Simon Scharpé

14.3k citations

196 papers · 12.5k · 2 hit papers · h-index 60

Impact in

Biological Psychiatry top 0.02%
- Tryptophan and brain disorders
Behavioral Neuroscience top 0.1%
- Stress Responses and Cortisol

Papers in

Biological Psychiatry 40
- Tryptophan and brain disorders 40
Oncology 87
- Peptidase Inhibition and Analysis 78

Co-authors: Ingrid De Meester (71 shared papers)Michael H. J. Maes (75 shared papers)Anne‐Marie Lambeir (34 shared papers)Robert M. Verkerk (33 shared papers)Christine Durinx (11 shared papers)Eugène Bosmans (16 shared papers)Hugo M. Neels (33 shared papers)Paul Cosyns (24 shared papers)
Journals: Psychiatry Research (11 papers)Clinica Chimica Acta (11 papers)Journal of Affective Disorders (11 papers)Clinical Chemistry (8 papers)Biological Psychiatry (7 papers)
Partner nations: Belgium United States Netherlands

In The Last Decade

Simon Scharpé

194 papers receiving 11.9k citations

Simon Scharpé's Hit Papers

align trajectories log scale

Dipeptidyl-Peptidase IV from Bench to Bedside: An Update on Structural Properties, Functions, and Clinical Aspects of the Enzyme DPP IV 2003 · 842 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2003 Critical Reviews in Clinical Laboratory Sciences
1998 Cytokine

Peers

Countries citing papers authored by Simon Scharpé

Since Specialization

Citations

This map shows the geographic impact of Simon Scharpé's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Simon Scharpé with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Simon Scharpé more than expected).

Fields of papers citing papers by Simon Scharpé

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Simon Scharpé. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Simon Scharpé. The network helps show where Simon Scharpé may publish in the future.

