Mark E. Fraley

1.9k citations

32 papers · 1.1k · h-index 19

Impact in

Organic Chemistry top 5%
- Synthesis and biological activity
- Cyclization and Aryne Chemistry
- Synthesis and Biological Evaluation
- Chemical synthesis and alkaloids
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
- Multicomponent Synthesis of Heterocycles
Toxicology top 5%

Papers in

Molecular Biology 16
- DNA Repair Mechanisms 3
- Angiogenesis and VEGF in Cancer 3
- Ubiquitin and proteasome pathways 2
Oncology 14
- Cancer Treatment and Pharmacology 7
- HER2/EGFR in Cancer Research 6
- Cancer-related Molecular Pathways 3

Co-authors: Norma J. Tom (4 shared papers)Andrew G. Myers (4 shared papers)David J. Madar (3 shared papers)Scott B. Cohen (3 shared papers)George D. Hartman (13 shared papers)Robert S. Rubino (3 shared papers)Kathleen Coll (7 shared papers)Kenneth A. Thomas (7 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (10 papers)Journal of the American Chemical Society (3 papers)Cancer Research (2 papers)Expert Opinion on Therapeutic Patents (2 papers)Expert Opinion on Investigational Drugs (1 paper)
Partner nations: United States Canada Ireland

In The Last Decade

Mark E. Fraley

32 papers receiving 1.0k citations

Peers

Countries citing papers authored by Mark E. Fraley

Since Specialization

Citations

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Fields of papers citing papers by Mark E. Fraley

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mark E. Fraley. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mark E. Fraley. The network helps show where Mark E. Fraley may publish in the future.

