Rienk Offringa

22.7k citations
191 papers · 17.6k · 3 hit papers · h-index 71

Impact in

  • Immunology top 0.05%
    • Immunotherapy and Immune Responses
    • Immune Cell Function and Interaction
    • T-cell and B-cell Immunology
  • Oncology top 0.2%
    • Cancer Immunotherapy and Biomarkers
    • CAR-T cell therapy research

Papers in

  • Immunology 148
    • Immunotherapy and Immune Responses 127
    • T-cell and B-cell Immunology 51
    • Immune Cell Function and Interaction 51
  • Oncology 74
    • CAR-T cell therapy research 44
    • Cancer Immunotherapy and Biomarkers 25
Co-authors
René E. M. Toes (45 shared papers)Cornelis J.M. Melief (71 shared papers)Sjoerd H. van der Burg (56 shared papers)Ellen I. H. van der Voort (15 shared papers)Cornelis J.M. Melief (17 shared papers)Stephen P. Schoenberger (11 shared papers)Cornelis J.M. Melief (21 shared papers)Jan W. Drijfhout (30 shared papers)
Journals
The Journal of Immunology (19 papers)Cancer Research (12 papers)International Journal of Cancer (12 papers)The Journal of Experimental Medicine (10 papers)Proceedings of the National Academy of Sciences (6 papers)
Partner nations
NetherlandsGermanyUnited States

In The Last Decade

Rienk Offringa

188 papers receiving 17.2k citations

Rienk Offringa's Hit Papers

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia 2009 · 812 citations
8120+9+18Years since publication50010001.5k2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

  • it has ≥500 total citations;
  • it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
  • it reaches the top citation threshold in at least one of its specific research topics.
  1. 2009 New England Journal of Medicine
  2. 2001 The Journal of Experimental Medicine
  3. 1998 Nature

Peers

Rienk Offringa
Comparison fields: 5 of 116
  • Immunology 12.8k
  • Oncology 5.6k
  • Epidemiology 3.0k
  • Virology 345
  • Molecular Biology 5.0k
Replace Cornelis J.M. Melief with:
Cornelis J.M. Melief Netherlands
W. Martin Kast United States
Esteban Celis United States
Sjoerd H. van der Burg Netherlands
Peter Van Endert France
Ferry Ossendorp Netherlands
Walter J. Storkus United States
Daniel E. Speiser Switzerland
Tanja D. de Gruijl Netherlands
Luc Teyton United States
Rienk Offringa relative to Cornelis J.M. Melief Netherlands Cornelis J.M. Melief's profile →
Citations per field
00.5×1.5×
Cornelis J.M. Melief · 1×
Citations per year

Countries citing papers authored by Rienk Offringa

Since Specialization
Citations

This map shows the geographic impact of Rienk Offringa's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Rienk Offringa with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Rienk Offringa more than expected).

Fields of papers citing papers by Rienk Offringa

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Rienk Offringa. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Rienk Offringa. The network helps show where Rienk Offringa may publish in the future.

Co-authors

The 25 scholars most cited alongside Rienk Offringa, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Rienk Offringa Line = papers co-authored together Rienk Offringa links everyone, so they are left out of the graph.

All Works

20 of 20 papers shown

Showing the 20 most-cited of 191 papers — load more, or switch the sort, to bring in the rest.

