Douglas E. V. Pires

14.2k citations

93 papers · 9.3k · 6 hit papers · h-index 35

Impact in

Computational Theory and Mathematics top 0.1%
- Computational Drug Discovery Methods
Molecular Biology top 1%
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Bioinformatics and Genomic Networks

Papers in

Molecular Biology 53
- Protein Structure and Dynamics 20
- RNA and protein synthesis mechanisms 14
- Bioinformatics and Genomic Networks 10
- Machine Learning in Bioinformatics 6
Computational Theory and Mathematics 20
- Computational Drug Discovery Methods 20

Co-authors: David B. Ascher (72 shared papers)Tom L. Blundell (9 shared papers)Carlos H. M. Rodrigues (19 shared papers)T.L. Blundell (1 shared paper)Yoochan Myung (12 shared papers)Raquel C. de Melo-Minardi (7 shared papers)Wagner Meira (7 shared papers)Carlos Henrique da Silveira (6 shared papers)
Journals: Nucleic Acids Research (16 papers)Bioinformatics (9 papers)Briefings in Bioinformatics (9 papers)Journal of Chemical Information and Modeling (5 papers)Scientific Reports (5 papers)
Partner nations: Australia United Kingdom Brazil

In The Last Decade

Douglas E. V. Pires

89 papers receiving 9.2k citations

Douglas E. V. Pires's Hit Papers

6 papers align trajectories log scale

DDMut: predicting effects of mutations on protein stability using deep learning 2023 · 114 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2023 Nucleic Acids Research
2020 Protein Science
2018 Nucleic Acids Research
2015 Journal of Medicinal Chemistry
2014 Nucleic Acids Research
2013 Bioinformatics

Peers

Countries citing papers authored by Douglas E. V. Pires

Since Specialization

Citations

This map shows the geographic impact of Douglas E. V. Pires's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Douglas E. V. Pires with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Douglas E. V. Pires more than expected).

Fields of papers citing papers by Douglas E. V. Pires

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Douglas E. V. Pires. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Douglas E. V. Pires. The network helps show where Douglas E. V. Pires may publish in the future.