Co-authors

The 25 scholars most cited alongside Simon Scharpé, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Simon Scharpé Line = papers co-authored together Simon Scharpé links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 196 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Dipeptidyl-Peptidase IV from Bench to Bedside: An Update on Structural Properties, Functions, and Clinical Aspects of the Enzyme DPP IV Critical Reviews in Clinical Laboratory Sciences ·Anne‐Marie Lambeir, Christine Durinx, Simon Scharpé, Ingrid De Meester Hit paper breakdown →	2003	842
2	THE EFFECTS OF PSYCHOLOGICAL STRESS ON HUMANS: INCREASED PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND Th1-LIKE RESPONSE IN STRESS-INDUCED ANXIETY Cytokine ·Michael H. J. Maes, Cai Song, Aihua Lin, Raf De Jongh, An Van Gastel, Günter Kenis, Eugène Bosmans, Ingrid De Meester, Ina H. Benoy, Hugo M. Neels, Paul Demedts, Aleksandar Janča, Simon Scharpé, Ronald S. Smith Hit paper breakdown →	1998	663
3	Kynurenine pathway in major depression: Evidence of impaired neuroprotection Journal of Affective Disorders ·Aye-Mu Myint, Yong Ku Kim, Robert M. Verkerk, Simon Scharpé, Harry M. W. Steinbusch, Brian E. Leonard	2006	458
4	CD26, let it cut or cut it down Immunology Today ·Ingrid De Meester, Stephan Korom, Jo Van Damme, Simon Scharpé	1999	404
5	IDO and interferon-α-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity Molecular Psychiatry ·Marieke Wichers, Ger H. Koek, Geert Robaeys, Robert M. Verkerk, Simon Scharpé, Michael H. J. Maes	2004	394
6	Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression Psychiatry Research ·Michael H. J. Maes, Simon Scharpé, Herbert Y. Meltzer, Eugène Bosmans, Eduard Suy, Joseph R. Calabrese, Paul Cosyns	1993	382
7	Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs Psychiatry Research ·Michael H. J. Maes, Joris Delange, Rakesch Ranjan, Herbert Y. Meltzer, Roger Desnyder, Walter Cooremans, Simon Scharpé	1997	304
8	The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6 Schizophrenia Research ·Aihua Lin, Günter Kenis, Stefano Bignotti, Giani Jean Battisa Tura, Raf De Jong, E. Bosmans, Rosaria Pioli, Carlo Alfredo Altamura, Simon Scharpé, Michael H. J. Maes	1998	290
9	Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: Further evidence for an immune response Psychiatry Research ·Michael H. J. Maes, Simon Scharpé, Herbert Y. Meltzer, Ghadeer Okayli, Eugène Bosmans, Peter D'Hondt, Bart Vanden Bossche, Paul Cosyns	1994	266
10	Kinetic Investigation of Chemokine Truncation by CD26/Dipeptidyl Peptidase IV Reveals a Striking Selectivity within the Chemokine Family Journal of Biological Chemistry ·Anne‐Marie Lambeir, Paul Proost, Christine Durinx, Gunther Bal, Kristel Senten, Koen Augustyns, Simon Scharpé, Jo Van Damme, Ingrid De Meester	2001	243
11	Molecular characterization of dipeptidyl peptidase activity in serum European Journal of Biochemistry ·Christine Durinx, Anne‐Marie Lambeir, Eugène Bosmans, Jean‐Bernard Falmagne, Raf Berghmans, Achiel Haemers, Simon Scharpé, Ingrid De Meester	2000	240
12	Amino-terminal Truncation of Chemokines by CD26/Dipeptidyl-peptidase IV Journal of Biological Chemistry ·Paul Proost, Ingrid De Meester, Dominique Schols, Sofie Struyf, Anne‐Marie Lambeir, Anja Wuyts, Ghislain Opdenakker, Erik De Clercq, Simon Scharpé, Jo Van Damme	1998	234
13	The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression Journal of Affective Disorders ·Cai Song, Aihua Lin, Stefania Bonaccorso, Carine Heide, Robert M. Verkerk, Günter Kenis, Eugène Bosmans, Simon Scharpé, Alex Whelan, Paul Cosyns, Raf De Jongh, Michael H. J. Maes	1998	213
14	Components of biological variation, including seasonality, in blood concentrations of TSH, TT3, FT4, PRL, cortisol and testosterone in healthy volunteers Clinical Endocrinology ·Michael H. J. Maes, K. Mommen, Diana M. Hendrickx, Dirk Peeters, Peter D'Hondt, Rakesch Ranjan, Frans De Meyer, Simon Scharpé	1997	204
15	Hypozincemia in depression Journal of Affective Disorders ·Michael H. J. Maes, Patrick C. D’Haese, Simon Scharpé, Peter D'Hondt, Paul Cosyns, Marc E. De Broe	1994	191
16	Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation Life Sciences ·Michael H. J. Maes, Robert M. Verkerk, S. Bonaccorso, Willem Ombelet, Eugène Bosmans, Simon Scharpé	2002	183
17	Increased 24‐hour urinary cortisol excretion in patients with post‐traumatic stress disorder and patients with major depression, but not h patients with fibromyalgia Acta Psychiatrica Scandinavica ·Michael H. J. Maes, Ai Lin, S. Bonacccorso, Fran Van Hunsel, Ann Van Gastel, Laure Delmeire, Massimo Biondi, E. Bosmans, Günter Kenis, Simon Scharpé	1998	179
18	Fluoro-Olefins as Peptidomimetic Inhibitors of Dipeptidyl Peptidases Journal of Medicinal Chemistry ·Pieter Van der Veken, Kristel Senten, István Kertész, Ingrid De Meester, Anne‐Marie Lambeir, Marie-Berthe Maes, Simon Scharpé, Achiel Haemers, Koen Augustyns	2004	160
19	Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment‐resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity Acta Psychiatrica Scandinavica ·Michael H. J. Maes, Robert M. Verkerk, Eric Vandoolaeghe, Aihua Lin, Simon Scharpé	1998	153
20	Therapeutic drug monitoring of old and newer anti-epileptic drugs Clinical Chemistry and Laboratory Medicine (CCLM) ·Hugo M. Neels, Ann C. Sierens, Kristine Naelaerts, Simon Scharpé, George M. Hatfield, Willy E. Lambert	2004	151

About Simon Scharpé

Simon Scharpé is a scholar working on Biological Psychiatry, Oncology, Behavioral Neuroscience, Cellular and Molecular Neuroscience and Endocrinology, Diabetes and Metabolism, having authored 196 papers that have together received 12.5k indexed citations. Recurring topics across this work include Peptidase Inhibition and Analysis (78 papers), Neuropeptides and Animal Physiology (53 papers), Tryptophan and brain disorders (40 papers), Stress Responses and Cortisol (34 papers), Diabetes Treatment and Management (26 papers), Bipolar Disorder and Treatment (10 papers), Adenosine and Purinergic Signaling (9 papers) and Signaling Pathways in Disease (7 papers). The work is most often cited by research in Biological Psychiatry (3.3k citations), Behavioral Neuroscience (2.2k citations), Oncology (3.6k citations), Cellular and Molecular Neuroscience (2.1k citations) and Endocrinology, Diabetes and Metabolism (1.6k citations). Simon Scharpé has collaborated with scholars based in Belgium, United States and Netherlands. Frequent co-authors include Ingrid De Meester, Michael H. J. Maes, Anne‐Marie Lambeir, Robert M. Verkerk, Christine Durinx, Eugène Bosmans, Hugo M. Neels, Paul Cosyns, Herbert Y. Meltzer and Peter D'Hondt. Their work appears in journals such as Psychiatry Research, Clinica Chimica Acta, Journal of Affective Disorders, Clinical Chemistry and Biological Psychiatry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Simon Scharpé

Simon Scharpé's Hit Papers

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