Stuart W. McCombie

5.2k citations

89 papers · 4.1k · 1 hit paper · h-index 27

Impact in

Virology top 1%
- HIV Research and Treatment
Organic Chemistry top 0.5%
- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques

Papers in

Organic Chemistry 56
- Synthetic Organic Chemistry Methods 12
- Synthesis of β-Lactam Compounds 11
- Asymmetric Synthesis and Catalysis 9
- Carbohydrate Chemistry and Synthesis 8
- Chemical Synthesis and Reactions 8
Molecular Biology 38
- Chemical Synthesis and Analysis 9

Co-authors: Derek H. R. Barton (2 shared papers)Jayaram R. Tagat (20 shared papers)Kevin M. Smith (9 shared papers)Bahige M. Baroudy (8 shared papers)G. W. Kenner (7 shared papers)A.K. Ganguly (17 shared papers)Julie Strizki (6 shared papers)John W. Clader (7 shared papers)
Journals: Tetrahedron Letters (25 papers)Bioorganic & Medicinal Chemistry Letters (16 papers)Journal of the Chemical Society Perkin Transactions 1 (7 papers)The Journal of Organic Chemistry (6 papers)Tetrahedron (4 papers)
Partner nations: United States United Kingdom Switzerland

In The Last Decade

Stuart W. McCombie

88 papers receiving 3.7k citations

Stuart W. McCombie's Hit Papers

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A new method for the deoxygenation of secondary alcohols 1975 · 1.5k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1975 Journal of the Chemical Society Perkin Transactions 1

Peers

Countries citing papers authored by Stuart W. McCombie

Since Specialization

Citations

This map shows the geographic impact of Stuart W. McCombie's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stuart W. McCombie with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stuart W. McCombie more than expected).

Fields of papers citing papers by Stuart W. McCombie

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stuart W. McCombie. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stuart W. McCombie. The network helps show where Stuart W. McCombie may publish in the future.