Co-authors

The 25 scholars most cited alongside Douglas E. V. Pires, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Douglas E. V. Pires Line = papers co-authored together Douglas E. V. Pires links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 93 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures Journal of Medicinal Chemistry ·Douglas E. V. Pires, Tom L. Blundell, David B. Ascher Hit paper breakdown →	2015	3892
2	mCSM: predicting the effects of mutations in proteins using graph-based signatures Bioinformatics ·Douglas E. V. Pires, David B. Ascher, Tom L. Blundell Hit paper breakdown →	2013	762
3	DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability Nucleic Acids Research ·Carlos H. M. Rodrigues, Douglas E. V. Pires, David B. Ascher Hit paper breakdown →	2018	737
4	DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach Nucleic Acids Research ·Douglas E. V. Pires, David B. Ascher, T.L. Blundell Hit paper breakdown →	2014	666
5	DynaMut2: Assessing changes in stability and flexibility upon single and multiple point missense mutations Protein Science ·Carlos H. M. Rodrigues, Douglas E. V. Pires, David B. Ascher Hit paper breakdown →	2020	357
6	mCSM-PPI2: predicting the effects of mutations on protein–protein interactions Nucleic Acids Research ·Carlos H. M. Rodrigues, Yoochan Myung, Douglas E. V. Pires, David B. Ascher	2019	244
7	DDMut: predicting effects of mutations on protein stability using deep learning Nucleic Acids Research ·Yunzhuo Zhou, Qisheng Pan, Douglas E. V. Pires, Carlos H. M. Rodrigues, David B. Ascher Hit paper breakdown →	2023	114
8	mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance Scientific Reports ·Douglas E. V. Pires, Tom L. Blundell, David B. Ascher	2016	107
9	mCSM–NA: predicting the effects of mutations on protein–nucleic acids interactions Nucleic Acids Research ·Douglas E. V. Pires, David B. Ascher	2017	102
10	mCSM-AB: a web server for predicting antibody–antigen affinity changes upon mutation with graph-based signatures Nucleic Acids Research ·Douglas E. V. Pires, David B. Ascher	2016	100
11	CSM-lig: a web server for assessing and comparing protein–small molecule affinities Nucleic Acids Research ·Douglas E. V. Pires, David B. Ascher	2016	93
12	Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance BMC Medicine ·Jody Phelan, Francesc Coll, Ruth McNerney, David B. Ascher, Douglas E. V. Pires, (unknown), Nele Coeck, Grant Hill-Cawthorne, Mridul Nair, Kim Mallard, Andrew Ramsay, Susana Campino, Martin L. Hibberd, Arnab Pain, Leen Rigouts, Taane G. Clark	2016	90
13	Germline Mutations in theCDKN2BTumor Suppressor Gene Predispose to Renal Cell Carcinoma Cancer Discovery ·Mariam Jafri, N. Wake, David B. Ascher, Douglas E. V. Pires, Dean Gentle, Mark R. Morris, Eleanor Rattenberry, Michael A. Simpson, Richard C. Trembath, Astrid Weber, Emma R. Woodward, Alan Donaldson, Tom L. Blundell, Farida Latif, Eamonn R. Maher	2015	78
14	In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity Scientific Reports ·Douglas E. V. Pires, Jing Chen, Tom L. Blundell, David B. Ascher	2016	75
15	Protein cutoff scanning: A comparative analysis of cutoff dependent and cutoff free methods for prospecting contacts in proteins Proteins Structure Function and Bioinformatics ·Carlos Henrique da Silveira, Douglas E. V. Pires, Raquel C. de Melo-Minardi, Cristina Oliveira Ribeiro, C J M Veloso, Júlio César Dias Lopes, Wagner Meira, Goran Neshich, Carlos H.I. Ramos, Raul Habesch, Marcelo M. Santoro	2008	71
16	mCSM-membrane: predicting the effects of mutations on transmembrane proteins Nucleic Acids Research ·Douglas E. V. Pires, Carlos H. M. Rodrigues, David B. Ascher	2020	71
17	Cutoff Scanning Matrix (CSM): structural classification and function prediction by protein inter-residue distance patterns BMC Genomics ·Douglas E. V. Pires, Raquel C. de Melo-Minardi, Marcos Augusto dos Santos, Carlos Henrique da Silveira, Marcelo M. Santoro, Wagner Meira	2011	67
18	Platinum: a database of experimentally measured effects of mutations on structurally defined protein–ligand complexes Nucleic Acids Research ·Douglas E. V. Pires, Tom L. Blundell, David B. Ascher	2014	67
19	ThermoMutDB: a thermodynamic database for missense mutations Nucleic Acids Research ·Joicymara S. Xavier, Thanh Nguyen, Malancha Karmarkar, Stephanie Portelli, Pâmela Marinho Rezende, João Paulo Linhares Velloso, David B. Ascher, Douglas E. V. Pires	2020	65
20	mCSM-AB2: guiding rational antibody design using graph-based signatures Bioinformatics ·Yoochan Myung, Carlos H. M. Rodrigues, David B. Ascher, Douglas E. V. Pires	2019	56

About Douglas E. V. Pires

Douglas E. V. Pires is a scholar working on Molecular Biology, Computational Theory and Mathematics, Genetics, Materials Chemistry and Radiology, Nuclear Medicine and Imaging, having authored 93 papers that have together received 9.3k indexed citations. Recurring topics across this work include Protein Structure and Dynamics (20 papers), Computational Drug Discovery Methods (20 papers), RNA and protein synthesis mechanisms (14 papers), Bioinformatics and Genomic Networks (10 papers), Enzyme Structure and Function (8 papers), Monoclonal and Polyclonal Antibodies Research (7 papers), Genomics and Rare Diseases (7 papers) and Machine Learning in Bioinformatics (6 papers). The work is most often cited by research in Computational Theory and Mathematics (2.2k citations), Molecular Biology (4.8k citations), Toxicology (202 citations), Infectious Diseases (946 citations) and Pharmacology (454 citations). Douglas E. V. Pires has collaborated with scholars based in Australia, United Kingdom and Brazil. Frequent co-authors include David B. Ascher, Tom L. Blundell, Carlos H. M. Rodrigues, T.L. Blundell, Yoochan Myung, Raquel C. de Melo-Minardi, Wagner Meira, Carlos Henrique da Silveira, Yunzhuo Zhou and Stephanie Portelli. Their work appears in journals such as Nucleic Acids Research, Bioinformatics, Briefings in Bioinformatics, Journal of Chemical Information and Modeling and Scientific Reports.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Douglas E. V. Pires

Douglas E. V. Pires's Hit Papers

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About Douglas E. V. Pires

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