Paul E. Brennan

15.7k citations

117 papers · 5.0k · 1 hit paper · h-index 39

Impact in

Hematology top 0.5%
- Multiple Myeloma Research and Treatments
Molecular Biology top 2%
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Chemical Synthesis and Analysis
- Cancer-related gene regulation

Papers in

Molecular Biology 91
- Protein Degradation and Inhibitors 40
- Histone Deacetylase Inhibitors Research 17
- Ubiquitin and proteasome pathways 15
- Epigenetics and DNA Methylation 9
- Cancer-related gene regulation 8
Hematology 27
- Multiple Myeloma Research and Treatments 27

Co-authors: Stefan Knapp (33 shared papers)Susanne Müller (22 shared papers)O. Fedorov (15 shared papers)P. Filippakopoulos (11 shared papers)Christopher J. Schofield (8 shared papers)S. Picaud (9 shared papers)C. Tallant (15 shared papers)Martin Philpott (9 shared papers)
Journals: Journal of Medicinal Chemistry (18 papers)Angewandte Chemie International Edition (7 papers)MedChemComm (5 papers)Nature Communications (3 papers)Chemical Communications (3 papers)
Partner nations: United Kingdom United States Germany

In The Last Decade

Paul E. Brennan

114 papers receiving 4.9k citations

Paul E. Brennan's Hit Papers

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Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane 2022 · 193 citations

Peers

Countries citing papers authored by Paul E. Brennan

Since Specialization

Citations

This map shows the geographic impact of Paul E. Brennan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paul E. Brennan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paul E. Brennan more than expected).

Fields of papers citing papers by Paul E. Brennan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paul E. Brennan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paul E. Brennan. The network helps show where Paul E. Brennan may publish in the future.

