Zelton Dave Sharp

9.8k citations

73 papers · 8.1k · 2 hit papers · h-index 28

Impact in

Aging top 0.05%
- Genetics, Aging, and Longevity in Model Organisms
Geriatrics and Gerontology top 0.5%

Papers in

Aging 16
- Genetics, Aging, and Longevity in Model Organisms 16
Molecular Biology 54
- Genomics and Chromatin Dynamics 13
- RNA Research and Splicing 10
- CRISPR and Genetic Engineering 10
- PI3K/AKT/mTOR signaling in cancer 8

Co-authors: Randy Strong (12 shared papers)Martin A. Javors (10 shared papers)James F. Nelson (5 shared papers)Nancy L. Nadon (4 shared papers)Richard A. Miller (4 shared papers)Kevin Flurkey (3 shared papers)Clinton M. Astle (3 shared papers)Elizabeth Fernández (3 shared papers)
Journals: Molecular and Cellular Biology (6 papers)The Journals of Gerontology Series A (5 papers)Journal of Biological Chemistry (4 papers)Aging Cell (4 papers)Journal of Cellular Biochemistry (3 papers)
Partner nations: United States Czechia France

In The Last Decade

Zelton Dave Sharp

72 papers receiving 7.9k citations

Zelton Dave Sharp's Hit Papers

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Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice 2010 · 763 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2010 The Journals of Gerontology Series A
2009 Nature

Peers

Countries citing papers authored by Zelton Dave Sharp

Since Specialization

Citations

This map shows the geographic impact of Zelton Dave Sharp's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Zelton Dave Sharp with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Zelton Dave Sharp more than expected).

Fields of papers citing papers by Zelton Dave Sharp

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Zelton Dave Sharp. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Zelton Dave Sharp. The network helps show where Zelton Dave Sharp may publish in the future.

