Simon J. Cook

13.6k citations

136 papers · 11.3k · 4 hit papers · h-index 56

Impact in

Molecular Biology top 0.5%
- Protein Kinase Regulation and GTPase Signaling
- Melanoma and MAPK Pathways
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
Cell Biology top 0.5%

Papers in

Molecular Biology 107
- Melanoma and MAPK Pathways 46
- Protein Kinase Regulation and GTPase Signaling 39
- Cell death mechanisms and regulation 25
- Ubiquitin and proteasome pathways 12
- PI3K/AKT/mTOR signaling in cancer 12
- Epigenetics and DNA Methylation 7
Oncology 33
- Cytokine Signaling Pathways and Interactions 15
- Cancer-related Molecular Pathways 10

Co-authors: Kathryn Balmanno (34 shared papers)Frank McCormick (6 shared papers)H. Llewelyn Roderick (2 shared papers)Michael J.O. Wakelam (13 shared papers)Kathryn Hadfield (7 shared papers)Matthew J. Sale (14 shared papers)Paul D. Smith (9 shared papers)Nicola J. Darling (2 shared papers)
Journals: Biochemical Journal (16 papers)Journal of Biological Chemistry (13 papers)Cellular Signalling (12 papers)Biochemical Society Transactions (10 papers)Oncogene (9 papers)
Partner nations: United Kingdom United States Germany

In The Last Decade

Simon J. Cook

131 papers receiving 11.1k citations

Simon J. Cook's Hit Papers

align trajectories log scale

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road 2015 · 449 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Nature reviews. Cancer
2008 Nature reviews. Cancer
2003 Journal of Biological Chemistry
1993 Science

Peers

Countries citing papers authored by Simon J. Cook

Since Specialization

Citations

This map shows the geographic impact of Simon J. Cook's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Simon J. Cook with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Simon J. Cook more than expected).

Fields of papers citing papers by Simon J. Cook

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Simon J. Cook. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Simon J. Cook. The network helps show where Simon J. Cook may publish in the future.

