Tom D. Heightman

10.2k citations

56 papers · 4.2k · 2 hit papers · h-index 30

Impact in

Organic Chemistry top 1%
- Carbohydrate Chemistry and Synthesis
Biotechnology top 1%
- Enzyme Production and Characterization

Papers in

Organic Chemistry 22
- Click Chemistry and Applications 7
- Carbohydrate Chemistry and Synthesis 7
Molecular Biology 45
- Protein Degradation and Inhibitors 14
- Histone Deacetylase Inhibitors Research 12
- Epigenetics and DNA Methylation 11
- Ubiquitin and proteasome pathways 5
- Cancer-related gene regulation 5

Co-authors: Andrea T. Vasella (7 shared papers)Christopher N. Johnson (3 shared papers)Honorine Lebraud (7 shared papers)David J. Wright (2 shared papers)Martin Philpott (6 shared papers)O. Fedorov (6 shared papers)Stefan Knapp (6 shared papers)Anthony Tumber (6 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (5 papers)Angewandte Chemie International Edition (4 papers)Journal of Medicinal Chemistry (4 papers)Helvetica Chimica Acta (3 papers)Chemical Science (3 papers)
Partner nations: United Kingdom United States Switzerland

In The Last Decade

Tom D. Heightman

56 papers receiving 4.1k citations

Tom D. Heightman's Hit Papers

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Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras 2016 · 345 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2016 ACS Central Science
1999 Angewandte Chemie International Edition

Peers

Countries citing papers authored by Tom D. Heightman

Since Specialization

Citations

This map shows the geographic impact of Tom D. Heightman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tom D. Heightman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tom D. Heightman more than expected).

Fields of papers citing papers by Tom D. Heightman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tom D. Heightman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tom D. Heightman. The network helps show where Tom D. Heightman may publish in the future.

