Alfred Singer

19.5k citations
191 papers · 14.2k · 1 hit paper · h-index 66

Impact in

  • Immunology top 0.05%
    • T-cell and B-cell Immunology
    • Immune Cell Function and Interaction
    • Immunotherapy and Immune Responses
    • Immune Response and Inflammation
  • Oncology top 0.5%
    • CAR-T cell therapy research
    • Cancer Immunotherapy and Biomarkers

Papers in

  • Immunology 172
    • T-cell and B-cell Immunology 158
    • Immune Cell Function and Interaction 120
    • Immunotherapy and Immune Responses 80
    • Immune Response and Inflammation 7
  • Radiology, Nuclear Medicine and Imaging 44
    • Monoclonal and Polyclonal Antibodies Research 43
Co-authors
Lionel Feigenbaum (20 shared papers)Jung‐Hyun Park (14 shared papers)Batu Erman (16 shared papers)Terry I. Guinter (24 shared papers)Susan O. Sharrow (32 shared papers)Stanley Adoro (7 shared papers)Amala Alag (12 shared papers)Motoko Y. Kimura (9 shared papers)
Journals
The Journal of Experimental Medicine (42 papers)The Journal of Immunology (35 papers)Immunity (16 papers)Nature Immunology (14 papers)Proceedings of the National Academy of Sciences (11 papers)
Partner nations
United StatesTürkiyeJapan

In The Last Decade

Alfred Singer

190 papers receiving 13.8k citations

Alfred Singer's Hit Papers

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells 2010 · 2.9k citations
2.9k0+5+10Years since publication50010001.5k2.0k2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

  • it has ≥500 total citations;
  • it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
  • it reaches the top citation threshold in at least one of its specific research topics.
  1. 2010 Nature Immunology

Peers

Alfred Singer
Comparison fields: 5 of 140
  • Immunology 11.3k
  • Oncology 2.5k
  • Transplantation 197
  • Immunology and Allergy 343
  • Radiology, Nuclear Medicine and Imaging 1.1k
Replace Ronald H. Schwartz with:
Ronald H. Schwartz United States
Richard A. Kroczek Germany
Víctor H. Engelhard United States
Peter J. van den Elsen Netherlands
Nancy H. Ruddle United States
Carola G. Vinuesa Australia
Fred Ramsdell United States
Armand Bensussan France
David M. Tarlinton Australia
Kristin A. Hogquist United States
Alfred Singer relative to Ronald H. Schwartz United States Ronald H. Schwartz's profile →
Citations per field
00.5×2×3×3.6×
Ronald H. Schwartz · 1×
Citations per year

Countries citing papers authored by Alfred Singer

Since Specialization
Citations

This map shows the geographic impact of Alfred Singer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfred Singer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfred Singer more than expected).

Fields of papers citing papers by Alfred Singer

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfred Singer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfred Singer. The network helps show where Alfred Singer may publish in the future.

Co-authors

The 25 scholars most cited alongside Alfred Singer, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Alfred Singer Line = papers co-authored together Alfred Singer links everyone, so they are left out of the graph.

All Works

20 of 20 papers shown

Showing the 20 most-cited of 191 papers — load more, or switch the sort, to bring in the rest.

