Patrick Casara

3.2k citations

58 papers · 2.9k · 1 hit paper · h-index 25

Impact in

Biochemistry top 2%
- Amino Acid Enzymes and Metabolism
Molecular Biology top 5%
- Polyamine Metabolism and Applications
- Cell death mechanisms and regulation

Papers in

Biochemistry 8
- Amino Acid Enzymes and Metabolism 8
Organic Chemistry 17
- Synthesis and biological activity 6
- Asymmetric Synthesis and Catalysis 4
- Organic Chemistry Synthesis Methods 3

Co-authors: Brian W. Metcalf (10 shared papers)Michel J. Jung (9 shared papers)Charles Danzin (10 shared papers)Philippe Bey (5 shared papers)Jean‐Paul Vevert (1 shared paper)Bruce J. Lippert (2 shared papers)Nikolaus Seiler (2 shared papers)Frank N. Bolkenius (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry Letters (9 papers)Tetrahedron Letters (6 papers)Biochemical Pharmacology (4 papers)Antimicrobial Agents and Chemotherapy (3 papers)Journal of Medicinal Chemistry (3 papers)
Partner nations: France United Kingdom Canada

In The Last Decade

Patrick Casara

58 papers receiving 2.4k citations

Patrick Casara's Hit Papers

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Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs 1978 · 935 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

1978 Journal of the American Chemical Society

Peers

Countries citing papers authored by Patrick Casara

Since Specialization

Citations

This map shows the geographic impact of Patrick Casara's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick Casara with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick Casara more than expected).

Fields of papers citing papers by Patrick Casara

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick Casara. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick Casara. The network helps show where Patrick Casara may publish in the future.

