Gerald Koelsch

4.7k citations

53 papers · 3.5k · 2 hit papers · h-index 27

Impact in

Computational Theory and Mathematics top 0.2%
- Computational Drug Discovery Methods
Physiology top 1%
- Alzheimer's disease research and treatments

Papers in

Molecular Biology 39
- Protein Structure and Dynamics 9
- Machine Learning in Bioinformatics 7
- Glycosylation and Glycoproteins Research 6
- RNA and protein synthesis mechanisms 5
Physiology 20
- Alzheimer's disease research and treatments 19

Co-authors: Jordan Tang (36 shared papers)Arun K. Ghosh (21 shared papers)Xinli Lin (11 shared papers)Shili Wu (2 shared papers)Hong Lin (13 shared papers)Azar Dashti (1 shared paper)Robert T. Turner (14 shared papers)Jacques Ermolieff (5 shared papers)
Journals: Biochemistry (9 papers)Journal of Biological Chemistry (5 papers)Advances in experimental medicine and biology (4 papers)Bioorganic & Medicinal Chemistry Letters (3 papers)Alzheimer s & Dementia (3 papers)
Partner nations: United States Japan Czechia

In The Last Decade

Gerald Koelsch

51 papers receiving 3.4k citations

Gerald Koelsch's Hit Papers

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Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein 2000 · 641 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2000 Proceedings of the National Academy of Sciences
2000 Science

Peers

Countries citing papers authored by Gerald Koelsch

Since Specialization

Citations

This map shows the geographic impact of Gerald Koelsch's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gerald Koelsch with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gerald Koelsch more than expected).

Fields of papers citing papers by Gerald Koelsch

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gerald Koelsch. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gerald Koelsch. The network helps show where Gerald Koelsch may publish in the future.

