Rienk Offringa

22.7k citations
194 papers · 18.3k · 3 hit papers · h-index 71

Impact in

  • Immunology top 0.05%
    • Immunotherapy and Immune Responses
    • Immune Cell Function and Interaction
    • T-cell and B-cell Immunology
  • Oncology top 0.2%
    • Cancer Immunotherapy and Biomarkers
    • CAR-T cell therapy research

Papers in

  • Immunology 151
    • Immunotherapy and Immune Responses 129
    • Immune Cell Function and Interaction 54
    • T-cell and B-cell Immunology 53
  • Oncology 75
    • CAR-T cell therapy research 45
    • Cancer Immunotherapy and Biomarkers 25
Co-authors
René E. M. Toes (47 shared papers)Cornelis J.M. Melief (72 shared papers)Sjoerd H. van der Burg (57 shared papers)Ellen I. H. van der Voort (15 shared papers)Cornelis J.M. Melief (18 shared papers)Stephen P. Schoenberger (11 shared papers)Cornelis J.M. Melief (21 shared papers)Jan W. Drijfhout (30 shared papers)
Journals
The Journal of Immunology (19 papers)Cancer Research (12 papers)International Journal of Cancer (12 papers)The Journal of Experimental Medicine (10 papers)European Journal of Immunology (6 papers)
Partner nations
NetherlandsGermanyUnited States

In The Last Decade

Rienk Offringa

190 papers receiving 17.8k citations

Rienk Offringa's Hit Papers

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia 2009 · 861 citations
8610+9+18Years since publication50010001.5k2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

  • it has ≥500 total citations;
  • it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
  • it reaches the top citation threshold in at least one of its specific research topics.
  1. 2009 New England Journal of Medicine
  2. 2001 The Journal of Experimental Medicine
  3. 1998 Nature

Peers

Rienk Offringa
Comparison fields: 5 of 118
  • Immunology 13.3k
  • Oncology 5.9k
  • Epidemiology 3.2k
  • Virology 356
  • Molecular Biology 5.2k
Replace Cornelis J.M. Melief with:
Cornelis J.M. Melief Netherlands
W. Martin Kast United States
Esteban Celis United States
Sjoerd H. van der Burg Netherlands
Peter Van Endert France
Walter J. Storkus United States
Ferry Ossendorp Netherlands
Daniel E. Speiser Switzerland
Tanja D. de Gruijl Netherlands
Luc Teyton United States
Rienk Offringa relative to Cornelis J.M. Melief Netherlands Cornelis J.M. Melief's profile →
Citations per field
00.5×1.5×
Cornelis J.M. Melief · 1×
Citations per year

Countries citing papers authored by Rienk Offringa

Since Specialization
Citations

This map shows the geographic impact of Rienk Offringa's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Rienk Offringa with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Rienk Offringa more than expected).

Fields of papers citing papers by Rienk Offringa

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Rienk Offringa. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Rienk Offringa. The network helps show where Rienk Offringa may publish in the future.

Co-authors

The 25 scholars most cited alongside Rienk Offringa, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Rienk Offringa Line = papers co-authored together Rienk Offringa links everyone, so they are left out of the graph.

All Works

20 of 20 papers shown

Showing the 20 most-cited of 194 papers — load more, or switch the sort, to bring in the rest.

