David R. Witty

1.6k citations

36 papers · 1.3k · h-index 19

Impact in

Organic Chemistry top 2%
- Carbohydrate Chemistry and Synthesis
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
Pharmaceutical Science top 5%
- Fluorine in Organic Chemistry

Papers in

Organic Chemistry 23
- Carbohydrate Chemistry and Synthesis 8
- Synthesis and Catalytic Reactions 5
- Click Chemistry and Applications 3
Molecular Biology 21
- Chemical Synthesis and Analysis 10
- Glycosylation and Glycoproteins Research 3
- Receptor Mechanisms and Signaling 3

Co-authors: George W. J. Fleet (14 shared papers)Nigel G. Ramsden (4 shared papers)Francis X. Wilson (8 shared papers)Paul W. Smith (1 shared paper)Abraham Karpas (1 shared paper)Gary S. Jacob (1 shared paper)Thomas W. Rademacher (1 shared paper)A.S. Tyms (1 shared paper)
Journals: Tetrahedron Letters (8 papers)Bioorganic & Medicinal Chemistry Letters (6 papers)Tetrahedron Asymmetry (4 papers)Tetrahedron (3 papers)Synthesis (1 paper)
Partner nations: United Kingdom United States Italy

In The Last Decade

David R. Witty

36 papers receiving 1.2k citations

Peers

Countries citing papers authored by David R. Witty

Since Specialization

Citations

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Fields of papers citing papers by David R. Witty

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David R. Witty. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David R. Witty. The network helps show where David R. Witty may publish in the future.