Co-authors

The 25 scholars most cited alongside Patrick Casara, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Patrick Casara Line = papers co-authored together Patrick Casara links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 58 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs Journal of the American Chemical Society ·Brian W. Metcalf, Philippe Bey, Charles Danzin, Michel J. Jung, Patrick Casara, Jean‐Paul Vevert Hit paper breakdown →	1978	935
2	4‐Amino‐hex‐5‐enoic Acid, a Selective Catalytic Inhibitor of 4‐Aminobutyric‐Acid Aminotransferase in Mammalian Brain European Journal of Biochemistry ·Bruce J. Lippert, Brian W. Metcalf, Michel J. Jung, Patrick Casara	1977	348
3	N-(2,3-Butadienyl)-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase Journal of Medicinal Chemistry ·Philippe Bey, Frank N. Bolkenius, Nikolaus Seiler, Patrick Casara	1985	127
4	S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth Oncotarget ·Patrick Casara, James E. P. Davidson, Audrey Clapéron, Gaëtane Le Toumelin-Braizat, Meike Vogler, Alain Bruno, Maïa Chanrion, Gaëlle Lysiak-Auvity	2018	97
5	Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase Antimicrobial Agents and Chemotherapy ·Alan J. Bitonti, Timothy L. Byers, Tammy L. Bush, Patrick Casara, Cyrus J. Bacchi, Allen B. Clarkson, Peter P. McCann, Albert Sjoerdsma	1990	93
6	Blockade of αvβ3 and αvβ5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells Blood ·Sylvie Maubant, Dominique Saint-Dizier, Morgane Boutillon, Françoise Perron‐Sierra, Patrick Casara, John Angus Hickman, Ellen Van Obberghen‐Schilling +1 other	2006	89
7	Regiospecific 1,4 addition of a propargylic anion. A general synthon for 2-substituted propargylamines as potential catalytic irreversible enzyme inhibitors. Tetrahedron Letters ·Brian W. Metcalf, Patrick Casara	1975	70
8	New quinolinic derivatives as centrally active antioxidants Bioorganic & Medicinal Chemistry Letters ·Gilbert Dorey, Brian Paul Lockhart, Pierre J. Lestage, Patrick Casara	2000	64
9	Irreversible inhibition of rat S-adenosylmethionine decarboxylase by 5′-{[(Z)-4-amino-2-butenyl]methylamino}-5′-deoxyadenosine Biochemical Pharmacology ·Charles Danzin, Pierrette Marchal, Patrick Casara	1990	55
10	Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1 ACS Omega ·James B. Murray, James E. P. Davidson, I‐Jen Chen, Ben J. Davis, Pawel Dokurno, Allan Michael Jordan, Natalia Matassova, C. Pedder	2019	55
11	Effects of (2R, 5R)‐6‐heptyne‐2,5‐diamine, a potent inhibitor of l ‐ornithine decarboxylase, on rat hepatoma cells cultured in vitro European Journal of Biochemistry ·Pierre S. Mamont, Marlyse SIAT, Anne‐Marie JODER‐OHLENBUSCH, Annie Bernhardt, Patrick Casara	1984	53
12	5'-{[(Z)-4-Amino-2-butenyl]methylamino}-5'-deoxyadenosine: a potent enzyme-activated irreversible inhibitor of S-adenosyl-L-methionine decarboxylase from Escherichia coli Journal of the American Chemical Society ·Patrick Casara, Pierrette Marchal, Joseph Wagner, Charles Danzin	1989	51
13	.alpha.-Ethynyl and .alpha.-vinyl analogs of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase Journal of Medicinal Chemistry ·Charles Danzin, Patrick Casara, Brian W. Metcalf +1 other	1981	49
14	A One-Step Synthesis of 2-(2-Pyridyl)-3H-indol-3-one N-Oxide: Is It an Efficient Spin Trap for Hydroxyl Radical? The Journal of Organic Chemistry ·Gerald M. Rosen, Pei Tsai, Eugene D. Barth, Gilbert Dorey, Patrick Casara, Michael Spedding, Howard J. Halpern	2000	49
15	General synthetic access to α-allenyl amines and α-allenyl-α-aminoacids as potential enzyme activated irreversible inhibitors of PLP dependent enzymes Tetrahedron Letters ·Patrick Casara, K. JUND, Philippe Bey	1984	48
16	(2R,5R)-6-heptyne-2,5-diamine, an extremely potent inhibitor of mammalian ornithine decarboxylase Biochemical and Biophysical Research Communications ·Charles Danzin, Patrick Casara, Brian W. Metcalf, Michel J. Jung +1 other	1983	42
17	Mechanism of the stereospecific irreversible inhibition of bacterial glutamic acid decarboxylase by (R)-(-)-4-aminohex-5-ynoic acid, an analog of 4-aminobutyric acid Biochemistry ·Michel J. Jung, Brian W. Metcalf, Bruce J. Lippert, Patrick Casara	1978	41
18	Catalytic irreversible inhibition of bacterial and plant arginine decarboxylase activities by novel substrate and product analogues Biochemical Journal ·Alan J. Bitonti, Patrick Casara, P. P. McCann, Philippe Bey	1987	41
19	Substituted benzocyloheptenes as potent and selective αv integrin antagonists Bioorganic & Medicinal Chemistry Letters ·Françoise Perron‐Sierra, Dominique Saint Dizier, Marc Bertrand, Annie Genton, Patrick Casara +1 other	2002	39
20	Trimethylsilylacetylene-N-carboethoxy glycinate dianion - a general synthon for α-acetylenic α-amino acids. Tetrahedron Letters ·Patrick Casara, Brian W. Metcalf	1978	32

About Patrick Casara

Patrick Casara is a scholar working on Biochemistry, Organic Chemistry, Molecular Biology, Infectious Diseases and Immunology and Allergy, having authored 58 papers that have together received 2.9k indexed citations. Recurring topics across this work include Polyamine Metabolism and Applications (14 papers), Amino Acid Enzymes and Metabolism (8 papers), HIV/AIDS drug development and treatment (6 papers), Synthesis and biological activity (6 papers), Cell death mechanisms and regulation (5 papers), Asymmetric Synthesis and Catalysis (4 papers), Organic Chemistry Synthesis Methods (3 papers) and Chemical Synthesis and Analysis (3 papers). The work is most often cited by research in Biochemistry (210 citations), Molecular Biology (1.5k citations), Organic Chemistry (511 citations), Immunology and Allergy (63 citations) and Cellular and Molecular Neuroscience (201 citations). Patrick Casara has collaborated with scholars based in France, United Kingdom and Canada. Frequent co-authors include Brian W. Metcalf, Michel J. Jung, Charles Danzin, Philippe Bey, Jean‐Paul Vevert, Bruce J. Lippert, Nikolaus Seiler, Frank N. Bolkenius, Alan J. Bitonti and Gilbert Dorey. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, Biochemical Pharmacology, Antimicrobial Agents and Chemotherapy and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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