Can E. Senkal

4.2k citations
38 papers · 3.4k · 1 hit paper · h-index 26

Impact in

  • Cell Biology top 1%
    • Endoplasmic Reticulum Stress and Disease
    • Cellular transport and secretion
  • Biochemistry top 1%
    • Lipid metabolism and biosynthesis

Papers in

  • Molecular Biology 36
    • Sphingolipid Metabolism and Signaling 33
    • Lipid Membrane Structure and Behavior 6
    • Peroxisome Proliferator-Activated Receptors 4
    • Genomics, phytochemicals, and oxidative stress 2
  • Cell Biology 15
    • Endoplasmic Reticulum Stress and Disease 9
    • Cellular transport and secretion 5
Co-authors
Besim Öğretmen (21 shared papers)Jacek Bielawski (11 shared papers)Suriyan Ponnusamy (9 shared papers)Yusuf A. Hannun (18 shared papers)Lina M. Obeid (15 shared papers)Shanmugam Panneer Selvam (4 shared papers)Sahar A. Saddoughi (6 shared papers)Salih Gencer (4 shared papers)
Journals
The FASEB Journal (8 papers)Journal of Biological Chemistry (7 papers)Proceedings of the National Academy of Sciences (2 papers)EMBO Molecular Medicine (2 papers)Molecular Cancer Therapeutics (2 papers)
Partner nations
United StatesTürkiyeEgypt

In The Last Decade

Can E. Senkal

36 papers receiving 3.4k citations

Can E. Senkal's Hit Papers

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy 2012 · 437 citations
4370+4+9Years since publication100200300400
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

  • it has ≥500 total citations;
  • it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
  • it reaches the top citation threshold in at least one of its specific research topics.
  1. 2012 Nature Chemical Biology

Peers

Can E. Senkal
Comparison fields: 5 of 99
  • Cell Biology 761
  • Biochemistry 337
  • Molecular Biology 2.8k
  • Physiology 99
  • Physiology 478
Replace Kazuyuki Kitatani with:
Kazuyuki Kitatani Japan
Suriyan Ponnusamy United States
Manel Joaquin Spain
Nada Y. Kalaany United States
Satoshi Yasuda Japan
Ashley J. Snider United States
Chunying Yang United States
Benjamin J. Pettus United States
Daniel M. Raben United States
Gerta Hoxhaj United States
Can E. Senkal relative to Kazuyuki Kitatani Japan Kazuyuki Kitatani's profile →
Citations per field
00.5×1.5×2.1×
Kazuyuki Kitatani · 1×
Citations per year

Countries citing papers authored by Can E. Senkal

Since Specialization
Citations

This map shows the geographic impact of Can E. Senkal's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Can E. Senkal with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Can E. Senkal more than expected).

Fields of papers citing papers by Can E. Senkal

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Can E. Senkal. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Can E. Senkal. The network helps show where Can E. Senkal may publish in the future.

Co-authors

The 25 scholars most cited alongside Can E. Senkal, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Can E. Senkal Line = papers co-authored together Can E. Senkal links everyone, so they are left out of the graph.

All Works

20 of 20 papers shown

Showing the 20 most-cited of 38 papers — load more, or switch the sort, to bring in the rest.

