Fritz Eckstein

13.8k citations

199 papers · 12.3k · 2 hit papers · h-index 56

Impact in

Molecular Biology top 0.5%
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Biochemical and Molecular Research
Virology top 2%

Papers in

Molecular Biology 159
- DNA and Nucleic Acid Chemistry 83
- RNA and protein synthesis mechanisms 65
- Advanced biosensing and bioanalysis techniques 51
- RNA modifications and cancer 22
- Biochemical and Molecular Research 19
- Chemical Synthesis and Analysis 13
Organic Chemistry 45
- Organophosphorus compounds synthesis 13

Co-authors: David M.J. Lilley (9 shared papers)Johann Ott (4 shared papers)Kay L. Nakamaye (4 shared papers)János Ludwig (5 shared papers)Gerald D. Gish (3 shared papers)Fritz Benseler (9 shared papers)WALTER A. SCHMIDT (4 shared papers)Roger Sidney Goody (3 shared papers)
Journals: Biochemistry (38 papers)Nucleic Acids Research (20 papers)European Journal of Biochemistry (17 papers)The Journal of Organic Chemistry (7 papers)Methods in enzymology on CD-ROM/Methods in enzymology (5 papers)
Partner nations: Germany United States United Kingdom

In The Last Decade

Fritz Eckstein

193 papers receiving 11.2k citations

Fritz Eckstein's Hit Papers

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Phosphorothioates, Essential Components of Therapeutic Oligonucleotides 2014 · 563 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2014 Nucleic Acid Therapeutics
1985 Nucleic Acids Research

Peers

Countries citing papers authored by Fritz Eckstein

Since Specialization

Citations

This map shows the geographic impact of Fritz Eckstein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Fritz Eckstein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Fritz Eckstein more than expected).

Fields of papers citing papers by Fritz Eckstein

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Fritz Eckstein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Fritz Eckstein. The network helps show where Fritz Eckstein may publish in the future.

Co-authors

The 25 scholars most cited alongside Fritz Eckstein, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Fritz Eckstein Line = papers co-authored together Fritz Eckstein links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 199 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA Nucleic Acids Research ·W. John Taylor, Johann Ott, Fritz Eckstein Hit paper breakdown →	1985	810
2	Nucleic Acids and Molecular Biology Nucleic acids and molecular biology ·Fritz Eckstein, David M.J. Lilley	1994	571
3	Phosphorothioates, Essential Components of Therapeutic Oligonucleotides Nucleic Acid Therapeutics ·Fritz Eckstein Hit paper breakdown →	2014	563
4	Inhibition of restriction endonuclease Nel I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis Nucleic Acids Research ·Kay L. Nakamaye, Fritz Eckstein	1986	524
5	Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes Science ·Wolfgang A. Pieken, David Benee Olsen, Fritz Benseler, Helle Aurup, Fritz Eckstein	1991	406
6	Rapid and efficient synthesis of nucleoside 5'-0-(1-thiotriphosphates), 5'-triphosphates and 2',3'-cyclophosphorothioates using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one The Journal of Organic Chemistry ·János Ludwig, Fritz Eckstein	1989	334
7	Phosphorothioate Oligodeoxynucleotides: What Is Their Origin and What Is Unique About Them? Antisense and Nucleic Acid Drug Development ·Fritz Eckstein	2000	325
8	5′–3′ Exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis Nucleic Acids Research ·Jon R. Sayers, WALTER A. SCHMIDT, Fritz Eckstein	1988	311
9	MODIFIED OLIGONUCLEOTIDES: Synthesis and Strategy for Users Annual Review of Biochemistry ·Sandeep Kumar Verma, Fritz Eckstein	1998	267
10	The Structure, Function and Application of the Hammerhead Ribozyme European Journal of Biochemistry ·Klara R. Birikh, Paul A. Heaton, Fritz Eckstein	1997	238
11	The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA Nucleic Acids Research ·John William Taylor, WALTER A. SCHMIDT, Richard Cosstick, And̀rzej Okruszek, Fritz Eckstein	1985	237
12	The magnesium ion-dependent adenosine triphosphatase of myosin. Two-step processes of adenosine triphosphate association and adenosine diphosphate dissociation Biochemical Journal ·Clive R. Bagshaw, John F. Eccleston, Fritz Eckstein, Roger Sidney Goody, H. Gutfreund, David Rostron Trentham	1974	235
13	A Three-Dimensional Model for the Hammerhead Ribozyme Based on Fluorescence Measurements Science ·Thomas Tuschl, Christoph Gohlke, Thomas M. Jovin, Éric Westhof, Fritz Eckstein	1994	208
14	Synthesis and properties of diastereoisomers of adenosine 5'-(O-1-thiotriphosphate) and adenosine 5'-(O-2-thiotriphosphate) Biochemistry ·Fritz Eckstein, Roger Sidney Goody	1976	203
15	DNA and RNA Sequence Determination Based on Phosphorothioate Chemistry Science ·Gerald D. Gish, Fritz Eckstein	1988	198
16	Phosphorothioate Analogues of Nucleotides—Tools for the Investigation of Biochemical Processes Angewandte Chemie International Edition in English ·Fritz Eckstein	1983	190
17	Left-handed DNA: from Synthetic Polymers to Chromosomes Journal of Biomolecular Structure and Dynamics ·Thomas M. Jovin, Lawrence P. McIntosh, Donna J. Arndt‐Jovin, David A. Zarling, Michel Robert‐Nicoud, Johan H. van de Sande, Keith F. Jorgenson, Fritz Eckstein	1983	172
18	Synthesis and configurational analysis of a dinucleoside phosphate isotopically chiral at phosphorus. Stereochemical course of Penicillium citrinum nuclease P1 reaction Biochemistry ·Barry V. L. Potter, Bernard A. Connolly, Fritz Eckstein	1983	154
19	Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration Nucleic Acids Research ·Hans van Tol, Jamal M. Buzayan, Paul A. Feldstein, Fritz Eckstein, George E. Bruening	1990	153
20	Phosphorothioates in molecular biology Trends in Biochemical Sciences ·Fritz Eckstein, Gerald D. Gish	1989	152

About Fritz Eckstein

Fritz Eckstein is a scholar working on Molecular Biology, Organic Chemistry, Infectious Diseases, Physiology and Pharmacology, having authored 199 papers that have together received 12.3k indexed citations. Recurring topics across this work include DNA and Nucleic Acid Chemistry (83 papers), RNA and protein synthesis mechanisms (65 papers), Advanced biosensing and bioanalysis techniques (51 papers), RNA modifications and cancer (22 papers), Biochemical and Molecular Research (19 papers), HIV/AIDS drug development and treatment (18 papers), Organophosphorus compounds synthesis (13 papers) and Chemical Synthesis and Analysis (13 papers). The work is most often cited by research in Molecular Biology (10.3k citations), Virology (299 citations), Infectious Diseases (967 citations), Organic Chemistry (1.4k citations) and Biochemistry (350 citations). Fritz Eckstein has collaborated with scholars based in Germany, United States and United Kingdom. Frequent co-authors include David M.J. Lilley, Johann Ott, Kay L. Nakamaye, János Ludwig, Gerald D. Gish, Fritz Benseler, WALTER A. SCHMIDT, Roger Sidney Goody, Thomas Tuschl and Jon R. Sayers. Their work appears in journals such as Biochemistry, Nucleic Acids Research, European Journal of Biochemistry, The Journal of Organic Chemistry and Methods in enzymology on CD-ROM/Methods in enzymology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Fritz Eckstein

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About Fritz Eckstein

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