John E. Le Lay

2.5k citations

27 papers · 1.8k · h-index 22

Impact in

Surgery top 5%
- Pancreatic function and diabetes
Cancer Research top 10%
- MicroRNA in disease regulation

Papers in

Surgery 14
- Pancreatic function and diabetes 13
- Cholesterol and Lipid Metabolism 1
Molecular Biology 10
- Metabolism, Diabetes, and Cancer 3
- Epigenetics and DNA Methylation 2
- Genomics and Chromatin Dynamics 2

Co-authors: Klaus H. Kaestner (19 shared papers)Marc Montminy (4 shared papers)Susan A. Hedrick (2 shared papers)Young‐Sil Yoon (1 shared paper)Bing Luan (1 shared paper)Rexford S. Ahima (2 shared papers)Roland W. Stein (2 shared papers)Eva Henderson (2 shared papers)
Journals: Diabetes (3 papers)Journal of Clinical Investigation (2 papers)Molecular Endocrinology (2 papers)Diabetologia (2 papers)Proceedings of the National Academy of Sciences (2 papers)
Partner nations: United States Germany Spain

In The Last Decade

John E. Le Lay

27 papers receiving 1.7k citations

Peers

Replace Risheng Ye with:

Risheng Ye United States

Anton Bauer Austria

Joanne Rasschaert Belgium

Raffaele Teperino Germany

Tasuku IMAI Japan

Hee‐Woong Lim United States

Weiping J. Zhang China

Chantal Filloux France

Yifei Miao United States

Ingrid C. Gaemers Netherlands

John E. Le Lay relative to Risheng Ye United States Risheng Ye's profile →

Citations per field

00.5×1.5×2×2.5×

Risheng Ye · 1×

×1.9 473/243

SURGE

×1.6 133/84

CR

×0.9 546/627

MB

×2.5 70/28

HEPAT

×0.5 193/401

EPIDE

Citations per year

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Countries citing papers authored by John E. Le Lay

Since Specialization

Citations

This map shows the geographic impact of John E. Le Lay's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John E. Le Lay with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John E. Le Lay more than expected).

Fields of papers citing papers by John E. Le Lay

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John E. Le Lay. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John E. Le Lay. The network helps show where John E. Le Lay may publish in the future.

