I‐Wu Chen

1.6k citations

22 papers · 872 · h-index 16

Impact in

Pharmacology top 5%
- Pharmacogenetics and Drug Metabolism
Virology top 10%
- HIV Research and Treatment

Papers in

Oncology 12
- Drug Transport and Resistance Mechanisms 5
- Peptidase Inhibition and Analysis 4
Infectious Diseases 8
- HIV/AIDS drug development and treatment 8

Co-authors: Jiunn H. Lin (10 shared papers)Masato Chiba (5 shared papers)Masayo Yamazaki (3 shared papers)F A deLuna (5 shared papers)Jerome Hochman (2 shared papers)William Neway (1 shared paper)Janice Rowe (1 shared paper)Tomoyuki Ohe (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry Letters (7 papers)Journal of Medicinal Chemistry (3 papers)Drug Metabolism and Disposition (2 papers)Pharmaceutical Research (2 papers)Biochemical Pharmacology (1 paper)
Partner nations: United States Japan

In The Last Decade

I‐Wu Chen

22 papers receiving 810 citations

Peers

Countries citing papers authored by I‐Wu Chen

Since Specialization

Citations

This map shows the geographic impact of I‐Wu Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by I‐Wu Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites I‐Wu Chen more than expected).

Fields of papers citing papers by I‐Wu Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by I‐Wu Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by I‐Wu Chen. The network helps show where I‐Wu Chen may publish in the future.