Co-authors

The 25 scholars most cited alongside Tom D. Heightman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Tom D. Heightman Line = papers co-authored together Tom D. Heightman links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 56 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Recent Insights into Inhibition, Structure, and Mechanism of Configuration-Retaining Glycosidases Angewandte Chemie International Edition ·Tom D. Heightman, Andrea T. Vasella Hit paper breakdown →	1999	516
2	Recent Insights into Inhibition, Structure, and Mechanism of Configuration-Retaining Glycosidases Angewandte Chemie International Edition ·Tom D. Heightman, Andrea T. Vasella	1999	494
3	Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras ACS Central Science ·Honorine Lebraud, David J. Wright, Christopher N. Johnson, Tom D. Heightman Hit paper breakdown →	2016	345
4	BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones Nature Structural & Molecular Biology ·Tomohiko Kanno, Yuka Kanno, Gary LeRoy, Eric I. Campos, Hong‐Wei Sun, Stephen R. Brooks, Golnaz Vahedi, Tom D. Heightman, Benjamin Aaron Garcia, Danny Reinberg, Ulrich K. Siebenlist, John J. O’Shea, Keiko Ozato	2014	243
5	A Structural View of the Action ofEscherichia coli(lacZ) β-Galactosidase, Biochemistry ·D.H. Juers, Tom D. Heightman, Andrea T. Vasella, John D. McCarter, Lloyd F. Mackenzie, Stephen G. Withers, Brian W. Matthews	2001	200
6	3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands Journal of Medicinal Chemistry ·David S. Hewings, Minghua Wang, Martin Philpott, O. Fedorov, Sagar Uttarkar, P. Filippakopoulos, S. Picaud, Chaitanya Vuppusetty, Brian D. Marsden, Stefan Knapp, Stuart J. Conway, Tom D. Heightman	2011	189
7	Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors PLoS ONE ·Oliver N. F. King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R. Rose, Stanley S. Ng, Amy M. Quinn, Ganesha Rai, Bryan T. Mott, Paul Beswick, Robert J. Klose, Udo Oppermann, Ajit Jadhav, Tom D. Heightman, David J. Maloney, Christopher John Schofield, Anton Simeonov	2010	189
8	High-resolution native and complex structures of thermostable β-mannanase from Thermomonospora fusca – substrate specificity in glycosyl hydrolase family 5 Structure ·M. Hilge, Sergio M. Gloor, Wojciech R. Rypniewski, Oliver Sauer, Tom D. Heightman, Wolfgang Zimmermann, Kaspar H. Winterhalter, Klaus Piontek	1998	154
9	BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes Molecular and Cellular Biology ·Mira C. Patel, Maxime Debrosse, Matthew D. Smith, Anup Dey, Walter Huynh, Naoyuki Sarai, Tom D. Heightman, Tomohiko Tamura, Keiko Ozato	2013	142
10	A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases Journal of the American Chemical Society ·Xuelai Luo, Yongxiang Liu, Stefan Kubicek, Johanna Myllyharju, Anthony Tumber, Stanley S. Ng, Ka Hing Che, Jessica D. Podoll, Tom D. Heightman, Udo Oppermann, Stuart L. Schreiber, Xiang Wang	2011	131
11	Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery Molecular BioSystems ·Martin Philpott, Jing Yang, Tony Tumber, O. Fedorov, Sagar Uttarkar, P. Filippakopoulos, S. Picaud, Tracy Keates, Ildikó Felletár, Alessio Ciulli, Stefan Knapp, Tom D. Heightman	2011	114
12	A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced‐Fit Pocket Stabilized by a Cation–π Interaction Angewandte Chemie International Edition ·Timothy P. C. Rooney, P. Filippakopoulos, O. Fedorov, S. Picaud, Wilian Augusto Cortopassi, Duncan A. Hay, Sarah Martin, Anthony Tumber, Catherine M. Rogers, Martin Philpott, Minghua Wang, Amber L. Thompson, Tom D. Heightman, David C. Pryde, Andrew S. Cook, Robert S. Paton, Susanne Müller, Stefan Knapp, Paul E. Brennan, Stuart J. Conway	2014	98
13	Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines Chemical Science ·Rachel Grainger, Tom D. Heightman, Steven V. Ley, Fabio Menezes de Souza Lima, Christopher N. Johnson	2018	94
14	Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors ACS Medicinal Chemistry Letters ·John A. Spencer, Jahangir Amin, Minghua Wang, Graham Packham, Sharifah Sakinah Syed Alwi, Graham J. Tizzard, Simon John Coles, Ronald M. Paranal, James E. Bradner, Tom D. Heightman	2011	87
15	Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain Journal of Medicinal Chemistry ·Fleur M. Ferguson, O. Fedorov, A. Chaikuad, Martin Philpott, J.R.C. Muniz, Ildikó Felletár, F. von Delft, Tom D. Heightman, Stefan Knapp, Chris Abell, Alessio Ciulli	2013	79
16	Inhibition of Histone Demethylases by 4‐Carboxy‐2,2′‐Bipyridyl Compounds ChemMedChem ·Kai‐Hsuan Chang, Oliver N. F. King, Anthony Tumber, Esther C. Y. Woon, Tom D. Heightman, M.A. McDonough, Christopher John Schofield, Nathan R. Rose	2011	65
17	Neue Erkenntnisse über Hemmung, Struktur und Mechanismus konfigurationserhaltender Glycosidasen Angewandte Chemie ·Tom D. Heightman, Andrea T. Vasella	1999	62
18	Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP) Journal of Medicinal Chemistry ·Emiliano Tamanini, Ildiko M. Buck, Gianni Chessari, Elisabetta Chiarparin, James E. H. Day, Martyn Frederickson, Charlotte Griffiths-Jones, Keisha Hearn, Tom D. Heightman, Aman Iqbal, Christopher N. Johnson, Edward J. Lewis, Vanessa Martins, Torren M. Peakman, Michael Reader, Sharna J. Rich, George A. Ward, Pamela A. Williams, Nicola E. Wilsher	2017	59
19	The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains MedChemComm ·Duncan A. Hay, O. Fedorov, P. Filippakopoulos, Sarah Martin, Martin Philpott, S. Picaud, David S. Hewings, Sagar Uttakar, Tom D. Heightman, Stuart J. Conway, Stefan Knapp, Paul E. Brennan	2012	57
20	Fragment-based drug discovery: opportunities for organic synthesis RSC Medicinal Chemistry ·Jeffrey D. St. Denis, Richard J. Hall, Christopher W. Murray, Tom D. Heightman, David C. Rees	2020	57

About Tom D. Heightman

Tom D. Heightman is a scholar working on Organic Chemistry, Molecular Biology, Hematology, Endocrine and Autonomic Systems and Biotechnology, having authored 56 papers that have together received 4.2k indexed citations. Recurring topics across this work include Protein Degradation and Inhibitors (14 papers), Histone Deacetylase Inhibitors Research (12 papers), Epigenetics and DNA Methylation (11 papers), Multiple Myeloma Research and Treatments (8 papers), Click Chemistry and Applications (7 papers), Carbohydrate Chemistry and Synthesis (7 papers), Ubiquitin and proteasome pathways (5 papers) and Cancer-related gene regulation (5 papers). The work is most often cited by research in Organic Chemistry (1.7k citations), Biotechnology (457 citations), Molecular Biology (3.1k citations), Hematology (431 citations) and Oncology (428 citations). Tom D. Heightman has collaborated with scholars based in United Kingdom, United States and Switzerland. Frequent co-authors include Andrea T. Vasella, Christopher N. Johnson, Honorine Lebraud, David J. Wright, Martin Philpott, O. Fedorov, Stefan Knapp, Anthony Tumber, S. Picaud and Minghua Wang. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Angewandte Chemie International Edition, Journal of Medicinal Chemistry, Helvetica Chimica Acta and Chemical Science.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Tom D. Heightman

Tom D. Heightman's Hit Papers

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