#Work
1
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Nature ·Stephen P. Schoenberger, René E. M. Toes, Ellen I. H. van der Voort, Rienk Offringa, Cornelis J.M. Melief
Hit paper breakdown →		19982169
2
Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses
The Journal of Experimental Medicine ·Roger P.M. Sutmuller, Leonie M. van Duivenvoorde, Andrea van Elsas, Ton N. Schumacher, Manon E. Wildenberg, James P. Allison, René E. M. Toes, Rienk Offringa, Cornelis J.M. Melief
Hit paper breakdown →		2001834
3
Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia
New England Journal of Medicine ·Gemma G. Kenter, Marij J.P. Welters, A. Rob P.M. Valentijn, Margriet J. Löwik, Dorien M. A. Berends-van der Meer, Annelies P.G. Vloon, Farah Essahsah, Lorraine M. Fathers, Rienk Offringa, Jan W. Drijfhout, Amon R. Wafelman, Jaap Oostendorp, Gert Jan Fleuren, Sjoerd H. van der Burg, Cornelis J.M. Melief
Hit paper breakdown →		2009812
4
CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
Nature Medicine ·Linda Diehl, Annemieke Th. den Boer, Stephen P. Schoenberger, Ellen I. H. van der Voort, Ton N. Schumacher, Cornelis J.M. Melief, Rienk Offringa, René E. M. Toes
1999399
5
Established Human Papillomavirus Type 16-Expressing Tumors Are Effectively Eradicated Following Vaccination with Long Peptides
The Journal of Immunology ·Sander Zwaveling, Sandra C. Ferreira Mota, Jan Nouta, Mark E. Johnson, Grayson B. Lipford, Rienk Offringa, Sjoerd H. van der Burg, Cornelis J.M. Melief
2002351
6
High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer
Cancer Research ·Sytse J. Piersma, Ekaterina S. Jordanova, Mariëtte I.E. van Poelgeest, Kitty M.C. Kwappenberg, Jeanette M. van der Hulst, Jan W. Drijfhout, Cornelis J.M. Melief, Gemma G. Kenter, Gert Jan Fleuren, Rienk Offringa, Sjoerd H. van der Burg
2007337
7
The Minor Histocompatibility Antigen HA-1: A Diallelic Gene with a Single Amino Acid Polymorphism
Science ·Joke M. M. den Haan, Leslie M. Meadows, Wei Wang, Jos Pool, Els Blokland, T Bishop, Carla Reinhardus, Jeffrey Shabanowitz, Rienk Offringa, Donald F. Hunt, Víctor H. Engelhard, Els Goulmy
1998336
8
Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine
Clinical Cancer Research ·Marij J.P. Welters, Gemma G. Kenter, Sytse J. Piersma, Annelies P.G. Vloon, Margriet J.G. Löwik, Dorien M. A. Berends-van der Meer, Jan W. Drijfhout, A. Rob P.M. Valentijn, Amon R. Wafelman, Jaap Oostendorp, Gert Jan Fleuren, Rienk Offringa, Cornelis J.M. Melief, Sjoerd H. van der Burg
2008311
9
Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein
The Journal of Experimental Medicine ·Jan Paul Medema, Joan de Jong, Thorbald van Hall, Cornelis J.M. Melief, Rienk Offringa
1999280
10
Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors
Proceedings of the National Academy of Sciences ·Jan Paul Medema, Joan de Jong, Lucy T.C. Peltenburg, Els M.E. Verdegaal, Arko Gorter, Sandra A. Bres, Kees L. M. C. Franken, Michael Hahne, Juan Pablo Albar, Cornelis J.M. Melief, Rienk Offringa
2001277
11
Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes
Cell ·W. Martin Kast, Rienk Offringa, Peter J. Peters, Arie C. Voordouw, Rob H. Meloen, Alex J. van der Eb, Cornelis J.M. Melief
1989264
12
CD25+ cell depletion hastens the onset of severe disease in collagen‐induced arthritis
Arthritis & Rheumatism ·Mary E. Morgan, Roger P.M. Sutmuller, Hendrik J. Witteveen, Leonie M. van Duivenvoorde, Eric Zanelli, Cornelis J.M. Melief, A. J. Snijders, Rienk Offringa, René R. P. de Vries, René E. M. Toes
2003264
13
Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine
The Journal of Experimental Medicine ·Andrea van Elsas, Roger P.M. Sutmuller, Arthur A. Hurwitz, Jennifer Ziskin, Jennifer Villaseñor, Jan Paul Medema, Willem W. Overwijk, Nicholas P. Restifo, Cornelis J.M. Melief, Rienk Offringa, James P. Allison
2001254
14
Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.
Proceedings of the National Academy of Sciences ·René E. M. Toes, Rienk Offringa, R. Blom, Cornelis J.M. Melief, W. Martin Kast
1996252
15
Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity
Clinical Cancer Research ·Gemma G. Kenter, Marij J.P. Welters, A. Rob P.M. Valentijn, Margriet J.G. Löwik, Dorien M. A. Berends-van der Meer, Annelies P.G. Vloon, Jan W. Drijfhout, Amon R. Wafelman, Jaap Oostendorp, Gert Jan Fleuren, Rienk Offringa, Sjoerd H. van der Burg, Cornelis J.M. Melief
2008249
16
Human Papillomavirus Type 16-Positive Cervical Cancer Is Associated with Impaired CD4+ T-Cell Immunity against Early Antigens E2 and E6
Cancer Research ·Annemieke de Jong, Mariëtte I.E. van Poelgeest, Jeanette M. van der Hulst, Jan W. Drijfhout, Gert Jan Fleuren, Cornelis J.M. Melief, Gemma G. Kenter, Rienk Offringa, Sjoerd H. van der Burg
2004238
17
CD8+ CTL Priming by Exact Peptide Epitopes in Incomplete Freund’s Adjuvant Induces a Vanishing CTL Response, whereas Long Peptides Induce Sustained CTL Reactivity
The Journal of Immunology ·Martijn S. Bijker, Susan J. F. van den Eeden, Kees L. M. C. Franken, Cornelis J.M. Melief, Rienk Offringa, Sjoerd H. van der Burg
2007219
18
Efficient Identification of Novel Hla-A*0201–Presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen Prame by Proteasome-Mediated Digestion Analysis
The Journal of Experimental Medicine ·Jan H. Kessler, N. J. C. M. Beekman, Sandra A. Bres-Vloemans, Pauline Verdijk, Peter A. van Veelen, Antoinette M. Kloosterman-Joosten, Debby C.J. Vissers, George J.A. ten Bosch, Michel G.D. Kester, Alice J.A.M. Sijts, Jan W. Drijfhout, Ferry Ossendorp, Rienk Offringa, Cornelis J.M. Melief
2001217
19
An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells
Cancer Cell ·Nicholas S. Wilson, Becky Yang, Annie Yang, Stefanie Loeser, Scot A. Marsters, David A. Lawrence, Yun Li, Robert Pitti, Klára Tótpál, Sharon Yee, Sarajane Ross, Jean-Michel Vernes, Yanmei Lu, Cam Adams, Rienk Offringa, Bob Kelley, S.G. Hymowitz, Dylan Daniel, Gloria Meng, Avi Ashkenazi
2011214
20
CD40 stimulation leads to effective therapy of CD40 − tumors through induction of strong systemic cytotoxic T lymphocyte immunity
Proceedings of the National Academy of Sciences ·Geertje J. D. van Mierlo, Annemieke Th. den Boer, Jan Paul Medema, Ellen I. H. van der Voort, Marieke F. Fransen, Rienk Offringa, Cornelis J.M. Melief, René E. M. Toes
2002189

