Hitoshi Osaka

9.3k citations

235 papers · 5.1k · h-index 37

Impact in

Clinical Biochemistry top 0.5%
- Metabolism and Genetic Disorders
Developmental Neuroscience top 2%

Papers in

Molecular Biology 111
- RNA regulation and disease 34
- Mitochondrial Function and Pathology 23
- RNA Research and Splicing 14
- RNA modifications and cancer 13
Genetics 40
- Genetics and Neurodevelopmental Disorders 25

Co-authors: Naomichi Matsumoto (41 shared papers)Hirotomo Saitsu (33 shared papers)Ken Inoue (24 shared papers)Noriko Miyake (25 shared papers)Mitsuhiro Kato (11 shared papers)Yoshinori Tsurusaki (19 shared papers)Kiyomi Nishiyama (9 shared papers)Keiji Wada (13 shared papers)
Journals: Brain and Development (41 papers)Journal of the Neurological Sciences (9 papers)Human Mutation (7 papers)Scientific Reports (7 papers)Pediatric Neurology (6 papers)
Partner nations: Japan United States Netherlands

In The Last Decade

Hitoshi Osaka

223 papers receiving 5.0k citations

Peers

Countries citing papers authored by Hitoshi Osaka

Since Specialization

Citations

This map shows the geographic impact of Hitoshi Osaka's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hitoshi Osaka with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hitoshi Osaka more than expected).

Fields of papers citing papers by Hitoshi Osaka

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hitoshi Osaka. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hitoshi Osaka. The network helps show where Hitoshi Osaka may publish in the future.