#Work
1
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
Nature Chemical Biology ·R. David Sentelle, Can E. Senkal, Wenhui Jiang, Suriyan Ponnusamy, Salih Gencer, Shanmugam Panneer Selvam, Venkat K. Ramshesh, Yuri K. Peterson, John J. Lemasters, Zdzisław M. Szulc, Jacek Bielawski, Besim Öğretmen
Hit paper breakdown →		2012437
2
Sphingolipids and Cancer: Ceramide and Sphingosine-1-Phosphate in the Regulation of Cell Death and Drug Resistance
Future Oncology ·Suriyan Ponnusamy, Marisa Meyers‐Needham, Can E. Senkal, Sahar A. Saddoughi, David Sentelle, Shanmugam Panneer Selvam, Arelis Salas, Besim Öğretmen
2010253
3
Antiapoptotic roles of ceramide‐synthase‐6‐generated C 16 ‐ceramide via selective regulation of the ATF6/ CHOP arm of ER‐stress‐response pathways
The FASEB Journal ·Can E. Senkal, Suriyan Ponnusamy, Jacek Bielawski, Yusuf A. Hannun, Besim Öğretmen
2009226
4
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis
EMBO Molecular Medicine ·Sahar A. Saddoughi, Salih Gencer, Yuri K. Peterson, Katherine E. Ward, Archana Mukhopadhyay, Joshua J. Oaks, Jacek Bielawski, Zdzisław M. Szulc, Raquela J. Thomas, Shanmugam Panneer Selvam, Can E. Senkal, Elizabeth Garrett‐Mayer, Ryan De Palma, Dzmitry Fedarovich, Angen Liu, Amyn A. Habib, Robert V. Stahelin, Danilo Perrotti, Besim Öğretmen
2012222
5
Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell Carcinomas
Journal of Biological Chemistry ·Serap Köybaşı, Can E. Senkal, Kamala Sundararaj, Stefka D. Spassieva, Jacek Bielawski, Walid Osta, Terry A. Day, James C. Jiang, S. Michal Jazwinski, Yusuf A. Hannun, Lina M. Obeid, Besim Öğretmen
2004194
6
Alterations of Ceramide/Sphingosine 1-Phosphate Rheostat Involved in the Regulation of Resistance to Imatinib-induced Apoptosis in K562 Human Chronic Myeloid Leukemia Cells
Journal of Biological Chemistry ·Yusuf Baran, Arelis Salas, Can E. Senkal, Ufuk Gündüz, Jacek Bielawski, Lina M. Obeid, Besim Öğretmen
2007189
7
Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets
Cell Metabolism ·Can E. Senkal, Mohamed Salama, Ashley J. Snider, Janet Allopenna, Nadia A. Rana, Antonius Koller, Yusuf A. Hannun, Lina M. Obeid
2017188
8
Direct interaction between the inhibitor 2 and ceramide via sphingolipid‐protein binding is involved in the regulation of protein phosphatase 2A activity and signaling
The FASEB Journal ·Archana Mukhopadhyay, Sahar A. Saddoughi, Pengfei Song, Iyad Sultan, Suriyan Ponnusamy, Can E. Senkal, C.F. Snook, Hugh Arnold, Rosalie C. Sears, Yusuf A. Hanniui, Besim Öğretmen
2008177
9
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas
Molecular Cancer Therapeutics ·Can E. Senkal, Suriyan Ponnusamy, Michael J. Rossi, Jacek Bialewski, Debijyati Sinha, James C. Jiang, S. Michal Jazwinski, Yusuf A. Hannun, Besim Öğretmen
2007148
10
Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): Attenuation of C18-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis
Cancer Letters ·Serdar Karahatay, Kesha Thomas, Serap Köybaşı, Can E. Senkal, Saeed Elojeimy, Xiang Liu, Jacek Bielawski, Terry A. Day, M. Boyd Gillespie, Debajyoti Sinha, James S. Norris, Yusuf A. Hannun, Besim Öğretmen
2007142
11
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells
Oncogene ·Shai White‐Gilbertson, Thomas D. Mullen, Can E. Senkal, Ping Lü, Besim Öğretmen, Lina M. Obeid, Christina Voelkel‐Johnson
2009132
12
Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+ and ER/Golgi Membrane Network
Journal of Biological Chemistry ·Can E. Senkal, Suriyan Ponnusamy, Yefim Manevich, Marisa Meyers‐Needham, Sahar A. Saddoughi, Archana Mukhopadyay, Paul Dent, Jacek Bielawski, Besim Öğretmen
2011119
13
Sphingolipids in mitochondria
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids ·María José Hernandez‐Corbacho, Mohamed Salama, Daniel Canals, Can E. Senkal, Lina M. Obeid
2016102
14
Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation
Proceedings of the National Academy of Sciences ·Michael V. Airola, Prajna Shanbhogue, A. Shamseddine, Kip E. Guja, Can E. Senkal, Rohan Maini, Nana Bartke, Bill X. Wu, Lina M. Obeid, Miguel García–Díaz, Yusuf A. Hannun
201783
15
Potent Antitumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or in Combination with Gemcitabine against Human Head and Neck Squamous Cell Carcinomas in Vitro and in Vivo
Journal of Pharmacology and Experimental Therapeutics ·Can E. Senkal, Suriyan Ponnusamy, Michael J. Rossi, Kamala Sundararaj, Zdzisław M. Szulc, Jacek Bielawski, Alicja Bielawska, Mario Meyer, Bengü Çobanoğlu, Serap Köybaşı, Debajyoti Sinha, Terry A. Day, Lina M. Obeid, Yusuf A. Hannun, Besim Öğretmen
200680
16
Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways
Journal of Biological Chemistry ·Pamela A. Young, Can E. Senkal, Amanda L. Suchanek, Trisha J. Grevengoed, Dennis D. Lin, Liyang Zhao, Amanda E. Crunk, Eric L. Klett, Joachim Füllekrug, Lina M. Obeid, Rosalind Coleman
201877
17
TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis
Science Signaling ·Salih Gencer, Natalia V. Oleinik, Jisun Kim, Shanmugam Panneer Selvam, Ryan De Palma, Mohammed Dany, Rose Nganga, Raquela J. Thomas, Can E. Senkal, Philip H. Howe, Besim Öğretmen
201768
18
Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death
Journal of Biological Chemistry ·María José Hernandez‐Corbacho, Daniel Canals, Mohamad M. Adada, Mengling Liu, Can E. Senkal, Jae Kyo Yi, Cungui Mao, Chiara Luberto, Yusuf A. Hannun, Lina M. Obeid
201562
19
Mechanisms of ceramide‐mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1
The FASEB Journal ·Leslie G. Wooten‐Blanks, Pengfei Song, Can E. Senkal, Besim Öğretmen
200761
20
Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for Monitoring Response
Clinical Cancer Research ·Sahar A. Saddoughi, Elizabeth Garrett‐Mayer, Uzair B. Chaudhary, Paul E. O’Brien, Larry B. Afrin, Terry A. Day, M. Boyd Gillespie, Anand K. Sharma, Christina S. T. Wilhoit, Robin Bostick, Can E. Senkal, Yusuf A. Hannun, Jacek Bielawski, George R. Simon, Keisuke Shirai, Besim Öğretmen
201160