About Rienk Offringa

Rienk Offringa is a scholar working on Immunology, Oncology, Molecular Biology, Epidemiology and Genetics, having authored 191 papers that have together received 17.6k indexed citations. Recurring topics across this work include Immunotherapy and Immune Responses (127 papers), T-cell and B-cell Immunology (51 papers), Immune Cell Function and Interaction (51 papers), CAR-T cell therapy research (44 papers), Cervical Cancer and HPV Research (26 papers), Virus-based gene therapy research (26 papers), Cancer Immunotherapy and Biomarkers (25 papers) and vaccines and immunoinformatics approaches (25 papers). The work is most often cited by research in Immunology (12.8k citations), Oncology (5.6k citations), Epidemiology (3.0k citations), Virology (345 citations) and Molecular Biology (5.0k citations). Rienk Offringa has collaborated with scholars based in Netherlands, Germany and United States. Frequent co-authors include René E. M. Toes, Cornelis J.M. Melief, Sjoerd H. van der Burg, Ellen I. H. van der Voort, Cornelis J.M. Melief, Stephen P. Schoenberger, Cornelis J.M. Melief, Jan W. Drijfhout, Gemma G. Kenter and Gert Jan Fleuren. Their work appears in journals such as The Journal of Immunology, Cancer Research, International Journal of Cancer, The Journal of Experimental Medicine and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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