Roberta Cascella

5.0k citations

57 papers · 3.3k · 3 hit papers · h-index 30

Impact in

Physiology top 1%
- Alzheimer's disease research and treatments
Neurology top 1%
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research

Papers in

Physiology 41
- Alzheimer's disease research and treatments 41
Molecular Biology 35
- Prion Diseases and Protein Misfolding 10
- Lipid Membrane Structure and Behavior 8
- Protein Structure and Dynamics 7

Co-authors: Cristina Cecchi (46 shared papers)Fabrizio Chiti (31 shared papers)Christopher M. Dobson (14 shared papers)Giovanna Cenini (2 shared papers)Ana Lloret (1 shared paper)Nunilo Cremades (4 shared papers)Serene W. Chen (6 shared papers)Alessandra Bigi (16 shared papers)
Journals: Oncotarget (3 papers)ACS Chemical Biology (3 papers)Journal of Alzheimer s Disease (3 papers)FEBS Journal (2 papers)Free Radical Biology and Medicine (2 papers)
Partner nations: Italy United Kingdom Spain

In The Last Decade

Roberta Cascella

57 papers receiving 3.3k citations

Roberta Cascella's Hit Papers

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The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells 2021 · 166 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2021 Nature Communications
2019 Oxidative Medicine and Cellular Longevity
2017 Science

Peers

Countries citing papers authored by Roberta Cascella

Since Specialization

Citations

This map shows the geographic impact of Roberta Cascella's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Roberta Cascella with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Roberta Cascella more than expected).

Fields of papers citing papers by Roberta Cascella

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Roberta Cascella. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Roberta Cascella. The network helps show where Roberta Cascella may publish in the future.