Co-authors

The 25 scholars most cited alongside Mark E. Fraley, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Mark E. Fraley Line = papers co-authored together Mark E. Fraley links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 32 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	A Convergent Synthetic Route to (+)-Dynemicin A and Analogs of Wide Structural Variability Journal of the American Chemical Society ·Andrew G. Myers, Norma J. Tom, Mark E. Fraley, Scott B. Cohen, David J. Madar	1997	173
2	Synthesis and Initial SAR Studies of 3,6-Disubstituted Pyrazolo[1,5-a]pyrimidines: A New Class of KDR Kinase Inhibitors Bioorganic & Medicinal Chemistry Letters ·Mark E. Fraley, William F. Hoffman, Robert S. Rubino, Randall W. Hungate, Andrew J. Tebben, Ruth Z. Rutledge, Rosemary C. McFall, William R. Huckle, Richard Kendall, Kathleen Coll, Kenneth A. Thomas	2002	108
3	Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics Bioorganic & Medicinal Chemistry Letters ·Mark E. Fraley, Robert S. Rubino, William F. Hoffman, Scott R. Hambaugh, Kenneth L. Arrington, Randall W. Hungate, Mark T. Bilodeau, Andrew J. Tebben, Ruth Z. Rutledge, Richard Kendall, Rosemary C. McFall, William R. Huckle, Kathleen Coll, Kenneth A. Thomas	2002	80
4	Synthesis of (+)-dynemicin A and analogs of wide structural variability: establishment of the absolute configuration of natural dynemicin A Chemistry & Biology ·Andrew G. Myers, Mark E. Fraley, Norma J. Tom, Scott B. Cohen, David J. Madar	1995	75
5	Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor Journal of Pharmacology and Experimental Therapeutics ·Eric L. Moore, Mark E. Fraley, Ian M. Bell, Christopher S. Burgey, Rebecca B. White, Chi‐Chung Li, Christopher P. Regan, Andrew Danziger, Maria S. Michener, Eric D. Hostetler, Pradeep Banerjee, Christopher Salvatore	2020	57
6	An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis Molecular and Cellular Biology ·Weikang Tao, Victoria J. South, Ronald E. Diehl, Joseph P. Davide, Laura Sepp‐Lorenzino, Mark E. Fraley, Kenneth L. Arrington, Robert B. Lobell	2006	49
7	Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Mark E. Fraley, Kenneth L. Arrington, Carolyn A. Buser, Patrice A. Ciecko, Kathleen Coll, Christine Fernandes, George D. Hartman, William F. Hoffman, Joseph J. Lynch, Rosemary C. McFall, Keith Rickert, Romi Singh, Sheri Smith, Kenneth A. Thomas, Bradley K. Wong	2003	46
8	Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein Bioorganic & Medicinal Chemistry Letters ·Christopher D. Cox, Michael J. Breslin, David B. Whitman, Paul J. Coleman, R. M. Garbaccio, Mark E. Fraley, Matthew M. Zrada, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Robert B. Lobell, Weikang Tao, Marc Abrams, Vicki J. South, Hans E. Huber, Nancy E. Kohl, George D. Hartman	2007	43
9	Kinase insert domain-containing receptor kinase inhibitors as anti-angiogenic agents Expert Opinion on Investigational Drugs ·George D. Hartman, Mark E. Fraley, Mark T. Bilodeau	2002	41
10	Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR Bioorganic & Medicinal Chemistry Letters ·Zhicai Wu, Mark E. Fraley, Mark T. Bilodeau, Mildred L. Kaufman, Edward S. Tasber, Adrienne E. Balitza, George D. Hartman, Kathleen Coll, Keith Rickert, Jennifer M. Shipman, Bin Shi, Laura Sepp‐Lorenzino, Kenneth A. Thomas	2004	40
11	3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts Bioorganic & Medicinal Chemistry Letters ·Edward J. Brnardic, Mark E. Fraley, R. M. Garbaccio, M. E. Layton, John M. Sanders, Chris Culberson, Marlene A. Jacobson, Brian C. Magliaro, Pete H. Hutson, Julie A. O’Brien, Sarah L. Huszar, Jason M. Uslaner, Kerry L. Fillgrove, Cuyue Tang, Yuhsin Kuo, Sylvie M. Sur, George D. Hartman	2010	34
12	Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia Expert Opinion on Therapeutic Patents ·Mark E. Fraley	2009	33
13	Insights into the Mechanism of DNA Cleavage by Dynemicin A as Revealed by DNA-Binding and -Cleavage Studies of Synthetic Analogs Journal of the American Chemical Society ·Andrew G. Myers, Scott B. Cohen, Norma J. Tom, David J. Madar, Mark E. Fraley	1995	32
14	Rapid X-ray diffraction analysis of HIV-1 protease–inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme Acta Crystallographica Section D Biological Crystallography ·S. Munshi, Z. Chen, Yihong Li, David B. Olsen, Mark E. Fraley, Randall W. Hungate, Lawrence C. Kuo	1998	29
15	Highly Convergent Route to Dynemicins of Wide Structural Variability. Enantioselective Synthesis of Quinone Imine Precursors to Natural and Nonnatural Dynemicins Journal of the American Chemical Society ·Andrew G. Myers, Mark E. Fraley, Norma J. Tom	1994	27
16	Two methods for the preparation of 2-cyclohexenones from resin-bound 1,3-cyclohexanedione Tetrahedron Letters ·Mark E. Fraley, Robert S. Rubino	1997	27
17	Property-Based Design of KDR Kinase Inhibitors Current Medicinal Chemistry ·Mark E. Fraley, William F. Hoffman, Kenneth L. Arrington, Randy W. Hungate, George D. Hartman, Rosemary C. McFall, Kathleen Coll, Keith Rickert, Kenneth A. Thomas, Georgia B. McGaughey	2004	25
18	A Novel Orally Bioavailable Inhibitor of Kinase Insert Domain-Containing Receptor Induces Antiangiogenic Effects and Prevents Tumor Growth *in Vivo* Cancer Research ·Laura Sepp‐Lorenzino, Elaine Rands, Xianzhi Mao, Brett Connolly, Jennifer M. Shipman, Joanne Antanavage, Susan L. Hill, Lenora J. Davis, Stephen C. Beck, Keith Rickert, Kathleen Coll, Patrice A. Ciecko, Mark E. Fraley, William F. Hoffman, George D. Hartman, David Heimbrook, W. Wayt Gibbs, Nancy E. Kohl, Kenneth A. Thomas	2004	22
19	Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates Bioorganic & Medicinal Chemistry Letters ·Vadim Dudkin, Keith Rickert, Constantine Kreatsoulas, Cheng Wang, Kenneth L. Arrington, Mark E. Fraley, George D. Hartman, Yowei Yan, Mari Ikuta, Steven M. Stirdivant, Robert Drakas, Eileen S. Walsh, Kelly Hamilton, Carolyn A. Buser, Robert B. Lobell, Laura Sepp‐Lorenzino	2012	20
20	Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor ACS Medicinal Chemistry Letters ·R. M. Garbaccio, Edward J. Brnardic, Mark E. Fraley, George D. Hartman, Pete H. Hutson, Julie A. O’Brien, Brian C. Magliaro, Jason M. Uslaner, Sarah L. Huszar, Kerry L. Fillgrove, James H. Small, Cuyue Tang, Yuhsin Kuo, Marlene A. Jacobson	2010	17

About Mark E. Fraley

Mark E. Fraley is a scholar working on Molecular Biology, Oncology, Organic Chemistry, Cell Biology and Cellular and Molecular Neuroscience, having authored 32 papers that have together received 1.1k indexed citations. Recurring topics across this work include Cancer Treatment and Pharmacology (7 papers), HER2/EGFR in Cancer Research (6 papers), Microtubule and mitosis dynamics (5 papers), DNA Repair Mechanisms (3 papers), Migraine and Headache Studies (3 papers), Cancer-related Molecular Pathways (3 papers), Angiogenesis and VEGF in Cancer (3 papers) and Ubiquitin and proteasome pathways (2 papers). The work is most often cited by research in Organic Chemistry (608 citations), Toxicology (50 citations), Molecular Biology (430 citations), Oncology (137 citations) and Cell Biology (84 citations). Mark E. Fraley has collaborated with scholars based in United States, Canada and Ireland. Frequent co-authors include Norma J. Tom, Andrew G. Myers, David J. Madar, Scott B. Cohen, George D. Hartman, Robert S. Rubino, Kathleen Coll, Kenneth A. Thomas, William F. Hoffman and Mark T. Bilodeau. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of the American Chemical Society, Cancer Research, Expert Opinion on Therapeutic Patents and Expert Opinion on Investigational Drugs.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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