#Work
1
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Nature ·Stephen P. Schoenberger, René E. M. Toes, Ellen I. H. van der Voort, Rienk Offringa, Cornelis J.M. Melief
Hit paper breakdown →		19982238
2
Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses
The Journal of Experimental Medicine ·Roger P.M. Sutmuller, Leonie M. van Duivenvoorde, Andrea van Elsas, Ton N. Schumacher, Manon E. Wildenberg, James P. Allison, René E. M. Toes, Rienk Offringa, Cornelis J.M. Melief
Hit paper breakdown →		2001876
3
Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia
New England Journal of Medicine ·Gemma G. Kenter, Marij J.P. Welters, A. Rob P.M. Valentijn, Margriet J. Löwik, Dorien M. A. Berends-van der Meer, Annelies P.G. Vloon, Farah Essahsah, Lorraine M. Fathers, Rienk Offringa, Jan W. Drijfhout, Amon R. Wafelman, Jaap Oostendorp, Gert Jan Fleuren, Sjoerd H. van der Burg, Cornelis J.M. Melief
Hit paper breakdown →		2009861
4
CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
Nature Medicine ·Linda Diehl, Annemieke Th. den Boer, Stephen P. Schoenberger, Ellen I. H. van der Voort, Ton N. Schumacher, Cornelis J.M. Melief, Rienk Offringa, René E. M. Toes
1999413
5
Established Human Papillomavirus Type 16-Expressing Tumors Are Effectively Eradicated Following Vaccination with Long Peptides
The Journal of Immunology ·Sander Zwaveling, Sandra C. Ferreira Mota, Jan Nouta, Mark E. Johnson, Grayson B. Lipford, Rienk Offringa, Sjoerd H. van der Burg, Cornelis J.M. Melief
2002364
6
High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer
Cancer Research ·Sytse J. Piersma, Ekaterina S. Jordanova, Mariëtte I.E. van Poelgeest, Kitty M.C. Kwappenberg, Jeanette M. van der Hulst, Jan W. Drijfhout, Cornelis J.M. Melief, Gemma G. Kenter, Gert Jan Fleuren, Rienk Offringa, Sjoerd H. van der Burg
2007350
7
The Minor Histocompatibility Antigen HA-1: A Diallelic Gene with a Single Amino Acid Polymorphism
Science ·Joke M. M. den Haan, Leslie M. Meadows, Wei Wang, Jos Pool, Els Blokland, T Bishop, Carla Reinhardus, Jeffrey Shabanowitz, Rienk Offringa, Donald F. Hunt, Víctor H. Engelhard, Els Goulmy
1998347
8
Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine
Clinical Cancer Research ·Marij J.P. Welters, Gemma G. Kenter, Sytse J. Piersma, Annelies P.G. Vloon, Margriet J.G. Löwik, Dorien M. A. Berends-van der Meer, Jan W. Drijfhout, A. Rob P.M. Valentijn, Amon R. Wafelman, Jaap Oostendorp, Gert Jan Fleuren, Rienk Offringa, Cornelis J.M. Melief, Sjoerd H. van der Burg
2008323
9
Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors
Proceedings of the National Academy of Sciences ·Jan Paul Medema, Joan de Jong, Lucy T.C. Peltenburg, Els M.E. Verdegaal, Arko Gorter, Sandra A. Bres, Kees L. M. C. Franken, Michael Hahne, Juan Pablo Albar, Cornelis J.M. Melief, Rienk Offringa
2001294
10
Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein
The Journal of Experimental Medicine ·Jan Paul Medema, Joan de Jong, Thorbald van Hall, Cornelis J.M. Melief, Rienk Offringa
1999290
11
Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes
Cell ·W. Martin Kast, Rienk Offringa, Peter J. Peters, Arie C. Voordouw, Rob H. Meloen, Alex J. van der Eb, Cornelis J.M. Melief
1989275
12
Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine
The Journal of Experimental Medicine ·Andrea van Elsas, Roger P.M. Sutmuller, Arthur A. Hurwitz, Jennifer Ziskin, Jennifer Villaseñor, Jan Paul Medema, Willem W. Overwijk, Nicholas P. Restifo, Cornelis J.M. Melief, Rienk Offringa, James P. Allison
2001267
13
CD25+ cell depletion hastens the onset of severe disease in collagen‐induced arthritis
Arthritis & Rheumatism ·Mary E. Morgan, Roger P.M. Sutmuller, Hendrik J. Witteveen, Leonie M. van Duivenvoorde, Eric Zanelli, Cornelis J.M. Melief, A. J. Snijders, Rienk Offringa, René R. P. de Vries, René E. M. Toes
2003266
14
Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity
Clinical Cancer Research ·Gemma G. Kenter, Marij J.P. Welters, A. Rob P.M. Valentijn, Margriet J.G. Löwik, Dorien M. A. Berends-van der Meer, Annelies P.G. Vloon, Jan W. Drijfhout, Amon R. Wafelman, Jaap Oostendorp, Gert Jan Fleuren, Rienk Offringa, Sjoerd H. van der Burg, Cornelis J.M. Melief
2008260
15
Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.
Proceedings of the National Academy of Sciences ·René E. M. Toes, Rienk Offringa, R. Blom, Cornelis J.M. Melief, W. Martin Kast
1996260
16
Human Papillomavirus Type 16-Positive Cervical Cancer Is Associated with Impaired CD4+ T-Cell Immunity against Early Antigens E2 and E6
Cancer Research ·Annemieke de Jong, Mariëtte I.E. van Poelgeest, Jeanette M. van der Hulst, Jan W. Drijfhout, Gert Jan Fleuren, Cornelis J.M. Melief, Gemma G. Kenter, Rienk Offringa, Sjoerd H. van der Burg
2004252
17
Efficient Identification of Novel Hla-A*0201–Presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen Prame by Proteasome-Mediated Digestion Analysis
The Journal of Experimental Medicine ·Jan H. Kessler, N. J. C. M. Beekman, Sandra A. Bres-Vloemans, Pauline Verdijk, Peter A. van Veelen, Antoinette M. Kloosterman-Joosten, Debby C.J. Vissers, George J.A. ten Bosch, Michel G.D. Kester, Alice J.A.M. Sijts, Jan W. Drijfhout, Ferry Ossendorp, Rienk Offringa, Cornelis J.M. Melief
2001226
18
CD8+ CTL Priming by Exact Peptide Epitopes in Incomplete Freund’s Adjuvant Induces a Vanishing CTL Response, whereas Long Peptides Induce Sustained CTL Reactivity
The Journal of Immunology ·Martijn S. Bijker, Susan J. F. van den Eeden, Kees L. M. C. Franken, Cornelis J.M. Melief, Rienk Offringa, Sjoerd H. van der Burg
2007225
19
An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells
Cancer Cell ·Nicholas S. Wilson, Becky Yang, Annie Yang, Stefanie Loeser, Scot A. Marsters, David A. Lawrence, Yun Li, Robert Pitti, Klára Tótpál, Sharon Yee, Sarajane Ross, Jean-Michel Vernes, Yanmei Lu, Cam Adams, Rienk Offringa, Bob Kelley, S.G. Hymowitz, Dylan Daniel, Gloria Meng, Avi Ashkenazi
2011217
20
Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: clinical evaluation of a phase I–II trial
European Journal of Cancer ·Willemien J. van Driel, Maaike E. Ressing, Gemma G. Kenter, Remco M.P. Brandt, E. J. T. Krul, A.B. van Rossum, Ed Schuuring, Rienk Offringa, Thomas Bauknecht, A. Tamm-Hermelink, Peter A. van Dam, Gert Jan Fleuren, W. Martin Kast, C J Melief, J. Baptist Trimbos
1999193

