Si Chen

4.9k citations

135 papers · 3.7k · 1 hit paper · h-index 35

Impact in

Cancer Research top 2%
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
Pharmacology top 1%
- Pharmacogenetics and Drug Metabolism

Papers in

Molecular Biology 75
- RNA Interference and Gene Delivery 12
- RNA modifications and cancer 9
Cancer Research 37
- Cancer-related molecular mechanisms research 18
- MicroRNA in disease regulation 16

Co-authors: Lei Guo (42 shared papers)Baitang Ning (17 shared papers)Lina Zhang (1 shared paper)Chunyu Chang (1 shared paper)William H. Tolleson (11 shared papers)Nan Mei (15 shared papers)Jiekun Xuan (4 shared papers)Dianke Yu (11 shared papers)
Journals: Biochemical Pharmacology (6 papers)Archives of Toxicology (6 papers)Scientific Reports (5 papers)Toxicological Sciences (5 papers)Chemico-Biological Interactions (3 papers)
Partner nations: China United States Germany

In The Last Decade

Si Chen

128 papers receiving 3.6k citations

Si Chen's Hit Papers

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Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion 2025 · 57 citations

Peers

Countries citing papers authored by Si Chen

Since Specialization

Citations

This map shows the geographic impact of Si Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Si Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Si Chen more than expected).

Fields of papers citing papers by Si Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Si Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Si Chen. The network helps show where Si Chen may publish in the future.