#Work
1
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Nature Immunology ·Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter, Batu Erman, Amala Alag, Marta Catálfamo, Motoko Y. Kimura, Yongzhi Cui, Philip J. Lucas, Ronald E. Gress, Masato Kubo, Lothar Hennighausen, Lionel Feigenbaum, Alfred Singer
Hit paper breakdown →		20102940
2
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
Nature Immunology ·Xuguang Tai, Michelle L. Cowan, Lionel Feigenbaum, Alfred Singer
2005480
3
Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines
Immunity ·Jung‐Hyun Park, Qing Yu, Batu Erman, Jacob Appelbaum, Diego E. Montoya–Durango, H. Leighton Grimes, Alfred Singer
2004389
4
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice
Nature reviews. Immunology ·Alfred Singer, Stanley Adoro, Jung‐Hyun Park
2008340
5
Crosstalk in the mouse thymus
Immunology Today ·Willem van Ewijk, (unknown), Alfred Singer
1994221
6
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.
The Journal of Experimental Medicine ·Jennifer A. Punt, Barbara A. Osborne, Yousuke Takahama, Susan O. Sharrow, Alfred Singer
1994216
7
Coreceptor Reversal in the Thymus
Immunity ·Enrico Brugnera, Avinash Bhandoola, Ricardo Cibotti, Qing Yu, Terry I. Guinter, Yoshio Yamashita, Susan O. Sharrow, Alfred Singer
2000209
8
Basis of CTLA-4 function in regulatory and conventional CD4+ T cells
Blood ·Xuguang Tai, François Van Laethem, Leonid A. Pobezinsky, Terry I. Guinter, Susan O. Sharrow, Anthony J. Adams, Larry Granger, Michael J. Kruhlak, Tullia Lindsten, Craig B. Thompson, Lionel Feigenbaum, Alfred Singer
2012208
9
T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex
Science ·Paul E. Love, Elizabeth W. Shores, Mark D. Johnson, Michel L. Tremblay, Eric J. Lee, Alexander Grinberg, Sing Ping Huang, Alfred Singer, Heiner Westphal
1993197
10
Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection
Immunity ·Harumi Suzuki, Jennifer A. Punt, Lawrence G. Granger, Alfred Singer
1995183
11
Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals
Immunity ·Xuguang Tai, Batu Erman, Amala Alag, Jie Mu, Motoko Y. Kimura, Gil Katz, Terry I. Guinter, Tom M. McCaughtry, Ruth Etzensperger, Lionel Feigenbaum, Dinah S. Singer, Alfred Singer
2013174
12
Inhibition of T‐cell receptor beta‐chain gene rearrangement by overexpression of the non‐receptor protein tyrosine kinase p56lck.
The EMBO Journal ·Sarah Anderson, Kristin M. Abraham, Toshinori Nakayama, Alfred Singer, Roger M. Perlmutter
1992167
13
Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.
The Journal of Experimental Medicine ·Aaron S. Rosenberg, Toshiaki Mizuochi, S O Sharrow, Alfred Singer
1987165
14
Disorganization and restoration of thymic medullary epithelial cells in T cell receptor‐negative scid mice: Evidence that receptor‐bearing lymphocytes influence maturation of the thymic microenvironment
European Journal of Immunology ·Elizabeth W. Shores, Willem van Ewijk, Alfred Singer
1991154
15
Deletion of CD4 and CD8 Coreceptors Permits Generation of αβT Cells that Recognize Antigens Independently of the MHC
Immunity ·François Van Laethem, Sophia D. Sarafova, Jung‐Hyun Park, Xuguang Tai, Leonid A. Pobezinsky, Terry I. Guinter, Stanley Adoro, Anthony J. Adams, Susan O. Sharrow, Lionel Feigenbaum, Alfred Singer
2007146
16
Self recognition in allogeneic radiation bone marrow chimeras. A radiation- resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells
The Journal of Experimental Medicine ·Alfred Singer, K S Hathcock, R J Hodes
1981143
17
Clonal deletion and the fate of autoreactive thymocytes that survive negative selection
Nature Immunology ·Leonid A. Pobezinsky, Georgi S. Angelov, Xuguang Tai, Susanna Jeurling, François Van Laethem, Lionel Feigenbaum, Jung‐Hyun Park, Alfred Singer
2012138
18
Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.
The Journal of Experimental Medicine ·David L. Wiest, Lydia C. Yuan, J. Jefferson, Patricia Benveniste, Maria Tsokos, Richard D. Klausner, Laurie H. Glimcher, Lawrence E. Samelson, Alfred Singer
1993134
19
Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.
The Journal of Experimental Medicine ·Joseph L. Roberts, Susan O. Sharrow, Alfred Singer
1990129
20
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
Nature Immunology ·Jung‐Hyun Park, Stanley Adoro, Philip J. Lucas, Sophia D. Sarafova, Amala Alag, Loretta L. Doan, Batu Erman, Xiaolong Liu, Wilfried Ellmeier, Rémy Bosselut, Lionel Feigenbaum, Alfred Singer
2007128

About Alfred Singer

Alfred Singer is a scholar working on Immunology, Radiology, Nuclear Medicine and Imaging, Oncology, Molecular Biology and Genetics, having authored 191 papers that have together received 14.2k indexed citations. Recurring topics across this work include T-cell and B-cell Immunology (158 papers), Immune Cell Function and Interaction (120 papers), Immunotherapy and Immune Responses (80 papers), Monoclonal and Polyclonal Antibodies Research (43 papers), CAR-T cell therapy research (20 papers), Glycosylation and Glycoproteins Research (8 papers), Immune Response and Inflammation (7 papers) and Diabetes and associated disorders (6 papers). The work is most often cited by research in Immunology (11.3k citations), Oncology (2.5k citations), Transplantation (197 citations), Immunology and Allergy (343 citations) and Radiology, Nuclear Medicine and Imaging (1.1k citations). Alfred Singer has collaborated with scholars based in United States, Türkiye and Japan. Frequent co-authors include Lionel Feigenbaum, Jung‐Hyun Park, Batu Erman, Terry I. Guinter, Susan O. Sharrow, Stanley Adoro, Amala Alag, Motoko Y. Kimura, Xuguang Tai and Philip J. Lucas. Their work appears in journals such as The Journal of Experimental Medicine, The Journal of Immunology, Immunity, Nature Immunology and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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