Terrence E. O’Brien

575 citations

16 papers · 458 · 1 hit paper · h-index 13

Impact in

Pharmacology top 10%
- Microbial Natural Products and Biosynthesis
Molecular Medicine
- Antibiotic Resistance in Bacteria

Papers in

Pharmacology 5
- Microbial Natural Products and Biosynthesis 5
Molecular Biology 14
- Plant biochemistry and biosynthesis 6
- Plant Gene Expression Analysis 3
- Biochemical and Molecular Research 2
- Biological Activity of Diterpenoids and Biflavonoids 2
- Natural product bioactivities and synthesis 2

Co-authors: Dean Joseph Tantillo (9 shared papers)Justin B. Siegel (7 shared papers)David E. Anderson (3 shared papers)Jared T. Shaw (3 shared papers)James B. Ames (3 shared papers)Jared T. Moore (3 shared papers)Jason B. Siegel (1 shared paper)Yue Zhang (2 shared papers)
Journals: ACS Chemical Biology (2 papers)ACS Catalysis (2 papers)ACS Medicinal Chemistry Letters (2 papers)ACS Omega (1 paper)Biochemistry (1 paper)
Partner nations: United States Russia Italy

In The Last Decade

Terrence E. O’Brien

16 papers receiving 446 citations

Terrence E. O’Brien's Hit Papers

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AI is a viable alternative to high throughput screening: a 318-target study 2024 · 90 citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2024 Scientific Reports

Peers

Countries citing papers authored by Terrence E. O’Brien

Since Specialization

Citations

This map shows the geographic impact of Terrence E. O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Terrence E. O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Terrence E. O’Brien more than expected).

Fields of papers citing papers by Terrence E. O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Terrence E. O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Terrence E. O’Brien. The network helps show where Terrence E. O’Brien may publish in the future.

Co-authors

The 25 scholars most cited alongside Terrence E. O’Brien, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Terrence E. O’Brien Line = papers co-authored together Terrence E. O’Brien links everyone, so they are left out of the graph.