Co-authors

The 25 scholars most cited alongside Stuart W. McCombie, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Stuart W. McCombie Line = papers co-authored together Stuart W. McCombie links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	A new method for the deoxygenation of secondary alcohols Journal of the Chemical Society Perkin Transactions 1 ·Derek H. R. Barton, Stuart W. McCombie Hit paper breakdown →	1975	1472
2	HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use Proceedings of the National Academy of Sciences ·Alexandra Trkola, Shawn E. Kuhmann, Julie Strizki, Elizabeth S. Maxwell, Tom Ketas, Tom Morgan, Pavel Pugach, Serena Xu, Lisa Wojcik, Jayaram R. Tagat, Anandan Palani, Sherry Shapiro, John W. Clader, Stuart W. McCombie, Gregory R. Reyes, Bahige M. Baroudy, John P. Moore	2002	264
3	Homogeneous, palladium(0)-catalyzed exchange deprotection of allylic esters, carbonates and carbamates The Journal of Organic Chemistry ·Paul D. Jeffrey, Stuart W. McCombie	1982	215
4	Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry Journal of Virology ·Fotini Tsamis, Svetlana Gavrilov, Francis Kajumo, Christoph Seibert, Shawn E. Kuhmann, Tom Ketas, Alexandra Trkola, Anadan Palani, John W. Clader, Jayaram R. Tagat, Stuart W. McCombie, Bahige M. Baroudy, John P. Moore, Thomas P. Sakmar, Tatjana Dragic	2003	180
5	Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-{2-methoxy-1(R)-4-(trifluoromethyl)phenyl}ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a Potent, Highly Selective, and Orally Bioavailable CCR5 Antagonist Journal of Medicinal Chemistry ·Jayaram R. Tagat, Stuart W. McCombie, Dennis V. Nazareno, Marc Labroli, Yushi Xiao, Ruo W. Steensma, Julie Strizki, Bahige M. Baroudy, Kathleen Cox, Jean E. Lachowicz, Geoffrey B. Varty, Robert W. Watkins	2004	118
6	Interaction of small molecule inhibitors of HIV-1 entry with CCR5 Virology ·Christoph Seibert, Weiwen Ying, Svetlana Gavrilov, Fotini Tsamis, Shawn E. Kuhmann, Anandan Palani, Jayaram R. Tagat, John W. Clader, Stuart W. McCombie, Bahige M. Baroudy, Steven O. Smith, Tatjana Dragic, John P. Moore, Thomas P. Sakmar	2006	101
7	Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2,4-Dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoro- methyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-Oxide (Sch-350634), an Orally Bioavailable, Potent CCR5 Antagonist Journal of Medicinal Chemistry ·Jayaram R. Tagat, Ruo W. Steensma, Stuart W. McCombie, Dennis V. Nazareno, Sue‐Ing Lin, Bernard R. Neustadt, Kathleen Cox, Serena Xu, Lisa Wojcik, Michael G. Murray, Nicole Vantuno, Bahige M. Baroudy, Julie Strizki	2001	93
8	Pyrroles and related compounds. Part XXIV. Separation and oxidative degradation of chlorophyll derivatives Journal of the Chemical Society Perkin Transactions 1 ·G. W. Kenner, Stuart W. McCombie, Kevin M. Smith	1973	83
9	Inhibition of the development of collagen‐induced arthritis in rhesus monkeys by a small molecular weight antagonist of CCR5 Arthritis & Rheumatism ·Michel Vierboom, Paul J. Zavodny, Chuan‐Chu Chou, Jayaram R. Tagat, Catherine Pugliese‐Sivo, Julie Strizki, Ruo W. Steensma, Stuart W. McCombie, (unknown), Ed Remarque, Margreet Jonker, Satwant K. Narula, Bert’t Hart	2005	78
10	Piperazine-Based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element Bioorganic & Medicinal Chemistry Letters ·Jayaram R. Tagat, Stuart W. McCombie, Ruo W. Steensma, Sue‐Ing Lin, Dennis V. Nazareno, Bahige M. Baroudy, Nicole Vantuno, Serena Xu, Jia Liu	2001	53
11	Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides Bioorganic & Medicinal Chemistry Letters ·Stuart W. McCombie, Jayaram R. Tagat, Susan F. Vice, Sue‐Ing Lin, Ruo W. Steensma, Anandan Palani, Bernard R. Neustadt, Bahige M. Baroudy, Julie Strizki, M. Endres, Kathleen Cox, Niya Dan, Chuan‐Chu Chou	2003	46
12	Interaction of vicinal and nonvicinal amino-hydroxy group pairs in aminoglycoside-aminocyclitol antibiotics with transition metal cations. Selective N protection Journal of the American Chemical Society ·T. L. NAGABHUSHAN, Alan Cooper, William N. Turner, H. Tsai, Stuart W. McCombie, Alan K. Mallams, D. F. Rane, John J. Wright, Paul Reichert	1978	44
13	Concise Formation of 4-Benzyl Piperidines and Related Derivatives Using a Suzuki Protocol The Journal of Organic Chemistry ·Susan F. Vice, Tom Bara, Annette Bauer, Colleen A. Evans, Jennifer Lynn Ford, Hubert Josien, Stuart W. McCombie, Michael A. Miller, Dennis V. Nazareno, Anandan Palani, J. R. TAGAT	2001	42
14	Controlling benzylic functionality and stereochemistry: 1. Synthesis of the secopseudopterosin aglycone Tetrahedron Letters ·Stuart W. McCombie, Brian Cox, Sue‐Ing Lin, Ashit K. Ganguly, Andrew T. McPhail	1991	42
15	One-pot, three-component synthesis of arylidenesuccinates and related compounds Tetrahedron Letters ·Stuart W. McCombie, C. A. LUCHACO	1997	41
16	Synthesis of an optically pure 3-unsubstituted β-lactam using an asymmetric Reformatsky reaction and its conversion to cholesterol absorption inhibitors Tetrahedron Letters ·B. B. SHANKAR, Michael P. Kirkup, Stuart W. McCombie, J. W. CLADER, A.K. Ganguly	1996	38
17	Cyclofunctionalisation reactions of epoxyalcohol derivatives. 3. cyclisationacyl migration of n-benzoylcarbamates to stereodefined oxazolidinones. A new, diastereospecific route to thiamphenicol. Tetrahedron Letters ·Stuart W. McCombie, T. L. NAGABHUSHAN	1987	37
18	Synthesis of oxophlorins (oxyporphyrins) from magnesium and zinc porphyrin chelates Journal of the Chemical Society Perkin Transactions 1 ·Graham H. Barnett, Mervyn F. Hudson, Stuart W. McCombie, Kevin M. Smith	1973	36
19	Mild N-dealkylation of tertiary, benzylic amines with acid chlorides: Application to solid-phase chemistry Tetrahedron Letters ·Michael W. Miller, Susan F. Vice, Stuart W. McCombie	1998	35
20	Reflections on the mechanism of the Barton-McCombie Deoxygenation and on its consequences† Tetrahedron ·Stuart W. McCombie, Béatrice Quiclet‐Sire, Samir Z. Zard	2018	35

About Stuart W. McCombie

Stuart W. McCombie is a scholar working on Organic Chemistry, Molecular Biology, Pharmacology, Inorganic Chemistry and Materials Chemistry, having authored 89 papers that have together received 4.1k indexed citations. Recurring topics across this work include Synthetic Organic Chemistry Methods (12 papers), Synthesis of β-Lactam Compounds (11 papers), Porphyrin and Phthalocyanine Chemistry (9 papers), Asymmetric Synthesis and Catalysis (9 papers), Chemical Synthesis and Analysis (9 papers), Carbohydrate Chemistry and Synthesis (8 papers), Chemical Synthesis and Reactions (8 papers) and HIV Research and Treatment (8 papers). The work is most often cited by research in Virology (623 citations), Organic Chemistry (2.4k citations), Biotechnology (270 citations), Toxicology (101 citations) and Infectious Diseases (474 citations). Stuart W. McCombie has collaborated with scholars based in United States, United Kingdom and Switzerland. Frequent co-authors include Derek H. R. Barton, Jayaram R. Tagat, Kevin M. Smith, Bahige M. Baroudy, G. W. Kenner, A.K. Ganguly, Julie Strizki, John W. Clader, Ashit K. Ganguly and Dennis V. Nazareno. Their work appears in journals such as Tetrahedron Letters, Bioorganic & Medicinal Chemistry Letters, Journal of the Chemical Society Perkin Transactions 1, The Journal of Organic Chemistry and Tetrahedron.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Stuart W. McCombie

Stuart W. McCombie's Hit Papers

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About Stuart W. McCombie

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