Brian Dymock

5.3k citations

80 papers · 3.1k · h-index 31

Impact in

Biochemistry top 1%
- Sulfur Compounds in Biology
Genetics top 2%
- Myeloproliferative Neoplasms: Diagnosis and Treatment

Papers in

Molecular Biology 50
- Heat shock proteins research 11
- Histone Deacetylase Inhibitors Research 10
- Biochemical and Molecular Research 6
Oncology 18
- Cytokine Signaling Pathways and Interactions 9

Co-authors: Anders Poulsen (20 shared papers)Philip K. Moore (9 shared papers)Xavier Barril (8 shared papers)Paul Workman (9 shared papers)A.E. Surgenor (6 shared papers)Haishan Wang (10 shared papers)Anthony D. William (13 shared papers)Lisa Wright (6 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (13 papers)Journal of Medicinal Chemistry (10 papers)European Journal of Medicinal Chemistry (4 papers)Expert Opinion on Therapeutic Patents (3 papers)Future Medicinal Chemistry (3 papers)
Partner nations: Singapore United Kingdom United States

In The Last Decade

Brian Dymock

79 papers receiving 3.0k citations

Peers

Countries citing papers authored by Brian Dymock

Since Specialization

Citations

This map shows the geographic impact of Brian Dymock's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brian Dymock with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brian Dymock more than expected).

Fields of papers citing papers by Brian Dymock

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brian Dymock. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brian Dymock. The network helps show where Brian Dymock may publish in the future.