Co-authors

The 25 scholars most cited alongside Paul E. Brennan, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Paul E. Brennan Line = papers co-authored together Paul E. Brennan links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 117 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain Proceedings of the National Academy of Sciences ·S. Picaud, Christopher Wells, I. Felletar, Deborah H. Brotherton, Sarah Martin, P. Savitsky, Beatriz Díez-Dacal, Martin Philpott, C. Bountra, Hannah Lingard, O. Fedorov, Susanne Müller, Paul E. Brennan, Stefan Knapp, P. Filippakopoulos	2013	365
2	K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac Science ·Yin Yao Dong, A.C.W. Pike, Alexandra Mackenzie, Conor McClenaghan, Prafulla Aryal, Liang Dong, Andrew Quigley, Mariana Grieben, S. Goubin, Shubhashish Mukhopadhyay, G.F. Ruda, Michael V. Clausen, Lishuang Cao, Paul E. Brennan, N. Burgess-Brown, Mark S.P. Sansom, Stephen J. Tucker, Elisabeth P. Carpenter	2015	241
3	Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains Journal of the American Chemical Society ·Duncan A. Hay, Oleg Fedorov, Sarah Martin, Dean C. Singleton, C. Tallant, Christopher Wells, S. Picaud, Martin Philpott, Octovia Monteiro, Catherine Rogers, Stuart J. Conway, Timothy P. C. Rooney, Anthony Tumber, Clarence Yapp, P. Filippakopoulos, Mark E. Bunnage, Susanne Müller, Stefan Knapp, Christopher J. Schofield, Paul E. Brennan	2014	212
4	CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses Proceedings of the National Academy of Sciences ·Ariane Hammitzsch, C. Tallant, O. Fedorov, Alison O’Mahony, Paul E. Brennan, Duncan A. Hay, Fernando O. Martínez, Hussein Al‐Mossawi, Jelle de Wit, Matteo Vecellio, Christopher Wells, B P Wordsworth, Susanne Müller, Stefan Knapp, Paul Bowness	2015	201
5	PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains Cancer Research ·S. Picaud, David Da Costa, Angeliki Thanasopoulou, P. Filippakopoulos, Paul V. Fish, Martin Philpott, O. Fedorov, Paul E. Brennan, Mark E. Bunnage, Dafydd R. Owen, James E. Bradner, Philippe Tanière, Brendan O’Sullivan, Susanne Müller, Juerg Schwaller, Tatjana Stanković, Stefan Knapp	2013	195
6	Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane Nature ·Nils Frank, Jeremy Nugent, Bethany R. Shire, Helena D. Pickford, Patrick Rabe, Alistair J. Sterling, Tryfon Zarganes‐Tzitzikas, Thomas Grimes, Amber L. Thompson, Russell C. Smith, Christopher J. Schofield, Paul E. Brennan, Fernanda Duarte, Edward A. Anderson Hit paper breakdown →	2022	193
7	Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit Journal of Medicinal Chemistry ·Paul V. Fish, P. Filippakopoulos, Gerwyn Bish, Paul E. Brennan, Mark E. Bunnage, Andrew S. Cook, Oleg Federov, Brian S. Gerstenberger, Hannah M. Jones, Stefan Knapp, Brian D. Marsden, Karl Nocka, Dafydd R. Owen, Martin Philpott, S. Picaud, Michael J. Primiano, Michael J. Ralph, Nunzio Sciammetta, John D. Trzupek	2012	152
8	Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions Journal of Medicinal Chemistry ·David S. Hewings, Timothy P. C. Rooney, Laura E. Jennings, Duncan A. Hay, Christopher J. Schofield, Paul E. Brennan, Stefan Knapp, Stuart J. Conway	2012	138
9	Recent Progress in Histone Demethylase Inhibitors Journal of Medicinal Chemistry ·Tom E. McAllister, Katherine S. England, Richard J. Hopkinson, Paul E. Brennan, Akane Kawamura, Christopher J. Schofield	2015	137
10	LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor Angewandte Chemie International Edition ·Peter G. K. Clark, Lucas Campos Curcino Vieira, C. Tallant, O. Fedorov, Dean C. Singleton, Catherine Rogers, Octovia Monteiro, James M. Bennett, Roberta Baronio, Susanne Müller, Danette L. Daniels, Jacqui Méndez, Stefan Knapp, Paul E. Brennan, Darren J. Dixon	2015	135
11	Fragment-based hit identification: thinking in 3D Drug Discovery Today ·Andrew Morley, Angelo Pugliese, Kristian Birchall, Justin Bower, Paul E. Brennan, Nathan Brown, Tim Chapman, (unknown), Ian H. Gilbert, Swen Hoelder, Allan M. Jordan, Steven V. Ley, Andy Merritt, David S. Miller, Martin E. Swarbrick, Paul G. Wyatt	2013	130
12	Contribution of Tobacco and Alcohol to the High Rates of Squamous Cell Carcinoma of the Supraglottis and Glottis in Central Europe American Journal of Epidemiology ·Mia Hashibe, Paolo Boffetta, David Zaridze, Oxana Shangina, N. Szeszenia-Dabrowska, Dana Mateș, Eleonora Fabianova, P. Rudnai, Paul E. Brennan	2007	119
13	Highly selective inhibition of histone demethylases by de novo macrocyclic peptides Nature Communications ·Akane Kawamura, Martin Münzel, Tatsuya Kojima, Clarence Yapp, Bhaskar Bhushan, Yuki Goto, Anthony Tumber, Takayuki Katoh, Oliver N. F. King, Toby Passioura, Louise J. Walport, Stephanie B. Hatch, Sarah K. Madden, Susanne Müller, Paul E. Brennan, Rasheduzzaman Chowdhury, Richard J. Hopkinson, Hiroaki Suga, Christopher J. Schofield	2017	117
14	LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor Angewandte Chemie ·Peter G. K. Clark, Lucas Campos Curcino Vieira, C. Tallant, O. Fedorov, Dean C. Singleton, Catherine Rogers, Octovia Monteiro, James M. Bennett, Roberta Baronio, Susanne Müller, Danette L. Daniels, Jacqui Méndez, Stefan Knapp, Paul E. Brennan, Darren J. Dixon	2015	111
15	Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands Journal of Medicinal Chemistry ·David S. Hewings, O. Fedorov, P. Filippakopoulos, Sarah Martin, S. Picaud, Anthony Tumber, Christopher Wells, Monica M. Olcina, Katherine M. Freeman, Andrew B. Gill, Alison J. Ritchie, David W. Sheppard, Angela J. Russell, Ester M. Hammond, Stefan Knapp, Paul E. Brennan, Stuart J. Conway	2013	103
16	A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain Chemical Science ·Oakley B. Cox, T. Krojer, P.M. Collins, Octovia Monteiro, R. Talon, A.R. Bradley, O. Fedorov, Jahangir Amin, Brian D. Marsden, John Spencer, F. von Delft, Paul E. Brennan	2015	103
17	Targeting the Small GTPase Superfamily through Their Regulatory Proteins Angewandte Chemie International Edition ·Janine L. Gray, F. von Delft, Paul E. Brennan	2019	101
18	A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced‐Fit Pocket Stabilized by a Cation–π Interaction Angewandte Chemie International Edition ·Timothy P. C. Rooney, P. Filippakopoulos, O. Fedorov, S. Picaud, Wilian A. Cortopassi, Duncan A. Hay, Sarah Martin, Anthony Tumber, Catherine Rogers, Martin Philpott, Minghua Wang, Amber L. Thompson, Tom D. Heightman, David C. Pryde, Andrew S. Cook, Robert S. Paton, Susanne Müller, Stefan Knapp, Paul E. Brennan, Stuart J. Conway	2014	92
19	A multicenter case–control study of diet and lung cancer among non-smokers Cancer Causes & Control ·Paul E. Brennan, Cristina Fortes, Joel R. Butler, Antonio Agudo, Simone Benhamou, Sarah C. Darby, Michael Gerken, Karl-Heinz Jöckel, Michaela Kreuzer, Sandra Mallone, Fredrik Nyberg, Hermann Pohlabeln, G. Ferro, Paolo Boffetta	2000	86
20	A chemical toolbox for the study of bromodomains and epigenetic signaling Nature Communications ·Qin Wu, David Heidenreich, Stanley Zhou, Suzanne Ackloo, Andreas Krämer, Kiran Nakka, Evelyne Lima‐Fernandes, Geneviève Deblois, Shili Duan, Ravi N. Vellanki, Fengling Li, Masoud Vedadi, F. Jeffrey Dilworth, Mathieu Lupien, Paul E. Brennan, C.H. Arrowsmith, Susanne Müller, Oleg Fedorov, P. Filippakopoulos, Stefan Knapp	2019	84

