Bruce E. Tomczuk

2.0k citations

38 papers · 1.2k · 1 hit paper · h-index 20

Impact in

Oncology top 5%
- HER2/EGFR in Cancer Research
- Peptidase Inhibition and Analysis
Organic Chemistry top 5%
- Click Chemistry and Applications
- Synthesis and Biological Evaluation

Papers in

Molecular Biology 16
- Chemical Synthesis and Analysis 6
Organic Chemistry 14
- Click Chemistry and Applications 4
- Synthesis and Catalytic Reactions 4
- Synthesis and Biological Evaluation 4

Co-authors: Sean W. Smith (1 shared paper)Nareshkumar Jain (1 shared paper)Carl Crysler (17 shared papers)John Spurlino (11 shared papers)Tianbao Lu (9 shared papers)Carl L. Manthey (14 shared papers)Roger Bone (10 shared papers)Carl R. Illig (9 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (20 papers)Journal of Medicinal Chemistry (7 papers)European Journal of Medicinal Chemistry (2 papers)Biopharmaceutics & Drug Disposition (2 papers)Current Microbiology (1 paper)
Partner nations: United States Belgium

In The Last Decade

Bruce E. Tomczuk

38 papers receiving 1.1k citations

Bruce E. Tomczuk's Hit Papers

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Current ADC Linker Chemistry 2015 · 349 citations

Peers

Countries citing papers authored by Bruce E. Tomczuk

Since Specialization

Citations

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Fields of papers citing papers by Bruce E. Tomczuk

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bruce E. Tomczuk. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bruce E. Tomczuk. The network helps show where Bruce E. Tomczuk may publish in the future.

