Peter J. Brown

18.8k citations

152 papers · 10.6k · 3 hit papers · h-index 49

Impact in

Biochemistry top 0.2%
Molecular Biology top 0.5%
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer

Papers in

Molecular Biology 90
- Epigenetics and DNA Methylation 42
- Cancer-related gene regulation 39
- Histone Deacetylase Inhibitors Research 13
- Peroxisome Proliferator-Activated Receptors 11
- Genomics and Chromatin Dynamics 9
- Protein Degradation and Inhibitors 9
- RNA modifications and cancer 8
Organic Chemistry 15

Co-authors: Timothy M. Willson (12 shared papers)Daniel D. Sternbach (5 shared papers)Brad R. Henke (2 shared papers)Steven A. Kliewer (5 shared papers)Jürgen M. Lehmann (5 shared papers)G. Bruce Wisely (2 shared papers)Scott S. Sundseth (3 shared papers)Cecilia S. Koble (2 shared papers)
Journals: Journal of Medicinal Chemistry (25 papers)ACS Medicinal Chemistry Letters (6 papers)Journal of Reproductive Immunology (4 papers)Journal of the American Chemical Society (3 papers)MedChemComm (3 papers)
Partner nations: United States Canada United Kingdom

In The Last Decade

Peter J. Brown

150 papers receiving 10.1k citations

Peter J. Brown's Hit Papers

align trajectories log scale

The PPARs: From Orphan Receptors to Drug Discovery 2000 · 1.6k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2000 Journal of Medicinal Chemistry
1999 Molecular Cell
1997 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by Peter J. Brown

Since Specialization

Citations

This map shows the geographic impact of Peter J. Brown's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Peter J. Brown with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Peter J. Brown more than expected).

Fields of papers citing papers by Peter J. Brown

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Peter J. Brown. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Peter J. Brown. The network helps show where Peter J. Brown may publish in the future.