Co-authors

The 25 scholars most cited alongside Roberta Cascella, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Roberta Cascella Line = papers co-authored together Roberta Cascella links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 57 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers Science ·Giuliana Fusco, Serene W. Chen, Philip T. F. Williamson, Roberta Cascella, Michele Perni, James A. Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades, Liming Ying, Christopher M. Dobson, Alfonso De Simone Hit paper breakdown →	2017	520
2	Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View Oxidative Medicine and Cellular Longevity ·Giovanna Cenini, Ana Lloret, Roberta Cascella Hit paper breakdown →	2019	372
3	The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells Nature Communications ·Roberta Cascella, Serene W. Chen, Alessandra Bigi, José D. Camino, Catherine K. Xu, Christopher M. Dobson, Fabrizio Chiti, Nunilo Cremades, Cristina Cecchi Hit paper breakdown →	2021	166
4	Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity ACS Chemical Biology ·Benedetta Mannini, Estefania Mulvihill, Caterina Sgromo, Roberta Cascella, Reza Khodarahmi‬, Matteo Ramazzotti, Christopher M. Dobson, Cristina Cecchi, Fabrizio Chiti	2014	166
5	Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers Proceedings of the National Academy of Sciences ·Benedetta Mannini, Roberta Cascella, Mariagioia Zampagni, Maria van Waarde-Verhagen, Sarah Meehan, Cintia Roodveldt, Silvia Campioni, Matilde Boninsegna, Amanda Penco, Annalisa Relini, Harm H. Kampinga, Christopher M. Dobson, Mark R. Wilson, Cristina Cecchi, Fabrizio Chiti	2012	131
6	Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress Oxidative Medicine and Cellular Longevity ·Annika Höhn, Antonella Tramutola, Roberta Cascella	2020	124
7	Calcium Dyshomeostasis in Alzheimer’s Disease Pathogenesis International Journal of Molecular Sciences ·Roberta Cascella, Cristina Cecchi	2021	121
8	Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight Oncotarget ·Stefania Rigacci, Caterina Miceli, Chiara Nediani, Andrea Berti, Roberta Cascella, Daniela Pantano, Pamela Nardiello, Ilaria Luccarini, Fiorella Casamenti, Massimo Stefani	2015	109
9	Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases Scientific Reports ·Elisa Evangelisti, Roberta Cascella, Matteo Becatti, Giovanna Marrazza, Christopher M. Dobson, Fabrizio Chiti, Massimo Stefani, Cristina Cecchi	2016	97
10	Selenium and zinc: Two key players against cadmium-induced neuronal toxicity Toxicology in Vitro ·Jacopo Junio Valerio Branca, Gabriele Morucci, Mario Maresca, Barbara Tenci, Roberta Cascella, Ferdinando Paternostro, Carla Ghelardini, Massimo Gulisano, Lorenzo Di Cesare Mannelli, Alessandra Pacini	2018	87
11	Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies Cellular and Molecular Life Sciences ·Roberta Cascella, Alessandra Bigi, Nunilo Cremades, Cristina Cecchi	2022	72
12	Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers Journal of Cell Science ·Elisa Evangelisti, Cristina Cecchi, Roberta Cascella, Caterina Sgromo, Matteo Becatti, Christopher M. Dobson, Fabrizio Chiti, Massimo Stefani	2012	72
13	Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ·Roberta Cascella, Simona Conti, Benedetta Mannini, Xinyi Li, Joel N. Buxbaum, Bruno Tiribilli, Fabrizio Chiti, Cristina Cecchi	2013	67
14	Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies Journal of Biological Chemistry ·Roberta Cascella, Claudia Capitini, Giulia Fani, Christopher M. Dobson, Cristina Cecchi, Fabrizio Chiti	2016	67
15	TDP-43 Inclusion Bodies Formed in Bacteria Are Structurally Amorphous, Non-Amyloid and Inherently Toxic to Neuroblastoma Cells PLoS ONE ·Claudia Capitini, Simona Conti, Michele Perni, Francesca Guidi, Roberta Cascella, Angela De Poli, Amanda Penco, Annalisa Relini, Cristina Cecchi, Fabrizio Chiti	2014	67
16	Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers Biomacromolecules ·Seyyed Abolghasem Ghadami, Sean Chia, Francesco Simone Ruggeri, Georg Meisl, Francesco Bemporad, Johnny Habchi, Roberta Cascella, Christopher M. Dobson, Michele Vendruscolo, Tuomas P. J. Knowles, Fabrizio Chiti	2020	64
17	Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors ACS Chemical Neuroscience ·Giulia Fani, Benedetta Mannini, Giulia Vecchi, Roberta Cascella, Cristina Cecchi, Christopher M. Dobson, Michele Vendruscolo, Fabrizio Chiti	2021	57
18	Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions The FASEB Journal ·Concetta Di Natale, Pasqualina Liana Scognamiglio, Roberta Cascella, Cristina Cecchi, Anna Russo, Marilisa Leone, Amanda Penco, Annalisa Relini, Luca Federici, Adele Di Matteo, Fabrizio Chiti, Luigi Vitagliano, Daniela Marasco	2015	56
19	Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models Free Radical Biology and Medicine ·Mariagioia Zampagni, Daniel Wright, Roberta Cascella, Giampiero D’Adamio, Fiorella Casamenti, Elisa Evangelisti, Francesca Cardona, Andrea Goti, Benedetta Nacmias, Sandro Sorbi, Gianfranco Liguri, Cristina Cecchi	2012	54
20	Extracellular chaperones prevent Aβ42-induced toxicity in rat brains Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ·Roberta Cascella, Simona Conti, Francesca Tatini, Elisa Evangelisti, Tania Scartabelli, Fiorella Casamenti, Mark R. Wilson, Fabrizio Chiti, Cristina Cecchi	2013	52

About Roberta Cascella

Roberta Cascella is a scholar working on Physiology, Molecular Biology, Neurology, Cell Biology and Cellular and Molecular Neuroscience, having authored 57 papers that have together received 3.3k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (41 papers), Parkinson's Disease Mechanisms and Treatments (13 papers), Prion Diseases and Protein Misfolding (10 papers), Lipid Membrane Structure and Behavior (8 papers), Amyotrophic Lateral Sclerosis Research (7 papers), Protein Structure and Dynamics (7 papers), Nerve injury and regeneration (4 papers) and Endoplasmic Reticulum Stress and Disease (4 papers). The work is most often cited by research in Physiology (1.6k citations), Neurology (841 citations), Neurology (259 citations), Biological Psychiatry (72 citations) and Aging (49 citations). Roberta Cascella has collaborated with scholars based in Italy, United Kingdom and Spain. Frequent co-authors include Cristina Cecchi, Fabrizio Chiti, Christopher M. Dobson, Giovanna Cenini, Ana Lloret, Nunilo Cremades, Serene W. Chen, Alessandra Bigi, Michele Vendruscolo and Elisa Evangelisti. Their work appears in journals such as Oncotarget, ACS Chemical Biology, Journal of Alzheimer s Disease, FEBS Journal and Free Radical Biology and Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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