Co-authors

The 25 scholars most cited alongside John E. Le Lay, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John E. Le Lay Line = papers co-authored together John E. Le Lay links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 27 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	CREB pathway links PGE2 signaling with macrophage polarization Proceedings of the National Academy of Sciences ·Bing Luan, Young‐Sil Yoon, John E. Le Lay, Klaus H. Kaestner, Susan A. Hedrick, Marc Montminy	2015	238
2	MafB Diabetes ·Isabella Artner, John E. Le Lay, Yan Hang, Lynda Elghazi, Jonathan Cummings Schisler, Eva Henderson, Beatriz Sosa‐Pineda, Roland W. Stein	2006	170
3	Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling Journal of Clinical Investigation ·Russell Miller, Qingwei Chu, John E. Le Lay, Philipp E. Scherer, Rexford S. Ahima, Klaus H. Kaestner, Marc Foretz, Benoı̂t Viollet	2011	151
4	TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts Journal of Clinical Investigation ·Diana L. Bernstein, John E. Le Lay, Elena G. Ruano, Klaus H. Kaestner	2015	113
5	Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting Diabetes ·John E. Le Lay, Ming Yu, Ali Naji, Klaus H. Kaestner +1 other	2013	110
6	Foxa1 and Foxa2 Maintain the Metabolic and Secretory Features of the Mature β-Cell Molecular Endocrinology ·Nan Gao, John E. Le Lay, Wei Dong Qin, Nicolai M. Doliba, Jonathan Schug, Alan J. Fox, Olga Smirnova, Franz M. Matschinsky	2010	96
7	Hepatic function is preserved in the absence of mature microRNAs # Hepatology ·Nicholas J. Hand, Zankhana R. Master, John E. Le Lay, Joshua R. Friedman	2008	95
8	CRTC2 (TORC2) Contributes to the Transcriptional Response to Fasting in the Liver but Is Not Required for the Maintenance of Glucose Homeostasis Cell Metabolism ·John E. Le Lay, Geetu Tuteja, Peter White, Ravindra N. Dhir, Rexford S. Ahima, Klaus H. Kaestner	2009	80
9	The Fox Genes in the Liver: From Organogenesis to Functional Integration Physiological Reviews ·John E. Le Lay, Klaus H. Kaestner	2010	74
10	Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance Cell Reports ·Émilie Blanchet, Sam Van de Velde, Shigenobu Matsumura, Ergeng Hao, John E. Le Lay, Klaus H. Kaestner, Marc Montminy	2015	67
11	CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells Molecular Metabolism ·Soona Shin, John E. Le Lay, Logan J. Everett, Rana K. Gupta, Kiran Rafiq, Klaus H. Kaestner	2014	52
12	Tissue-specific regulation of mouse MicroRNA genes in endoderm-derived tissues Nucleic Acids Research ·Yan Ping Gao, Jonathan Schug, Lindsay B. McKenna, John E. Le Lay, Klaus H. Kaestner, Linda E. Greenbaum	2010	49
13	CCAAT/Enhancer Binding Protein-β Is a Transcriptional Regulator of Peroxisome-Proliferator-Activated Receptor-γ Coactivator-1α in the Regenerating Liver Molecular Endocrinology ·H Joe Wang, Tanuja Harshani Peiris, A. Mowery, John E. Le Lay, Linda E. Greenbaum +1 other	2008	47
14	Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver BMC Genomics ·Logan J. Everett, John E. Le Lay, Sabina Lukovac, David J. Steger, Mitchell A. Lazar, Klaus H. Kaestner +1 other	2013	47
15	The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation Nature Communications ·Jeniffer B. Hernandez, Christina C. Chang, Mathias Leblanc, David Robert Grimm, John E. Le Lay, Klaus H. Kaestner, Ye Zheng, Marc Montminy	2015	46
16	Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas Mechanisms of Development ·Maria L. Golson, John E. Le Lay, Nan Gao, Nuria C. Bramswig, Kathleen M. Loomes, Rebecca J. Oakey, Catherine Lee May, Peter White	2009	45
17	Increased Hippocampal Neurogenesis and Accelerated Response to Antidepressants in Mice with Specific Deletion of CREB in the Hippocampus: Role of cAMP Response-Element Modulator τ Journal of Neuroscience ·Brigitta B. Gundersen, Lisa A. Briand, Jennifer L Onksen, John E. Le Lay, Klaus H. Kaestner, Julie A. Blendy	2013	43
18	C/EBPβ Activates E2F-regulated Genes in Vivo via Recruitment of the Coactivator CREB-binding Protein/P300 Journal of Biological Chemistry ·Haitao Wang, Brian Larris, Tanuja Harshani Peiris, John E. Le Lay, Linda E. Greenbaum +2 others	2007	42
19	The BisPCR2 method for targeted bisulfite sequencing Epigenetics & Chromatin ·Diana L. Bernstein, Vasumathi Kameswaran, John E. Le Lay, Karyn L. Sheaffer, Klaus H. Kaestner	2015	40
20	Involvement of PDX-1 in activation of human insulin gene transcription Journal of Endocrinology ·John E. Le Lay, Roland W. Stein	2006	38

About John E. Le Lay

John E. Le Lay is a scholar working on Surgery, Molecular Biology, Hepatology, Cancer Research and Developmental Neuroscience, having authored 27 papers that have together received 1.8k indexed citations. Recurring topics across this work include Pancreatic function and diabetes (13 papers), Metabolism, Diabetes, and Cancer (3 papers), Epigenetics and DNA Methylation (2 papers), Liver physiology and pathology (2 papers), Genomics and Chromatin Dynamics (2 papers), MicroRNA in disease regulation (2 papers), Adipokines, Inflammation, and Metabolic Diseases (2 papers) and Cholesterol and Lipid Metabolism (1 paper). The work is most often cited by research in Surgery (473 citations), Cancer Research (133 citations), Molecular Biology (546 citations), Hepatology (70 citations) and Epidemiology (193 citations). John E. Le Lay has collaborated with scholars based in United States, Germany and Spain. Frequent co-authors include Klaus H. Kaestner, Marc Montminy, Susan A. Hedrick, Young‐Sil Yoon, Bing Luan, Rexford S. Ahima, Roland W. Stein, Eva Henderson, Elena G. Ruano and Joshua R. Friedman. Their work appears in journals such as Diabetes, Journal of Clinical Investigation, Molecular Endocrinology, Diabetologia and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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John E. Le Lay

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