Co-authors

The 25 scholars most cited alongside Peter J. Brown, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Peter J. Brown Line = papers co-authored together Peter J. Brown links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 152 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ Proceedings of the National Academy of Sciences ·Steven A. Kliewer, Scott S. Sundseth, Stacey A. Jones, Peter J. Brown, G. Bruce Wisely, Cecilia S. Koble, Pallavi R. Devchand, Walter Wahli, Timothy M. Willson, James M. Lenhard, Jürgen M. Lehmann Hit paper breakdown →	1997	1888
2	The PPARs: From Orphan Receptors to Drug Discovery Journal of Medicinal Chemistry ·Timothy M. Willson, Peter J. Brown, Daniel D. Sternbach, Brad R. Henke Hit paper breakdown →	2000	1594
3	Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors Molecular Cell ·H. Eric Xu, Millard H. Lambert, Valerie G. Montana, Derek J. Parks, Steven G. Blanchard, Peter J. Brown, Daniel D. Sternbach, Jürgen M. Lehmann, G. Bruce Wisely, Timothy M. Willson, Steven A. Kliewer, Michael V. Milburn Hit paper breakdown →	1999	979
4	An Anthropological Perspective on Obesity Annals of the New York Academy of Sciences ·Peter J. Brown, Melvin Konner	1987	287
5	Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP Journal of Medicinal Chemistry ·Feng Liu, Dalia Baršytė-Lovejoy, Fengling Li, Yan Xiong, Victoria Korboukh, Xi‐Ping Huang, Abdellah Allali‐Hassani, William P. Janzen, Bryan L. Roth, Stephen V. Frye, C.H. Arrowsmith, Peter J. Brown, Masoud Vedadi, Jian Jin	2013	214
6	Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a Journal of Medicinal Chemistry ·Feng Liu, Xin Chen, Abdellah Allali‐Hassani, Amy Quinn, Gregory A. Wasney, Aiping Dong, Dalia Barsyte, I. Kozieradzki, Guillermo Senisterra, Irene Chau, Alena Siarheyeva, Dmitri Kireev, Ajit Jadhav, J. Martin Herold, Stephen V. Frye, C.H. Arrowsmith, Peter J. Brown, Anton Simeonov, Masoud Vedadi, Jian Jin	2009	207
7	A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases ACS Chemical Biology ·Mohammad S. Eram, Yudao Shen, Magdalena M. Szewczyk, Hong Wu, Guillermo Senisterra, Fengling Li, Kyle V. Butler, H. Ümit Kanıskan, Brandon A. Speed, Carlo dela Seña, Aiping Dong, Hong Zeng, Matthieu Schapira, Peter J. Brown, C.H. Arrowsmith, Dalia Baršytė-Lovejoy, Jing Liu, Masoud Vedadi, Jian Jin	2015	201
8	Activation of Peroxisome Proliferator–Activated Receptor-α Protects the Heart From Ischemia/Reperfusion Injury Circulation ·Tianli Yue, Weike Bao, Beat M. Jucker, Juan-Li Gu, Anne M. Romanic, Peter J. Brown, Jianqi Cui, Douglas T. Thudium, Rogely Boyce, Cynthia L. Burns-Kurtis, Rosanna C. Mirabile, Karpagam Aravindhan, Eliot H. Ohlstein	2003	171
9	Identification of a subtype selective human PPARα agonist through parallel-array synthesis Bioorganic & Medicinal Chemistry Letters ·Peter J. Brown, L. William Stuart, Kevin P. Hurley, Michael C. Lewis, Deborah A. Winegar, Joan G. Wilson, William O. Wilkison, Olivia Ittoop, Timothy M. Willson	2001	157
10	Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a ACS Medicinal Chemistry Letters ·Ramzi F. Sweis, Marina Pliushchev, Peter J. Brown, Jun Guo, Fengling Li, David Maag, Andrew M. Petros, Nirupama B. Soni, Chris Tse, Masoud Vedadi, Michael R. Michaelides, Gary G. Chiang, William N. Pappano	2014	157
11	The indole 2-3-quinodimethane strategy for the synthesis of indole alkaloids Accounts of Chemical Research ·Philip Magnus, Timothy Gallagher, Peter J. Brown, Paul Pappalardo	1984	148
12	Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines Journal of Medicinal Chemistry ·Feng Liu, Dalia Baršytė-Lovejoy, Abdellah Allali‐Hassani, Yunlong He, J. Martin Herold, Xin Chen, Christopher M. Yates, Stephen V. Frye, Peter J. Brown, Jing Huang, Masoud Vedadi, C.H. Arrowsmith, Jian Jin	2011	136
13	LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity ACS Medicinal Chemistry Letters ·Zahid Bonday, Guillermo S. Cortez, Michael J. Grogan, Stephen Antonysamy, Kenneth Weichert, Wayne P. Bocchinfuso, Fengling Li, (unknown), Binghui Li, Mary M. Mader, C.H. Arrowsmith, Peter J. Brown, Mohammad S. Eram, Magdalena M. Szewczyk, Dalia Baršytė-Lovejoy, Masoud Vedadi, Ernesto Guccione, Robert M. Campbell	2018	128
14	Identification of Novel Functionally Selective κ-Opioid Receptor Scaffolds Molecular Pharmacology ·Kate L. White, Alex Scopton, M. Rives, R. V. Bikbulatov, Prabhakar R. Polepally, Peter J. Brown, Terrance Kenakin, Jonathan A. Javitch, Jordan K. Zjawiony, Bryan L. Roth	2013	118
15	Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2 Journal of the American Chemical Society ·Weihong Zheng, Glorymar Ibáñez, Hong Wu, Gil Blum, Hong Zeng, Aiping Dong, Fengling Li, Taraneh Hajian, Abdellah Allali‐Hassani, M.F. Amaya, Alena Siarheyeva, Wenyu Yu, Peter J. Brown, Matthieu Schapira, Masoud Vedadi, Jinrong Min, Minkui Luo	2012	117
16	A Ureido-Thioisobutyric Acid (GW9578) Is a Subtype-Selective PPARα Agonist with Potent Lipid-Lowering Activity Journal of Medicinal Chemistry ·Peter J. Brown, Deborah A. Winegar, Kelli D. Plunket, Linda B. Moore, Michael C. Lewis, Joan G. Wilson, Scott S. Sundseth, Cecilia S. Koble, Zhendong Wu, James Chapman, Jürgen M. Lehmann, Steven A. Kliewer, Timothy M. Willson	1999	107
17	Synthesis of (.+-.)-10,22-dioxokopsane and (.+-.)-kopsanone, heptacyclic indole alkaloids. Synthetic and mechanistic studies Journal of the American Chemical Society ·Philip Magnus, Timothy Gallagher, Peter J. Brown, John C. Huffman	1984	105
18	Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1 eLife ·Joseph S. Harrison, Evan M. Cornett, Dennis Goldfarb, Paul A. DaRosa, Zimeng M. Li, Feng Yan, Bradley M. Dickson, Angela H. Guo, Daniel V Cantu, Lilia Kaustov, Peter J. Brown, C.H. Arrowsmith, Dorothy A. Erie, Michael B. Major, Rachel E. Klevit, Krzysztof Krajewski, Brian Kuhlman, Brian D. Strahl, Scott B. Rothbart	2016	104
19	Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations PLoS ONE ·Hong Wu, Hong Zeng, Aiping Dong, Fengling Li, Hao He, Guillermo Senisterra, Alma Seitova, Shili Duan, Peter J. Brown, Masoud Vedadi, C.H. Arrowsmith, Matthieu Schapira	2013	103
20	Small-Molecule Ligands of Methyl-Lysine Binding Proteins Journal of Medicinal Chemistry ·J. Martin Herold, Tim J. Wigle, Jacqueline L. Norris, Robert Lam, Victoria Korboukh, Cen Gao, Lindsey A. Ingerman, Dmitri Kireev, Guillermo Senisterra, Masoud Vedadi, Ashutosh Tripathy, Peter J. Brown, C.H. Arrowsmith, Jian Jin, William P. Janzen, Stephen V. Frye	2011	101