Co-authors

The 25 scholars most cited alongside I‐Wu Chen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with I‐Wu Chen Line = papers co-authored together I‐Wu Chen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 22 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	In Vitro Substrate Identification Studies for P-glycoprotein-Mediated Transport: Species Difference and Predictability of in Vivo Results Journal of Pharmacology and Experimental Therapeutics ·Masayo Yamazaki, William Neway, Tomoyuki Ohe, I‐Wu Chen, Janice Rowe, Jerome Hochman, Masato Chiba, Jiunn H. Lin	2001	210
2	Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction . PubMed ·Jiunn H. Lin, Masato Chiba, I‐Wu Chen, Joy A. Nishime, F A deLuna, Masayo Yamazaki, Yuh J. Lin	1999	76
3	Metabolite identification of small interfering RNA duplex by high‐resolution accurate mass spectrometry Rapid Communications in Mass Spectrometry ·Zou Yan, Philip R. Tiller, I‐Wu Chen, Michael B. Beverly, Jerome Hochman	2008	64
4	On the Absorption of Alendronate in Rats Journal of Pharmaceutical Sciences ·Jiunn H. Lin, I‐Wu Chen, F A deLuna	1994	63
5	Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position Journal of Medicinal Chemistry ·Dong-Mei Feng, Stephen J. Gardell, Sidney D. Lewis, Mark G. Bock, Zhongguo Chen, Roger Freidinger, Adel M. Naylor-Olsen, Harri G. Ramjit, Richard Woltmann, Elizabeth Baskin, Joseph J. Lynch, Robert J. Lucas, Jules A. Shafer, Kimberley B. Dancheck, I‐Wu Chen, Shi‐Shan Mao, Julie A. Krueger, Timothy R. Hare, A. M. Mulichak, Joseph P. Vacca	1997	57
6	L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor Bioorganic & Medicinal Chemistry Letters ·Philip E.J. Sanderson, Kellie J. Cutrona, Bruce D. Dorsey, Dona L. Dyer, Colleen M. McDonough, Adel M. Naylor-Olsen, I‐Wu Chen, Zhongguo Chen, Jacquelynn J. Cook, Stephen J. Gardell, Julie A. Krueger, Sidney D. Lewis, Jiunn H. Lin, Bobby J. Lucas, Elizabeth A. Lyle, Joseph J. Lynch, Maria T. Stranieri, Kari Vastag, Jules A. Shafer, Joseph P. Vacca	1998	56
7	Potent Noncovalent Thrombin Inhibitors That Utilize the Unique Amino Acid d-Dicyclohexylalanine in the P3 Position. Implications on Oral Bioavailability and Antithrombotic Efficacy Journal of Medicinal Chemistry ·Thomas J. Tucker, William C. Lumma, Sidney D. Lewis, Stephen J. Gardell, Bobby J. Lucas, Elizabeth Baskin, Richard Woltmann, Joseph J. Lynch, Elizabeth A. Lyle, Sandra D. Appleby, I‐Wu Chen, Kimberley B. Dancheck, Joseph P. Vacca	1997	50
8	A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors Bioorganic & Medicinal Chemistry Letters ·James P. Guare, John Wai, Robert Gomez, Neville J. Anthony, Samson M. Jolly, Amanda R. Cortes, Joseph P. Vacca, Peter J. Felock, Kara A. Stillmock, William A. Schleif, Gregory Moyer, Lori J. Gabryelski, Lixia Jin, I‐Wu Chen, Daria J. Hazuda, Steven D. Young	2006	38
9	Effect of Dexamethasone on the Intestinal First-Pass Metabolism of Indinavir in Rats: Evidence of Cytochrome P-450 A and p-Glycoprotein Induction Drug Metabolism and Disposition ·Jiunn H. Lin, Masato Chiba, I‐Wu Chen, Joy A. Nishime, F A deLuna, Masayo Yamazaki, Yuh J. Lin	1999	34
10	Synthesis of a Series of Potent and Orally Bioavailable Thrombin Inhibitors That Utilize 3,3-Disubstituted Propionic Acid Derivatives in the P₃ Position Journal of Medicinal Chemistry ·Thomas J. Tucker, William C. Lumma, Sidney D. Lewis, Stephen J. Gardell, Bobby J. Lucas, Jack T. Sisko, Joseph J. Lynch, Elizabeth A. Lyle, Elizabeth Baskin, Richard Woltmann, Sandra D. Appleby, I‐Wu Chen, Kimberley B. Dancheck, Adel M. Naylor-Olsen, Julie A. Krueger, Carolyn M. Cooper, Joseph P. Vacca	1997	33
11	Regiospecific Intestinal Absorption of the HIV Protease Inhibitor L-735,524 in Beagle Dogs Pharmaceutical Research ·Gloria Y. Kwei, Linda Novak, Lisa Hettrick, Elisabeth R. Reiss, Dražen Ostović, Alice E. Loper, Chung Y. Lui, Raymond J. Higgins, I‐Wu Chen, Juinn H. Lin	1995	25
12	Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors Bioorganic & Medicinal Chemistry Letters ·John Wai, Bo Young Kim, Thorsten E. Fisher, Linghang Zhuang, Mark W. Embrey, Peter Williams, Donnette D. Staas, Chris Culberson, Terry A. Lyle, Joseph P. Vacca, Daria J. Hazuda, Peter J. Felock, William A. Schleif, Lori J. Gabryelski, Lixia Jin, I‐Wu Chen, Joan D. Ellis, Rama Mallai, Steven D. Young	2007	23