About Rienk Offringa

Rienk Offringa is a scholar working on Immunology, Oncology, Molecular Biology, Epidemiology and Genetics, having authored 194 papers that have together received 18.3k indexed citations. Recurring topics across this work include Immunotherapy and Immune Responses (129 papers), Immune Cell Function and Interaction (54 papers), T-cell and B-cell Immunology (53 papers), CAR-T cell therapy research (45 papers), Cervical Cancer and HPV Research (26 papers), Virus-based gene therapy research (26 papers), Cancer Immunotherapy and Biomarkers (25 papers) and vaccines and immunoinformatics approaches (25 papers). The work is most often cited by research in Immunology (13.3k citations), Oncology (5.9k citations), Epidemiology (3.2k citations), Virology (356 citations) and Molecular Biology (5.2k citations). Rienk Offringa has collaborated with scholars based in Netherlands, Germany and United States. Frequent co-authors include René E. M. Toes, Cornelis J.M. Melief, Sjoerd H. van der Burg, Ellen I. H. van der Voort, Cornelis J.M. Melief, Stephen P. Schoenberger, Cornelis J.M. Melief, Jan W. Drijfhout, Gemma G. Kenter and Gert Jan Fleuren. Their work appears in journals such as The Journal of Immunology, Cancer Research, International Journal of Cancer, The Journal of Experimental Medicine and European Journal of Immunology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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