp41 First Heptad Repeat Involves Distinct Regions of gp41 and Is Consistently Modulated by gp120 Interactions with the Coreceptor Journal of Virology ·Cynthia A. Derdeyn, Julie M. Decker, Jeffrey N. Sfakianos, Zhi‐Jun Zhang, William A. O’Brien, Lee Ratner, George M. Shaw, Eric Hunter	2001	160
14	Identification of human immunodeficiency virus envelope gene sequences influencing viral entry into CD4-positive HeLa cells, T-leukemia cells, and macrophages Journal of Virology ·Bruce Chesebro, Jane Nishio, S Perryman, Alan J. Cann, William A. O’Brien, I S Chen, K Wehrly	1991	144
15	Kinetics of human immunodeficiency virus type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursors Journal of Virology ·William A. O’Brien, A Namazi, Hamid R. Kalhor, Si‐Hua Mao, Jerome A. Zack, I S Chen	1994	141
16	Natural Killer Cells from HIV-1+ Patients Produce C-C Chemokines and Inhibit HIV-1 Infection The Journal of Immunology ·Todd A. Fehniger, Georges Herbein, Haixin Yu, Michael I. Para, Zale P. Bernstein, William A. O’Brien, Michael A. Caligiuri	1998	126
17	The region of the envelope gene of human immunodeficiency virus type 1 responsible for determination of cell tropism Journal of Virology ·Alan J. Cann, Mark J. Churcher, Marie Boyd, William A. O’Brien, Junshuang Zhao, Jerome A. Zack, I S Chen	1992	121
18	Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and/or 23-valent polysaccharide vaccine among HIV-infected adults Vaccine ·Daniel R. Feikin, Cheryl M. Elie, Matthew Bidwell Goetz, Jeffrey L. Lennox, George M. Carlone, Sandra Romero‐Steiner, Patricia Holder, William A. O’Brien, Cynthia G. Whitney, Jay C. Butler, Robert F. Breiman	2001	117
19	The effect of exercise training on aerobic fitness, immune indices, and quality of life in HIV+ patients Medicine & Science in Sports & Exercise ·WILLIAM W. STRINGER, MARINA BEREZOVSKAYA, William A. O’Brien, Christopher Beck, RICHARD CASABURI	1998	104
20	Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that also controls macrophage tropism Journal of Virology ·Norman E. Sharpless, William A. O’Brien, Eric Verdin, Conrad Kufta, I S Chen, Monique Dubois‐Dalcq	1992	88

About William A. O’Brien

William A. O’Brien is a scholar working on Virology, Infectious Diseases, Immunology, Epidemiology and Emergency Medicine, having authored 65 papers that have together received 6.5k indexed citations. Recurring topics across this work include HIV Research and Treatment (39 papers), HIV/AIDS drug development and treatment (24 papers), HIV/AIDS Research and Interventions (16 papers), Immune Cell Function and Interaction (15 papers), HIV-related health complications and treatments (7 papers), T-cell and B-cell Immunology (6 papers), Pneumocystis jirovecii pneumonia detection and treatment (4 papers) and Pneumonia and Respiratory Infections (2 papers). The work is most often cited by research in Virology (4.1k citations), Infectious Diseases (2.7k citations), Immunology (2.0k citations), Emergency Medicine (437 citations) and Epidemiology (1.2k citations). William A. O’Brien has collaborated with scholars based in United States, Spain and Brazil. Frequent co-authors include Georges Herbein, Jerome A. Zack, Yoshio Koyanagi, Irvin S. Y. Chen, George M. Shaw, Julie M. Decker, Lee Ratner, Cynthia A. Derdeyn, Eric Hunter and Si‐Hua Mao. Their work appears in journals such as Journal of Virology, JAIDS Journal of Acquired Immune Deficiency Syndromes, Clinical Infectious Diseases, Virology and Nature.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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William A. O’Brien

William A. O’Brien's Hit Papers

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