Co-authors

The 25 scholars most cited alongside Bruce E. Tomczuk, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Bruce E. Tomczuk Line = papers co-authored together Bruce E. Tomczuk links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	Current ADC Linker Chemistry Pharmaceutical Research ·Nareshkumar Jain, Sean W. Smith, Sanjeevani Ghone, Bruce E. Tomczuk Hit paper breakdown →	2015	349
2	Design, Synthesis, and Biological Evaluation of Novel Potent and Selective α_vβ₃/α_vβ₅ Integrin Dual Inhibitors with Improved Bioavailability. Selection of the Molecular Core Journal of Medicinal Chemistry ·Juan Marugán, Carl L. Manthey, Beth Anaclerio, Lou Lafrance, Tianbao Lu, Tom Markotan, Kristi Leonard, Carl Crysler, Stephen Eisennagel, Malini Dasgupta, Bruce E. Tomczuk	2005	61
3	Antagonists that demonstrate species differences in neurokinin-1 receptors. Molecular Pharmacology ·Kenneth C. Appell, B J Fragale, Jane Loscig, Suresh B. Singh, Bruce E. Tomczuk	1992	57
4	2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as nonbenzodiazepine anticonvulsants and anxiolytics Journal of Medicinal Chemistry ·Bruce E. Tomczuk, C. R. Taylor, L. Meredith Moses, Deborah Sutherland, Young S. Lo, David N. Johnson, William B. Kinnier, Brian F. Kilpatrick	1991	53
5	Inhibition of Matrix Metalloproteinases by Hydroxamates Containing Heteroatom-Based Modifications of the P1' Group Journal of Medicinal Chemistry ·Madhusudhan Gowravaram, Jeffrey S. Johnson, Daniel Delecki, Ewell R. Cook, Bruce E. Tomczuk, Arup K. Ghose, Alan M. Mathiowetz, John Spurlino, Byron Rubin, Douglas L. Smith, Tricia A. Pulvino, Robert C. Wahl	1995	48
6	Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Mark J. Wall, Jinsheng Chen, Sanath K. Meegalla, Shelley K. Ballentine, Kenneth J. Wilson, Renée L. DesJarlais, Carsten J. Schubert, Margery A. Chaikin, Carl Crysler, Ioanna P. Petrounia, Robert R. Donatelli, Edward J. Yurkow, Lisa Boczon, Marie J. Mazzulla, Mark R. Player, Raymond J. Patch, Carl L. Manthey, Christopher J. Molloy, Bruce E. Tomczuk, Carl R. Illig	2008	45
7	Discovery of novel FMS kinase inhibitors as anti-inflammatory agents Bioorganic & Medicinal Chemistry Letters ·Carl R. Illig, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Shelley K. Ballentine, Matthias Rudolph, Renée L. DesJarlais, Yanmin Chen, Carsten J. Schubert, Ioanna P. Petrounia, Carl Crysler, Christopher J. Molloy, Margery A. Chaikin, Carl L. Manthey, Mark R. Player, Bruce E. Tomczuk, Sanath K. Meegalla	2008	41
8	2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors Bioorganic & Medicinal Chemistry Letters ·Lily Lee, K. D. Kreutter, Wenxi Pan, Carl Crysler, John Spurlino, Mark R. Player, Bruce E. Tomczuk, Tianbao Lu	2007	35
9	Determination of Pharmacophoric Geometry for Collagenase Inhibitors Using a Novel Computational Method and Its Verification Using Molecular Dynamics, NMR, and X-ray Crystallography Journal of the American Chemical Society ·Arup K. Ghose, Margaret E. Logan, Adi M. Treasurywala, Hsin Wang, Robert C. Wahl, Bruce E. Tomczuk, Madhusudhan Gowravaram, Edward P. Jaeger, John J. Wendoloski	1995	35
10	Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors Bioorganic & Medicinal Chemistry Letters ·Lei Qiao, Christian A. Baumann, Carl Crysler, Nisha Ninan, M.C. Abad, John Spurlino, Renée L. DesJarlais, Jukka Kervinen, Mike P. Neeper, Shariff Bayoumy, Robyn Williams, Ingrid C. Deckman, Malini Dasgupta, Rolanda L. Reed, Norman Huebert, Bruce E. Tomczuk, K.J.M. Moriarty	2005	34
11	Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors Bioorganic & Medicinal Chemistry Letters ·Richard Söll, Tianobao Lu, Bruce E. Tomczuk, Carl R. Illig, Cynthia L. Fedde, Stephen Eisennagel, Roger Bone, (unknown), John Spurlino, F. Raymond Salemme	2000	33
12	Discovery and Clinical Evaluation of 1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif Journal of Medicinal Chemistry ·Tianbao Lu, Thomas Markotan, Shelley K. Ballentine, Edward C. Giardino, John Spurlino, Kathryn Brown, Bruce E. Maryanoff, Bruce E. Tomczuk, Bruce P. Damiano, Umesh Shukla, David W. End, Patricia Andrade-Gordon, Roger Bone, Mark R. Player	2010	28
13	Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141) Journal of Medicinal Chemistry ·Carl R. Illig, Carl L. Manthey, Mark J. Wall, Sanath K. Meegalla, Jinsheng Chen, Kenneth J. Wilson, Shelley K. Ballentine, Renée L. DesJarlais, Carsten J. Schubert, Carl Crysler, Yanmin Chen, Christopher J. Molloy, Margery A. Chaikin, Robert R. Donatelli, Edward J. Yurkow, Zhou Zhao, Mark R. Player, Bruce E. Tomczuk	2011	28
14	Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor Bioorganic & Medicinal Chemistry Letters ·Michael P. Winters, Carl Crysler, Nalin L. Subasinghe, Declan Ryan, Lynette Leong, Shuyuan Zhao, Robert R. Donatelli, Edward J. Yurkow, Marie J. Mazzulla, Lisa Boczon, Carl L. Manthey, Christopher J. Molloy, Holly Raymond, Lynne A. Murray, Laura McAlonan, Bruce E. Tomczuk	2008	28
15	Structure-based optimization of a potent class of arylamide FMS inhibitors Bioorganic & Medicinal Chemistry Letters ·Sanath K. Meegalla, Mark J. Wall, Jinsheng Chen, Kenneth J. Wilson, Shelley K. Ballentine, Renée L. DesJarlais, Carsten J. Schubert, Carl Crysler, Yanmin Chen, Christopher J. Molloy, Margery A. Chaikin, Carl L. Manthey, Mark R. Player, Bruce E. Tomczuk, Carl R. Illig	2008	26
16	Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors Bioorganic & Medicinal Chemistry Letters ·Bruce E. Tomczuk, Tianbao Lu, Richard Söll, Cynthia L. Fedde, Aihua Wang, (unknown), Carl Crysler, Malini Dasgupta, Stephen Eisennagel, John Spurlino, Roger Bone	2003	24
17	Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif Bioorganic & Medicinal Chemistry Letters ·K. D. Kreutter, Tianbao Lu, Lily Lee, Edward C. Giardino, Sharmila Patel, Hui Huang, Guozhang Xu, Mark Fitzgerald, Barbara J. Haertlein, V. Mohan, Carl Crysler, Stephen Eisennagel, Malini Dasgupta, Martin McMillan, John Spurlino, Norman Huebert, Bruce E. Maryanoff, Bruce E. Tomczuk, Bruce P. Damiano, Mark R. Player	2008	24
18	In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors Bioorganic & Medicinal Chemistry Letters ·Tianbao Lu, Bruce E. Tomczuk, Carl R. Illig, Roger Bone, (unknown), John Spurlino, F. Raymond Salemme, Richard Söll	1998	20
19	Non-peptidic αvβ3 antagonists containing indol-1-yl propionic acids Bioorganic & Medicinal Chemistry Letters ·Kristi Leonard, Wenxi Pan, Beth Anaclerio, Joan M. Gushue, Zihong Guo, Renée L. DesJarlais, Marge A. Chaikin, Jennifer Lattanze, Carl Crysler, Carl L. Manthey, Bruce E. Tomczuk, Juan Marugán	2005	20
20	Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis Bioorganic & Medicinal Chemistry Letters ·Tianbao Lu, Thomas Markotan, Frank T. Coppo, Bruce E. Tomczuk, Carl Crysler, Stephen Eisennagel, John Spurlino, Lisa Gremminger, Richard Söll, Edward C. Giardino, Roger Bone	2004	19

About Bruce E. Tomczuk

Bruce E. Tomczuk is a scholar working on Molecular Biology, Organic Chemistry, Oncology, Hematology and Immunology, having authored 38 papers that have together received 1.2k indexed citations. Recurring topics across this work include Peptidase Inhibition and Analysis (8 papers), Chemical Synthesis and Analysis (6 papers), Cell Adhesion Molecules Research (5 papers), Blood Coagulation and Thrombosis Mechanisms (5 papers), Click Chemistry and Applications (4 papers), Synthesis and Catalytic Reactions (4 papers), Coagulation, Bradykinin, Polyphosphates, and Angioedema (4 papers) and Synthesis and Biological Evaluation (4 papers). The work is most often cited by research in Oncology (390 citations), Organic Chemistry (415 citations), Radiology, Nuclear Medicine and Imaging (225 citations), Immunology and Allergy (53 citations) and Hematology (94 citations). Bruce E. Tomczuk has collaborated with scholars based in United States and Belgium. Frequent co-authors include Sean W. Smith, Nareshkumar Jain, Carl Crysler, John Spurlino, Tianbao Lu, Carl L. Manthey, Roger Bone, Carl R. Illig, Mark R. Player and Kenneth C. Appell. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Biopharmaceutics & Drug Disposition and Current Microbiology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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About Bruce E. Tomczuk

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