Co-authors

The 25 scholars most cited alongside Hitoshi Osaka, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Hitoshi Osaka Line = papers co-authored together Hitoshi Osaka links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 235 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy Nature Genetics ·Hirotomo Saitsu, Mitsuhiro Kato, Takeshi Mizuguchi, Keisuke Hamada, Hitoshi Osaka, Jun Tohyama, Katsuhisa Uruno, Satoko Kumada, Kiyomi Nishiyama, Akira Nishimura, Ippei Okada, Yukiko Yoshimura, Syu-ichi Hirai, Tatsuro Kumada, Kiyoshi Hayasaka, Atsuo Fukuda, Kazuhiro Ogata, Naomichi Matsumoto	2008	384
2	Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron Human Molecular Genetics ·Hitoshi Osaka	2003	310
3	De novo mutations of voltage-gated sodium channel α _II gene SCN2A in intractable epilepsies Neurology ·Ikuo Ogiwara, Koichi Ito, Yukio Sawaishi, Hitoshi Osaka, Emi Mazaki, Ikuyo Inoue, M Montal, Tsutomu Hashikawa, T Shike, Tateki Fujiwara, Yushi Inoue, Makoto Kaneda, Kazuhiro Yamakawa	2009	154
4	Genomic Rearrangements Resulting in PLP1 Deletion Occur by Nonhomologous End Joining and Cause Different Dysmyelinating Phenotypes in Males and Females The American Journal of Human Genetics ·Ken Inoue, Hitoshi Osaka, Virginia C. Thurston, Joe T.R. Clarke, Akira Yoneyama, Lisa Rosenbarker, Thomas D. Bird, M. E. Hodes, Lisa G. Shaffer, James R. Lupski	2002	125
5	Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants Biochemical and Biophysical Research Communications ·Kaori Nishikawa, Hang Li, Ryoichi Kawamura, Hitoshi Osaka, Yu-Lai Wang, Yoko Hara, Takatsugu Hirokawa, Yoshimasa Manago, Taiju Amano, Mami Noda, Shunsuke Aoki, Keiji Wada	2003	125
6	Mutations in POLR3A and POLR3B Encoding RNA Polymerase III Subunits Cause an Autosomal-Recessive Hypomyelinating Leukoencephalopathy The American Journal of Human Genetics ·Hirotomo Saitsu, Hitoshi Osaka, Masayuki Sasaki, Jun‐ichi Takanashi, Keisuke Hamada, Akio Yamashita, Hidehiro Shibayama, Masaaki Shiina, Yukiko Kondo, Kiyomi Nishiyama, Yoshinori Tsurusaki, Noriko Miyake, Hiroshi Doi, Kazuhiro Ogata, Ken Inoue, Naomichi Matsumoto	2011	112
7	Gene therapy improves motor and mental function of aromatic l-amino acid decarboxylase deficiency Brain ·Karin Kojima, Takeshi Nakajima, Naoyuki Taga, Akihiko Miyauchi, Mitsuhiro Kato, Ayumi Matsumoto, Takahiro Ikeda, Kazuyuki Nakamura, Tetsuo Kubota, Hiroaki Mizukami, Sayaka Ono, Y. Onuki, Toshihiko Satō, Hitoshi Osaka, Shin‐ichi Muramatsu, Takanori Yamagata	2018	105
8	Proteolipid protein gene duplications causing Pelizaeus-Merzbacher disease: Molecular mechanism and phenotypic manifestations Annals of Neurology ·Ken Inoue, Hitoshi Osaka, Kiyoshi Imaizumi, Atsuo Nezu, Jun‐ichi Takanashi, Junko Arii, Keiko Murayama, Jiro Ono, Yoshiharu Kikawa, Takashi Mito, Lisa G. Shaffer, James R. Lupski	1999	101
9	Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes Stem Cell Reports ·Yuko Numasawa-Kuroiwa, Yohei Okada, Shinsuke Shibata, Noriyuki Kishi, Wado Akamatsu, Masanobu Shoji, Atsushi Nakanishi, Manabu Oyama, Hitoshi Osaka, Ken Inoue, Kazutoshi Takahashi, Shinya Yamanaka, Kenjiro Kosaki, Takao Takahashi, Hideyuki Okano	2014	100
10	A duplicated PLP gene causing Pelizaeus-Merzbacher disease detected by comparative multiplex PCR. PubMed ·Ken Inoue, Hitoshi Osaka, Natsuki Sugiyama, Chiaki Kawanishi, Hideki Onishi, A Nezu, Kazue Kimura, Y. Yamada, Kenji Kosaka	1996	95
11	Diagnostic utility of whole exome sequencing in patients showing cerebellar and/or vermis atrophy in childhood Neurogenetics ·Chihiro Ohba, Hitoshi Osaka, Mizue Iai, Sumimasa Yamashita, Yume Suzuki, Noriko Aida, Nobuyuki Shimozawa, Ayumi Takamura, Hiroshi Doi, Atsuko Katsumoto, Kiyomi Nishiyama, Yoshinori Tsurusaki, Mitsuko Nakashima, Noriko Miyake, Yoshikatsu Eto, Fumiaki Tanaka, Naomichi Matsumoto, Hirotomo Saitsu	2013	89
12	De Novo Mutations inSLC35A2Encoding a UDP-Galactose Transporter Cause Early-Onset Epileptic Encephalopathy Human Mutation ·Hirofumi Kodera, Kazuyuki Nakamura, Hitoshi Osaka, Yoshihiro Maegaki, Kazuhiro Haginoya, Shuji Mizumoto, Mitsuhiro Kato, Nobuhiko Okamoto, Mizue Iai, Yukiko Kondo, Kiyomi Nishiyama, Yoshinori Tsurusaki, Mitsuko Nakashima, Noriko Miyake, Kiyoshi Hayasaka, Kazuyuki Sugahara, Isao Yuasa, Yoshinao Wada, Naomichi Matsumoto, Hirotomo Saitsu	2013	86
13	Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant Neurochemistry International ·Rieko Setsuie, Yu-Lai Wang, Hideki Mochizuki, Hitoshi Osaka, Hideki Hayakawa, Nobutsune Ichihara, Hang Li, Akiko Furuta, Yae Sano, Yingjie Sun, Jungkee Kwon, Tomohiro Kabuta, Kenji Yoshimi, Shunsuke Aoki, Yoshikuni Mizuno, Mami Noda, Keiji Wada	2006	82
14	PIGA mutations cause early-onset epileptic encephalopathies and distinctive features Neurology ·Mitsuhiro Kato, Hirotomo Saitsu, Yoshiko Murakami, Kenjiro Kikuchi, Shuei Watanabe, Mizue Iai, Kazushi Miya, Ryuki Matsuura, Rumiko Takayama, Chihiro Ohba, Mitsuko Nakashima, Yoshinori Tsurusaki, Noriko Miyake, Shin‐ichiro Hamano, Hitoshi Osaka, Kiyoshi Hayasaka, Taroh Kinoshita, Naomichi Matsumoto	2014	75
15	Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl‐terminal hydrolase L‐1, reveals oxidation of key proteins Journal of Neurochemistry ·Alessandra Castegna, Visith Thongboonkerd, Jon B. Klein, Bert C. Lynn, Yulai Wang, Hitoshi Osaka, Keiji Wada, D. Allan Butterfield	2004	67
16	Role of Ubiquitin Carboxy Terminal Hydrolase-L1 in Neural Cell Apoptosis Induced by Ischemic Retinal Injury in Vivo American Journal Of Pathology ·Takayuki Harada, Chikako Harada, Yu-Lai Wang, Hitoshi Osaka, Kazuhito Amanai, Kohichi Tanaka, Shuichi Takizawa, Rieko Setsuie, Mikako Sakurai, Yae Sato, Mami Noda, Keiji Wada	2004	67
17	Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice Molecular Reproduction and Development ·Yu-Lai Wang, Wanzhao Liu, Yingjie Sun, Jungkee Kwon, Rieko Setsuie, Hitoshi Osaka, Mami Noda, Shunsuke Aoki, Yasuhiro Yoshikawa, Keiji Wada	2005	66
18	De Novo and Inherited Mutations in COL4A2, Encoding the Type IV Collagen α2 Chain Cause Porencephaly The American Journal of Human Genetics ·Yuriko Yoneda, Kazuhiro Haginoya, Hiroshi Arai, Shigeo Yamaoka, Yoshinori Tsurusaki, Hiroshi Doi, Noriko Miyake, Kenji Yokochi, Hitoshi Osaka, Mitsuhiro Kato, Naomichi Matsumoto, Hirotomo Saitsu	2011	61
19	CASK aberrations in male patients with Ohtahara syndrome and cerebellar hypoplasia Epilepsia ·Hirotomo Saitsu, Mitsuhiro Kato, Hitoshi Osaka, Nobuko Moriyama, Hideki Horita, Kiyomi Nishiyama, Yuriko Yoneda, Yukiko Kondo, Yoshinori Tsurusaki, Hiroshi Doi, Noriko Miyake, Kiyoshi Hayasaka, Naomichi Matsumoto	2012	59
20	A new case of GABA transaminase deficiency facilitated by proton MR spectroscopy Journal of Inherited Metabolic Disease ·Megumi Tsuji, Noriko Aida, Takayuki Obata, Moyoko Tomiyasu, Noritaka Furuya, Kenji Kurosawa, Abdellatif Errami, K. Michael Gibson, Gajja S. Salomons, Cornelis Jakobs, Hitoshi Osaka	2010	51