About Paul E. Brennan

Paul E. Brennan is a scholar working on Molecular Biology, Hematology, Organic Chemistry, Oncology and Computational Theory and Mathematics, having authored 117 papers that have together received 5.0k indexed citations. Recurring topics across this work include Protein Degradation and Inhibitors (40 papers), Multiple Myeloma Research and Treatments (27 papers), Histone Deacetylase Inhibitors Research (17 papers), Ubiquitin and proteasome pathways (15 papers), Computational Drug Discovery Methods (10 papers), Epigenetics and DNA Methylation (9 papers), Cancer-related gene regulation (8 papers) and Peptidase Inhibition and Analysis (8 papers). The work is most often cited by research in Hematology (1.0k citations), Molecular Biology (3.6k citations), Organic Chemistry (920 citations), Oncology (565 citations) and Virology (82 citations). Paul E. Brennan has collaborated with scholars based in United Kingdom, United States and Germany. Frequent co-authors include Stefan Knapp, Susanne Müller, O. Fedorov, P. Filippakopoulos, Christopher J. Schofield, S. Picaud, C. Tallant, Martin Philpott, Duncan A. Hay and Octovia Monteiro. Their work appears in journals such as Journal of Medicinal Chemistry, Angewandte Chemie International Edition, MedChemComm, Nature Communications and Chemical Communications.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Paul E. Brennan

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