About Can E. Senkal

Can E. Senkal is a scholar working on Molecular Biology, Cell Biology, Biochemistry, Epidemiology and Organic Chemistry, having authored 38 papers that have together received 3.4k indexed citations. Recurring topics across this work include Sphingolipid Metabolism and Signaling (33 papers), Endoplasmic Reticulum Stress and Disease (9 papers), Lipid metabolism and biosynthesis (7 papers), Lipid Membrane Structure and Behavior (6 papers), Cellular transport and secretion (5 papers), Peroxisome Proliferator-Activated Receptors (4 papers), Autophagy in Disease and Therapy (4 papers) and Genomics, phytochemicals, and oxidative stress (2 papers). The work is most often cited by research in Cell Biology (761 citations), Biochemistry (337 citations), Molecular Biology (2.8k citations), Physiology (99 citations) and Physiology (478 citations). Can E. Senkal has collaborated with scholars based in United States, Türkiye and Egypt. Frequent co-authors include Besim Öğretmen, Jacek Bielawski, Suriyan Ponnusamy, Yusuf A. Hannun, Lina M. Obeid, Shanmugam Panneer Selvam, Sahar A. Saddoughi, Salih Gencer, Zdzisław M. Szulc and Marisa Meyers‐Needham. Their work appears in journals such as The FASEB Journal, Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, EMBO Molecular Medicine and Molecular Cancer Therapeutics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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