About Peter J. Brown

Peter J. Brown is a scholar working on Molecular Biology, Organic Chemistry, Hematology, Physiology and Radiology, Nuclear Medicine and Imaging, having authored 152 papers that have together received 10.6k indexed citations. Recurring topics across this work include Epigenetics and DNA Methylation (42 papers), Cancer-related gene regulation (39 papers), Histone Deacetylase Inhibitors Research (13 papers), Peroxisome Proliferator-Activated Receptors (11 papers), Monoclonal and Polyclonal Antibodies Research (9 papers), Genomics and Chromatin Dynamics (9 papers), Protein Degradation and Inhibitors (9 papers) and RNA modifications and cancer (8 papers). The work is most often cited by research in Biochemistry (872 citations), Molecular Biology (7.4k citations), Physiology (1.6k citations), Cancer Research (790 citations) and Pharmacology (723 citations). Peter J. Brown has collaborated with scholars based in United States, Canada and United Kingdom. Frequent co-authors include Timothy M. Willson, Daniel D. Sternbach, Brad R. Henke, Steven A. Kliewer, Jürgen M. Lehmann, G. Bruce Wisely, Scott S. Sundseth, Cecilia S. Koble, C.H. Arrowsmith and James M. Lenhard. Their work appears in journals such as Journal of Medicinal Chemistry, ACS Medicinal Chemistry Letters, Journal of Reproductive Immunology, Journal of the American Chemical Society and MedChemComm.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Peter J. Brown

Peter J. Brown's Hit Papers

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