About Hitoshi Osaka

Hitoshi Osaka is a scholar working on Molecular Biology, Genetics, Cellular and Molecular Neuroscience, Clinical Biochemistry and Cell Biology, having authored 235 papers that have together received 5.1k indexed citations. Recurring topics across this work include RNA regulation and disease (34 papers), Metabolism and Genetic Disorders (28 papers), Genetics and Neurodevelopmental Disorders (25 papers), Mitochondrial Function and Pathology (23 papers), RNA Research and Splicing (14 papers), RNA modifications and cancer (13 papers), Neuroscience and Neuropharmacology Research (12 papers) and Cellular transport and secretion (11 papers). The work is most often cited by research in Clinical Biochemistry (501 citations), Developmental Neuroscience (220 citations), Cellular and Molecular Neuroscience (889 citations), Genetics (1.2k citations) and Neurology (323 citations). Hitoshi Osaka has collaborated with scholars based in Japan, United States and Netherlands. Frequent co-authors include Naomichi Matsumoto, Hirotomo Saitsu, Ken Inoue, Noriko Miyake, Mitsuhiro Kato, Yoshinori Tsurusaki, Kiyomi Nishiyama, Keiji Wada, Takanori Yamagata and Palmer Taylor. Their work appears in journals such as Brain and Development, Journal of the Neurological Sciences, Human Mutation, Scientific Reports and Pediatric Neurology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Hitoshi Osaka

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About Hitoshi Osaka

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