P. Brick

7.4k citations

40 papers · 6.3k · 4 hit papers · h-index 27

Impact in

Molecular Biology top 1%
- RNA and protein synthesis mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Protein Structure and Dynamics
- RNA modifications and cancer
- DNA and Nucleic Acid Chemistry
Oncology top 5%
- Drug Transport and Resistance Mechanisms

Papers in

Molecular Biology 31
- RNA and protein synthesis mechanisms 15
- DNA and Nucleic Acid Chemistry 7
- Protein Structure and Dynamics 6
- DNA Repair Mechanisms 4
- RNA modifications and cancer 4
- bioluminescence and chemiluminescence research 3
Materials Chemistry 18
- Enzyme Structure and Function 18

Co-authors: Nicholas P. Franks (6 shared papers)Stephen Curry (4 shared papers)D. M. Blow (15 shared papers)Hendrik Mandelkow (1 shared paper)Elena Conti (3 shared papers)David L. Ollis (5 shared papers)Thomas A. Steitz (4 shared papers)Talapady N. Bhat (2 shared papers)
Journals: Journal of Molecular Biology (10 papers)Structure (3 papers)Nature (3 papers)Biochemistry (3 papers)Nucleic Acids Research (2 papers)
Partner nations: United Kingdom United States France

In The Last Decade

P. Brick

40 papers receiving 6.1k citations

P. Brick's Hit Papers

align trajectories log scale

Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites 1998 · 1.2k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1998 Nature Structural Biology
1996 Structure
1985 Nature
1985 Nature

Peers

Countries citing papers authored by P. Brick

Since Specialization

Citations

This map shows the geographic impact of P. Brick's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by P. Brick with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites P. Brick more than expected).

Fields of papers citing papers by P. Brick

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by P. Brick. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by P. Brick. The network helps show where P. Brick may publish in the future.

Co-authors

The 25 scholars most cited alongside P. Brick, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with P. Brick Line = papers co-authored together P. Brick links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 40 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites Nature Structural Biology ·Stephen Curry, Hendrik Mandelkow, P. Brick, Nicholas P. Franks Hit paper breakdown →	1998	1193
2	Hydrogen bonding and biological specificity analysed by protein engineering Nature ·Alan R. Fersht, Jianping Shi, J.W. Knill-Jones, Denise M. Lowe, Anthony J. Wilkinson, D. M. Blow, P. Brick, Paul Carter, Mary Miu Yee Waye, Greg Winter Hit paper breakdown →	1985	887
3	Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP Nature ·David L. Ollis, P. Brick, R. Hamlin, N. G. Xuong, Thomas A. Steitz Hit paper breakdown →	1985	731
4	Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes Structure ·Elena Conti, Nicholas P. Franks, P. Brick Hit paper breakdown →	1996	506
5	Fatty acid binding to human serum albumin: new insights from crystallographic studies Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids ·Stephen Curry, P. Brick, Nicholas P. Franks	1999	440
6	Structure of tyrosyl-tRNA synthetase refined at 2.3 Å resolution Journal of Molecular Biology ·P. Brick, Talapady N. Bhat, D. M. Blow	1989	342
7	Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed β-propeller Structure ·Jing Li, P. Brick, MC O'Hare, Tadeusz Skarżyński, LF Lloyd, VA Curry, IM Clark, HF Bigg, B L Hazleman, TE Cawston, DM Blow	1995	210
8	Structural Basis for the Inhibition of Firefly Luciferase by a General Anesthetic Biophysical Journal ·Nicholas P. Franks, Andrew Jenkins, Elena Conti, W.R. Lieb, P. Brick	1998	183
9	Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy Structure ·Siân Rowsell, Richard A. Pauptit, Alec D. Tucker, Roger G. Melton, D. M. Blow, P. Brick	1997	152
10	Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases. PubMed ·Jun Li, Alice Vrielink, P. Brick, D. M. Blow	1993	150
11	Crystal structure of cholesterol oxidase complexed with a steroid substrate: Implications for flavin adenine dinucleotide dependent alcohol oxidases Biochemistry ·Jiayao Li, Alice Vrielink, P. Brick, D. M. Blow	1993	144
12	Tyrosyl-tRNA synthetase forms a mononucleotide-binding fold Journal of Molecular Biology ·Talapady N. Bhat, D. M. Blow, P. Brick, Jens Nyborg	1982	134
13	Collagenase: a key enzyme in collagen turnover Biochemistry and Cell Biology ·W. D. Shingleton, T. E. Cawston, Deborah J. Hodges, P. Brick	1996	132
14	Crystal structure of a Kunitz-type trypsin inhibitor from Erythrina coffra seeds Journal of Molecular Biology ·Silvia Onesti, P. Brick, D. M. Blow	1991	116
15	Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Journal of Biological Chemistry ·James R. Birtley, Stephen R. Knox, Agnès M. Jaulent, P. Brick, Robin J. Leatherbarrow, Stephen Curry	2005	115
16	The Elongator subunit Elp3 contains a Fe ₄ S ₄ cluster and binds S‐adenosylmethionine Molecular Microbiology ·Christina Paraskevopoulou, Shirley A. Fairhurst, David Lowe, P. Brick, Silvia Onesti	2005	108
17	Crystal structure of a deletion mutant of a tyrosyl-tRNA synthetase complexed with tyrosine Journal of Molecular Biology ·P. Brick, D. M. Blow	1987	102
18	Crystal structure of a NAD-dependent d-glycerate dehydrogenase at 2·4 Å resolution Journal of Molecular Biology ·Jonathan D. Goldberg, Toyokazu Yoshida, P. Brick	1994	98
19	Structure of an Archaeal Homolog of the Eukaryotic RNA Polymerase II RPB4/RPB7 Complex Molecular Cell ·Flavia Todone, P. Brick, Finn Werner, Robert O. J. Weinzierl, Silvia Onesti	2001	90
20	Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction Biochemistry ·G. Desogus, Flavia Todone, P. Brick, Silvia Onesti	2000	72

About P. Brick

P. Brick is a scholar working on Molecular Biology, Materials Chemistry, Genetics, Cancer Research and Infectious Diseases, having authored 40 papers that have together received 6.3k indexed citations. Recurring topics across this work include Enzyme Structure and Function (18 papers), RNA and protein synthesis mechanisms (15 papers), DNA and Nucleic Acid Chemistry (7 papers), Protein Structure and Dynamics (6 papers), Bacterial Genetics and Biotechnology (5 papers), DNA Repair Mechanisms (4 papers), RNA modifications and cancer (4 papers) and bioluminescence and chemiluminescence research (3 papers). The work is most often cited by research in Molecular Biology (5.2k citations), Oncology (890 citations), Biophysics (174 citations), Biotechnology (234 citations) and Genetics (743 citations). P. Brick has collaborated with scholars based in United Kingdom, United States and France. Frequent co-authors include Nicholas P. Franks, Stephen Curry, D. M. Blow, Hendrik Mandelkow, Elena Conti, David L. Ollis, Thomas A. Steitz, Talapady N. Bhat, R. Hamlin and Silvia Onesti. Their work appears in journals such as Journal of Molecular Biology, Structure, Nature, Biochemistry and Nucleic Acids Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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P. Brick

P. Brick's Hit Papers

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Fields of papers citing papers by P. Brick

All Works

About P. Brick

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