All Works

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16 of 16 papers shown

#	Work
1	AI is a viable alternative to high throughput screening: a 318-target study Scientific Reports ·Izhar Wallach, Denzil Bernard, Kong T. Nguyen, Gregory Ho, Adrian R. Morrison, Adrian Stecuła, Andreana M. Rosnik, Ann Marie O’Sullivan Hit paper breakdown →	2024	90
2	Comparison of Small Molecule Inhibitors of the Bacterial Cell Division Protein FtsZ and Identification of a Reliable Cross-Species Inhibitor ACS Chemical Biology ·David E. Anderson, Michelle B. Kim, Jared T. Moore, Terrence E. O’Brien, Nohemy A. Sorto, Charles I. Grove, Laura L. Lackner, James B. Ames	2012	71
3	Mechanistically informed predictions of binding modes for carbocation intermediates of a sesquiterpene synthase reaction Chemical Science ·Terrence E. O’Brien, Steve J. Bertolani, Dean Joseph Tantillo, Jason B. Siegel	2016	52
4	Predicting Productive Binding Modes for Substrates and Carbocation Intermediates in Terpene Synthases—Bornyl Diphosphate Synthase As a Representative Case ACS Catalysis ·Terrence E. O’Brien, Steven J. Bertolani, Yue Zhang, Justin B. Siegel, Dean Joseph Tantillo	2018	49
5	Synthesis and Evaluation of Quinazolines as Inhibitors of the Bacterial Cell Division Protein FtsZ ACS Medicinal Chemistry Letters ·Gabriella M. Nepomuceno, Katie M. Chan, Valerie Huynh, Kévin Martin, Jared T. Moore, Terrence E. O’Brien, Luiz A.E. Pollo, Francisco Sarabia	2015	35
6	Biosynthesis of the microtubule-destabilizing diterpene pseudolaric acid B from golden larch involves an unusual diterpene synthase Proceedings of the National Academy of Sciences ·Sibongile Mafu, Prema Sambandaswami Karunanithi, Teresa Ann Palazzo, Bronwyn L. Harrod, Selina Marakana Rodriguez, Iris Natalie Mollhoff, Terrence E. O’Brien, Tong Shen	2017	25
7	The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol ACS Medicinal Chemistry Letters ·Michelle B. Kim, Terrence E. O’Brien, Jared T. Moore, David E. Anderson, Marie H. Foss, Douglas B. Weibel, James B. Ames, Jared T. Shaw	2012	24
8	Computer-Aided Drug Design for Undergraduates Journal of Chemical Education ·Dean Joseph Tantillo, Justin B. Siegel, Carla M. Saunders, Teresa Ann Palazzo, Phillip P. Painter, Terrence E. O’Brien, Nicole N. Nuñez, Dustin H. Nouri	2019	23
9	Elucidating Substrate Promiscuity within the FabI Enzyme Family ACS Chemical Biology ·Gabriel S. Freund, Terrence E. O’Brien, Logan Vinson, Dylan Alexander Carlin, Andrew I. Yao, Wai Shun Mak, Ilias Tagkopoulos, Marc T. Facciotti	2017	18
10	Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R) Bioorganic & Medicinal Chemistry ·William Engen, Terrence E. O’Brien, Brendan Kelly, Jacinda Do, Liezel Rillera, Lance K. Stapleton, JACK F. YOUNGREN, Marc O. Anderson	2010	17
11	Changing Face: A Key Residue for the Addition of Water by Sclareol Synthase ACS Catalysis ·Meirong Jia, Terrence E. O’Brien, Yue Zhang, Justin B. Siegel, Dean Joseph Tantillo, Reuben J. Peters	2018	16
12	Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c Biochemistry ·Yue Zhang, Lisa M. Prach, Terrence E. O’Brien, Frank DiMaio, Daniil M. Prigozhin, Jacob E. Corn, Tom Alber, Justin B. Siegel	2020	13
13	Discovery of Novel Trace Amine-Associated Receptor 5 (TAAR5) Antagonists Using a Deep Convolutional Neural Network International Journal of Molecular Sciences ·Carlotta Bon, Ting‐Rong Chern, Elena Cichero, Terrence E. O’Brien, Stefano Gustincich, Raul R. Gainetdinov, Stefano Espinoza	2022	13
14	Docking carbocations into terpene synthase active sites using chemically meaningful constraints—The TerDockin approach Methods in enzymology on CD-ROM/Methods in enzymology ·Ian S. Torrence, Terrence E. O’Brien, Justin B. Siegel, Dean Joseph Tantillo	2024	6
15	Systematic Functional Analysis of Active-Site Residues in l -Threonine Dehydrogenase from Thermoplasma volcanium ACS Omega ·M.-L. Desjardins, Wai Shun Mak, Terrence E. O’Brien, Dylan Alexander Carlin, Dean Joseph Tantillo, Justin B. Siegel	2017	4
16	Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer Cancer Cell International ·Luís F.O. Silva, Nicholas Skiados, Nikitha Murugavel, Karen Cover, Nastassja Luna, Manish Gupta, Stephanie C. Contreras, Terrence E. O’Brien	2025	2

About Terrence E. O’Brien

Terrence E. O’Brien is a scholar working on Pharmacology, Molecular Biology, Computational Theory and Mathematics, Biochemistry and Cancer Research, having authored 16 papers that have together received 458 indexed citations. Recurring topics across this work include Plant biochemistry and biosynthesis (6 papers), Microbial Natural Products and Biosynthesis (5 papers), Computational Drug Discovery Methods (4 papers), Plant Gene Expression Analysis (3 papers), Bacteriophages and microbial interactions (2 papers), Biochemical and Molecular Research (2 papers), Biological Activity of Diterpenoids and Biflavonoids (2 papers) and Natural product bioactivities and synthesis (2 papers). The work is most often cited by research in Pharmacology (126 citations), Molecular Medicine (34 citations), Molecular Biology (309 citations), Computational Theory and Mathematics (70 citations) and Organic Chemistry (73 citations). Terrence E. O’Brien has collaborated with scholars based in United States, Russia and Italy. Frequent co-authors include Dean Joseph Tantillo, Justin B. Siegel, David E. Anderson, Jared T. Shaw, James B. Ames, Jared T. Moore, Jason B. Siegel, Yue Zhang, Nohemy A. Sorto and Laura L. Lackner. Their work appears in journals such as ACS Chemical Biology, ACS Catalysis, ACS Medicinal Chemistry Letters, ACS Omega and Biochemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Terrence E. O’Brien

Terrence E. O’Brien's Hit Papers

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All Works

About Terrence E. O’Brien

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