13	Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors Bioorganic & Medicinal Chemistry Letters ·Craig A. Coburn, Diane M. Rush, Peter Williams, Carl F. Homnick, Elizabeth A. Lyle, Sidney D. Lewis, Bobby J. Lucas, Jillian M Di Muzio-Mower, Marylou Juliano, Julie A. Krueger, Kari Vastag, I‐Wu Chen, Joseph P. Vacca	2000	22
14	Oxo-piperazine Derivatives of N-Arylpiperazinones as Inhibitors of Farnesyltransferase Bioorganic & Medicinal Chemistry Letters ·Christopher J Dinsmore, Jeffrey M. Bergman, Donna Wei, C. Blair Zartman, Joseph P. Davide, Ian Greenberg, Dongming Liu, Timothy J. O’Neill, W. Wayt Gibbs, Kenneth S. Koblan, Nancy E. Kohl, Robert B. Lobell, I‐Wu Chen, Debra A. McLoughlin, Timothy Olah, Samuel Graham, George D. Hartman, Theresa M. Williams	2001	22
15	C6 Modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption Bioorganic & Medicinal Chemistry Letters ·Richard C.A. Isaacs, Kellie J. Cutrona, Christina L. Newton, Philip E.J. Sanderson, Mark G. Solinsky, Elizabeth Baskin, I‐Wu Chen, C. M. S. Cooper, Jacquelynn J. Cook, Stephen J. Gardell, Sidney D. Lewis, Robert J. Lucas, Elizabeth A. Lyle, Joseph J. Lynch, Adel M. Naylor-Olsen, Maria T. Stranieri, Kari Vastag, Joseph P. Vacca	1998	22
16	Synthesis, antiviral activity, and bioavailability studies of γ-lactam derived HIV protease inhibitors Bioorganic & Medicinal Chemistry ·Randall W. Hungate, Jenny L. Chen, Ken E. Starbuck, Joseph P. Vacca, Stacey L. McDaniel, Rhonda B. Levin, Bruce D. Dorsey, James P. Guare, M. Katharine Holloway, Willie L. Whitter, Paul L. Darke, Joan A. Zugay, William A. Schleif, Emilio A. Emini, J C Quintero, Juinn H. Lin, I‐Wu Chen, Paul Anderson, Joel R. Huff	1994	17
17	Route-Dependent Nonlinear Pharmacokinetics of a Novel HIV Protease Inhibitor: Involvement of Enzyme Inactivation Drug Metabolism and Disposition ·Jiunn H. Lin, I‐Wu Chen, Masato Chiba, Joy A. Nishime, F A deLuna	2000	11
18	A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability Bioorganic & Medicinal Chemistry Letters ·B.Moon Kim, Joseph P. Vacca, James P. Guare, Colleen M. Hanifin, Stuart R. Michelson, P.L. Darke, Joan A. Zugay, Emilio A. Emini, William A. Schleif, Jiunn H. Lin, I‐Wu Chen, Kari Vastag, Dražen Ostović, Paul Anderson, Joel R. Huff	1994	11
19	Pharmacokinetics and metabolism of a RAS farnesyl transferase inhibitor in rats and dogs: in vitro-in vivo correlation. PubMed ·Rominder Singh, I‐Wu Chen, Lixia Jin, Maria V. Silva, Byron H. Arison, Jiunn H. Lin, Bradley K. Wong	2001	11
20	Metabolite–P450 Complex Formation by Methylenedioxyphenyl HIV Protease Inhibitors in Rat and Human Liver Microsomes Biochemical Pharmacology ·Masato Chiba, Joy A. Nishime, I‐Wu Chen, Kari Vastag, Yousif Sahly, Byeong Moon Kim, Bruce D. Dorsey, Joseph P. Vacca, Jiunn H. Lin	1998	10

About I‐Wu Chen

I‐Wu Chen is a scholar working on Oncology, Infectious Diseases, Molecular Biology, Organic Chemistry and Pharmacology, having authored 22 papers that have together received 872 indexed citations. Recurring topics across this work include HIV/AIDS drug development and treatment (8 papers), Drug Transport and Resistance Mechanisms (5 papers), Pharmacogenetics and Drug Metabolism (4 papers), Peptidase Inhibition and Analysis (4 papers), Blood Coagulation and Thrombosis Mechanisms (4 papers), HIV Research and Treatment (4 papers), Chemical synthesis and pharmacological studies (3 papers) and Chemical Synthesis and Analysis (3 papers). The work is most often cited by research in Pharmacology (120 citations), Virology (62 citations), Oncology (347 citations), Pediatrics, Perinatology and Child Health (161 citations) and Hematology (91 citations). I‐Wu Chen has collaborated with scholars based in United States and Japan. Frequent co-authors include Jiunn H. Lin, Masato Chiba, Masayo Yamazaki, F A deLuna, Jerome Hochman, William Neway, Janice Rowe, Tomoyuki Ohe, Joseph P. Vacca and Joy A. Nishime. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Drug Metabolism and Disposition, Pharmaceutical Research and Biochemical Pharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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