Co-authors

The 25 scholars most cited alongside Simon J. Cook, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Simon J. Cook Line = papers co-authored together Simon J. Cook links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 136 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Inhibition by cAMP of Ras-Dependent Activation of Raf Science ·Simon J. Cook, Frank McCormick Hit paper breakdown →	1993	870
2	Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival Nature reviews. Cancer ·H. Llewelyn Roderick, Simon J. Cook Hit paper breakdown →	2008	612
3	Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim Journal of Biological Chemistry ·Rebecca Ley, Kathryn Balmanno, Kathryn Hadfield, Claire R. Weston, Simon J. Cook Hit paper breakdown →	2003	527
4	Characterization of Two Alternately Spliced Forms of Phospholipase D1 Journal of Biological Chemistry ·Scott M. Hammond, John M. Jenco, Shigeru Nakashima, Karen A. Cadwallader, Qu-Ming Gu, Simon J. Cook, Yoshinori Nozawa, Glenn D. Prestwich, Michael A. Frohman, Andrew J. Morris	1997	483
5	MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road Nature reviews. Cancer ·Christopher J. Caunt, Matthew J. Sale, Paul D. Smith, Simon J. Cook Hit paper breakdown →	2015	449
6	Tumour cell survival signalling by the ERK1/2 pathway Cell Death and Differentiation ·Kathryn Balmanno, Simon J. Cook	2008	426
7	The role of MAPK signalling pathways in the response to endoplasmic reticulum stress Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Nicola J. Darling, Simon J. Cook	2014	337
8	RapV12 antagonizes Ras‐dependent activation of ERK1 and ERK2 by LPA and EGF in Rat‐1 fibroblasts. The EMBO Journal ·Simon J. Cook, Bonnee Rubinfeld, Iris Albert, Frank McCormick	1993	327
9	FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency Cell stem cell ·Gabriella Ficz, Timothy A. Hore, Fátima Santos, Heather Lee, Wendy Dean, Julia Arand, Felix Krueger, David Oxley, Yu‐Lee Paul, Jörn Walter, Simon J. Cook, Simon Andrews, Miguel R. Branco, Wolf Reik	2013	312
10	Regulatory phosphorylation of Bim: sorting out the ERK from the JNK Cell Death and Differentiation ·Rebecca Ley, Katherine Ewings, Kathryn Hadfield, Simon J. Cook	2005	257
11	Paclitaxel-Induced Nuclear Translocation of FOXO3a in Breast Cancer Cells Is Mediated by c-Jun NH2-Terminal Kinase and Akt Cancer Research ·Andrew Sunters, Patrícia A. Madureira, Karen M. Pomeranz, Muriel Aubert, Jan J. Brosens, Simon J. Cook, Boudewijn Burgering, R. Charles Coombes, Eric W.‐F. Lam	2006	223
12	Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells Oncogene ·Kathryn Balmanno, Simon J. Cook	1999	199
13	Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism Biochemical Journal ·Simon J. Cook, Michael J.O. Wakelam	1989	181
14	Extracellular Signal-regulated Kinases 1/2 Are Serum-stimulated “BimEL Kinases” That Bind to the BH3-only Protein BimEL Causing Its Phosphorylation and Turnover Journal of Biological Chemistry ·Rebecca Ley, Katherine Ewings, Kathryn Hadfield, E. A. Howes, Kathryn Balmanno, Simon J. Cook	2004	174
15	The Selective Protein Kinase C Inhibitor, Ro-31-8220, Inhibits Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression, Induces c-Jun Expression, and Activates Jun N-terminal Kinase Journal of Biological Chemistry ·Jerlyn Beltman, Frank McCormick, Simon J. Cook	1996	169
16	Amplification of the Driving Oncogene, KRAS or BRAF , Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells Science Signaling ·Annette S. Little, Kathryn Balmanno, Matthew J. Sale, Scott Newman, Jonathan R. Dry, Mark Hampson, Paul A. Edwards, Paul D. Smith, Simon J. Cook	2011	168
17	The Repertoire of Fos and Jun Proteins Expressed during the G₁ Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation Molecular and Cellular Biology ·Simon J. Cook, Natasha Aziz, Martin McMahon	1999	168
18	FGF signalling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency Clinical Epigenetics ·Gabriella Ficz, Timothy A. Hore, Fátima Santos, Heather Lee, Wendy Dean, Julia Arand, Felix Krueger, David Oxley, Yu‐Lee Paul, Jörn Walter, Simon J. Cook, Simon Andrews, Miguel R. Branco, Wolf Reik	2013	155
19	Activation of ERK1/2 by ΔRaf-1 : ER* represses Bim expression independently of the JNK or PI3K pathways Oncogene ·Claire R. Weston, Kathryn Balmanno, Claire Chalmers, Kathryn Hadfield, Sarah A Molton, Rebecca Ley, Erwin F. Wagner, Simon J. Cook	2003	155
20	De-regulated FGF receptors as therapeutic targets in cancer Pharmacology & Therapeutics ·Victoria Knights, Simon J. Cook	2009	149

About Simon J. Cook

Simon J. Cook is a scholar working on Molecular Biology, Oncology, Cell Biology, Immunology and Physiology, having authored 136 papers that have together received 11.3k indexed citations. Recurring topics across this work include Melanoma and MAPK Pathways (46 papers), Protein Kinase Regulation and GTPase Signaling (39 papers), Cell death mechanisms and regulation (25 papers), Cytokine Signaling Pathways and Interactions (15 papers), Ubiquitin and proteasome pathways (12 papers), PI3K/AKT/mTOR signaling in cancer (12 papers), Cancer-related Molecular Pathways (10 papers) and Epigenetics and DNA Methylation (7 papers). The work is most often cited by research in Molecular Biology (8.1k citations), Cell Biology (1.4k citations), Oncology (2.0k citations), Cancer Research (987 citations) and Immunology (1.3k citations). Simon J. Cook has collaborated with scholars based in United Kingdom, United States and Germany. Frequent co-authors include Kathryn Balmanno, Frank McCormick, H. Llewelyn Roderick, Michael J.O. Wakelam, Kathryn Hadfield, Matthew J. Sale, Paul D. Smith, Nicola J. Darling, Katherine Ewings and Claire R. Weston. Their work appears in journals such as Biochemical Journal, Journal of Biological Chemistry, Cellular Signalling, Biochemical Society Transactions and Oncogene.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Simon J. Cook

Simon J. Cook's Hit Papers

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