Weiru Wang

10.5k citations

93 papers · 8.2k · 3 hit papers · h-index 40

Impact in

Geriatrics and Gerontology top 1%
- Sirtuins and Resveratrol in Medicine
Molecular Biology top 1%
- Protein Kinase Regulation and GTPase Signaling
- Melanoma and MAPK Pathways
- Wnt/β-catenin signaling in development and cancer

Papers in

Geriatrics and Gerontology 12
- Sirtuins and Resveratrol in Medicine 12
Molecular Biology 45
- Protein Kinase Regulation and GTPase Signaling 18
- Melanoma and MAPK Pathways 9
- Biochemical and Molecular Research 7

Co-authors: Sung‐Hou Kim (11 shared papers)Rosalind Kim (8 shared papers)Joachim Rudolph (9 shared papers)Hisao A. Yokota (8 shared papers)Jaru Jancarik (4 shared papers)Rami N. Hannoush (4 shared papers)Lingyan Jin (1 shared paper)Guowei Fang (1 shared paper)
Journals: Journal of Medicinal Chemistry (12 papers)Proceedings of the National Academy of Sciences (12 papers)Bioorganic & Medicinal Chemistry Letters (11 papers)ACS Medicinal Chemistry Letters (6 papers)Structure (4 papers)
Partner nations: United States China United Kingdom

In The Last Decade

Weiru Wang

93 papers receiving 7.9k citations

Weiru Wang's Hit Papers

align trajectories log scale

Recurrent R-spondin fusions in colon cancer 2012 · 806 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2012 Nature
2010 Nature
2008 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by Weiru Wang

Since Specialization

Citations

This map shows the geographic impact of Weiru Wang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Weiru Wang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Weiru Wang more than expected).

Fields of papers citing papers by Weiru Wang

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Weiru Wang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Weiru Wang. The network helps show where Weiru Wang may publish in the future.