Co-authors

The 25 scholars most cited alongside Brian Dymock, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Brian Dymock Line = papers co-authored together Brian Dymock links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 80 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Structure-Activity Relationships in Purine-Based Inhibitor Binding to HSP90 Isoforms Chemistry & Biology ·Lisa Wright, Xavier Barril, Brian Dymock, Louisa Sheridan, A.E. Surgenor, Mandy Beswick, (unknown), Adam J. Collier, Andy Massey, (unknown), Alex Fink, Christophe Fromont, Wynne Aherne, Kathy Boxall, Swee Y. Sharp, Paul Workman, Roderick E. Hubbard	2004	223
2	Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design Journal of Medicinal Chemistry ·Brian Dymock, Xavier Barril, Paul A. Brough, Julie E. Cansfield, Andrew J. Massey, Edward McDonald, Roderick E. Hubbard, A.E. Surgenor, Stephen D. Roughley, Paul Webb, Paul Workman, Lisa Wright, (unknown)	2005	192
3	SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies Leukemia ·Stefan Hart, K C Goh, Veronica Novotny‐Diermayr, C. Y. Hu, Hannes Hentze, Yuxin Tan, Babita Madan, Chithra Amalini, Yung Kiang Loh, L C Ong, Anthony D. William, A Lee, Anders Poulsen, Ramesh Jayaraman, Kiat Hoe Ong, Kantharaj Ethirajulu, Brian Dymock, J W Wood	2011	160
4	Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma Journal of Medicinal Chemistry ·Anthony D. William, Angeline C.-H. Lee, Stéphanie Blanchard, Anders Poulsen, Ee Ling Teo, Harish Nagaraj, Evelyn Tan, Dizhong Chen, Meredith Williams, Eric T. Sun, Kee Chuan Goh, Wai Chung Ong, Siok Kun Goh, Stefan Hart, Ramesh Jayaraman, Mohammad Pasha, Kantharaj Ethirajulu, Jeanette M. Wood, Brian Dymock	2011	159
5	TG02, a novel oral multi-kinase inhibitor of CDKs, JAK2 and FLT3 with potent anti-leukemic properties Leukemia ·K C Goh, Veronica Novotny‐Diermayr, Stefan Hart, L C Ong, Yung Kiang Loh, Albert Cheong, Yuxin Tan, C. Hu, Ramesh Jayaraman, Anthony D. William, Eric T. Sun, Brian Dymock, Kiat Hoe Ong, Kantharaj Ethirajulu, Francis Burrows, J M Wood	2011	109
6	Design and Characterization of Libraries of Molecular Fragments for Use in NMR Screening against Protein Targets Journal of Chemical Information and Computer Sciences ·Nicolas Baurin, Fareed Aboul‐ela, Xavier Barril, Ben Davis, (unknown), Brian Dymock, Harry Finch, Christophe Fromont, Christine M. Richardson, Heather Simmonite, Roderick E. Hubbard	2004	102
7	GYY4137, a Novel Water-Soluble, H2S-Releasing Molecule Methods in enzymology on CD-ROM/Methods in enzymology ·Peter Rose, Brian Dymock, Philip K. Moore	2015	99
8	Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat Journal of Medicinal Chemistry ·Lianbin Yao, Nurulhuda Mustafa, Eng Chong Tan, Anders Poulsen, Prachi Singh, Minh‐Dao Duong‐Thi, Jeannie X. T. Lee, Pondy Murugappan Ramanujulu, Wee Joo Chng, J. J. Yen, Sten Ohlson, Brian Dymock	2017	94
9	Discovery of Kinase Spectrum Selective Macrocycle (16E)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the Treatment of Cancer Journal of Medicinal Chemistry ·Anthony D. William, Angeline C.-H. Lee, Kee Chuan Goh, Stéphanie Blanchard, Anders Poulsen, Ee Ling Teo, Harish Nagaraj, Chai Ping Lee, Haishan Wang, Meredith Williams, Eric T. Sun, Changyong Hu, Ramesh Jayaraman, Mohammad Pasha, Kantharaj Ethirajulu, Jeanette M. Wood, Brian Dymock	2011	85
10	Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines Journal of Medicinal Chemistry ·Eugene Guorong Yang, Nurulhuda Mustafa, Eng Chong Tan, Anders Poulsen, Pondy Murugappan Ramanujulu, Wee Joo Chng, J. J. Yen, Brian Dymock	2016	84
11	Discovery of New H₂S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity Journal of Medicinal Chemistry ·Feng Wei, Xin-Yi Teo, Wisna Novera, Pondy Murugappan Ramanujulu, Dong Liang, Dejian Huang, Philip K. Moore, Lih‐Wen Deng, Brian Dymock	2015	77
12	Hydrogen Sulfide Is an Endogenous Regulator of Aging in Caenorhabditis elegans Antioxidants and Redox Signaling ·Bedoor Qabazard, Ling Li, Jan Gruber, Meng Teng Peh, Li Fang Ng, (unknown), Peter Rose, Choon‐Hong Tan, Brian Dymock, Feng Wei, (unknown), Barry Halliwell, Stephen R. Stürzenbaum, Philip K. Moore	2013	77
13	4-Amino derivatives of the Hsp90 inhibitor CCT018159 Bioorganic & Medicinal Chemistry Letters ·Xavier Barril, Mandy Beswick, Adam J. Collier, (unknown), Brian Dymock, Alexandra Fink, Kate Grant, Robert I. Howes, Allan M. Jordan, Andrew J. Massey, A.E. Surgenor, Joanne Wayne, Paul Workman, Lisa Wright	2006	73
14	3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone Bioorganic & Medicinal Chemistry Letters ·Paul A. Brough, Xavier Barril, Mandy Beswick, Brian Dymock, (unknown), Lisa Wright, Kate Grant, Andrew J. Massey, A.E. Surgenor, Paul Workman	2005	71
15	Hydrogen Sulfide Promotes Adipogenesis in 3T3L1 Cells PLoS ONE ·Chin-Yi Tsai, Meng Teng Peh, Feng Wei, Brian Dymock, Philip K. Moore	2015	67
16	A fluorescence polarization assay for inhibitors of Hsp90 Analytical Biochemistry ·R. Howes, Xavier Barril, Brian Dymock, Kate Grant, Christopher J. Northfield, Alan Robertson, A.E. Surgenor, Joanne Wayne, L. Wright, Karen James, Thomas P. Matthews, Kwai Ming Cheung, Edward McDonald, Paul Workman, (unknown)	2006	66
17	Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality Nature Communications ·Mayumi Kitagawa, Pei-Ju Liao, Kyung Hee Lee, Jasmine C. Wong, See Cheng Shang, Noriaki Minami, Oltea Sampetrean, Hideyuki Saya, Lingyun Dai, Nayana Prabhu, Ka Diam Go, Radoslaw M. Sobota, Andreas Larsson, P. Nordlund, Frank McCormick, Sujoy Ghosh, David Epstein, Brian Dymock, Sang Hyun Lee	2017	63
18	A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo Pharmacological Research ·Caleb Huang, Feng Wei, Meng Teng Peh, Kaye Peh, Brian Dymock, Philip K. Moore	2016	60
19	Emerging therapies for hepatitis C virus infection PubMed ·Brian Dymock	2001	58
20	Adenine derived inhibitors of the molecular chaperone HSP90—SAR explained through multiple X-ray structures Bioorganic & Medicinal Chemistry Letters ·Brian Dymock, Xavier Barril, Mandy Beswick, Adam J. Collier, Nicholas G. Davies, (unknown), Alexandra Fink, Christophe Fromont, Roderick E. Hubbard, Andrew J. Massey, A.E. Surgenor, Lisa Wright	2003	56

About Brian Dymock

Brian Dymock is a scholar working on Molecular Biology, Oncology, Genetics, Computational Theory and Mathematics and Organic Chemistry, having authored 80 papers that have together received 3.1k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (12 papers), Heat shock proteins research (11 papers), Histone Deacetylase Inhibitors Research (10 papers), Myeloproliferative Neoplasms: Diagnosis and Treatment (9 papers), Cytokine Signaling Pathways and Interactions (9 papers), Sulfur Compounds in Biology (9 papers), Chronic Lymphocytic Leukemia Research (7 papers) and Biochemical and Molecular Research (6 papers). The work is most often cited by research in Biochemistry (308 citations), Genetics (324 citations), Computational Theory and Mathematics (522 citations), Molecular Biology (1.8k citations) and Oncology (519 citations). Brian Dymock has collaborated with scholars based in Singapore, United Kingdom and United States. Frequent co-authors include Anders Poulsen, Philip K. Moore, Xavier Barril, Paul Workman, A.E. Surgenor, Haishan Wang, Anthony D. William, Lisa Wright, Feng Wei and Roderick E. Hubbard. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Expert Opinion on Therapeutic Patents and Future Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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