Co-authors

The 25 scholars most cited alongside Zelton Dave Sharp, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Zelton Dave Sharp Line = papers co-authored together Zelton Dave Sharp links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 73 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Nature ·Randy Strong, Zelton Dave Sharp, James F. Nelson, Clinton M. Astle, Kevin Flurkey, Nancy L. Nadon, John Erby Wilkinson, Krystyna Frenkel Hit paper breakdown →	2009	3118
2	Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice The Journals of Gerontology Series A ·Richard A. Miller, Clinton M. Astle, Joseph A. Baur, Angela Rodriguez Boyd, Rafael de Cabo, Elizabeth Fernández, Kevin Flurkey, Martin A. Javors Hit paper breakdown →	2010	763
3	Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response Science ·Qing Zhong, Chi‐Fen Chen, Shang Li, Yumay Chen, Chuan-Cheng Wang, Jun Xiao, Phang‐Lang Chen, Zelton Dave Sharp	1999	523
4	Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction Aging Cell ·Richard A. Miller, David E. Harrison, Clinton M. Astle, Elizabeth Fernández, Kevin Flurkey, Melissa L. Han, Martin A. Javors, Xinna Li	2013	492
5	A general method for polyethylene-glycol-induced genetic transformation of bacteria and yeast Gene ·Robert J. Klebe, June V. Harriss, Zelton Dave Sharp, Michael G. Douglas	1983	430
6	The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment Proceedings of the National Academy of Sciences ·Phang‐Lang Chen, Chi‐Fen Chen, Yumay Chen, Jun Xiao, Zelton Dave Sharp, Wen‐Hwa Lee	1998	329
7	The Nuclear Localization Sequences of the BRCA1 Protein Interact with the Importin-α Subunit of the Nuclear Transport Signal Receptor Journal of Biological Chemistry ·Chi‐Fen Chen, Shang Li, Yumay Chen, Phang‐Lang Chen, Zelton Dave Sharp, Wen‐Hwa Lee	1996	178
8	Expression of BRC Repeats in Breast Cancer Cells Disrupts the BRCA2-Rad51 Complex and Leads to Radiation Hypersensitivity and Loss of G2/M Checkpoint Control Journal of Biological Chemistry ·Chi‐Fen Chen, Phang‐Lang Chen, Qing Zhong, Zelton Dave Sharp, Wen‐Hwa Lee	1999	174
9	Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage Journal of Biological Chemistry ·Shang Li, Phang‐Lang Chen, Thirugnana Subramanian, Govindasamy Chinnadurai, Gail Elizabeth Tomlinson, C. Kent Osborne, Zelton Dave Sharp, Wen‐Hwa Lee	1999	168
10	mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism Aging Cell ·Huibin Tang, Ken Inoki, Susan V. Brooks, Hideki Okazawa, Myung Jong Lee, Junying Wang, Michael Kim, Catherine L. Kennedy	2019	152
11	Evidence for Down-Regulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice The Journals of Gerontology Series A ·Zelton Dave Sharp, Andrzej Bartke	2005	126
12	Design of aging intervention studies: the NIA interventions testing program AGE ·Nancy L. Nadon, Randy Strong, Richard A. Miller, James F. Nelson, Martin A. Javors, Zelton Dave Sharp, Josep Maria Peralba +1 other	2008	122
13	Chronic mTOR inhibition in mice with rapamycin alters T , B , myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice Aging Cell ·Vincent J. Hurez, Vinh A Dao, Aijie Liu, Srilakshmi Pandeswara, Jonathan Gelfond, Lishi Sun, Molly Ann Bergman, Carlos J. Orihuela	2015	109
14	Estrogen-receptor-α exchange and chromatin dynamics are ligand- and domain-dependent Journal of Cell Science ·Zelton Dave Sharp, Maureen G. Mancini, Cruz A. Hinojos, Fangyan Dai, Valeria Berno, Adam T. Szafran, Kelly P. Smith, Tanmay T. Lele	2006	91
15	mTORC1 and p53 Cell Cycle ·Paul Hasty, Zelton Dave Sharp, Tyler Jay Curiel, Judith Campisi	2012	78
16	Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors Aging ·Carolina Becker Livi, Rulon L. Hardman, Barbara A. Christy, Sherry G Dodds, D.R. Jones, Charnae E. Williams, Randy Strong, Alex F. Bokov	2013	78
17	Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice Frontiers in Molecular Neuroscience ·Karl A. Rodriguez, Sherry G Dodds, Randy Strong, Verónica Galván, Zelton Dave Sharp, Rochelle Buffenstein	2014	76
18	Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs The Journals of Gerontology Series A ·Cheresa Calhoun, Pooja Shivshankar, Mirna Saker, Lauren B. Sloane, Carolina Becker Livi, Zelton Dave Sharp, Carlos J. Orihuela, Serge Adnot	2015	72
19	eRapa Restores a Normal Life Span in a FAP Mouse Model Cancer Prevention Research ·Paul Hasty, Carolina Becker Livi, Sherry G Dodds, D.R. Jones, Randy Strong, Martin A. Javors, Kathleen E. Fischer, Lauren B. Sloane	2013	61
20	Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus Proceedings of the National Academy of Sciences ·Yumay Chen, Phang‐Lang Chen, Chi‐Fen Chen, Zelton Dave Sharp, Wen‐Hwa Lee	1999	59

About Zelton Dave Sharp

Zelton Dave Sharp is a scholar working on Aging, Molecular Biology, Endocrinology, Diabetes and Metabolism, Genetics and Endocrine and Autonomic Systems, having authored 73 papers that have together received 8.1k indexed citations. Recurring topics across this work include Genetics, Aging, and Longevity in Model Organisms (16 papers), Genomics and Chromatin Dynamics (13 papers), Growth Hormone and Insulin-like Growth Factors (12 papers), RNA Research and Splicing (10 papers), CRISPR and Genetic Engineering (10 papers), PI3K/AKT/mTOR signaling in cancer (8 papers), Estrogen and related hormone effects (7 papers) and Circadian rhythm and melatonin (7 papers). The work is most often cited by research in Aging (2.4k citations), Geriatrics and Gerontology (462 citations), Endocrine and Autonomic Systems (792 citations), Physiology (2.1k citations) and Molecular Biology (4.6k citations). Zelton Dave Sharp has collaborated with scholars based in United States, Czechia and France. Frequent co-authors include Randy Strong, Martin A. Javors, James F. Nelson, Nancy L. Nadon, Richard A. Miller, Kevin Flurkey, Clinton M. Astle, Elizabeth Fernández, John Erby Wilkinson and Krystyna Frenkel. Their work appears in journals such as Molecular and Cellular Biology, The Journals of Gerontology Series A, Journal of Biological Chemistry, Aging Cell and Journal of Cellular Biochemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Zelton Dave Sharp

Zelton Dave Sharp's Hit Papers

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