Co-authors

The 25 scholars most cited alongside David R. Witty, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David R. Witty Line = papers co-authored together David R. Witty links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 36 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Inhibition of HIV replication by amino‐sugar derivatives FEBS Letters ·George W. J. Fleet, Abraham Karpas, Raymond A. Dwek, Linda E. Fellows, A.S. Tyms, S. Petursson, Sung K. Namgoong, Nigel G. Ramsden, Paul W. Smith, Jong Chan Son, Francis X. Wilson, David R. Witty, Gary S. Jacob, Thomas W. Rademacher	1988	311
2	The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase Bioorganic & Medicinal Chemistry Letters ·Murray J. B. Brown, Paul S. Carter, Ashley Fenwick, Andrew Fosberry, Dieter Hamprecht, Martin Hibbs, Richard L. Jarvest, Lucy Mensah, Peter H. Milner, Peter J. O’Hanlon, Andrew J. Pope, Christine M. Richardson, Andrew B. West, David R. Witty	2002	126
3	Practical synthesis of deoxymannojirimycin and mannonolactam from L-gulonolactone. Tetrahedron ·George W. J. Fleet, Nigel G. Ramsden, David R. Witty	1989	101
4	Synthesis of homochiral β-hydroxy-α-aminoacids [(2S,3R,4R)-3,4-dihydroxyproline and (2S,3R,4R)-3,4-dihydroxypipecolic aicd] and of 1,4-dideoxy-1,4-imino-D-arabinitol [DAB1] and fagomine [1,5-imino-1,2,5-trideoxy-D-arabino-hexitol] Tetrahedron Asymmetry ·George W. J. Fleet, David R. Witty	1990	79
5	Effect of Direct Injection of Melanin‐Concentrating Hormone into the Paraventricular Nucleus: Further Evidence for a Stimulatory Role in the Adrenal Axis via SLC‐1 Journal of Neuroendocrinology ·A. R. Kennedy, Jeannie F Todd, Waljit S. Dhillo, Leighton Seal, M.A. Ghatei, Cynthia O'Toole, Martin Hartley Jones, David R. Witty, K. Winborne, Graham J. Riley, Guillaume Hervieu, Shelagh Wilson, Stephen R. Bloom	2003	70
6	Unified Route to the Palmarumycin and Preussomerin Natural Products. Enantioselective Synthesis of (−)-Preussomerin G The Journal of Organic Chemistry ·Anthony G. M. Barrett, Frank E. Blaney, Andrew D. Campbell, Dieter Hamprecht, Thorsten Meyer, Andrew J. P. White, David R. Witty, David Williams	2002	57
7	Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues Bioorganic & Medicinal Chemistry Letters ·Richard L. Jarvest, Sula A Armstrong, John M. Berge, Pamela Brown, John S. Elder, Murray J. B. Brown, Royston C. B. Copley, Andrew K. Forrest, Dieter Hamprecht, Peter J. O’Hanlon, Darren J. Mitchell, Stephen Rittenhouse, David R. Witty	2004	45
8	Ring contraction of 2-o-trifluoromethanesulphonates of α-hydroxy-γ-lactones to oxetane carboxylic esters Tetrahedron Letters ·David R. Witty, George W. J. Fleet, K. VOGT, Francis X. Wilson, Y Wang, Richard Storer, P. L. MYERS, Christopher J. Wallis	1990	42
9	A practical synthesis of deoxymannojirimycin and of (2s,3R,4R,5R)-3,4,5-trihydroxypipecolic acid from D-glucose Tetrahedron ·George W. J. Fleet, Nigel G. Ramsden, David R. Witty	1989	41
10	Short syntheses of D-deoxymannojirimycin and D-mannonolactam from L-gulonolactone and of L-deoxymannojirimycin and L-mannonolactam from D-gulonolactone Tetrahedron Letters ·George W. J. Fleet, Nigel G. Ramsden, David R. Witty	1988	31
11	Synthesis of the potent antiviral oxetane nucleoside epinoroxetanocin from D-lyxonolactone Tetrahedron Asymmetry ·Y. Wang, George W. J. Fleet, Richard Storer, P. L. MYERS, Christopher J. Wallis, O. Doherty, D.J. Watkin, K. VOGT, David R. Witty, Francis X. Wilson, J.M. Peach	1990	30
12	Synthesis of oxetanocin Tetrahedron Letters ·Francis X. Wilson, George W. J. Fleet, K. VOGT, Y. Wang, David R. Witty, S. Choi, Richard Storer, P. L. MYERS, Christopher J. Wallis	1990	27
13	BT7480, a novel fully synthetic Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™) induces tumor localized CD137 agonism Journal for ImmunoTherapy of Cancer ·Kristen E. Hurov, Johanna Lahdenranta, Punit Upadhyaya, Eric Haines, Heather Cohen, Elizabeth Repash, Drasti Kanakia, Jun Ma, Julia Kristensson, Fanglei You, Carly Campbell, David R. Witty, Mike Kelly, Stephen J. Blakemore, Phil Jeffrey, Kevin McDonnell, Philip E. Brandish, Nicholas Keen	2021	26
14	Advances in the Design of 5-HT6 Receptor Ligands with Therapeutic Potential Progress in medicinal chemistry ·David R. Witty, Mahmood Ahmed, Tsu Tshen Chuang	2009	25
15	Crystal structures of ASK1‐inhibtor complexes provide a platform for structure‐based drug design Protein Science ·Onkar Singh, Anthony Shillings, Peter D. Craggs, Ian D. Wall, Paul Rowland, Tadeusz Skarżyński, Clare I. Hobbs, Phil Hardwick, Rob Tanner, Michelle Blunt, David R. Witty, Kathrine J. Smith	2013	23
16	Oxetane nucleosides with fluorine and azide substitutents: nucleophilic displacements on an oxetane ring Tetrahedron Letters ·Y. Wang, George W. J. Fleet, Francis X. Wilson, Richard Storer, Christopher J. Wallis, O. Doherty, D.J. Watkin, K. VOGT, David R. Witty, J.M. Peach	1991	23
17	Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849 Bioorganic & Medicinal Chemistry Letters ·David R. Witty, John H. Bateson, Guillaume Hervieu, Kamal Albarazanji, Philip D. Jeffrey, Dieter Hamprecht, Andrea Haynes, Christopher N. Johnson, Alison I. Muir, Peter J. O’Hanlon, Geoffrey Stemp, Alex J. Stevens, Kevin M. Thewlis, Kim Winborn	2006	19
18	Ring contraction of 3-deoxy-2-O-trifluoromethanesulphonates of α-hydroxy-γ-lactones to oxetanes Tetrahedron Letters ·David R. Witty, George W. J. Fleet, S. Choi, K. VOGT, Francis X. Wilson, Y. Wang, Richard Storer, P. L. MYERS, Christopher J. Wallis	1990	19
19	Synthesis of o-indan[1.1.1]cyclophane and potential indanyl subunits of the fullerenes Tetrahedron Letters ·Philip Magnus, David R. Witty, Andrew W. Stamford	1993	18
20	Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia ACS Medicinal Chemistry Letters ·David R. Witty, Giuseppe Alvaro, Dominique Derjean, Gerard M.P. Giblin, Kevin P. Gunn, Charles H. Large, David T. MacPherson, Valérie Morisset, Davina E. OWEN, Joanne Palmer, François Rugiero, Simon Tate, Christopher A. Hinckley, Himanshu Naik	2020	17

About David R. Witty

David R. Witty is a scholar working on Organic Chemistry, Molecular Biology, Pharmaceutical Science, Pharmacology and Endocrine and Autonomic Systems, having authored 36 papers that have together received 1.3k indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (10 papers), Carbohydrate Chemistry and Synthesis (8 papers), Fluorine in Organic Chemistry (8 papers), Synthesis and Catalytic Reactions (5 papers), Microbial Natural Products and Biosynthesis (4 papers), Click Chemistry and Applications (3 papers), Glycosylation and Glycoproteins Research (3 papers) and Receptor Mechanisms and Signaling (3 papers). The work is most often cited by research in Organic Chemistry (928 citations), Pharmaceutical Science (80 citations), Endocrine and Autonomic Systems (73 citations), Molecular Biology (651 citations) and Pharmacology (140 citations). David R. Witty has collaborated with scholars based in United Kingdom, United States and Italy. Frequent co-authors include George W. J. Fleet, Nigel G. Ramsden, Francis X. Wilson, Paul W. Smith, Abraham Karpas, Gary S. Jacob, Thomas W. Rademacher, A.S. Tyms, Jong Chan Son and Linda E. Fellows. Their work appears in journals such as Tetrahedron Letters, Bioorganic & Medicinal Chemistry Letters, Tetrahedron Asymmetry, Tetrahedron and Synthesis.

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