Co-authors

The 25 scholars most cited alongside Weiru Wang, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Weiru Wang Line = papers co-authored together Weiru Wang links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 93 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity Proceedings of the National Academy of Sciences ·James Y. Tsai, John Tayu Lee, Weiru Wang, Jiazhong Zhang, Hanna Cho, Shumeye Mamo, Ryan E. Bremer, Sam Gillette Hit paper breakdown →	2008	1134
2	Diverse somatic mutation patterns and pathway alterations in human cancers Nature ·Zhengyan Kan, Bijay Shankar Jaiswal, Jeremy Stinson, Vasantharajan Janakiraman, Deepali Bhatt, Howard Marvin Stern, Peng Yue, Peter M. Haverty Hit paper breakdown →	2010	891
3	Recurrent R-spondin fusions in colon cancer Nature ·Somasekar Seshagiri, Eric W. Stawiski, Steffen Durinck, Zora D. Modrusan, Elaine E. Storm, Caitlin B. Conboy, Subhra Chaudhuri, Yinghui Guan Hit paper breakdown →	2012	806
4	Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity Proceedings of the National Academy of Sciences ·Till Maurer, Lindsay S. Garrenton, Keith E. Pitts, Daniel J. Anderson, Nicholas J. Skelton, Benjamin P. Fauber, Borlan Pan, Shiva Malek	2012	524
5	RAF inhibitors that evade paradoxical MAPK pathway activation Nature ·Chao Zhang, Wayne R. Spevak, Ying Zhang, Yan Ma, Gaston G. M. Habets, Jiazhong Zhang, Jack Yu-Shih Lin, Todd J. A. Ewing	2015	317
6	Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes Nature Genetics ·Steffen Durinck, Eric W. Stawiski, Andrea Pavía-Jiménez, Zora D. Modrusan, Payal Kapur, Bijay Shankar Jaiswal, Na Zhang, Vanina Toffessi Tcheuyap	2014	298
7	Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation Cancer Cell ·Bijay Shankar Jaiswal, Vasantharajan Janakiraman, Noelyn M. Kljavin, Subhra Chaudhuri, Howard Marvin Stern, Weiru Wang, Zhengyan Kan, Hashem A. Dbouk	2009	256
8	A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo Science Translational Medicine ·Jasvinder K. Atwal, Yongmei Chen, Cecilia Chiu, Deborah L. Mortensen, William J. Meilandt, Yichin Liu, Christopher E. Heise, Kwame Hoyte	2011	244
9	Targeting Protein-Protein Interaction by Small Molecules The Annual Review of Pharmacology and Toxicology ·Lingyan Jin, Weiru Wang, Guowei Fang	2013	167
10	Structural Characterization of the Reaction Pathway in Phosphoserine Phosphatase: Crystallographic “snapshots” of Intermediate States Journal of Molecular Biology ·Weiru Wang, Ho S. Cho, Rosalind Kim, Jaru Jancarik, Hisao A. Yokota, Henry Nguyen, Igor V. Grigoriev, David E. Wemmer	2002	162
11	Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6 Structure ·Eric Bourhis, Weiru Wang, Christine Tam, Ji‐Young Hwang, Yingnan Zhang, Didier Spittler, Oscar W. Huang, Yan Gong	2011	140
12	Dynamic and clustering model of bacterial chemotaxis receptors: Structural basis for signaling and high sensitivity Proceedings of the National Academy of Sciences ·Sung‐Hou Kim, Weiru Wang, Kyeong Kyu Kim	2002	132
13	The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1 Proceedings of the National Academy of Sciences ·Weiru Wang, Chao Zhang, Adhirai Marimuthu, Heike I. Krupka, Maryam Tabrizizad, Rafe Shellooe, Upasana Mehra, Hoa Trong Nguyen	2005	130
14	Crystal Structure of Phosphoserine Phosphatase from Methanococcus jannaschii, a Hyperthermophile, at 1.8 Å Resolution Structure ·Weiru Wang, Rosalind Kim, Jaru Jancarik, Hisao A. Yokota, Sung‐Hou Kim	2001	128
15	Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent Proceedings of the National Academy of Sciences ·Dean R. Artis, Jack J. Lin, Chao Zhang, Weiru Wang, Upasana Mehra, Mylène Perreault, David V. Erbe, Heike I. Krupka	2008	120
16	BeF\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}\begin{equation}{\mathrm{_{3}^{-}}}\end{equation}\end{document} acts as a phosphate analog in proteins phosphorylated on aspartate: Structure of a BeF\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}\begin{equation}{\mathrm{_{3}^{-}}}\end{equation}\end{document} complex with phosphoserine phosphatase Proceedings of the National Academy of Sciences ·Ho Cho, Weiru Wang, Rosalind Kim, Hisao A. Yokota, Steven M. Damo, Sung‐Hou Kim, David E. Wemmer, Sydney Govons Kustu	2001	118
17	Regulation of the oncoprotein Smoothened by small molecules Nature Chemical Biology ·Hayley J. Sharpe, Weiru Wang, Rami N. Hannoush, Frédéric J. de Sauvage	2015	104
18	Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin Scientific Reports ·Mark H. Ultsch, Till Maurer, Mary A. Mathieu, Oskar Adolfsson, Andreas Muhs, Andrea Pfeifer, Maria Pihlgren, Travis W. Bainbridge	2016	103
19	Inhibitors of p21-Activated Kinases (PAKs) Journal of Medicinal Chemistry ·Joachim Rudolph, James J. Crawford, Klaus P. Hoeflich, Weiru Wang	2014	101
20	Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-Å resolution Proceedings of the National Academy of Sciences ·Xinlin Du, In‐Geol Choi, Rosalind Kim, Weiru Wang, Jaru Jancarik, Hisao A. Yokota, Sung‐Hou Kim	2000	96

About Weiru Wang

Weiru Wang is a scholar working on Geriatrics and Gerontology, Molecular Biology, Organic Chemistry, Computational Theory and Mathematics and Materials Chemistry, having authored 93 papers that have together received 8.2k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (18 papers), Synthesis and biological activity (16 papers), Enzyme Structure and Function (12 papers), Sirtuins and Resveratrol in Medicine (12 papers), Computational Drug Discovery Methods (11 papers), Melanoma and MAPK Pathways (9 papers), Biochemical and Molecular Research (7 papers) and Alzheimer's disease research and treatments (5 papers). The work is most often cited by research in Geriatrics and Gerontology (279 citations), Molecular Biology (4.1k citations), Cancer Research (607 citations), Computational Theory and Mathematics (694 citations) and Oncology (744 citations). Weiru Wang has collaborated with scholars based in United States, China and United Kingdom. Frequent co-authors include Sung‐Hou Kim, Rosalind Kim, Joachim Rudolph, Hisao A. Yokota, Jaru Jancarik, Rami N. Hannoush, Lingyan Jin, Guowei Fang, G. Fang and Kyeong Kyu Kim. Their work appears in journals such as Journal of Medicinal Chemistry, Proceedings of the National Academy of Sciences, Bioorganic & Medicinal Chemistry Letters, ACS Medicinal Chemistry Letters and Structure.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Weiru Wang

Weiru Wang's Hit Papers

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Fields of papers citing papers by Weiru Wang

All Works

About Weiru Wang

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