Co-authors

The 25 scholars most cited alongside Gerald Koelsch, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Gerald Koelsch Line = papers co-authored together Gerald Koelsch links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 53 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein Proceedings of the National Academy of Sciences ·Xinli Lin, Gerald Koelsch, Shili Wu, Debbie Downs, Azar Dashti, Jordan Tang Hit paper breakdown →	2000	641
2	Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor Science ·Hong Lin, Gerald Koelsch, Xinli Lin, Shili Wu, S. Terzyan, Arun K. Ghosh, Xuenjun C. Zhang, Jordan Tang Hit paper breakdown →	2000	566
3	Structure-Based Design: Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase) Journal of Medicinal Chemistry ·Arun K. Ghosh, Geoffrey Bilcer, Cynthia Harwood, Reiko Kawahama, Dong-Woo Shin, Khaja Azhar Hussain, Hong Lin, Jeffrey A. Loy, Chan Nguyen, Gerald Koelsch, Jacques Ermolieff, Jordan Tang	2001	184
4	Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase) Journal of the American Chemical Society ·Arun K. Ghosh, Dong-Woo Shin, Debbie Downs, Gerald Koelsch, Xinli Lin, Jacques Ermolieff, Jordan Tang	2000	171
5	Crystal Structure of Memapsin 2 (β-Secretase) in Complex with an Inhibitor OM00-3 Biochemistry ·Hong Lin, Robert T. Turner, Gerald Koelsch, D.H. Shin, Arun K. Ghosh, Jordan Tang	2002	158
6	Subsite Specificity of Memapsin 2 (β-Secretase): Implications for Inhibitor Design Biochemistry ·Robert T. Turner, Gerald Koelsch, Lin Hong, Pedro Castenheira, Arun K. Ghosh, Jordan Tang	2001	146
7	Proteolytic Activation of Recombinant Pro-memapsin 2 (Pro-β-secretase) Studied with New Fluorogenic Substrates Biochemistry ·Jacques Ermolieff, Jeffrey A. Loy, Gerald Koelsch, Jordan Tang	2000	115
8	Memapsin 2 (β‐secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2 FEBS Letters ·Xiangyuan He, Wan‐Pin Chang, Gerald Koelsch, Jordan Tang	2002	98
9	BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer’s Disease Pathology Molecules ·Gerald Koelsch	2017	95
10	β‐Secretase inhibitor GRL‐8234 rescues age‐related cognitive decline in APP transgenic mice The FASEB Journal ·Wan‐Pin Chang, Xiangping Huang, Deborah Downs, John R. Cirrito, Gerald Koelsch, David M. Holtzman, Arun K. Ghosh, Jordan Tang	2010	92
11	Multiple functions of pro‐parts of aspartic proteinase zymogens FEBS Letters ·Gerald Koelsch, Michael A. Mares, Peter Metcalf, Martin Fusek	1994	82
12	A hypothesis for the HLA-B27 immune dysregulation in spondyloarthropathy: contributions from enteric organisms, B27 structure, peptides bound by B27, and convergent evolution. Proceedings of the National Academy of Sciences ·R. Hal Scofield, W. Louise Warren, Gerald Koelsch, J B Harley	1993	80
13	The high‐resolution crystal structure of porcine pepsinogen Proteins Structure Function and Bioinformatics ·Jean A. Hartsuck, Gerald Koelsch, S. James Remington	1992	77
14	Enzymic characteristics of secreted aspartic proteases of Candida albicans Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ·Gerald Koelsch, Jordan Tang, Jeffrey A. Loy, Michel Monod, Kenneth W. Jackson, Stephen I. Foundling, Xinli Lin	2000	76
15	Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation Bioorganic & Medicinal Chemistry Letters ·Arun K. Ghosh, Nagaswamy Kumaragurubaran, Hong Lin, Sarang Kulkarni, Xiaoming Xu, Heather B. Miller, Dandepally Srinivasa Reddy, Vajira Weerasena, Robert T. Turner, Wan‐Pin Chang, Gerald Koelsch, Jordan Tang	2007	74
16	In vivo inhibition of Aβ production by memapsin 2 (β‐secretase) inhibitors Journal of Neurochemistry ·Wan‐Pin Chang, Gerald Koelsch, Stephen T.C. Wong, Deborah Downs, Huining Da, Vajira Weerasena, Brian Gordon, Thippeswamy Devasamudram, Geoffrey Bilcer, Arun K. Ghosh, Jordan Tang	2004	74
17	Design, Synthesis, and X-ray Structure of Potent Memapsin 2 (β-Secretase) Inhibitors with Isophthalamide Derivatives as the P₂_-P₃-Ligands Journal of Medicinal Chemistry ·Arun K. Ghosh, Nagaswamy Kumaragurubaran, Hong Lin, Sarang Kulkarni, Xiaoming Xu, Wan‐Pin Chang, Vajira Weerasena, Robert T. Turner, Gerald Koelsch, Geoffrey Bilcer, Jordan Tang	2007	73
18	Mapping and molecular modeling of a recognition domain for lysosomal enzyme targeting. Journal of Biological Chemistry ·Thomas Baranski, Gerald Koelsch, Jean A. Hartsuck, Stuart Kornfeld	1991	70
19	Biochemical and Structural Characterization of the Interaction of Memapsin 2 (β-Secretase) Cytosolic Domain with the VHS Domain of GGA Proteins Biochemistry ·Xiangyuan He, Guangyu Zhu, Gerald Koelsch, Karla K. Rodgers, Xuejun C. Zhang, Jordan Tang	2003	64
20	Structural Locations and Functional Roles of New Subsites S₅, S₆, and S₇ in Memapsin 2 (β-Secretase)^, Biochemistry ·Robert T. Turner, Hong Lin, Gerald Koelsch, Arun K. Ghosh, Jordan Tang	2004	62

About Gerald Koelsch

Gerald Koelsch is a scholar working on Molecular Biology, Physiology, Computational Theory and Mathematics, Biotechnology and Oncology, having authored 53 papers that have together received 3.5k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (19 papers), Computational Drug Discovery Methods (11 papers), Protein Structure and Dynamics (9 papers), Enzyme Production and Characterization (8 papers), Machine Learning in Bioinformatics (7 papers), Glycosylation and Glycoproteins Research (6 papers), Cholinesterase and Neurodegenerative Diseases (5 papers) and RNA and protein synthesis mechanisms (5 papers). The work is most often cited by research in Computational Theory and Mathematics (1.3k citations), Physiology (2.0k citations), Pharmacology (1.2k citations), Molecular Biology (1.7k citations) and Biotechnology (203 citations). Gerald Koelsch has collaborated with scholars based in United States, Japan and Czechia. Frequent co-authors include Jordan Tang, Arun K. Ghosh, Xinli Lin, Shili Wu, Hong Lin, Azar Dashti, Robert T. Turner, Jacques Ermolieff, S. Terzyan and Jeffrey A. Loy. Their work appears in journals such as Biochemistry, Journal of Biological Chemistry, Advances in experimental medicine and biology, Bioorganic & Medicinal Chemistry Letters and Alzheimer s & Dementia.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Gerald Koelsch

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