Co-authors

The 25 scholars most cited alongside Si Chen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Si Chen Line = papers co-authored together Si Chen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 135 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Novel hydrogels prepared via direct dissolution of chitin at low temperature: structure and biocompatibility Journal of Materials Chemistry ·Chunyu Chang, Si Chen, Lina Zhang	2011	206
2	Trimethylamine N‐Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease Molecular Nutrition & Food Research ·Xuying Tan, Yan Liu, Jing‐An Long, Si Chen, Gong‐Cheng Liao, Shangling Wu, Chunlei Li, Lijun Wang, Wenhua Ling, Huilian Zhu	2019	180
3	SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network Cancer Letters ·Xuefei Li, Yingxi Xu, Yanan Chen, Si Chen, Xianpei Jia, Tongchao Sun, Yanhua Liu, Xiru Li, Rong Xiang, Na Li	2013	164
4	Long non-coding RNA MEG3 inhibits adipogenesis and promotes osteogenesis of human adipose-derived mesenchymal stem cells via miR-140-5p Molecular and Cellular Biochemistry ·Zheng Li, Chanyuan Jin, Si Chen, Yunfei Zheng, Yiping Huang, Lingfei Jia, Wenshu Ge, Yongsheng Zhou	2017	105
5	Synergistic gene and drug tumor therapy using a chimeric peptide Biomaterials ·Kai Han, Si Chen, Wei‐Hai Chen, Qi Lei, Yun Liu, Ren‐Xi Zhuo, Xian‐Zheng Zhang	2013	104
6	Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure Scientific Reports ·Cheng-Li Ding, Zhifei Wu, Lei Huang, Yajie Wang, Jie Xue, Si Chen, Zixin Deng, Lianrong Wang, Zhiyin Song, Shi Chen	2015	101
7	Legumain: A biomarker for diagnosis and prognosis of human ovarian cancer Journal of Cellular Biochemistry ·Lina Wang, Si Chen, Mingna Zhang, Na Li, Yanan Chen, Weijun Su, Yanhua Liu, Dan Lü, Sanglin Li, Yixuan Yang, Zongjin Li, Dwayne G. Stupack, Pengpeng Qu, Huaidong Hu, Rong Xiang	2012	91
8	A surface charge-switchable and folate modified system for co-delivery of proapoptosis peptide and p53 plasmid in cancer therapy Biomaterials ·Si Chen, Lei Rong, Qi Lei, Pengxi Cao, Si‐Yong Qin, Diwei Zheng, Huizhen Jia, Jingyi Zhu, Si‐Xue Cheng, Ren‐Xi Zhuo, Xian‐Zheng Zhang	2015	88
9	Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity Chemico-Biological Interactions ·Jiekun Xuan, Si Chen, Baitang Ning, William H. Tolleson, Lei Guo	2015	87
10	TFAP2C promotes stemness and chemotherapeutic resistance in colorectal cancer via inactivating hippo signaling pathway Journal of Experimental & Clinical Cancer Research ·Xu Wang, Di Sun, Jiandong Tai, Si Chen, Miao Yu, Dong Ren, Lei Wang	2018	84
11	SOX2 regulates apoptosis through MAP4K4-Survivin signaling pathway in human lung cancer cells Carcinogenesis ·Si Chen, Xuefei Li, Dan Lü, Yingxi Xu, Wenjun Mou, Lina Wang, Yanan Chen, Yanhua Liu, Xiru Li, Luyuan Li, Lin Liu, Dwayne G. Stupack, Ralph A. Reisfeld, Rong Xiang, Na Li	2013	80
12	USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart Circulation ·Saiyang Xie, Shi‐qiang Liu, Tong Zhang, Wenke Shi, Yun Xing, Wenxi Fang, Min Zhang, Meng-Ya Chen, Si‐Chi Xu, Meng-qi Fan, Lanlan Li, Heng Zhang, Nan Zhao, Zhao-xiang Zeng, Si Chen, Xiaofeng Zeng, Wei Deng, Qizhu Tang	2023	76
13	Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways Acta Pharmacologica Sinica ·Dan Li, Yingying Guo, Xian-feng Cen, Hong-liang Qiu, Si Chen, Xiaofeng Zeng, Qian Zeng, Man Xu, Qizhu Tang	2021	76
14	p53-dependent upregulation of miR-16-2 by sanguinarine induces cell cycle arrest and apoptosis in hepatocellular carcinoma Cancer Letters ·Beilei Zhang, Xinan Wang, Jiacong Deng, Haifeng Zheng, Wei Liu, Si Chen, Jie Tian, Fu Wang	2019	66
15	Sertraline, an Antidepressant, Induces Apoptosis in Hepatic Cells Through the Mitogen-Activated Protein Kinase Pathway Toxicological Sciences ·Si Chen, Jiekun Xuan, Liqing Wan, Haixia Lin, Letha H. Couch, Nan Mei, Vasily N. Dobrovolsky, Lei Guo	2013	66
16	Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment Biomarkers in Medicine ·Igor Koturbash, William H. Tolleson, Lei Guo, Dianke Yu, Si Chen, Huixiao Hong, William B. Mattes, Baitang Ning	2015	66
17	Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells Scientific Reports ·Zhuhong Zhang, Si Chen, Mei Hu, Jiekun Xuan, Xiaoqing Guo, Letha H. Couch, Vasily N. Dobrovolsky, Lei Guo, Nan Mei	2015	63
18	Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion Cancer Cell ·Yinghua Zhu, Ziwei Zhou, Xin Du, Xiaorong Lin, Zhi-Mei Liang, Si Chen, Yiwei Sun, Yue Wang, Zhenkun Na, Zhi‐Yong Wu, Jiaxin Zhong, Beinan Han, Xiangping Zhu, Wenkui Fu, Hongde Li, Man‐Li Luo, Hai Hu Hit paper breakdown →	2025	57
19	Sertraline induces endoplasmic reticulum stress in hepatic cells Toxicology ·Si Chen, Jiekun Xuan, Letha H. Couch, Advait Iyer, Yuanfeng Wu, Quan‐Zhen Li, Lei Guo	2014	57
20	Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis Journal of Environmental Science and Health Part C ·Dongying Li, William H. Tolleson, Dianke Yu, Si Chen, Lei Guo, Wenming Xiao, Weida Tong, Baitang Ning	2019	56

About Si Chen

Si Chen is a scholar working on Molecular Biology, Cancer Research, Oncology, Pharmacology and Pharmacology, having authored 135 papers that have together received 3.7k indexed citations. Recurring topics across this work include Cancer-related molecular mechanisms research (18 papers), MicroRNA in disease regulation (16 papers), RNA Interference and Gene Delivery (12 papers), Drug Transport and Resistance Mechanisms (11 papers), Pharmacogenetics and Drug Metabolism (11 papers), RNA modifications and cancer (9 papers), Cannabis and Cannabinoid Research (8 papers) and Drug-Induced Hepatotoxicity and Protection (8 papers). The work is most often cited by research in Cancer Research (717 citations), Pharmacology (298 citations), Molecular Biology (1.9k citations), Biomaterials (303 citations) and Biological Psychiatry (47 citations). Si Chen has collaborated with scholars based in China, United States and Germany. Frequent co-authors include Lei Guo, Baitang Ning, Lina Zhang, Chunyu Chang, William H. Tolleson, Nan Mei, Jiekun Xuan, Dianke Yu, Xian‐Zheng Zhang and Ren‐Xi Zhuo. Their work appears in journals such as Biochemical Pharmacology, Archives of Toxicology, Scientific Reports, Toxicological Sciences and Chemico-Biological Interactions.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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About Si Chen

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